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The map label for this gene is dapA

Identifier: 162147663

GI number: 162147663

Start: 1913819

End: 1914712

Strand: Direct

Name: dapA

Synonym: GDI_1879

Alternate gene names: 162147663

Gene position: 1913819-1914712 (Clockwise)

Preceding gene: 162147662

Following gene: 162147664

Centisome position: 48.52

GC content: 68.23

Gene sequence:

>894_bases
GTGGAAACGACCATGTTCAAGGGTTCGATCACGGCCCTGATTACGCCGATGAACGACGACGGATCGCTGGATTTTTCGGG
CTTCGGTCGCTTTGTCGACTGGCAGGTCACCGAAGGGTCGTCCGGCGTGGTCCCGGTGGGCACGACGGGCGAGAGCCCGA
CCCTGACCCACGAGGAACATGCCCGCATCGTCGAATACACCGTCCAGGTCGTGGCGGGCCGGATCCCGGTCATCGCGGGC
GCCGGATCGAACAGCACGGCCGAGGCCGTCGGCATGGCGCGGCATGCGAAGAGCGTGGGCGCGGACGGCGTGCTGGTCGT
GGCGCCGTACTACAACAAGCCGACGCAGGAAGGGCTGTATCGCCATTTCATGACGGTGGCCGACGCCACGGACCTGCCGC
TGATCATCTACAACATTCCCGGACGGTCGGTCGTCGATATCTCGGTCGAGACCATGGCCCGCATGGCGCAGCATGCGCGC
ATCGTGGGCGTCAAGGACGCGACGGCCAACCTGTTGCGCCCGCTGCAGGTGCGCCGCGCGATCCGCCACAAGCCGTTCAC
CCAGTTGTCGGGCGAGGACGGGACCGTGGTGTCGTTCCTGGCCGCCGGAGGGGAAGGGTGCATCAGCGTCACCTCGAACA
TCGCACCGCGCCTGTGCGCGGAACTGCATCGCGCCTGGCAGGACGGGCGGGTGGCCGACGCCATGGCCATCCAGGACCGG
CTGTCGGCGGTGCATGATGCCCTGTTCTGCGAGAGCAATCCGGGCCCGGTGAAATACGCCGCCAGCCTGCTGGGCCTGGC
CGGCGAGACCTGCCGCCTGCCGCTGGCCCCGCTGGCCGAGGACTCCCGCATGCGGGTGCGTGAGGCGCTGACCGGCGCGG
GGCTGTTGAACTAG

Upstream 100 bases:

>100_bases
GGGCGATGGATGGTTGCCTTGCCATGTCGCCCGGCATTAACAGAACAGGCAGGACGGCCATCTGCCGGGAACGGCCCATT
TTTCAGACTGCGAGATTCGA

Downstream 100 bases:

>100_bases
CATCATGGCGGAAAAGAAAAAGAGCGGCATGATTTCGACCGGGATCGCGGCGCAGAACCGCAAGGGCCGCTTCAACTACA
CGATCCTGGAAACGCTGGAA

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
METTMFKGSITALITPMNDDGSLDFSGFGRFVDWQVTEGSSGVVPVGTTGESPTLTHEEHARIVEYTVQVVAGRIPVIAG
AGSNSTAEAVGMARHAKSVGADGVLVVAPYYNKPTQEGLYRHFMTVADATDLPLIIYNIPGRSVVDISVETMARMAQHAR
IVGVKDATANLLRPLQVRRAIRHKPFTQLSGEDGTVVSFLAAGGEGCISVTSNIAPRLCAELHRAWQDGRVADAMAIQDR
LSAVHDALFCESNPGPVKYAASLLGLAGETCRLPLAPLAEDSRMRVREALTGAGLLN

Sequences:

>Translated_297_residues
METTMFKGSITALITPMNDDGSLDFSGFGRFVDWQVTEGSSGVVPVGTTGESPTLTHEEHARIVEYTVQVVAGRIPVIAG
AGSNSTAEAVGMARHAKSVGADGVLVVAPYYNKPTQEGLYRHFMTVADATDLPLIIYNIPGRSVVDISVETMARMAQHAR
IVGVKDATANLLRPLQVRRAIRHKPFTQLSGEDGTVVSFLAAGGEGCISVTSNIAPRLCAELHRAWQDGRVADAMAIQDR
LSAVHDALFCESNPGPVKYAASLLGLAGETCRLPLAPLAEDSRMRVREALTGAGLLN
>Mature_297_residues
METTMFKGSITALITPMNDDGSLDFSGFGRFVDWQVTEGSSGVVPVGTTGESPTLTHEEHARIVEYTVQVVAGRIPVIAG
AGSNSTAEAVGMARHAKSVGADGVLVVAPYYNKPTQEGLYRHFMTVADATDLPLIIYNIPGRSVVDISVETMARMAQHAR
IVGVKDATANLLRPLQVRRAIRHKPFTQLSGEDGTVVSFLAAGGEGCISVTSNIAPRLCAELHRAWQDGRVADAMAIQDR
LSAVHDALFCESNPGPVKYAASLLGLAGETCRLPLAPLAEDSRMRVREALTGAGLLN

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=257, Percent_Identity=28.7937743190661, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI13540533, Length=238, Percent_Identity=29.8319327731092, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1788823, Length=293, Percent_Identity=46.0750853242321, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI87082415, Length=298, Percent_Identity=31.8791946308725, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1786463, Length=243, Percent_Identity=32.0987654320988, Blast_Score=141, Evalue=6e-35,
Organism=Escherichia coli, GI1789620, Length=279, Percent_Identity=27.9569892473118, Blast_Score=114, Evalue=6e-27,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_GLUDA (A9HIW2)

Other databases:

- EMBL:   AM889285
- EMBL:   CP001189
- RefSeq:   YP_001602124.1
- RefSeq:   YP_002274518.1
- ProteinModelPortal:   A9HIW2
- SMR:   A9HIW2
- GeneID:   5791524
- GeneID:   6973494
- GenomeReviews:   AM889285_GR
- GenomeReviews:   CP001189_GR
- KEGG:   gdj:Gdia_0103
- HOGENOM:   HBG358848
- OMA:   SGEDMTA
- ProtClustDB:   PRK03170
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 31539; Mature: 31539

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 165-165 BINDING 110-110

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METTMFKGSITALITPMNDDGSLDFSGFGRFVDWQVTEGSSGVVPVGTTGESPTLTHEEH
CCCEEECCCEEEEEEECCCCCCEECCCCCCEEEEEEECCCCCEEEECCCCCCCCCCHHHH
ARIVEYTVQVVAGRIPVIAGAGSNSTAEAVGMARHAKSVGADGVLVVAPYYNKPTQEGLY
HHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHH
RHFMTVADATDLPLIIYNIPGRSVVDISVETMARMAQHARIVGVKDATANLLRPLQVRRA
HHHHHHCCCCCCCEEEEECCCCEEEEEEHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHH
IRHKPFTQLSGEDGTVVSFLAAGGEGCISVTSNIAPRLCAELHRAWQDGRVADAMAIQDR
HHCCCCCCCCCCCCCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LSAVHDALFCESNPGPVKYAASLLGLAGETCRLPLAPLAEDSRMRVREALTGAGLLN
HHHHHHHHEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure
METTMFKGSITALITPMNDDGSLDFSGFGRFVDWQVTEGSSGVVPVGTTGESPTLTHEEH
CCCEEECCCEEEEEEECCCCCCEECCCCCCEEEEEEECCCCCEEEECCCCCCCCCCHHHH
ARIVEYTVQVVAGRIPVIAGAGSNSTAEAVGMARHAKSVGADGVLVVAPYYNKPTQEGLY
HHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHH
RHFMTVADATDLPLIIYNIPGRSVVDISVETMARMAQHARIVGVKDATANLLRPLQVRRA
HHHHHHCCCCCCCEEEEECCCCEEEEEEHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHH
IRHKPFTQLSGEDGTVVSFLAAGGEGCISVTSNIAPRLCAELHRAWQDGRVADAMAIQDR
HHCCCCCCCCCCCCCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LSAVHDALFCESNPGPVKYAASLLGLAGETCRLPLAPLAEDSRMRVREALTGAGLLN
HHHHHHHHEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA