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The map label for this gene is mip [H]

Identifier: 162147640

GI number: 162147640

Start: 1893946

End: 1894443

Strand: Reverse

Name: mip [H]

Synonym: GDI_1856

Alternate gene names: 162147640

Gene position: 1894443-1893946 (Counterclockwise)

Preceding gene: 162147641

Following gene: 162147639

Centisome position: 48.03

GC content: 64.86

Gene sequence:

>498_bases
ATGAAACGTCTGTCCCGCTTCATTCCCCTCCTTCTCGCTTCTTCCCTGGCCCTGCCGCTGGCGGCCTGCGGGGGGAGCCG
CCCCGAGGAATACAAGCCGGAGATGACCCCGGCGCAATTCATGGCCAAGGTCCGGGCCGAGCCCGGCGTCCAGTCGCTGC
CCGACGGCCTGGCCTACAAGGTCCTGAAATCCGGCCCCAAGGACGGGCAGAGCCCCGTTCCGGGCGATGTCATGATGGTG
ATCTACGAAGGCCGCCTGCCCGAAGGCGGCATCTTCGACAGTTCGGACCAGCACGGCCAGGGCGCCTATATGCAGATGCC
GCTGGACGGCGTCATCAAGGGCTGGATGGAAGGCCTGCCGCTGATGCATGTCGGCGATATCTGGATGCTCTACGTTCCGC
CGGAACTGGGGTATGGCCATCGCTCGATGGGCATCATCCCGGCGGACAGCCCGCTGGTCTTCAAGATCCAGCTTCTGGGT
GTCTCCAAGCCGCAGTAG

Upstream 100 bases:

>100_bases
CCTGCGTCTGCGTCTGGGCGCGCAGATCGGACGGCGCGGCGGCGCGCTGTAGGATCGCGTCCCGCATGTCGTTCCATTCG
TCCTGTCTGACCGAGGTGTC

Downstream 100 bases:

>100_bases
CCGGCATGTCCCCCCGGACCGGACGGCTTGACCGGACGGGGGGAAACGCCTGAAAAGAACGGCCATGCAACGCATCTTTT
CCGGCATTCAGCCGACCGGC

Product: peptidyl-prolyl cis-trans isomerase Mip

Products: NA

Alternate protein names: PPIase; Macrophage infectivity potentiator; Rotamase [H]

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MKRLSRFIPLLLASSLALPLAACGGSRPEEYKPEMTPAQFMAKVRAEPGVQSLPDGLAYKVLKSGPKDGQSPVPGDVMMV
IYEGRLPEGGIFDSSDQHGQGAYMQMPLDGVIKGWMEGLPLMHVGDIWMLYVPPELGYGHRSMGIIPADSPLVFKIQLLG
VSKPQ

Sequences:

>Translated_165_residues
MKRLSRFIPLLLASSLALPLAACGGSRPEEYKPEMTPAQFMAKVRAEPGVQSLPDGLAYKVLKSGPKDGQSPVPGDVMMV
IYEGRLPEGGIFDSSDQHGQGAYMQMPLDGVIKGWMEGLPLMHVGDIWMLYVPPELGYGHRSMGIIPADSPLVFKIQLLG
VSKPQ
>Mature_165_residues
MKRLSRFIPLLLASSLALPLAACGGSRPEEYKPEMTPAQFMAKVRAEPGVQSLPDGLAYKVLKSGPKDGQSPVPGDVMMV
IYEGRLPEGGIFDSSDQHGQGAYMQMPLDGVIKGWMEGLPLMHVGDIWMLYVPPELGYGHRSMGIIPADSPLVFKIQLLG
VSKPQ

Specific function: May be an essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Secreted (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI8923659, Length=90, Percent_Identity=41.1111111111111, Blast_Score=66, Evalue=1e-11,
Organism=Escherichia coli, GI87082390, Length=124, Percent_Identity=40.3225806451613, Blast_Score=88, Evalue=2e-19,
Organism=Escherichia coli, GI1789745, Length=123, Percent_Identity=39.0243902439024, Blast_Score=83, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324194, Length=105, Percent_Identity=38.0952380952381, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320727, Length=90, Percent_Identity=41.1111111111111, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008104
- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 17877; Mature: 17877

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
6.7 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
6.7 %Met     (Mature Protein)
7.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLSRFIPLLLASSLALPLAACGGSRPEEYKPEMTPAQFMAKVRAEPGVQSLPDGLAYK
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHH
VLKSGPKDGQSPVPGDVMMVIYEGRLPEGGIFDSSDQHGQGAYMQMPLDGVIKGWMEGLP
HHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHCCCC
LMHVGDIWMLYVPPELGYGHRSMGIIPADSPLVFKIQLLGVSKPQ
EEEECCEEEEEECCCCCCCCCCCCEEECCCCEEEEEEEECCCCCC
>Mature Secondary Structure
MKRLSRFIPLLLASSLALPLAACGGSRPEEYKPEMTPAQFMAKVRAEPGVQSLPDGLAYK
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHH
VLKSGPKDGQSPVPGDVMMVIYEGRLPEGGIFDSSDQHGQGAYMQMPLDGVIKGWMEGLP
HHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHCCCC
LMHVGDIWMLYVPPELGYGHRSMGIIPADSPLVFKIQLLGVSKPQ
EEEECCEEEEEECCCCCCCCCCCCEEECCCCEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8535514; 12704232 [H]