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The map label for this gene is glmU

Identifier: 162147561

GI number: 162147561

Start: 1806268

End: 1807653

Strand: Direct

Name: glmU

Synonym: GDI_1777

Alternate gene names: 162147561

Gene position: 1806268-1807653 (Clockwise)

Preceding gene: 162147559

Following gene: 162147562

Centisome position: 45.8

GC content: 71.43

Gene sequence:

>1386_bases
ATGAATGCCACCGTCCCGTCCGCGGCGCCCGCTGACCTGCCCGCCCATCGTCCCGCCACCGCCGTCATCCTGGCGGCCGG
GATGGGGACGCGCATGAAGTCCGATCGTCCGAAGGTGATGCACCCGCTGGCCGGGCAGCCGATGCTGCGCTACCTGCTGG
ACAATGCCGCCTCGGTCTTCGACCGGATCGTCGTCGTGGTCGGGCCGGGCATGGAGCAGGTCGCCGCCCTGGCCGCGCCG
CACGCCGTCGTGGTGCAGCAGGACAGGCTGGGCACCGCCCACGCGGCGGCCCAGGCCGCGGACCTGTTCGGGACCGGCGA
TGTCGCGGTCCTGTATGGCGACAACCCGCTGATCACGGCGGACAGCATGCGCCGCATGCTGGCGTGCCGGGCGGGCGAGG
GGAACAGCGAGGGGGCGGGCCTGGCCCTGATGGCCATGCGGCCGCGCGATCCCGGACGCTATGGCCGCGTGGTGACGCAG
GACGGGCTGGTCCGGCGCATCGTCGAATGGGCTGACGCGTCGGACGAGGAGCGGGCGATCACCCTGTGCAATGCCGGCGT
GCTGTGCGCGGGGGCGGAGGATTTCCGCCGCTGGCTGGGTGCCGTGCGCAACGATAACGCCCAGGGCGAGTATTATCTGG
GCGACGTGGTGGCCATGGCGGTGGCCGAAGGACGGCAGGTCCGTGCCGTCGAAGCACCCGAGGACGAGTTGCGCGGCATC
AATTCCCGTGCCGAACTGGCCGAGGCCGAAGCCTGCGTGCAGCGCCGGCTGCGCGCCGCGGCGCTGGATGGCGGGGCGAC
GCTGGTGGCGCCCGAAACGGTGTTCCTGGCCGCCGACACGGTGCTGGAACCCGACGTTCTGGTCCAGCCCCATGTCGTCT
TCGGGCCGGGCGTGACGGTGCGGCGGGGGGCGGAAATCCGCGCCTTCAGTCATCTGGAAGGCTGCGTGGTCGGGCCGGGG
GCGCTGATCGGCCCCTATGCGCGGCTGCGGCCGGGCAGCGATGTCGGGGCCGCCGCCCATGTCGGCAATTTCGTCGAACT
GAAGGCCACGACCCTGGGGGCGGGGGCGAAGGCCAATCACCTGTCCTATCTGGGCGATGCGACGATCGGCCCGGCGACGA
ATATCGGCGCGGGCACGATCACGTGCAATTATGACGGGGTGTTCAAGCACCGGACGGACATCGGCGCGGGATGCTTCGTG
GGATCGAACGCGATTCTGGTCGCCCCCGTCAGCATCGGCGACGGCGCGCTGGTTGCCGCCGGCAGCGTCATCACCCAGGA
CGTGCTGCCCGACGCCATGGCGCTGGGCCGGGCCCGGCAGACGAACAAGGACGGACGCGGGGCCAGCTTGCAGGCGGCGC
TGCGCAGGAAGAAGGAACAGGGCTGA

Upstream 100 bases:

>100_bases
TGGGCGATGCGATCGATCGCAGTATTTCGTAAACCTAAGTGATGCTCATGCATTGCGCCAAGGTTTGACAGGTCCGATGC
CCGCCCGCTACCCGCATGCC

Downstream 100 bases:

>100_bases
TGTGCGGCATTGTCGGCGTCGTCGGGTGCAAGTGTGCGACCCCGGTCATCTTCGACGCCCTGCGGCGGCTGGAATATCGC
GGCTATGATTCCGCCGGGAT

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MNATVPSAAPADLPAHRPATAVILAAGMGTRMKSDRPKVMHPLAGQPMLRYLLDNAASVFDRIVVVVGPGMEQVAALAAP
HAVVVQQDRLGTAHAAAQAADLFGTGDVAVLYGDNPLITADSMRRMLACRAGEGNSEGAGLALMAMRPRDPGRYGRVVTQ
DGLVRRIVEWADASDEERAITLCNAGVLCAGAEDFRRWLGAVRNDNAQGEYYLGDVVAMAVAEGRQVRAVEAPEDELRGI
NSRAELAEAEACVQRRLRAAALDGGATLVAPETVFLAADTVLEPDVLVQPHVVFGPGVTVRRGAEIRAFSHLEGCVVGPG
ALIGPYARLRPGSDVGAAAHVGNFVELKATTLGAGAKANHLSYLGDATIGPATNIGAGTITCNYDGVFKHRTDIGAGCFV
GSNAILVAPVSIGDGALVAAGSVITQDVLPDAMALGRARQTNKDGRGASLQAALRRKKEQG

Sequences:

>Translated_461_residues
MNATVPSAAPADLPAHRPATAVILAAGMGTRMKSDRPKVMHPLAGQPMLRYLLDNAASVFDRIVVVVGPGMEQVAALAAP
HAVVVQQDRLGTAHAAAQAADLFGTGDVAVLYGDNPLITADSMRRMLACRAGEGNSEGAGLALMAMRPRDPGRYGRVVTQ
DGLVRRIVEWADASDEERAITLCNAGVLCAGAEDFRRWLGAVRNDNAQGEYYLGDVVAMAVAEGRQVRAVEAPEDELRGI
NSRAELAEAEACVQRRLRAAALDGGATLVAPETVFLAADTVLEPDVLVQPHVVFGPGVTVRRGAEIRAFSHLEGCVVGPG
ALIGPYARLRPGSDVGAAAHVGNFVELKATTLGAGAKANHLSYLGDATIGPATNIGAGTITCNYDGVFKHRTDIGAGCFV
GSNAILVAPVSIGDGALVAAGSVITQDVLPDAMALGRARQTNKDGRGASLQAALRRKKEQG
>Mature_461_residues
MNATVPSAAPADLPAHRPATAVILAAGMGTRMKSDRPKVMHPLAGQPMLRYLLDNAASVFDRIVVVVGPGMEQVAALAAP
HAVVVQQDRLGTAHAAAQAADLFGTGDVAVLYGDNPLITADSMRRMLACRAGEGNSEGAGLALMAMRPRDPGRYGRVVTQ
DGLVRRIVEWADASDEERAITLCNAGVLCAGAEDFRRWLGAVRNDNAQGEYYLGDVVAMAVAEGRQVRAVEAPEDELRGI
NSRAELAEAEACVQRRLRAAALDGGATLVAPETVFLAADTVLEPDVLVQPHVVFGPGVTVRRGAEIRAFSHLEGCVVGPG
ALIGPYARLRPGSDVGAAAHVGNFVELKATTLGAGAKANHLSYLGDATIGPATNIGAGTITCNYDGVFKHRTDIGAGCFV
GSNAILVAPVSIGDGALVAAGSVITQDVLPDAMALGRARQTNKDGRGASLQAALRRKKEQG

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=448, Percent_Identity=40.4017857142857, Blast_Score=316, Evalue=3e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_GLUDA (A9HI46)

Other databases:

- EMBL:   AM889285
- EMBL:   CP001189
- RefSeq:   YP_001602022.1
- RefSeq:   YP_002274424.1
- ProteinModelPortal:   A9HI46
- SMR:   A9HI46
- GeneID:   5790030
- GeneID:   6973395
- GenomeReviews:   AM889285_GR
- GenomeReviews:   CP001189_GR
- KEGG:   gdj:Gdia_0007
- HOGENOM:   HBG688195
- OMA:   MERTCLA
- ProtClustDB:   PRK14353
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 47793; Mature: 47793

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 360-360 BINDING 86-86 BINDING 155-155 BINDING 169-169 BINDING 184-184 BINDING 384-384 BINDING 402-402 BINDING 420-420 BINDING 437-437

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNATVPSAAPADLPAHRPATAVILAAGMGTRMKSDRPKVMHPLAGQPMLRYLLDNAASVF
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
DRIVVVVGPGMEQVAALAAPHAVVVQQDRLGTAHAAAQAADLFGTGDVAVLYGDNPLITA
HEEEEEECCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCEEEH
DSMRRMLACRAGEGNSEGAGLALMAMRPRDPGRYGRVVTQDGLVRRIVEWADASDEERAI
HHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCEECCCHHHHHHHHHHCCCCCCCEE
TLCNAGVLCAGAEDFRRWLGAVRNDNAQGEYYLGDVVAMAVAEGRQVRAVEAPEDELRGI
EEECCCEEEECHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHCCCEEEEECCCHHHHHCC
NSRAELAEAEACVQRRLRAAALDGGATLVAPETVFLAADTVLEPDVLVQPHVVFGPGVTV
CCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCEEEEEECCCCCCCCEECCEEEECCCCEE
RRGAEIRAFSHLEGCVVGPGALIGPYARLRPGSDVGAAAHVGNFVELKATTLGAGAKANH
ECCCCEEEHHCCCCEEECCCHHHCCHHHCCCCCCCCHHHHCCCEEEEEEEEECCCCCCCC
LSYLGDATIGPATNIGAGTITCNYDGVFKHRTDIGAGCFVGSNAILVAPVSIGDGALVAA
HHCCCCCCCCCCCCCCCEEEEECCCCCEEECCCCCCCEEECCCEEEEEEEECCCCCEEEC
GSVITQDVLPDAMALGRARQTNKDGRGASLQAALRRKKEQG
CHHHHHHHHHHHHHHCCHHCCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MNATVPSAAPADLPAHRPATAVILAAGMGTRMKSDRPKVMHPLAGQPMLRYLLDNAASVF
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
DRIVVVVGPGMEQVAALAAPHAVVVQQDRLGTAHAAAQAADLFGTGDVAVLYGDNPLITA
HEEEEEECCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCEEEH
DSMRRMLACRAGEGNSEGAGLALMAMRPRDPGRYGRVVTQDGLVRRIVEWADASDEERAI
HHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCEECCCHHHHHHHHHHCCCCCCCEE
TLCNAGVLCAGAEDFRRWLGAVRNDNAQGEYYLGDVVAMAVAEGRQVRAVEAPEDELRGI
EEECCCEEEECHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHCCCEEEEECCCHHHHHCC
NSRAELAEAEACVQRRLRAAALDGGATLVAPETVFLAADTVLEPDVLVQPHVVFGPGVTV
CCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCEEEEEECCCCCCCCEECCEEEECCCCEE
RRGAEIRAFSHLEGCVVGPGALIGPYARLRPGSDVGAAAHVGNFVELKATTLGAGAKANH
ECCCCEEEHHCCCCEEECCCHHHCCHHHCCCCCCCCHHHHCCCEEEEEEEEECCCCCCCC
LSYLGDATIGPATNIGAGTITCNYDGVFKHRTDIGAGCFVGSNAILVAPVSIGDGALVAA
HHCCCCCCCCCCCCCCCEEEEECCCCCEEECCCCCCCEEECCCEEEEEEEECCCCCEEEC
GSVITQDVLPDAMALGRARQTNKDGRGASLQAALRRKKEQG
CHHHHHHHHHHHHHHCCHHCCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA