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The map label for this gene is coaBC [H]

Identifier: 162147551

GI number: 162147551

Start: 1794070

End: 1795761

Strand: Reverse

Name: coaBC [H]

Synonym: GDI_1767

Alternate gene names: 162147551

Gene position: 1795761-1794070 (Counterclockwise)

Preceding gene: 162147552

Following gene: 162147550

Centisome position: 45.53

GC content: 71.39

Gene sequence:

>1692_bases
GTGGCCGCCCCCCAGCCGGCCGCCCCTCACCCCGCCGGGGGGCGCACGGTCCTGCTGATCGTCTGCGGGGGGATCGCGGC
GTACAAGACCCTGGAACTGATCCGGCTGCTGACGGCGGACGGCGTGCGCGTGCGCACCGTCCTGACCCGGGCGGGCGCGC
AGTTCGTCACCCCGCTCAGCCTTCAGGCCCTGACCGGGGAACGGGTGTTCAGCGACCTGTTCTCGCTGACCGACGAGAGC
GAGATGGGGCATATCGTCCTGTCCCGCTCGGGCGACCTGCTGGTGGTCTGCCCGGCGACGGCGGACATCATGGCCCGCAT
GGTCACGGGCCAGGCCGACGATTTGGCCAGCACCGTGCTGCTGGCGACCGACAAGCCGGTCATGATCGCGCCCGCGATGA
ATGTCCGCATGTGGGAACATCCCGCGACCCAGGCCAACCTGGCCACCCTGACCGCGCGCGGCGTCGCGGTCGTCGGGCCC
GAAACCGGCCTGATGGCCTGCAACGAGACCGGGCCCGGCCGCCTGGCCGAACCCGCGCGGATCGCCGAGGCGATCTTCGG
CCACTTCGCGGCCGGCGTGCGAAGCCCGTCTCTGGCCAGGCGGCACGCGCTTGTCACCGCCGGGCCGACGCACGAGCCGA
TCGATCCGGTGCGGTACCTGGCCAACCGGTCGTCGGGCCGGCAGGGTTACGAAATCGCGGCGGCGCTGGCGGCGCACGGC
GCGCGCGTGACGCTGGTCAGCGGCCCGGTGGATATTCCGCCCCCGCCCGGTGTCGAACTGCGCGCCGTGGAAACCGCGAT
CCAGATGCAGGATGCCTGCCAGGACGCGCTGCCCTGCGACATCGCCGTCTGCACCGCCGCCGTGGCCGACTGGCGCGTCG
CCCAGACCTCCGGTCACAAGATGAAGAAGGCCCCCGGCGCGCCCCCGCCGGTCCTGACCCTGGTGCCCAATCCCGATATC
CTGGCGCAGTTGTCGCTGCCCGGCCCCGCGCGGCCGGCCCTGGTGGTGGGATTTGCCGCCGAAACCGACGATGTCGAGCA
GCATGCCGGCACCAAGCGGCTGGACAAGGGCTGCGACTGGATCGTCGCCAACGACGTGCGGCCGGAAACCGGCATCATGG
GCGGGACGGAAAACGAGATCACCCTCATCACCGCCGATGGCGCCGAACGCTGGCCGCGCCAGGACAAGGAATCCGTGGCC
CGGCAGCTGGCCCGGCGGATCGCCGCCTTCTTTTCCCCCGACCGGAGTGTCCATGACCGTGCCCATCGTGTCTGCCATGC
CGCGGACTGCCGCTGCCGGCTATCCACCGCCGGCGCCGCGGGCATTGACCTGCTGGCGGCGGTGACCGAACCCATTGTGG
TGGTGGCGGGGGCGCGGGTGCTGGTGCCCACCGGCCTGTGTATCGCCCTGCCCCCGGGCTACGAACTGCAGGTTCGCCCC
CGGTCCGGCCTGGCGCTGAAGCACGGGATCACGCTGCCCAATTCGCCCGGCACGATCGACGAGGATTATCGCGGCGAAAT
CGGCATCATCCTGCTGAATACCGGTGACGCGCCCCTGACCATCGAACGCGGCATGCGCATCGCCCAGGCCGTGCTGGCCC
CCGTCGTCCGCGCCGCATGGCAGGAAGTCGAGACGCTGGACGAAACCACGCGATCCTCCGGCGGCTTCGGCAGCACGGGC
GTCAGCCCGTAA

Upstream 100 bases:

>100_bases
CGCTGGCCGGCATGATGCGCGCCGCGGGGCTGGAGCGCGTGTCGGTCCGCAACCTGTCGGGCGGGATCGCCGCCATCCAT
TCCGGCTGGCGGATCTGAAC

Downstream 100 bases:

>100_bases
CGCGCGGCTGAGGCCCCCGGGGCGCGACGCCCCGGGACAACAGGAAAGAGGTTCATGACGGCGAGTTCGCTGCCCGCCCC
TTCGTCCCGCCCGGCCCGGC

Product: coenzyme A biosynthesis bifunctional protein CoaBC

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 563; Mature: 562

Protein sequence:

>563_residues
MAAPQPAAPHPAGGRTVLLIVCGGIAAYKTLELIRLLTADGVRVRTVLTRAGAQFVTPLSLQALTGERVFSDLFSLTDES
EMGHIVLSRSGDLLVVCPATADIMARMVTGQADDLASTVLLATDKPVMIAPAMNVRMWEHPATQANLATLTARGVAVVGP
ETGLMACNETGPGRLAEPARIAEAIFGHFAAGVRSPSLARRHALVTAGPTHEPIDPVRYLANRSSGRQGYEIAAALAAHG
ARVTLVSGPVDIPPPPGVELRAVETAIQMQDACQDALPCDIAVCTAAVADWRVAQTSGHKMKKAPGAPPPVLTLVPNPDI
LAQLSLPGPARPALVVGFAAETDDVEQHAGTKRLDKGCDWIVANDVRPETGIMGGTENEITLITADGAERWPRQDKESVA
RQLARRIAAFFSPDRSVHDRAHRVCHAADCRCRLSTAGAAGIDLLAAVTEPIVVVAGARVLVPTGLCIALPPGYELQVRP
RSGLALKHGITLPNSPGTIDEDYRGEIGIILLNTGDAPLTIERGMRIAQAVLAPVVRAAWQEVETLDETTRSSGGFGSTG
VSP

Sequences:

>Translated_563_residues
MAAPQPAAPHPAGGRTVLLIVCGGIAAYKTLELIRLLTADGVRVRTVLTRAGAQFVTPLSLQALTGERVFSDLFSLTDES
EMGHIVLSRSGDLLVVCPATADIMARMVTGQADDLASTVLLATDKPVMIAPAMNVRMWEHPATQANLATLTARGVAVVGP
ETGLMACNETGPGRLAEPARIAEAIFGHFAAGVRSPSLARRHALVTAGPTHEPIDPVRYLANRSSGRQGYEIAAALAAHG
ARVTLVSGPVDIPPPPGVELRAVETAIQMQDACQDALPCDIAVCTAAVADWRVAQTSGHKMKKAPGAPPPVLTLVPNPDI
LAQLSLPGPARPALVVGFAAETDDVEQHAGTKRLDKGCDWIVANDVRPETGIMGGTENEITLITADGAERWPRQDKESVA
RQLARRIAAFFSPDRSVHDRAHRVCHAADCRCRLSTAGAAGIDLLAAVTEPIVVVAGARVLVPTGLCIALPPGYELQVRP
RSGLALKHGITLPNSPGTIDEDYRGEIGIILLNTGDAPLTIERGMRIAQAVLAPVVRAAWQEVETLDETTRSSGGFGSTG
VSP
>Mature_562_residues
AAPQPAAPHPAGGRTVLLIVCGGIAAYKTLELIRLLTADGVRVRTVLTRAGAQFVTPLSLQALTGERVFSDLFSLTDESE
MGHIVLSRSGDLLVVCPATADIMARMVTGQADDLASTVLLATDKPVMIAPAMNVRMWEHPATQANLATLTARGVAVVGPE
TGLMACNETGPGRLAEPARIAEAIFGHFAAGVRSPSLARRHALVTAGPTHEPIDPVRYLANRSSGRQGYEIAAALAAHGA
RVTLVSGPVDIPPPPGVELRAVETAIQMQDACQDALPCDIAVCTAAVADWRVAQTSGHKMKKAPGAPPPVLTLVPNPDIL
AQLSLPGPARPALVVGFAAETDDVEQHAGTKRLDKGCDWIVANDVRPETGIMGGTENEITLITADGAERWPRQDKESVAR
QLARRIAAFFSPDRSVHDRAHRVCHAADCRCRLSTAGAAGIDLLAAVTEPIVVVAGARVLVPTGLCIALPPGYELQVRPR
SGLALKHGITLPNSPGTIDEDYRGEIGIILLNTGDAPLTIERGMRIAQAVLAPVVRAAWQEVETLDETTRSSGGFGSTGV
SP

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI4503423, Length=125, Percent_Identity=44.8, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI70906441, Length=125, Percent_Identity=44.8, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI70906444, Length=125, Percent_Identity=45.6, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI71725351, Length=197, Percent_Identity=31.9796954314721, Blast_Score=84, Evalue=4e-16,
Organism=Escherichia coli, GI87082301, Length=402, Percent_Identity=44.0298507462687, Blast_Score=290, Evalue=2e-79,
Organism=Escherichia coli, GI1790071, Length=127, Percent_Identity=44.8818897637795, Blast_Score=105, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI71988561, Length=125, Percent_Identity=45.6, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17560194, Length=200, Percent_Identity=29, Blast_Score=72, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6319729, Length=126, Percent_Identity=38.0952380952381, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI19921126, Length=127, Percent_Identity=40.1574803149606, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24583610, Length=127, Percent_Identity=40.1574803149606, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24657262, Length=186, Percent_Identity=29.5698924731183, Blast_Score=86, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 59007; Mature: 58876

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAPQPAAPHPAGGRTVLLIVCGGIAAYKTLELIRLLTADGVRVRTVLTRAGAQFVTPLS
CCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCEEEEHHHHHCCCHHCCCCC
LQALTGERVFSDLFSLTDESEMGHIVLSRSGDLLVVCPATADIMARMVTGQADDLASTVL
HHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHCCCCHHHHCEEE
LATDKPVMIAPAMNVRMWEHPATQANLATLTARGVAVVGPETGLMACNETGPGRLAEPAR
EECCCCEEEECCCCEEEECCCCCCCCEEEEEECCEEEECCCCCEEEECCCCCCCCCCHHH
IAEAIFGHFAAGVRSPSLARRHALVTAGPTHEPIDPVRYLANRSSGRQGYEIAAALAAHG
HHHHHHHHHHHCCCCCCHHHHEEEEECCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCC
ARVTLVSGPVDIPPPPGVELRAVETAIQMQDACQDALPCDIAVCTAAVADWRVAQTSGHK
CEEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEECCCCCC
MKKAPGAPPPVLTLVPNPDILAQLSLPGPARPALVVGFAAETDDVEQHAGTKRLDKGCDW
HHCCCCCCCCEEEECCCCCEEEEECCCCCCCCEEEEEEECCCCHHHHHCCHHHHHCCCCE
IVANDVRPETGIMGGTENEITLITADGAERWPRQDKESVARQLARRIAAFFSPDRSVHDR
EEECCCCCCCCCCCCCCCCEEEEECCCHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHH
AHRVCHAADCRCRLSTAGAAGIDLLAAVTEPIVVVAGARVLVPTGLCIALPPGYELQVRP
HHHHHHHCCCEEEEECCCCCHHHHHHHHHCCEEEEECCEEEEECCEEEECCCCCEEEEEC
RSGLALKHGITLPNSPGTIDEDYRGEIGIILLNTGDAPLTIERGMRIAQAVLAPVVRAAW
CCCCEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHH
QEVETLDETTRSSGGFGSTGVSP
HHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
AAPQPAAPHPAGGRTVLLIVCGGIAAYKTLELIRLLTADGVRVRTVLTRAGAQFVTPLS
CCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCEEEEHHHHHCCCHHCCCCC
LQALTGERVFSDLFSLTDESEMGHIVLSRSGDLLVVCPATADIMARMVTGQADDLASTVL
HHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHCCCCHHHHCEEE
LATDKPVMIAPAMNVRMWEHPATQANLATLTARGVAVVGPETGLMACNETGPGRLAEPAR
EECCCCEEEECCCCEEEECCCCCCCCEEEEEECCEEEECCCCCEEEECCCCCCCCCCHHH
IAEAIFGHFAAGVRSPSLARRHALVTAGPTHEPIDPVRYLANRSSGRQGYEIAAALAAHG
HHHHHHHHHHHCCCCCCHHHHEEEEECCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCC
ARVTLVSGPVDIPPPPGVELRAVETAIQMQDACQDALPCDIAVCTAAVADWRVAQTSGHK
CEEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEECCCCCC
MKKAPGAPPPVLTLVPNPDILAQLSLPGPARPALVVGFAAETDDVEQHAGTKRLDKGCDW
HHCCCCCCCCEEEECCCCCEEEEECCCCCCCCEEEEEEECCCCHHHHHCCHHHHHCCCCE
IVANDVRPETGIMGGTENEITLITADGAERWPRQDKESVARQLARRIAAFFSPDRSVHDR
EEECCCCCCCCCCCCCCCCEEEEECCCHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHH
AHRVCHAADCRCRLSTAGAAGIDLLAAVTEPIVVVAGARVLVPTGLCIALPPGYELQVRP
HHHHHHHCCCEEEEECCCCCHHHHHHHHHCCEEEEECCEEEEECCEEEECCCCCEEEEEC
RSGLALKHGITLPNSPGTIDEDYRGEIGIILLNTGDAPLTIERGMRIAQAVLAPVVRAAW
CCCCEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHH
QEVETLDETTRSSGGFGSTGVSP
HHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]