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The map label for this gene is copA [H]

Identifier: 162147303

GI number: 162147303

Start: 1515615

End: 1517387

Strand: Direct

Name: copA [H]

Synonym: GDI_1508

Alternate gene names: 162147303

Gene position: 1515615-1517387 (Clockwise)

Preceding gene: 162147302

Following gene: 162147304

Centisome position: 38.43

GC content: 69.26

Gene sequence:

>1773_bases
ATGATTTTTCCATCCTCGACGGGGCGGGGCGCGATGACGCGCCGCCGCTTCGTGGTCGGGGCCGGCGTGTGGGGTGCGGC
GGCCGCGACCGGCGCCGGTGCGCGGGCGTTCGCGCCGCCTTCCGGCATCCCCGCCCCCCGGCCCGGCACCCGTTTCGACC
TTGCGATCGGTCACGTCCCGGTCAACGTCACGGGCGCGCGCGTCCGCGCGGTCGGCGTCAACGGATCGACCCCGGCGCCG
ATCCTGCGCTGGCGACAGGGCGATACGGTCGAACTGACCGTCACCAACCGGCTGCACGAACCCAGTTCGATCCACTGGCA
CGGTATTCGGCTGCCGGCCGGCATGGACGGTGTCCCGGGCCTCAGCTTCGGTGGCATCGCGCCGGGCGAAAGCTTCACCT
ACCGTTTCCCCGTACGGCAGAGCGGCACCTACTGGTACCACAGCCATTCCGGCTTCCAGGAGCAGACCGGCCTGTACGGC
GCCATCGTCATCGACCCGGGCAGCGGCGACACCCGGCGGTGCGACCGCGATTATGTGCTGGTGCTGTCGGACTGGACCGA
CGTGGACCCGGCGGACATCGTCTCCAACCTGAAATTCCAGAGCGACTATTACAATTTCCGCCAGCGCACGGTCGGCACCT
TCTTCCGCGACGCGCACCGCCAGGGGCTGGGCGCCGCGGTGCGGGACCGCCTGGCCTGGGGGGGCATGAACATGGCGCCG
ACCGACATCCTGGACGTGTCGGGCATCGTCTACACCTACCTGGTCAACGGGCAGTCCCCCCGCGCCAACTGGACCGGCCT
GTTCCGCCCCGGCGAACGCATCCGTCTGCGCATCATCAATGCCGCGTCGATGACCCTGTTCGACGTGCGGATTCCCGGAC
TGGCGATGACCGTCGTGCAGGCCGACGGGAACGACGTGGAACCGGTGACGGTGGACGAATTCCGCATCGGGCCCGCCGAA
ACCTACGACGTGATCGTGACCCCCGCCGCCGCCGGCCCCTATACGATCTTCGCGCAGGCCGAGGATCGCACGGGCTACGC
GCGCGGCACGCTGGCCACCGCCCCGGGCCTCGCCGGCCCCGTGCCGCCCATGGACCCCCGCCCGCTGCGCACCATGGCGG
ACATGGGCATGGGCGGCATGGCCCCGCCCGCGAAAACCGGCAACGCGCCCGCCATGGACGGTATGGACATGTCCGGAATG
TCCGGAATGGACATGGACCCCAAGGAGATGGAACCCCCGGCCGCGCCACATCAGGCGCCGCCCGCGCCGAAGCTGAAGCC
GGGGGTCGAGGTGCAGAATGTCGCCGCCATGCCCATGGACCGGCTGGCGGAACCGGGGGACGGGCTGGACCATAACGGCC
GCCGCGTCCTGACCTATGCCGATCTGCGGGCGACCGTCCCCGGCATCGATCCCCGCCCGCCGTCGCGCGAGATCACCCTG
CACCTGACCGGCAACATGGAACGCTTCATCTGGGGCTTCGACGGCAGGAAGTTCTCGGAAGCCGCGCCGATCCGGCTCGC
GCGGGGGGAGCGGGTCCGCTTCGTCCTGATCAACGACACGATGATGGAACACCCGATCCACCTGCACGGGTTGTGGAGCG
AGCTGGAAAACGGGCAGGGGGACCGCCGCCCCTACAAGCACACGATTACCGTCAAGCCGGGCGAGCGGCTGAGCTATCTG
GTCACGGCCGACGAACCCGGATTATGGGCCTATCACTGCCATCTGCTCTACCATATGGCAGTCGGCATGTTCCGCACGGT
GGTGGTGTCGTGA

Upstream 100 bases:

>100_bases
CCGCCCAGACGGATGGCCTGACCCCAGGTCTGACCGTTTCGGGATTCGGCCGTATGCGTGCGGCCGGGCCCGTCTTTCTT
CTTTGGCGGATGACAGAGCC

Downstream 100 bases:

>100_bases
CCCGGCGGCCCATCCTCGGTATCGCCGTCGCCCTGCTGGCGGCGGGCGCGCTGCCCGGCCAGGTCCGGGCGCAGGCCATG
CCGATGGCGCCGGCGGCCGG

Product: copper resistance protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 590; Mature: 590

Protein sequence:

>590_residues
MIFPSSTGRGAMTRRRFVVGAGVWGAAAATGAGARAFAPPSGIPAPRPGTRFDLAIGHVPVNVTGARVRAVGVNGSTPAP
ILRWRQGDTVELTVTNRLHEPSSIHWHGIRLPAGMDGVPGLSFGGIAPGESFTYRFPVRQSGTYWYHSHSGFQEQTGLYG
AIVIDPGSGDTRRCDRDYVLVLSDWTDVDPADIVSNLKFQSDYYNFRQRTVGTFFRDAHRQGLGAAVRDRLAWGGMNMAP
TDILDVSGIVYTYLVNGQSPRANWTGLFRPGERIRLRIINAASMTLFDVRIPGLAMTVVQADGNDVEPVTVDEFRIGPAE
TYDVIVTPAAAGPYTIFAQAEDRTGYARGTLATAPGLAGPVPPMDPRPLRTMADMGMGGMAPPAKTGNAPAMDGMDMSGM
SGMDMDPKEMEPPAAPHQAPPAPKLKPGVEVQNVAAMPMDRLAEPGDGLDHNGRRVLTYADLRATVPGIDPRPPSREITL
HLTGNMERFIWGFDGRKFSEAAPIRLARGERVRFVLINDTMMEHPIHLHGLWSELENGQGDRRPYKHTITVKPGERLSYL
VTADEPGLWAYHCHLLYHMAVGMFRTVVVS

Sequences:

>Translated_590_residues
MIFPSSTGRGAMTRRRFVVGAGVWGAAAATGAGARAFAPPSGIPAPRPGTRFDLAIGHVPVNVTGARVRAVGVNGSTPAP
ILRWRQGDTVELTVTNRLHEPSSIHWHGIRLPAGMDGVPGLSFGGIAPGESFTYRFPVRQSGTYWYHSHSGFQEQTGLYG
AIVIDPGSGDTRRCDRDYVLVLSDWTDVDPADIVSNLKFQSDYYNFRQRTVGTFFRDAHRQGLGAAVRDRLAWGGMNMAP
TDILDVSGIVYTYLVNGQSPRANWTGLFRPGERIRLRIINAASMTLFDVRIPGLAMTVVQADGNDVEPVTVDEFRIGPAE
TYDVIVTPAAAGPYTIFAQAEDRTGYARGTLATAPGLAGPVPPMDPRPLRTMADMGMGGMAPPAKTGNAPAMDGMDMSGM
SGMDMDPKEMEPPAAPHQAPPAPKLKPGVEVQNVAAMPMDRLAEPGDGLDHNGRRVLTYADLRATVPGIDPRPPSREITL
HLTGNMERFIWGFDGRKFSEAAPIRLARGERVRFVLINDTMMEHPIHLHGLWSELENGQGDRRPYKHTITVKPGERLSYL
VTADEPGLWAYHCHLLYHMAVGMFRTVVVS
>Mature_590_residues
MIFPSSTGRGAMTRRRFVVGAGVWGAAAATGAGARAFAPPSGIPAPRPGTRFDLAIGHVPVNVTGARVRAVGVNGSTPAP
ILRWRQGDTVELTVTNRLHEPSSIHWHGIRLPAGMDGVPGLSFGGIAPGESFTYRFPVRQSGTYWYHSHSGFQEQTGLYG
AIVIDPGSGDTRRCDRDYVLVLSDWTDVDPADIVSNLKFQSDYYNFRQRTVGTFFRDAHRQGLGAAVRDRLAWGGMNMAP
TDILDVSGIVYTYLVNGQSPRANWTGLFRPGERIRLRIINAASMTLFDVRIPGLAMTVVQADGNDVEPVTVDEFRIGPAE
TYDVIVTPAAAGPYTIFAQAEDRTGYARGTLATAPGLAGPVPPMDPRPLRTMADMGMGGMAPPAKTGNAPAMDGMDMSGM
SGMDMDPKEMEPPAAPHQAPPAPKLKPGVEVQNVAAMPMDRLAEPGDGLDHNGRRVLTYADLRATVPGIDPRPPSREITL
HLTGNMERFIWGFDGRKFSEAAPIRLARGERVRFVLINDTMMEHPIHLHGLWSELENGQGDRRPYKHTITVKPGERLSYL
VTADEPGLWAYHCHLLYHMAVGMFRTVVVS

Specific function: Required for the copper-inducible expression of copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=616, Percent_Identity=25.6493506493506, Blast_Score=89, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6321067, Length=563, Percent_Identity=23.6234458259325, Blast_Score=97, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6320714, Length=293, Percent_Identity=26.2798634812287, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323703, Length=270, Percent_Identity=28.1481481481481, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24650186, Length=565, Percent_Identity=23.8938053097345, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI221330000, Length=579, Percent_Identity=24.3523316062176, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI18859919, Length=271, Percent_Identity=28.7822878228782, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI28574104, Length=292, Percent_Identity=27.0547945205479, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI221329998, Length=271, Percent_Identity=28.0442804428044, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI281360167, Length=271, Percent_Identity=28.0442804428044, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24585842, Length=271, Percent_Identity=28.0442804428044, Blast_Score=84, Evalue=4e-16,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 64108; Mature: 64108

Theoretical pI: Translated: 7.89; Mature: 7.89

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFPSSTGRGAMTRRRFVVGAGVWGAAAATGAGARAFAPPSGIPAPRPGTRFDLAIGHVP
CCCCCCCCCCCCEEEEEEEECCCHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCEE
VNVTGARVRAVGVNGSTPAPILRWRQGDTVELTVTNRLHEPSSIHWHGIRLPAGMDGVPG
EEEECCEEEEEECCCCCCCCEEEECCCCEEEEEEECCCCCCCCEEEEEEECCCCCCCCCC
LSFGGIAPGESFTYRFPVRQSGTYWYHSHSGFQEQTGLYGAIVIDPGSGDTRRCDRDYVL
CCCCCCCCCCCEEEEECCCCCCCEEEECCCCCHHHCCCEEEEEEECCCCCCCCCCCCEEE
VLSDWTDVDPADIVSNLKFQSDYYNFRQRTVGTFFRDAHRQGLGAAVRDRLAWGGMNMAP
EEECCCCCCHHHHHHCCEECHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCC
TDILDVSGIVYTYLVNGQSPRANWTGLFRPGERIRLRIINAASMTLFDVRIPGLAMTVVQ
CHHHCCCCEEEEEEECCCCCCCCCEEEECCCCEEEEEEEEECCEEEEEEECCCEEEEEEE
ADGNDVEPVTVDEFRIGPAETYDVIVTPAAAGPYTIFAQAEDRTGYARGTLATAPGLAGP
CCCCCCCCEEECCEECCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCEEEECCCCCCC
VPPMDPRPLRTMADMGMGGMAPPAKTGNAPAMDGMDMSGMSGMDMDPKEMEPPAAPHQAP
CCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCC
PAPKLKPGVEVQNVAAMPMDRLAEPGDGLDHNGRRVLTYADLRATVPGIDPRPPSREITL
CCCCCCCCCCEEHEECCCHHHHCCCCCCCCCCCCEEEEEECCEEECCCCCCCCCCCEEEE
HLTGNMERFIWGFDGRKFSEAAPIRLARGERVRFVLINDTMMEHPIHLHGLWSELENGQG
EEECCCEEEEEECCCCCCCCCCCEEEECCCEEEEEEECCHHHHCCEEEEEHHHHHHCCCC
DRRPYKHTITVKPGERLSYLVTADEPGLWAYHCHLLYHMAVGMFRTVVVS
CCCCCEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIFPSSTGRGAMTRRRFVVGAGVWGAAAATGAGARAFAPPSGIPAPRPGTRFDLAIGHVP
CCCCCCCCCCCCEEEEEEEECCCHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCEE
VNVTGARVRAVGVNGSTPAPILRWRQGDTVELTVTNRLHEPSSIHWHGIRLPAGMDGVPG
EEEECCEEEEEECCCCCCCCEEEECCCCEEEEEEECCCCCCCCEEEEEEECCCCCCCCCC
LSFGGIAPGESFTYRFPVRQSGTYWYHSHSGFQEQTGLYGAIVIDPGSGDTRRCDRDYVL
CCCCCCCCCCCEEEEECCCCCCCEEEECCCCCHHHCCCEEEEEEECCCCCCCCCCCCEEE
VLSDWTDVDPADIVSNLKFQSDYYNFRQRTVGTFFRDAHRQGLGAAVRDRLAWGGMNMAP
EEECCCCCCHHHHHHCCEECHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCC
TDILDVSGIVYTYLVNGQSPRANWTGLFRPGERIRLRIINAASMTLFDVRIPGLAMTVVQ
CHHHCCCCEEEEEEECCCCCCCCCEEEECCCCEEEEEEEEECCEEEEEEECCCEEEEEEE
ADGNDVEPVTVDEFRIGPAETYDVIVTPAAAGPYTIFAQAEDRTGYARGTLATAPGLAGP
CCCCCCCCEEECCEECCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCEEEECCCCCCC
VPPMDPRPLRTMADMGMGGMAPPAKTGNAPAMDGMDMSGMSGMDMDPKEMEPPAAPHQAP
CCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCC
PAPKLKPGVEVQNVAAMPMDRLAEPGDGLDHNGRRVLTYADLRATVPGIDPRPPSREITL
CCCCCCCCCCEEHEECCCHHHHCCCCCCCCCCCCEEEEEECCEEECCCCCCCCCCCEEEE
HLTGNMERFIWGFDGRKFSEAAPIRLARGERVRFVLINDTMMEHPIHLHGLWSELENGQG
EEECCCEEEEEECCCCCCCCCCCEEEECCCEEEEEEECCHHHHCCEEEEEHHHHHHCCCC
DRRPYKHTITVKPGERLSYLVTADEPGLWAYHCHLLYHMAVGMFRTVVVS
CCCCCEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]