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The map label for this gene is sdhA [H]

Identifier: 162147199

GI number: 162147199

Start: 1405538

End: 1407349

Strand: Reverse

Name: sdhA [H]

Synonym: GDI_1404

Alternate gene names: 162147199

Gene position: 1407349-1405538 (Counterclockwise)

Preceding gene: 162147200

Following gene: 162147198

Centisome position: 35.68

GC content: 66.83

Gene sequence:

>1812_bases
ATGAACGCGATCACTCTCCCTTCATCAAATGCCTATCGGATCGTCGATCACGCCTATGACGTGGTCGTCGTCGGCGCCGG
CGGATCGGGTCTGCGCGCCACGCTGGGCATGGGCGCCGCCGGCCTGAAGACCGCCTGCGTCACCAAGGTCTTCCCCACCC
GCAGCCATACCGTCGCCGCCCAGGGCGGCATCGGCGCGTCCCTGGGCAACATGGCCGAGGACAACTGGCGCTGGCACATG
TACGACACCGTCAAGGGGTCGGACTGGCTGGGCGACCAGGACGCCATCGAATACATGTGCCGCGAGGCGGTTCCCGCCGT
GCAGGAACTGGAACATCTGGGTGTTCCGTTCTCGCGCACCGAGGAAGGCAAGATCTACCAGCGCCCCTTCGGCGGCCACA
TGCGCAATTACGGCGAGGCCCCGGTGCCCCGCGCCTGCGCCGCCGCCGACCGCACCGGCCATGCCATCCTGCACACGCTG
TACCAGCAGTGCCTGAAGCATAACGTCGAATTCTTCGTCGAATATTTTGCCCTGGACCTGATCATGGACGACCAGGGCGC
CTGCCGCGGCGTGATCGCGTGGTGCCTGGAAGACGGTTCGATCCACCGCTTCCGCGCCCAGACGGTGGTGCTGGCGACCG
GCGGCTACGGCCGTGCCTACCAGTCCTGCACGTCGGCCCACACCTGCACGGGTGACGGCGGCGGCATGGCGATGCGCGCG
GGCGTGCCGACCCAGGACATGGAATTCGTCCAGTTCCACCCGACCGGCATCTATCCGGCCGGCTGCCTGCTGACCGAAGG
CTGCCGTGGCGAGGGCGGATACCTGACCAATTCCGAGGGCGAGCGCTTCATGGAGCGCTACGCGCCGACCGCCAAGGACC
TGGCGTCGCGCGACGTGGTGTCGCGCTCGATGACCATCGAGATCAACGAGGGTCGCGGCTGCGGCCCGAAAAAGGACTAC
ATGCTGCTGCACCTGGAGCATCTGGGTGCGGACCTGCTGCATGAGCGCCTGCCGGGCATTTCCGAGACCGCGCGCATCTT
CGCCGGCATCGACGTGACCAAGGAGCCGGTGCCCGTCCTGCCGACCGTGCATTACAACATGGGCGGCATTCCCACGAACT
ATCATGGCGAGGTCATCCGCCCGACGGCCGACAATGTGGACGCTGTCGTGCCCGGCCTGATGGCGGTGGGCGAGGCCGCG
TGCGTGTCGGTGCATGGCGCCAACCGCCTGGGCACCAATTCGCTGCTGGACCTGGTGGTGTTCGGCCGCGCGGCCGCCAA
GCGCGCCGCCGAGCTGATCAAGCCCATGGAGACCATCGCCCCGCTGCCCCCCAAGGCGGGCGAGGCCGCGCTGGACCGCC
TGGACCGTCTGCGTTCGGCCAAGGGCGGCACCCACGTGTCGGTCATGCGCGACACGCTGCAGCGCACGATGCAGAAGCAT
GCCGCCGTCTTCCGCAACACCAAGAGCCTGGCGGAAGGCGTCGAGAAGATAAAGGACATATGGACGGGCGTGCCCGACCT
GTCGATTTCCGATCGCTCGCTGATCTGGAACACCGACCTGATGGAAGCGCTGGAATTCGAGAACCTGCTGGCCAACGCCA
CCGTTACCATGGCGGGCGCCGAGGCCCGGCACGAAAGCCGCGGCGCGCAGGCGCACGACGACTACCCCGAGCGTGACGAC
AAGAACTGGATGAAGCACACCGTCGCCCATCTGGACGACAAGGGTGGCGTGGAACTGTCCTACCGCCCGGTGCACATGAA
GACGCTGACCGACGAGGTCCAGGTCTTCCCCCCCAAAAAGCGCGTCTACTAA

Upstream 100 bases:

>100_bases
CGGTCCGTGAGTACAGAGACAGCGATACAGAGACAGTTCCGGCCCGGCGGCGACACAAGCCGTCCCGCGGGCCGGACGAG
CATCGGGACACGTCCAAGAA

Downstream 100 bases:

>100_bases
GCGAAGCGGCGGAAAAGGGACGAGACGATGGTCGAATTCAGCCTGCCAAAGAACAGCCAGATCGGGAAAGGCCGTATTTT
CACGGCCGCACCCGGCGCCA

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MNAITLPSSNAYRIVDHAYDVVVVGAGGSGLRATLGMGAAGLKTACVTKVFPTRSHTVAAQGGIGASLGNMAEDNWRWHM
YDTVKGSDWLGDQDAIEYMCREAVPAVQELEHLGVPFSRTEEGKIYQRPFGGHMRNYGEAPVPRACAAADRTGHAILHTL
YQQCLKHNVEFFVEYFALDLIMDDQGACRGVIAWCLEDGSIHRFRAQTVVLATGGYGRAYQSCTSAHTCTGDGGGMAMRA
GVPTQDMEFVQFHPTGIYPAGCLLTEGCRGEGGYLTNSEGERFMERYAPTAKDLASRDVVSRSMTIEINEGRGCGPKKDY
MLLHLEHLGADLLHERLPGISETARIFAGIDVTKEPVPVLPTVHYNMGGIPTNYHGEVIRPTADNVDAVVPGLMAVGEAA
CVSVHGANRLGTNSLLDLVVFGRAAAKRAAELIKPMETIAPLPPKAGEAALDRLDRLRSAKGGTHVSVMRDTLQRTMQKH
AAVFRNTKSLAEGVEKIKDIWTGVPDLSISDRSLIWNTDLMEALEFENLLANATVTMAGAEARHESRGAQAHDDYPERDD
KNWMKHTVAHLDDKGGVELSYRPVHMKTLTDEVQVFPPKKRVY

Sequences:

>Translated_603_residues
MNAITLPSSNAYRIVDHAYDVVVVGAGGSGLRATLGMGAAGLKTACVTKVFPTRSHTVAAQGGIGASLGNMAEDNWRWHM
YDTVKGSDWLGDQDAIEYMCREAVPAVQELEHLGVPFSRTEEGKIYQRPFGGHMRNYGEAPVPRACAAADRTGHAILHTL
YQQCLKHNVEFFVEYFALDLIMDDQGACRGVIAWCLEDGSIHRFRAQTVVLATGGYGRAYQSCTSAHTCTGDGGGMAMRA
GVPTQDMEFVQFHPTGIYPAGCLLTEGCRGEGGYLTNSEGERFMERYAPTAKDLASRDVVSRSMTIEINEGRGCGPKKDY
MLLHLEHLGADLLHERLPGISETARIFAGIDVTKEPVPVLPTVHYNMGGIPTNYHGEVIRPTADNVDAVVPGLMAVGEAA
CVSVHGANRLGTNSLLDLVVFGRAAAKRAAELIKPMETIAPLPPKAGEAALDRLDRLRSAKGGTHVSVMRDTLQRTMQKH
AAVFRNTKSLAEGVEKIKDIWTGVPDLSISDRSLIWNTDLMEALEFENLLANATVTMAGAEARHESRGAQAHDDYPERDD
KNWMKHTVAHLDDKGGVELSYRPVHMKTLTDEVQVFPPKKRVY
>Mature_603_residues
MNAITLPSSNAYRIVDHAYDVVVVGAGGSGLRATLGMGAAGLKTACVTKVFPTRSHTVAAQGGIGASLGNMAEDNWRWHM
YDTVKGSDWLGDQDAIEYMCREAVPAVQELEHLGVPFSRTEEGKIYQRPFGGHMRNYGEAPVPRACAAADRTGHAILHTL
YQQCLKHNVEFFVEYFALDLIMDDQGACRGVIAWCLEDGSIHRFRAQTVVLATGGYGRAYQSCTSAHTCTGDGGGMAMRA
GVPTQDMEFVQFHPTGIYPAGCLLTEGCRGEGGYLTNSEGERFMERYAPTAKDLASRDVVSRSMTIEINEGRGCGPKKDY
MLLHLEHLGADLLHERLPGISETARIFAGIDVTKEPVPVLPTVHYNMGGIPTNYHGEVIRPTADNVDAVVPGLMAVGEAA
CVSVHGANRLGTNSLLDLVVFGRAAAKRAAELIKPMETIAPLPPKAGEAALDRLDRLRSAKGGTHVSVMRDTLQRTMQKH
AAVFRNTKSLAEGVEKIKDIWTGVPDLSISDRSLIWNTDLMEALEFENLLANATVTMAGAEARHESRGAQAHDDYPERDD
KNWMKHTVAHLDDKGGVELSYRPVHMKTLTDEVQVFPPKKRVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=615, Percent_Identity=61.6260162601626, Blast_Score=732, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=586, Percent_Identity=54.4368600682594, Blast_Score=587, Evalue=1e-169,
Organism=Escherichia coli, GI1790597, Length=577, Percent_Identity=40.0346620450607, Blast_Score=389, Evalue=1e-109,
Organism=Escherichia coli, GI1788928, Length=556, Percent_Identity=32.3741007194245, Blast_Score=223, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17550100, Length=612, Percent_Identity=60.6209150326797, Blast_Score=718, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505833, Length=619, Percent_Identity=58.9660743134087, Blast_Score=703, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322701, Length=596, Percent_Identity=62.248322147651, Blast_Score=740, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322416, Length=598, Percent_Identity=61.371237458194, Blast_Score=720, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320788, Length=491, Percent_Identity=25.6619144602851, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17137288, Length=614, Percent_Identity=62.5407166123778, Blast_Score=758, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655642, Length=614, Percent_Identity=62.5407166123778, Blast_Score=758, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655647, Length=614, Percent_Identity=62.5407166123778, Blast_Score=758, Evalue=0.0,
Organism=Drosophila melanogaster, GI24663005, Length=616, Percent_Identity=54.5454545454545, Blast_Score=660, Evalue=0.0,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 65686; Mature: 65686

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAITLPSSNAYRIVDHAYDVVVVGAGGSGLRATLGMGAAGLKTACVTKVFPTRSHTVAA
CCEEECCCCCCEEEEECCEEEEEEECCCCCCCHHHCCCCCHHHHHHHHHHCCCCCCEEEE
QGGIGASLGNMAEDNWRWHMYDTVKGSDWLGDQDAIEYMCREAVPAVQELEHLGVPFSRT
CCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCCC
EEGKIYQRPFGGHMRNYGEAPVPRACAAADRTGHAILHTLYQQCLKHNVEFFVEYFALDL
CCCCEEECCCCCHHHCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IMDDQGACRGVIAWCLEDGSIHRFRAQTVVLATGGYGRAYQSCTSAHTCTGDGGGMAMRA
EECCCCCHHHHHHHHHCCCCEEEEEEEEEEEEECCCCHHHHHHCCCCCCCCCCCCEEEEC
GVPTQDMEFVQFHPTGIYPAGCLLTEGCRGEGGYLTNSEGERFMERYAPTAKDLASRDVV
CCCCCCCCEEEECCCCCCCCHHHEECCCCCCCCEEECCHHHHHHHHHCCCHHHHHHHHHH
SRSMTIEINEGRGCGPKKDYMLLHLEHLGADLLHERLPGISETARIFAGIDVTKEPVPVL
CCEEEEEECCCCCCCCCCCEEEEEHHHCCHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCC
PTVHYNMGGIPTNYHGEVIRPTADNVDAVVPGLMAVGEAACVSVHGANRLGTNSLLDLVV
CEEECCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHCCHHEEEECCCCCCCHHHHHHHHH
FGRAAAKRAAELIKPMETIAPLPPKAGEAALDRLDRLRSAKGGTHVSVMRDTLQRTMQKH
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
AAVFRNTKSLAEGVEKIKDIWTGVPDLSISDRSLIWNTDLMEALEFENLLANATVTMAGA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECHHHHHHHHHHHHHHCCEEEECCC
EARHESRGAQAHDDYPERDDKNWMKHTVAHLDDKGGVELSYRPVHMKTLTDEVQVFPPKK
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECEEHHHHCCCCEECCCHH
RVY
CCC
>Mature Secondary Structure
MNAITLPSSNAYRIVDHAYDVVVVGAGGSGLRATLGMGAAGLKTACVTKVFPTRSHTVAA
CCEEECCCCCCEEEEECCEEEEEEECCCCCCCHHHCCCCCHHHHHHHHHHCCCCCCEEEE
QGGIGASLGNMAEDNWRWHMYDTVKGSDWLGDQDAIEYMCREAVPAVQELEHLGVPFSRT
CCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCCC
EEGKIYQRPFGGHMRNYGEAPVPRACAAADRTGHAILHTLYQQCLKHNVEFFVEYFALDL
CCCCEEECCCCCHHHCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IMDDQGACRGVIAWCLEDGSIHRFRAQTVVLATGGYGRAYQSCTSAHTCTGDGGGMAMRA
EECCCCCHHHHHHHHHCCCCEEEEEEEEEEEEECCCCHHHHHHCCCCCCCCCCCCEEEEC
GVPTQDMEFVQFHPTGIYPAGCLLTEGCRGEGGYLTNSEGERFMERYAPTAKDLASRDVV
CCCCCCCCEEEECCCCCCCCHHHEECCCCCCCCEEECCHHHHHHHHHCCCHHHHHHHHHH
SRSMTIEINEGRGCGPKKDYMLLHLEHLGADLLHERLPGISETARIFAGIDVTKEPVPVL
CCEEEEEECCCCCCCCCCCEEEEEHHHCCHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCC
PTVHYNMGGIPTNYHGEVIRPTADNVDAVVPGLMAVGEAACVSVHGANRLGTNSLLDLVV
CEEECCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHCCHHEEEECCCCCCCHHHHHHHHH
FGRAAAKRAAELIKPMETIAPLPPKAGEAALDRLDRLRSAKGGTHVSVMRDTLQRTMQKH
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
AAVFRNTKSLAEGVEKIKDIWTGVPDLSISDRSLIWNTDLMEALEFENLLANATVTMAGA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECHHHHHHHHHHHHHHCCEEEECCC
EARHESRGAQAHDDYPERDDKNWMKHTVAHLDDKGGVELSYRPVHMKTLTDEVQVFPPKK
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECEEHHHHCCCCEECCCHH
RVY
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA