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The map label for this gene is guaB [H]

Identifier: 162147595

GI number: 162147595

Start: 1843325

End: 1844827

Strand: Direct

Name: guaB [H]

Synonym: GDI_1811

Alternate gene names: 162147595

Gene position: 1843325-1844827 (Clockwise)

Preceding gene: 162147593

Following gene: 162147596

Centisome position: 46.74

GC content: 68.33

Gene sequence:

>1503_bases
ATGTCTTCGCCCCATAATCCGCTATCCCATCCGCGCGTCGACGATCGCATCCGCGAGGCGCTGGCGTTCGACGACGTTCT
GGTCGTCCCGGCGGAATCCAATGTCCTGCCCGGACAGACCTCGACGAAAAGCCGCCTGACGCGCCGCATCGGCCTGAATA
TCCCGCTGATTTCCTCGGCCATGGACACGGTGACCGAGGACGCGATGGCCATCGCCATGGCGCAGCAGGGCGGCATGGGC
GTGATCCACAAGAATCTGAGCGTCGAGGAACAGGCCGAGCAGGTCCGGCGCGTGAAGCGTTTCGAATCCGGCATGGTCGT
CAATCCGGTGACGGTGTGGCCCGACCAGACCCTGGCCGACGTCAATGCGATCATGTCGCGCCACGGCATCAGCGGCCTGC
CGGTGATCGAGCGCGAGACCAAGCGGCTGGTCGGCATGCTGACCAACCGCGACGTCCGCTTCGCCACCGATCCCGCCCTG
CGCGTGGATTCGCTGATGACGCGGGAAAACCTGGTGACCGTCGGCGCCGATGTCGGCCACGACCAGGCGCGGCAGTTGCT
GCACCGCCACCGGATCGAGAAGCTGCTGGTAGTCGATGACGAAGGGCGCTGCGTCGGACTGATCACCGTCAAGGACATCG
AAAAGGCGGTCCTGCACCCGCTGGCCAACAAGGATGAGATGGGGCGCCTGCGCTGCGCCGCCGCGACCGGCGTGGGCGAG
GACGGGTTCACCCGCGCCCGGGCGCTGATCGAGGCCGGGGTGGATGTCGTGGTCGTCGATACCGCGCACGGCCATTCCTC
GGGCGTGCTGGACACGGTGGCGCGGGTCAAGGCGGTGGATGACCGGATCCAGGTCGTCGCCGGCAACGTCGCGACGCCCG
AGGCCGCCGTGGCGCTGATCGAGGCCGGGGCCGACTGCGTGAAGATCGGCATCGGCCCGGGGTCGATCTGCACCACGCGG
GTCGTGGCCGGCGTGGGCGTGCCGCAGTTCAGCGCGGTGCTGGAAACCTCGGCCGCGTGCCATGAGCTGGACGTGCCAGC
CATCGCCGATGGCGGCATACGGACGTCGGGCGACATCGTCAAGGCGATCGGGGCCGGGGCGGACGTGGTCATGATCGGCT
CGCTGCTGGCCGGGACCGAGGAAGCGCCGGGCGAGGTGTTCCTGTATGAAGGCCGGTCCTACAAATCCTATCGCGGGATG
GGCAGCCTGGGCGCCATGGCGCGCGGCTCGGCGGACCGGTATTTCCAGCAGGAGATCAAGGAAACCCACAAGATGGTCCC
CGAGGGGATCGAGGGGCGCGTCGCCTACAAGGGCGGCATGGACGCCGTGGTGCACCAACTGGTCGGTGGCCTGCGCGCCG
GCATGGGCTATACCGGGTCGGCCACGATCGCGGACCTGCAGGTTCGTGCGCGTTTCCGCCGCATCACGGGGGCGGGACTG
CGCGAAAGCCACGTCCATGACGTGGCGATCACGCGCGAGGCGCCGAATTACCGCCGCGACTGA

Upstream 100 bases:

>100_bases
TTTCCTTGCCACGACCCGATTCGCATCTTATGTGGAAGCGCCAACGGTCGGGTACCCGAGGCTCTGGGACCCATGCAATG
GTTGATGAGGTTCCAGAACG

Downstream 100 bases:

>100_bases
TAGGACCGACATGACCCCCAGTGCGCGGCTCGCCGCCGCGATCGATCTGCTGTCGGCGATGGAGGCCACGCCCCGTCGCC
CGGCGGATGCCGTCGCCAAT

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MSSPHNPLSHPRVDDRIREALAFDDVLVVPAESNVLPGQTSTKSRLTRRIGLNIPLISSAMDTVTEDAMAIAMAQQGGMG
VIHKNLSVEEQAEQVRRVKRFESGMVVNPVTVWPDQTLADVNAIMSRHGISGLPVIERETKRLVGMLTNRDVRFATDPAL
RVDSLMTRENLVTVGADVGHDQARQLLHRHRIEKLLVVDDEGRCVGLITVKDIEKAVLHPLANKDEMGRLRCAAATGVGE
DGFTRARALIEAGVDVVVVDTAHGHSSGVLDTVARVKAVDDRIQVVAGNVATPEAAVALIEAGADCVKIGIGPGSICTTR
VVAGVGVPQFSAVLETSAACHELDVPAIADGGIRTSGDIVKAIGAGADVVMIGSLLAGTEEAPGEVFLYEGRSYKSYRGM
GSLGAMARGSADRYFQQEIKETHKMVPEGIEGRVAYKGGMDAVVHQLVGGLRAGMGYTGSATIADLQVRARFRRITGAGL
RESHVHDVAITREAPNYRRD

Sequences:

>Translated_500_residues
MSSPHNPLSHPRVDDRIREALAFDDVLVVPAESNVLPGQTSTKSRLTRRIGLNIPLISSAMDTVTEDAMAIAMAQQGGMG
VIHKNLSVEEQAEQVRRVKRFESGMVVNPVTVWPDQTLADVNAIMSRHGISGLPVIERETKRLVGMLTNRDVRFATDPAL
RVDSLMTRENLVTVGADVGHDQARQLLHRHRIEKLLVVDDEGRCVGLITVKDIEKAVLHPLANKDEMGRLRCAAATGVGE
DGFTRARALIEAGVDVVVVDTAHGHSSGVLDTVARVKAVDDRIQVVAGNVATPEAAVALIEAGADCVKIGIGPGSICTTR
VVAGVGVPQFSAVLETSAACHELDVPAIADGGIRTSGDIVKAIGAGADVVMIGSLLAGTEEAPGEVFLYEGRSYKSYRGM
GSLGAMARGSADRYFQQEIKETHKMVPEGIEGRVAYKGGMDAVVHQLVGGLRAGMGYTGSATIADLQVRARFRRITGAGL
RESHVHDVAITREAPNYRRD
>Mature_499_residues
SSPHNPLSHPRVDDRIREALAFDDVLVVPAESNVLPGQTSTKSRLTRRIGLNIPLISSAMDTVTEDAMAIAMAQQGGMGV
IHKNLSVEEQAEQVRRVKRFESGMVVNPVTVWPDQTLADVNAIMSRHGISGLPVIERETKRLVGMLTNRDVRFATDPALR
VDSLMTRENLVTVGADVGHDQARQLLHRHRIEKLLVVDDEGRCVGLITVKDIEKAVLHPLANKDEMGRLRCAAATGVGED
GFTRARALIEAGVDVVVVDTAHGHSSGVLDTVARVKAVDDRIQVVAGNVATPEAAVALIEAGADCVKIGIGPGSICTTRV
VAGVGVPQFSAVLETSAACHELDVPAIADGGIRTSGDIVKAIGAGADVVMIGSLLAGTEEAPGEVFLYEGRSYKSYRGMG
SLGAMARGSADRYFQQEIKETHKMVPEGIEGRVAYKGGMDAVVHQLVGGLRAGMGYTGSATIADLQVRARFRRITGAGLR
ESHVHDVAITREAPNYRRD

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=480, Percent_Identity=40.2083333333333, Blast_Score=322, Evalue=7e-88,
Organism=Homo sapiens, GI66933016, Length=484, Percent_Identity=39.2561983471074, Blast_Score=322, Evalue=7e-88,
Organism=Homo sapiens, GI156616279, Length=480, Percent_Identity=40.2083333333333, Blast_Score=321, Evalue=9e-88,
Organism=Homo sapiens, GI34328928, Length=480, Percent_Identity=40.2083333333333, Blast_Score=321, Evalue=9e-88,
Organism=Homo sapiens, GI34328930, Length=480, Percent_Identity=40.2083333333333, Blast_Score=321, Evalue=9e-88,
Organism=Homo sapiens, GI217035152, Length=484, Percent_Identity=40.495867768595, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI217035148, Length=480, Percent_Identity=39.375, Blast_Score=307, Evalue=2e-83,
Organism=Homo sapiens, GI217035150, Length=480, Percent_Identity=37.5, Blast_Score=282, Evalue=6e-76,
Organism=Homo sapiens, GI156104880, Length=248, Percent_Identity=38.7096774193548, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI50541954, Length=248, Percent_Identity=38.7096774193548, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI50541952, Length=248, Percent_Identity=38.7096774193548, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI50541948, Length=248, Percent_Identity=38.7096774193548, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI50541956, Length=258, Percent_Identity=38.3720930232558, Blast_Score=162, Evalue=6e-40,
Organism=Escherichia coli, GI1788855, Length=482, Percent_Identity=57.0539419087137, Blast_Score=502, Evalue=1e-143,
Organism=Escherichia coli, GI1786293, Length=245, Percent_Identity=36.3265306122449, Blast_Score=151, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI71994385, Length=502, Percent_Identity=37.4501992031873, Blast_Score=273, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI71994389, Length=427, Percent_Identity=39.5784543325527, Blast_Score=264, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI17560440, Length=278, Percent_Identity=35.9712230215827, Blast_Score=169, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6323585, Length=492, Percent_Identity=38.0081300813008, Blast_Score=328, Evalue=1e-90,
Organism=Saccharomyces cerevisiae, GI6322012, Length=490, Percent_Identity=37.1428571428571, Blast_Score=327, Evalue=3e-90,
Organism=Saccharomyces cerevisiae, GI6323464, Length=491, Percent_Identity=38.0855397148676, Blast_Score=320, Evalue=3e-88,
Organism=Saccharomyces cerevisiae, GI6319352, Length=345, Percent_Identity=37.9710144927536, Blast_Score=251, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6319353, Length=128, Percent_Identity=34.375, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24641071, Length=481, Percent_Identity=37.8378378378378, Blast_Score=301, Evalue=7e-82,
Organism=Drosophila melanogaster, GI24641073, Length=481, Percent_Identity=37.8378378378378, Blast_Score=301, Evalue=7e-82,
Organism=Drosophila melanogaster, GI28571163, Length=439, Percent_Identity=38.496583143508, Blast_Score=275, Evalue=6e-74,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 53323; Mature: 53192

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPHNPLSHPRVDDRIREALAFDDVLVVPAESNVLPGQTSTKSRLTRRIGLNIPLISSA
CCCCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCCHHHHH
MDTVTEDAMAIAMAQQGGMGVIHKNLSVEEQAEQVRRVKRFESGMVVNPVTVWPDQTLAD
HHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCEECCEEECCCHHHHH
VNAIMSRHGISGLPVIERETKRLVGMLTNRDVRFATDPALRVDSLMTRENLVTVGADVGH
HHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHCCEEEECCCCCH
DQARQLLHRHRIEKLLVVDDEGRCVGLITVKDIEKAVLHPLANKDEMGRLRCAAATGVGE
HHHHHHHHHHCCCEEEEECCCCCEEEEEEHHHHHHHHHHHCCCCCCCCCEEEEEECCCCC
DGFTRARALIEAGVDVVVVDTAHGHSSGVLDTVARVKAVDDRIQVVAGNVATPEAAVALI
CHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHH
EAGADCVKIGIGPGSICTTRVVAGVGVPQFSAVLETSAACHELDVPAIADGGIRTSGDIV
HCCCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHH
KAIGAGADVVMIGSLLAGTEEAPGEVFLYEGRSYKSYRGMGSLGAMARGSADRYFQQEIK
HHHCCCCCHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHCCCHHHHHHHHHH
ETHKMVPEGIEGRVAYKGGMDAVVHQLVGGLRAGMGYTGSATIADLQVRARFRRITGAGL
HHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCC
RESHVHDVAITREAPNYRRD
CCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure 
SSPHNPLSHPRVDDRIREALAFDDVLVVPAESNVLPGQTSTKSRLTRRIGLNIPLISSA
CCCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCCHHHHH
MDTVTEDAMAIAMAQQGGMGVIHKNLSVEEQAEQVRRVKRFESGMVVNPVTVWPDQTLAD
HHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCEECCEEECCCHHHHH
VNAIMSRHGISGLPVIERETKRLVGMLTNRDVRFATDPALRVDSLMTRENLVTVGADVGH
HHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHCCEEEECCCCCH
DQARQLLHRHRIEKLLVVDDEGRCVGLITVKDIEKAVLHPLANKDEMGRLRCAAATGVGE
HHHHHHHHHHCCCEEEEECCCCCEEEEEEHHHHHHHHHHHCCCCCCCCCEEEEEECCCCC
DGFTRARALIEAGVDVVVVDTAHGHSSGVLDTVARVKAVDDRIQVVAGNVATPEAAVALI
CHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHH
EAGADCVKIGIGPGSICTTRVVAGVGVPQFSAVLETSAACHELDVPAIADGGIRTSGDIV
HCCCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHH
KAIGAGADVVMIGSLLAGTEEAPGEVFLYEGRSYKSYRGMGSLGAMARGSADRYFQQEIK
HHHCCCCCHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHCCCHHHHHHHHHH
ETHKMVPEGIEGRVAYKGGMDAVVHQLVGGLRAGMGYTGSATIADLQVRARFRRITGAGL
HHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCC
RESHVHDVAITREAPNYRRD
CCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA