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The map label for this gene is ldc [H]

Identifier: 162147147

GI number: 162147147

Start: 1351786

End: 1353111

Strand: Direct

Name: ldc [H]

Synonym: GDI_1352

Alternate gene names: 162147147

Gene position: 1351786-1353111 (Clockwise)

Preceding gene: 162147145

Following gene: 162147150

Centisome position: 34.27

GC content: 67.19

Gene sequence:

>1326_bases
GTGGTTTGCCCTCATATGCGCTCTCCACGCAACAACGCACGTGCCACTGGCCCTCTGAGGTTACGCAACGACGTCAAGCG
TTCTGGCAATCGGGACCCTTCGCCGGGCCCACTTGGTCGCTGGTCCGTTAGACCGTTTCGCAACTCCCTGTCCGGCATCG
ATCCGGACGGACGATACAGAAGGGAATTGGGTGCGATGACTCCCAAGATCGCCCGTTTTCTGGCCGAACAGGCCCCTGCC
ACGCCTTGCCTCGTCGTCGACGTCGATCGTGTCGAGGCCCGCTATCAGTCGCTGCGCGCGGCGCTGCCGCTGGCGCGCAT
CTATTATGCCGTGAAGGCCAATCCGGCGCCGGCCATCCTGCGCCGGCTGGTGTCCCTCGGCTCGGCGTTCGACGCCGCGT
CGTGGGAGGAAATCCGCCTTTGCCTCGCGGCCGGGGCCGCCGGGGCGGACATCTCGTTCGGCAACACGGTCAAGAAGGCA
TCCGCGATCGCCCAGGCCCACCAGGCCGGGGTGACCATGTTCGCCTTCGACAGCATCGAGGAACTGGAAAAGCTGGCGCG
TCACGCCCCCGGTTCGCGCGTCTATTGCCGCCTGATCGTCGAGAACGAGGGCGCGGAATGGCCGCTGTCGCGCAAGTTCG
GCACCACGCTGGACAGCGCGCGCGACCTGATGCTGCGCGCCCGCGACATGGGGCTGGACCCGTACGGCCTGTCGTTCCAT
GTCGGCAGCCAGCAGACCAGCACCGATGCGTACGAGGCCGCGATCGCGCGGGTGGGCATGCTGTTCACCGACCTGGCCGC
GGCCGGTCTGAACCTGCGCATGGTCAATCTGGGCGGCGGCTTCCCGATCCGCTACCGCGAGGACGTGCCCGAGATCGACC
GGTTCGCGGTGGCGATCAGCCACGCGATGACCGAGCATTTCGGCAATGACCTGCCGGAAATGATCGTCGAGCCCGGGCGC
TTCATCGTCGGCGATGCCGGCGTGGTGTCGTCGGAGGTCGTGCTGGTCACGCGGCGCGGGCAGCAGGACGGGCCACGCTG
GGTCTATCTGGATATCGGCCGCTTCGGCGGGCTGGCGGAGACCGAGGGCGAATCCATCCGCTACGGCATCCGCACGCCCC
ATGACGGATCGCCCGCCGGGCGGGTGGCCATCGCCGGCCCGACCTGCGACGGTGCCGACATCATGTACGAAAAGGCGCCC
TACGCCCTGCCGCTGGACCTGGCCTGCGGCGACCGGATCGAATTGCTGTCGACCGGGGCCTATGTCTCGACCTACTGCTC
GACCAGCTTCAACGGCTTCGCCCCGCTGACTGAGCATTATATCTGA

Upstream 100 bases:

>100_bases
GGTGGGGCCGTTACCGGCCGGGGAGAAGTGGCTGTTGGCCTGCATGACCCCTACCTAACGAAAAACATGCGCACGGGTCG
ATTTTTCTGTTGCGCCCAAA

Downstream 100 bases:

>100_bases
TGGACCGTGCAGGGGCGTGATGCCCCGCACACCGATCGGATCATAACGAATCGGTTTCCAAAGGCCGGCGGCCTTTGGCT
CCGGACTGCCCCCTACTCGA

Product: ornithine decarboxylase

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MVCPHMRSPRNNARATGPLRLRNDVKRSGNRDPSPGPLGRWSVRPFRNSLSGIDPDGRYRRELGAMTPKIARFLAEQAPA
TPCLVVDVDRVEARYQSLRAALPLARIYYAVKANPAPAILRRLVSLGSAFDAASWEEIRLCLAAGAAGADISFGNTVKKA
SAIAQAHQAGVTMFAFDSIEELEKLARHAPGSRVYCRLIVENEGAEWPLSRKFGTTLDSARDLMLRARDMGLDPYGLSFH
VGSQQTSTDAYEAAIARVGMLFTDLAAAGLNLRMVNLGGGFPIRYREDVPEIDRFAVAISHAMTEHFGNDLPEMIVEPGR
FIVGDAGVVSSEVVLVTRRGQQDGPRWVYLDIGRFGGLAETEGESIRYGIRTPHDGSPAGRVAIAGPTCDGADIMYEKAP
YALPLDLACGDRIELLSTGAYVSTYCSTSFNGFAPLTEHYI

Sequences:

>Translated_441_residues
MVCPHMRSPRNNARATGPLRLRNDVKRSGNRDPSPGPLGRWSVRPFRNSLSGIDPDGRYRRELGAMTPKIARFLAEQAPA
TPCLVVDVDRVEARYQSLRAALPLARIYYAVKANPAPAILRRLVSLGSAFDAASWEEIRLCLAAGAAGADISFGNTVKKA
SAIAQAHQAGVTMFAFDSIEELEKLARHAPGSRVYCRLIVENEGAEWPLSRKFGTTLDSARDLMLRARDMGLDPYGLSFH
VGSQQTSTDAYEAAIARVGMLFTDLAAAGLNLRMVNLGGGFPIRYREDVPEIDRFAVAISHAMTEHFGNDLPEMIVEPGR
FIVGDAGVVSSEVVLVTRRGQQDGPRWVYLDIGRFGGLAETEGESIRYGIRTPHDGSPAGRVAIAGPTCDGADIMYEKAP
YALPLDLACGDRIELLSTGAYVSTYCSTSFNGFAPLTEHYI
>Mature_441_residues
MVCPHMRSPRNNARATGPLRLRNDVKRSGNRDPSPGPLGRWSVRPFRNSLSGIDPDGRYRRELGAMTPKIARFLAEQAPA
TPCLVVDVDRVEARYQSLRAALPLARIYYAVKANPAPAILRRLVSLGSAFDAASWEEIRLCLAAGAAGADISFGNTVKKA
SAIAQAHQAGVTMFAFDSIEELEKLARHAPGSRVYCRLIVENEGAEWPLSRKFGTTLDSARDLMLRARDMGLDPYGLSFH
VGSQQTSTDAYEAAIARVGMLFTDLAAAGLNLRMVNLGGGFPIRYREDVPEIDRFAVAISHAMTEHFGNDLPEMIVEPGR
FIVGDAGVVSSEVVLVTRRGQQDGPRWVYLDIGRFGGLAETEGESIRYGIRTPHDGSPAGRVAIAGPTCDGADIMYEKAP
YALPLDLACGDRIELLSTGAYVSTYCSTSFNGFAPLTEHYI

Specific function: Decarboxylates both L-lysine and L-ornithine with similar catalytic efficiency [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=378, Percent_Identity=31.7460317460317, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI16506287, Length=358, Percent_Identity=27.3743016759777, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI22538418, Length=372, Percent_Identity=25.5376344086022, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI21361583, Length=372, Percent_Identity=25.5376344086022, Blast_Score=115, Evalue=8e-26,
Organism=Escherichia coli, GI1789203, Length=353, Percent_Identity=25.2124645892351, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562780, Length=372, Percent_Identity=29.3010752688172, Blast_Score=148, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6322664, Length=379, Percent_Identity=27.9683377308707, Blast_Score=137, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24586472, Length=364, Percent_Identity=30.4945054945055, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24586474, Length=356, Percent_Identity=28.3707865168539, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- InterPro:   IPR002433 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.17; =4.1.1.18 [H]

Molecular weight: Translated: 47904; Mature: 47904

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVCPHMRSPRNNARATGPLRLRNDVKRSGNRDPSPGPLGRWSVRPFRNSLSGIDPDGRYR
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCCHHHH
RELGAMTPKIARFLAEQAPATPCLVVDVDRVEARYQSLRAALPLARIYYAVKANPAPAIL
HHHHCCCHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCHHHEEEEEECCCHHHHH
RRLVSLGSAFDAASWEEIRLCLAAGAAGADISFGNTVKKASAIAQAHQAGVTMFAFDSIE
HHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEHHHHH
ELEKLARHAPGSRVYCRLIVENEGAEWPLSRKFGTTLDSARDLMLRARDMGLDPYGLSFH
HHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEE
VGSQQTSTDAYEAAIARVGMLFTDLAAAGLNLRMVNLGGGFPIRYREDVPEIDRFAVAIS
ECCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHH
HAMTEHFGNDLPEMIVEPGRFIVGDAGVVSSEVVLVTRRGQQDGPRWVYLDIGRFGGLAE
HHHHHHHCCCCHHHHHCCCCEEEECCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCC
TEGESIRYGIRTPHDGSPAGRVAIAGPTCDGADIMYEKAPYALPLDLACGDRIELLSTGA
CCCCCEEECCCCCCCCCCCCEEEEECCCCCCCCEEECCCCCCEEEECCCCCCEEEEECCC
YVSTYCSTSFNGFAPLTEHYI
HHHHHHCCCCCCCCCHHHCCC
>Mature Secondary Structure
MVCPHMRSPRNNARATGPLRLRNDVKRSGNRDPSPGPLGRWSVRPFRNSLSGIDPDGRYR
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCCHHHH
RELGAMTPKIARFLAEQAPATPCLVVDVDRVEARYQSLRAALPLARIYYAVKANPAPAIL
HHHHCCCHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCHHHEEEEEECCCHHHHH
RRLVSLGSAFDAASWEEIRLCLAAGAAGADISFGNTVKKASAIAQAHQAGVTMFAFDSIE
HHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEHHHHH
ELEKLARHAPGSRVYCRLIVENEGAEWPLSRKFGTTLDSARDLMLRARDMGLDPYGLSFH
HHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEE
VGSQQTSTDAYEAAIARVGMLFTDLAAAGLNLRMVNLGGGFPIRYREDVPEIDRFAVAIS
ECCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHH
HAMTEHFGNDLPEMIVEPGRFIVGDAGVVSSEVVLVTRRGQQDGPRWVYLDIGRFGGLAE
HHHHHHHCCCCHHHHHCCCCEEEECCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCC
TEGESIRYGIRTPHDGSPAGRVAIAGPTCDGADIMYEKAPYALPLDLACGDRIELLSTGA
CCCCCEEECCCCCCCCCCCCEEEEECCCCCCCCEEECCCCCCEEEECCCCCCEEEEECCC
YVSTYCSTSFNGFAPLTEHYI
HHHHHHCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11073919 [H]