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The map label for this gene is degP [H]

Identifier: 162147098

GI number: 162147098

Start: 1302496

End: 1304025

Strand: Direct

Name: degP [H]

Synonym: GDI_1303

Alternate gene names: 162147098

Gene position: 1302496-1304025 (Clockwise)

Preceding gene: 162147097

Following gene: 162147100

Centisome position: 33.02

GC content: 69.61

Gene sequence:

>1530_bases
ATGCGGGGCGGAATCCTGGCCGCGCTGGTTGCGGGAACCATGCTGGGGGGCGTGGCCGCCGACGGGCTGGTCCCCGTGGC
GCGGGCCGACGATACCGGGGTGATCCGTCCCGACACGCAGGTCCAGACCCTGCCGAACTTCGTCAACCTGGTGAAGCAGG
TCCGGCCCGCCGTGGTGTCGATCACCTCCAGCATCCGTGCCGAGGACCTGGGGGACGAAGGCGGCGGCGGCGCCGAGGGG
CAGCAGCAGATGCCCTTCCCGTTCCCCTTCCCGTTCCAGATGATGCCGCAGCAGCAGCGCCGCACGGTCGAGGCGCGGGG
ATCGGGCTTCATCATCTCGGCCGACGGCTATGTCGTGACCAACAACCATGTGGTCAAGGGCGCGACCAAGGTCACGGTGA
CGCTGGATGACGGCACCACCCTGCCGGCCAAGATCGTCGGCCGCGATTCCAAGACCGACCTCGCGCTGCTGAAGGTCACG
TCGCAGGGCAAGCTGCGCTTCATCGAACTGGGCGATTCCGACAAGGTCGAGCCCGGGGAATGGGTGGTCGCGGTCGGCAA
TCCCTACGGGCTGGGCGGCACGGTCACCGCCGGCATCGTTTCGGCGCGCGGGCGTGACATCGGCGACGGGCCGTACGATT
CGTTCATCCAGGTCGATGCCCCGATCAATCGCGGCAATTCCGGCGGCCCGCTCTTCACCCAGGACGGCAAGGTCGTGGGC
GTCAATACCGCCATCCTCTCGCCCTCGGGCGGGTCGATCGGCATCGGCTTCGCCATCCCGTCCGACGTGGTGAAGAACGT
CGTCTACCAGTTGCAGAAGACCGGGCACGTCACCCGGGGTTACCTCGGCGTGGTCGCGCAGGTGATCACGCCCGCGATGG
CCACGGCGCTGGGCCTGAAGCCCGCGGCGCCCGGCGCGCCGCCCAGCGGCGCCCTGGTCGCCAGTGTCAGCAACGGCAGC
CCGGCCGAAAAGGCGGGGATCAAGGCCGGGGACGTGATCACCACCCTGAACGGGCAGAAGATCGACAGCCCGCATGATCT
GGCGGTCAAGGTGGCCTCGATCGTGCCGGGCAGCAAGGCGGCGGTGAACTATATGCGCGGCACGGCCGCGCAGAGCACGA
CGGTCACGATCGCCAACCTCTCCGGCGCTCCGTCGCCCGACGGCGCGGTCGGGGACAGGAACGACGGCGGTCCGCGCCTG
GGCGTCTCGCTGTCGCCCCTGACGTCGGACCTGCGCCAGCAACTGGGCCTGGACGGGTCGGTGCGCGGCGTCGTCGTCAG
CGACGTCCAGTCGGGTTCGGCGGCGGAACAGGCCGGAATCCACGCGGGCGACGTGATCCAGGCGGTGGGCAACAAGCCGG
TGGAAAACCCCGGCGCTACCGTCACCGCCGTCCGCGCGGCGCTGAAATCCAACCAGTCGGTCCTGCTGCGCATCCTGCGC
AACGGGCAGAACATCTTCGTCGCCGTCACGCCGGGCTCGGATGAGGGCGACAGCGGCAACGGCAACAGCGACCCCGACGG
CAACGACTGA

Upstream 100 bases:

>100_bases
GACACAGGATGCGGGGCGGACCACTCCGGTCGCCCCGGAAACAATCAGGAATGCTATGTCTGACGAGCTTCAGCCGATGT
CTTCTCTCCGCGCCCGCCGG

Downstream 100 bases:

>100_bases
CGGGCGGGCGGCCGCCCTGCCGGGCGGCCCGCCATGTCGTACTTTTACTTCCGCCAGGTCGCCAGGAACGCGTCAACATC
CGCCACGCGCGTATAATAAC

Product: Serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MRGGILAALVAGTMLGGVAADGLVPVARADDTGVIRPDTQVQTLPNFVNLVKQVRPAVVSITSSIRAEDLGDEGGGGAEG
QQQMPFPFPFPFQMMPQQQRRTVEARGSGFIISADGYVVTNNHVVKGATKVTVTLDDGTTLPAKIVGRDSKTDLALLKVT
SQGKLRFIELGDSDKVEPGEWVVAVGNPYGLGGTVTAGIVSARGRDIGDGPYDSFIQVDAPINRGNSGGPLFTQDGKVVG
VNTAILSPSGGSIGIGFAIPSDVVKNVVYQLQKTGHVTRGYLGVVAQVITPAMATALGLKPAAPGAPPSGALVASVSNGS
PAEKAGIKAGDVITTLNGQKIDSPHDLAVKVASIVPGSKAAVNYMRGTAAQSTTVTIANLSGAPSPDGAVGDRNDGGPRL
GVSLSPLTSDLRQQLGLDGSVRGVVVSDVQSGSAAEQAGIHAGDVIQAVGNKPVENPGATVTAVRAALKSNQSVLLRILR
NGQNIFVAVTPGSDEGDSGNGNSDPDGND

Sequences:

>Translated_509_residues
MRGGILAALVAGTMLGGVAADGLVPVARADDTGVIRPDTQVQTLPNFVNLVKQVRPAVVSITSSIRAEDLGDEGGGGAEG
QQQMPFPFPFPFQMMPQQQRRTVEARGSGFIISADGYVVTNNHVVKGATKVTVTLDDGTTLPAKIVGRDSKTDLALLKVT
SQGKLRFIELGDSDKVEPGEWVVAVGNPYGLGGTVTAGIVSARGRDIGDGPYDSFIQVDAPINRGNSGGPLFTQDGKVVG
VNTAILSPSGGSIGIGFAIPSDVVKNVVYQLQKTGHVTRGYLGVVAQVITPAMATALGLKPAAPGAPPSGALVASVSNGS
PAEKAGIKAGDVITTLNGQKIDSPHDLAVKVASIVPGSKAAVNYMRGTAAQSTTVTIANLSGAPSPDGAVGDRNDGGPRL
GVSLSPLTSDLRQQLGLDGSVRGVVVSDVQSGSAAEQAGIHAGDVIQAVGNKPVENPGATVTAVRAALKSNQSVLLRILR
NGQNIFVAVTPGSDEGDSGNGNSDPDGND
>Mature_509_residues
MRGGILAALVAGTMLGGVAADGLVPVARADDTGVIRPDTQVQTLPNFVNLVKQVRPAVVSITSSIRAEDLGDEGGGGAEG
QQQMPFPFPFPFQMMPQQQRRTVEARGSGFIISADGYVVTNNHVVKGATKVTVTLDDGTTLPAKIVGRDSKTDLALLKVT
SQGKLRFIELGDSDKVEPGEWVVAVGNPYGLGGTVTAGIVSARGRDIGDGPYDSFIQVDAPINRGNSGGPLFTQDGKVVG
VNTAILSPSGGSIGIGFAIPSDVVKNVVYQLQKTGHVTRGYLGVVAQVITPAMATALGLKPAAPGAPPSGALVASVSNGS
PAEKAGIKAGDVITTLNGQKIDSPHDLAVKVASIVPGSKAAVNYMRGTAAQSTTVTIANLSGAPSPDGAVGDRNDGGPRL
GVSLSPLTSDLRQQLGLDGSVRGVVVSDVQSGSAAEQAGIHAGDVIQAVGNKPVENPGATVTAVRAALKSNQSVLLRILR
NGQNIFVAVTPGSDEGDSGNGNSDPDGND

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=266, Percent_Identity=41.3533834586466, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI22129776, Length=280, Percent_Identity=37.1428571428571, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI24308541, Length=252, Percent_Identity=38.0952380952381, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI7019477, Length=281, Percent_Identity=37.3665480427046, Blast_Score=149, Evalue=6e-36,
Organism=Escherichia coli, GI1786356, Length=475, Percent_Identity=37.4736842105263, Blast_Score=255, Evalue=4e-69,
Organism=Escherichia coli, GI1789629, Length=459, Percent_Identity=36.3834422657952, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1789630, Length=285, Percent_Identity=37.8947368421053, Blast_Score=162, Evalue=6e-41,
Organism=Drosophila melanogaster, GI24646839, Length=295, Percent_Identity=36.271186440678, Blast_Score=152, Evalue=5e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 51547; Mature: 51547

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGGILAALVAGTMLGGVAADGLVPVARADDTGVIRPDTQVQTLPNFVNLVKQVRPAVVS
CCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHH
ITSSIRAEDLGDEGGGGAEGQQQMPFPFPFPFQMMPQQQRRTVEARGSGFIISADGYVVT
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHCCCHHHHHHHHCCCCEEEEECCCEEEE
NNHVVKGATKVTVTLDDGTTLPAKIVGRDSKTDLALLKVTSQGKLRFIELGDSDKVEPGE
CCEEEECCEEEEEEECCCCCCCCEEECCCCCCCEEEEEEECCCCEEEEEECCCCCCCCCC
WVVAVGNPYGLGGTVTAGIVSARGRDIGDGPYDSFIQVDAPINRGNSGGPLFTQDGKVVG
EEEECCCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEECCCEEEE
VNTAILSPSGGSIGIGFAIPSDVVKNVVYQLQKTGHVTRGYLGVVAQVITPAMATALGLK
EEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
PAAPGAPPSGALVASVSNGSPAEKAGIKAGDVITTLNGQKIDSPHDLAVKVASIVPGSKA
CCCCCCCCCCCEEEEECCCCCHHHHCCCCCCEEEECCCCCCCCCHHHEEEEEHHCCCCHH
AVNYMRGTAAQSTTVTIANLSGAPSPDGAVGDRNDGGPRLGVSLSPLTSDLRQQLGLDGS
HHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEECEEECHHHHHHHHHHCCCCC
VRGVVVSDVQSGSAAEQAGIHAGDVIQAVGNKPVENPGATVTAVRAALKSNQSVLLRILR
CCEEEEECCCCCCCHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHH
NGQNIFVAVTPGSDEGDSGNGNSDPDGND
CCCEEEEEEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRGGILAALVAGTMLGGVAADGLVPVARADDTGVIRPDTQVQTLPNFVNLVKQVRPAVVS
CCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHH
ITSSIRAEDLGDEGGGGAEGQQQMPFPFPFPFQMMPQQQRRTVEARGSGFIISADGYVVT
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHCCCHHHHHHHHCCCCEEEEECCCEEEE
NNHVVKGATKVTVTLDDGTTLPAKIVGRDSKTDLALLKVTSQGKLRFIELGDSDKVEPGE
CCEEEECCEEEEEEECCCCCCCCEEECCCCCCCEEEEEEECCCCEEEEEECCCCCCCCCC
WVVAVGNPYGLGGTVTAGIVSARGRDIGDGPYDSFIQVDAPINRGNSGGPLFTQDGKVVG
EEEECCCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEECCCEEEE
VNTAILSPSGGSIGIGFAIPSDVVKNVVYQLQKTGHVTRGYLGVVAQVITPAMATALGLK
EEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
PAAPGAPPSGALVASVSNGSPAEKAGIKAGDVITTLNGQKIDSPHDLAVKVASIVPGSKA
CCCCCCCCCCCEEEEECCCCCHHHHCCCCCCEEEECCCCCCCCCHHHEEEEEHHCCCCHH
AVNYMRGTAAQSTTVTIANLSGAPSPDGAVGDRNDGGPRLGVSLSPLTSDLRQQLGLDGS
HHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEECEEECHHHHHHHHHHCCCCC
VRGVVVSDVQSGSAAEQAGIHAGDVIQAVGNKPVENPGATVTAVRAALKSNQSVLLRILR
CCEEEEECCCCCCCHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHH
NGQNIFVAVTPGSDEGDSGNGNSDPDGND
CCCEEEEEEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]