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The map label for this gene is thrS

Identifier: 162147243

GI number: 162147243

Start: 1450981

End: 1452906

Strand: Direct

Name: thrS

Synonym: GDI_1448

Alternate gene names: 162147243

Gene position: 1450981-1452906 (Clockwise)

Preceding gene: 162147242

Following gene: 162147244

Centisome position: 36.79

GC content: 69.06

Gene sequence:

>1926_bases
ATGCCTGCCATCACCCTGCCTGACGGATCCGTTCGCCGCTTTGACGGTCCGGTGACGGGCACTATGGTGGCGGAGTCCAT
CGGCCCGGGCCTGGCCCGCGCCGCGCTGGCGATGGAGGTGGACGGCGCGCTGGTCGACCTGTCGCGCGAAATCGCCGACG
ACGCGTCGGTCCGCTTCATCACCCGCAAGGACGACGCGGCGCTGGAGATGATCCGCCACGACACCGCCCATGTCCTGGCC
GAGGCCGTGCAGTCCCTGTGGCCCGGCACCCAGGTCACCATCGGCCCGTCGATCGAGAACGGCTTCTATTACGATTTCTA
TCGCAACGAGCCCTTCACGCCCGAGGACTTCCCCGCGATCGAGGCCCGCATGCGCGAGATCGTGGCCGCCAACGCCCGCT
TCGAGCGTGAGGTCTGGCCGCGCGACGAGGCGATCCGCTTCTTCGAGAACCGGGGCGAGCGCTTCAAGGCCGAACTGATC
CGCGACCTGCCGGAAAGCGAGCCGATCTCGATCTACCGCCAGGGCGAATGGCTGGACCTGTGCCGTGGCCCGCATCTGCG
CGGCACGGCGGACGTGGGCAGCGCCTTCAAGCTGATGAAGGTGGCCGGCGCCTACTGGCGCGGCGACCACCGCAACCCGA
TGCTGACGCGCATCTACGGCACCGCGTGGCGCGACCAGAAGGAACTGGACGCCCACCTGCACCGGCTGGAGGAAGCGGAA
CGCCGCGACCATCGCCGCATCGGGCGCGAGATGGACCTGTTCCATATCCAGGAAGAGGCCGTCGGTTCGATCTTCTGGCA
CCCCAAGGGCTGGCGCCTCTATACCGCGTTGCAGGATTACATGCGCCGCGCCCAGACCCGGGGCGGCTACCAGGAAGTCC
GCACCCCGCAACTGGTCGACCGCGCGCTGTGGGAGGCCTCGGGCCACTGGGACAAATATCGCGAGCACATGTTCATCGCG
ACGGTCGAGGACGAGGACAAGACCCTCGCGCTGAAGCCGATGAACTGCCCGTGCCATGTCCAGATCTTCCGCCACGGCCT
GCGGTCCTATCGCGAACTGCCGCTGCGCATGGCGGAATTCGGCGCCTGCCATCGCTACGAGCCCTCGGGCGCGCTGCACG
GCATCATGCGCGTGCGTTCGTTCACCCAGGATGACGCCCACATCTTCTGCACCGAGTCGCAGATCGCGGCCGAGACGGCG
CGCTTCGTGCGCATGCTGGCCGAAGTCTATGCCGACCTGGGCTTCGAAAGCTTCCGGGTGAAATTCGCCGACCGGCCGGA
ACAGCGCGCCGGCAGCGACGAGACCTGGGACCGGGCCGAGGGCGCGCTGATCGAGGCCTGCCGCCTGGCCGGCGTCGAAT
ACGAGTACAACCCCGGCGAGGGCGCGTTCTACGGGCCGAAACTGGAATTCGTGCTGCGCGACGCCATCGGCCGCGACTGG
CAGTGCGGCACCCTGCAGGTCGATTACGTGCTGCCCGAGCGGCTGGACGCGTCCTTCGTCGGCGAGGACAGCGCCCGCCA
CCGCCCGGTGATGCTGCATCGCGCGATCCTGGGCTCGTTCGAGCGCTTCCTGGGTATCCTGATCGAGCAGCATGCGGGCC
GGTTCCCGCTGTGGCTGGCGCCGGTGCAGGTGGTGGTGGCCTCGATCGTCACCGACGCCGCGCCCTATGCCGAACAGGTG
GCCGAGACGCTGACGCAGGCGGGCCTGGTGGTCGAGACCGACATCCGGAACGAGAAGATCAACGCCAAGGTGCGCGAGCA
CAGCCTGGCCCGCGTGCCGGTGATCCTGGTCGTCGGCCGCAAGGAGGCCGAGGACGGCACCGTCGCGATCCGCCGCCTGG
GCGGCGCGGCGCAGGAGGTCATGAGCCTGGCCGATGCCGCGACCGCGCTGGCGGCCGAGGCCCTGCCGCCCGACCTGCGC
CGGTAA

Upstream 100 bases:

>100_bases
TGCGCGTTGACGATCTGGCCACTCTGAGCGTGGATAGGGTTGCGGCCTGCCTCGGCTGACGCCATTACAGCGACTTCCCT
TTGTCTGGAGCATCGACATC

Downstream 100 bases:

>100_bases
GGCGCACGCCTTATTTCGACGGGGCCGGGCAACGATTCCGGTCGGACCCCGTTAGGCGGTCAGGTCCCGCCCGGGATGAC
ATTGTGCTGCCGGTGCATGG

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 641; Mature: 640

Protein sequence:

>641_residues
MPAITLPDGSVRRFDGPVTGTMVAESIGPGLARAALAMEVDGALVDLSREIADDASVRFITRKDDAALEMIRHDTAHVLA
EAVQSLWPGTQVTIGPSIENGFYYDFYRNEPFTPEDFPAIEARMREIVAANARFEREVWPRDEAIRFFENRGERFKAELI
RDLPESEPISIYRQGEWLDLCRGPHLRGTADVGSAFKLMKVAGAYWRGDHRNPMLTRIYGTAWRDQKELDAHLHRLEEAE
RRDHRRIGREMDLFHIQEEAVGSIFWHPKGWRLYTALQDYMRRAQTRGGYQEVRTPQLVDRALWEASGHWDKYREHMFIA
TVEDEDKTLALKPMNCPCHVQIFRHGLRSYRELPLRMAEFGACHRYEPSGALHGIMRVRSFTQDDAHIFCTESQIAAETA
RFVRMLAEVYADLGFESFRVKFADRPEQRAGSDETWDRAEGALIEACRLAGVEYEYNPGEGAFYGPKLEFVLRDAIGRDW
QCGTLQVDYVLPERLDASFVGEDSARHRPVMLHRAILGSFERFLGILIEQHAGRFPLWLAPVQVVVASIVTDAAPYAEQV
AETLTQAGLVVETDIRNEKINAKVREHSLARVPVILVVGRKEAEDGTVAIRRLGGAAQEVMSLADAATALAAEALPPDLR
R

Sequences:

>Translated_641_residues
MPAITLPDGSVRRFDGPVTGTMVAESIGPGLARAALAMEVDGALVDLSREIADDASVRFITRKDDAALEMIRHDTAHVLA
EAVQSLWPGTQVTIGPSIENGFYYDFYRNEPFTPEDFPAIEARMREIVAANARFEREVWPRDEAIRFFENRGERFKAELI
RDLPESEPISIYRQGEWLDLCRGPHLRGTADVGSAFKLMKVAGAYWRGDHRNPMLTRIYGTAWRDQKELDAHLHRLEEAE
RRDHRRIGREMDLFHIQEEAVGSIFWHPKGWRLYTALQDYMRRAQTRGGYQEVRTPQLVDRALWEASGHWDKYREHMFIA
TVEDEDKTLALKPMNCPCHVQIFRHGLRSYRELPLRMAEFGACHRYEPSGALHGIMRVRSFTQDDAHIFCTESQIAAETA
RFVRMLAEVYADLGFESFRVKFADRPEQRAGSDETWDRAEGALIEACRLAGVEYEYNPGEGAFYGPKLEFVLRDAIGRDW
QCGTLQVDYVLPERLDASFVGEDSARHRPVMLHRAILGSFERFLGILIEQHAGRFPLWLAPVQVVVASIVTDAAPYAEQV
AETLTQAGLVVETDIRNEKINAKVREHSLARVPVILVVGRKEAEDGTVAIRRLGGAAQEVMSLADAATALAAEALPPDLR
R
>Mature_640_residues
PAITLPDGSVRRFDGPVTGTMVAESIGPGLARAALAMEVDGALVDLSREIADDASVRFITRKDDAALEMIRHDTAHVLAE
AVQSLWPGTQVTIGPSIENGFYYDFYRNEPFTPEDFPAIEARMREIVAANARFEREVWPRDEAIRFFENRGERFKAELIR
DLPESEPISIYRQGEWLDLCRGPHLRGTADVGSAFKLMKVAGAYWRGDHRNPMLTRIYGTAWRDQKELDAHLHRLEEAER
RDHRRIGREMDLFHIQEEAVGSIFWHPKGWRLYTALQDYMRRAQTRGGYQEVRTPQLVDRALWEASGHWDKYREHMFIAT
VEDEDKTLALKPMNCPCHVQIFRHGLRSYRELPLRMAEFGACHRYEPSGALHGIMRVRSFTQDDAHIFCTESQIAAETAR
FVRMLAEVYADLGFESFRVKFADRPEQRAGSDETWDRAEGALIEACRLAGVEYEYNPGEGAFYGPKLEFVLRDAIGRDWQ
CGTLQVDYVLPERLDASFVGEDSARHRPVMLHRAILGSFERFLGILIEQHAGRFPLWLAPVQVVVASIVTDAAPYAEQVA
ETLTQAGLVVETDIRNEKINAKVREHSLARVPVILVVGRKEAEDGTVAIRRLGGAAQEVMSLADAATALAAEALPPDLRR

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38202255, Length=612, Percent_Identity=40.5228758169935, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI38570111, Length=597, Percent_Identity=39.5309882747069, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI20070344, Length=629, Percent_Identity=39.5866454689984, Blast_Score=420, Evalue=1e-117,
Organism=Escherichia coli, GI1788013, Length=642, Percent_Identity=51.2461059190031, Blast_Score=683, Evalue=0.0,
Organism=Escherichia coli, GI1786392, Length=170, Percent_Identity=27.0588235294118, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71984184, Length=625, Percent_Identity=39.84, Blast_Score=483, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI71984192, Length=625, Percent_Identity=39.84, Blast_Score=483, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6322112, Length=658, Percent_Identity=38.6018237082067, Blast_Score=466, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6322654, Length=393, Percent_Identity=36.1323155216285, Blast_Score=281, Evalue=3e-76,
Organism=Drosophila melanogaster, GI24583839, Length=630, Percent_Identity=39.5238095238095, Blast_Score=466, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24583842, Length=630, Percent_Identity=39.5238095238095, Blast_Score=466, Evalue=1e-131,
Organism=Drosophila melanogaster, GI28574141, Length=630, Percent_Identity=39.5238095238095, Blast_Score=466, Evalue=1e-131,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_GLUDA (A9HFP5)

Other databases:

- EMBL:   AM889285
- EMBL:   CP001189
- RefSeq:   YP_001601704.1
- RefSeq:   YP_002276522.1
- ProteinModelPortal:   A9HFP5
- SMR:   A9HFP5
- GeneID:   5791566
- GeneID:   6975577
- GenomeReviews:   AM889285_GR
- GenomeReviews:   CP001189_GR
- KEGG:   gdj:Gdia_2149
- HOGENOM:   HBG352811
- OMA:   GFEYEVE
- ProtClustDB:   PRK00413
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 72654; Mature: 72523

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAITLPDGSVRRFDGPVTGTMVAESIGPGLARAALAMEVDGALVDLSREIADDASVRFI
CCCEECCCCCCEECCCCCCHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEE
TRKDDAALEMIRHDTAHVLAEAVQSLWPGTQVTIGPSIENGFYYDFYRNEPFTPEDFPAI
ECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCCCCCCCCCHHH
EARMREIVAANARFEREVWPRDEAIRFFENRGERFKAELIRDLPESEPISIYRQGEWLDL
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEECCCHHHH
CRGPHLRGTADVGSAFKLMKVAGAYWRGDHRNPMLTRIYGTAWRDQKELDAHLHRLEEAE
HCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHH
RRDHRRIGREMDLFHIQEEAVGSIFWHPKGWRLYTALQDYMRRAQTRGGYQEVRTPQLVD
HHHHHHHCCCCHHEEECHHHCCCEEECCCCCCHHHHHHHHHHHHHHCCCHHHCCCHHHHH
RALWEASGHWDKYREHMFIATVEDEDKTLALKPMNCPCHVQIFRHGLRSYRELPLRMAEF
HHHHHCCCCHHHHHCCEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHH
GACHRYEPSGALHGIMRVRSFTQDDAHIFCTESQIAAETARFVRMLAEVYADLGFESFRV
CCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCHHEEE
KFADRPEQRAGSDETWDRAEGALIEACRLAGVEYEYNPGEGAFYGPKLEFVLRDAIGRDW
EECCCCHHHCCCCCCHHHHCHHHHHHHHHCCCCEEECCCCCCEECCHHHHHHHHHCCCCC
QCGTLQVDYVLPERLDASFVGEDSARHRPVMLHRAILGSFERFLGILIEQHAGRFPLWLA
CCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
PVQVVVASIVTDAAPYAEQVAETLTQAGLVVETDIRNEKINAKVREHSLARVPVILVVGR
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHCCCCCCCEEEEECC
KEAEDGTVAIRRLGGAAQEVMSLADAATALAAEALPPDLRR
CCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PAITLPDGSVRRFDGPVTGTMVAESIGPGLARAALAMEVDGALVDLSREIADDASVRFI
CCEECCCCCCEECCCCCCHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEE
TRKDDAALEMIRHDTAHVLAEAVQSLWPGTQVTIGPSIENGFYYDFYRNEPFTPEDFPAI
ECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCCCCCCCCCHHH
EARMREIVAANARFEREVWPRDEAIRFFENRGERFKAELIRDLPESEPISIYRQGEWLDL
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEECCCHHHH
CRGPHLRGTADVGSAFKLMKVAGAYWRGDHRNPMLTRIYGTAWRDQKELDAHLHRLEEAE
HCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHH
RRDHRRIGREMDLFHIQEEAVGSIFWHPKGWRLYTALQDYMRRAQTRGGYQEVRTPQLVD
HHHHHHHCCCCHHEEECHHHCCCEEECCCCCCHHHHHHHHHHHHHHCCCHHHCCCHHHHH
RALWEASGHWDKYREHMFIATVEDEDKTLALKPMNCPCHVQIFRHGLRSYRELPLRMAEF
HHHHHCCCCHHHHHCCEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHH
GACHRYEPSGALHGIMRVRSFTQDDAHIFCTESQIAAETARFVRMLAEVYADLGFESFRV
CCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCHHEEE
KFADRPEQRAGSDETWDRAEGALIEACRLAGVEYEYNPGEGAFYGPKLEFVLRDAIGRDW
EECCCCHHHCCCCCCHHHHCHHHHHHHHHCCCCEEECCCCCCEECCHHHHHHHHHCCCCC
QCGTLQVDYVLPERLDASFVGEDSARHRPVMLHRAILGSFERFLGILIEQHAGRFPLWLA
CCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
PVQVVVASIVTDAAPYAEQVAETLTQAGLVVETDIRNEKINAKVREHSLARVPVILVVGR
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHCCCCCCCEEEEECC
KEAEDGTVAIRRLGGAAQEVMSLADAATALAAEALPPDLRR
CCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA