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The map label for this gene is hemN [H]

Identifier: 162147071

GI number: 162147071

Start: 1272756

End: 1274120

Strand: Direct

Name: hemN [H]

Synonym: GDI_1276

Alternate gene names: 162147071

Gene position: 1272756-1274120 (Clockwise)

Preceding gene: 162147070

Following gene: 162147072

Centisome position: 32.27

GC content: 71.79

Gene sequence:

>1365_bases
ATGCCCTCTTCCGACCTGCTGATCCGGTACGGGGGCAACCTGCCGCGTTACACCAGCTACCCGACCGCGGCACAGTTCGA
TGCCTCGGTCGGGGCGGATGACAGCGAGGCGTGGCTGCGCGCCATGGCGCCGGGCACCCCGCTTTCGCTGTATCTTCATG
TTCCCTTCTGCGATGCGCTGTGCCTGTTCTGCGGGTGCAACACGTCTGTGATGCGCGACCCGGCCGGCCGTACGGCCTAT
GGCGCGCTGCTGATGGACGAACTGCGCAGGGTGGCCGGGCGCCTCGGCCCCGACCATCCGGTCCGCCACGTGCAGTGGGG
CGGCGGCACGCCGACGACCCTGCCGCCCGAGACCATGCGGGCCGCGATGCAGACGATCCGCCGGCTCTTCACCATCGAGC
GCGACGCGGAAATCGCGATCGAACTCGACCCCCGCCATATGCCCGACGCCTATCCCGACCTGCTGCGCACGCTGGGATTC
AACCGCGTCAGCCTGGGCGTCCAGGACCTGGACCCCGCCGTGCAGACGGCCTGCGGCCGAATCCAGAGCCGTGCCCAGAC
CGAGGACTGCGTCCGCCGCGTGCGCGCGGCCGGGATCGCCTCGGTCAATGTCGATCTGATCTATGGCCTGCCGTACCAGA
CGGTGGACGGCGCGGGCGAAACCGCGGCGACCGTCGCCGCCGCGCTGCGGCCCGACCGGCTGGCGGTGTTCGGCTACGCC
CATGTGCCCTGGAAGCAGAAGCGCCAGGCGCTGCTGCCCGAAAGCGTGCTGCCCGGCCCCGCCGAACGGCTGGCGCAACG
TGCGCGGATCGATGCGGTCCTGCGTGCCGCCGGGTATCGCGCGATCGGGCTGGACCATTATGCCCGGCCCGGCGACGCGC
TGACCCTCGCCGCCGAAGGCGGCACCATGCGCCGCAATTTCCAGGGTTATACCGTCGATCCGGCCCCGGTCCTGATCGGG
ATCGGCGCCTCGGCGATTTCCTCCTATCCCCAGGGCATGACCCAGAACGCCCTGACCGCCGCCGCCTACGCGCGGCTGAT
GGGCCAGGGCACCGACACCCTGCCGGTGGTGCGGGGGGTGCGCCGCACCGATGACGACCGGCTGCGCGGGGCGGTGATCG
AACGGCTGATGTGCGACCTGCGGGTCGATCCGGCGGCGATCGGCGCCCATCATGGCGTGCCCGCGACCTGGTTCGCCGAT
GCCATGCCCGGCCTGCACCAGGCGGCGGCGGACGGGATCGTGACGCTGGACGGCGCGATGATCCGCATGACCGACGCGGG
ACGGCCCTTCCTGCGCAACATCGCCGCCCTGTTCGACGCGCATCGCGCCCCCCCGGGTGCCGCCCGCCATGCCGGCGCCC
TGTAG

Upstream 100 bases:

>100_bases
GGTGGCGGCGTCGATGGCGTTCCGCGCATCAAGGTGCATGACTCGCTGGACCCGACGGTGGTAGGCGCCGGTATCGAATA
CCGGTTCTGATCCCGTGGGG

Downstream 100 bases:

>100_bases
GACGCGGCTTCAGGGCTTCCGCCGCGGGTGGGCCGAAATTCTTGAAAATCCATGCCGGATGGCGCACTACCTGCGGTTCC
CGCTCATCAGTCCCCTTGTC

Product: oxygen-independent coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MPSSDLLIRYGGNLPRYTSYPTAAQFDASVGADDSEAWLRAMAPGTPLSLYLHVPFCDALCLFCGCNTSVMRDPAGRTAY
GALLMDELRRVAGRLGPDHPVRHVQWGGGTPTTLPPETMRAAMQTIRRLFTIERDAEIAIELDPRHMPDAYPDLLRTLGF
NRVSLGVQDLDPAVQTACGRIQSRAQTEDCVRRVRAAGIASVNVDLIYGLPYQTVDGAGETAATVAAALRPDRLAVFGYA
HVPWKQKRQALLPESVLPGPAERLAQRARIDAVLRAAGYRAIGLDHYARPGDALTLAAEGGTMRRNFQGYTVDPAPVLIG
IGASAISSYPQGMTQNALTAAAYARLMGQGTDTLPVVRGVRRTDDDRLRGAVIERLMCDLRVDPAAIGAHHGVPATWFAD
AMPGLHQAAADGIVTLDGAMIRMTDAGRPFLRNIAALFDAHRAPPGAARHAGAL

Sequences:

>Translated_454_residues
MPSSDLLIRYGGNLPRYTSYPTAAQFDASVGADDSEAWLRAMAPGTPLSLYLHVPFCDALCLFCGCNTSVMRDPAGRTAY
GALLMDELRRVAGRLGPDHPVRHVQWGGGTPTTLPPETMRAAMQTIRRLFTIERDAEIAIELDPRHMPDAYPDLLRTLGF
NRVSLGVQDLDPAVQTACGRIQSRAQTEDCVRRVRAAGIASVNVDLIYGLPYQTVDGAGETAATVAAALRPDRLAVFGYA
HVPWKQKRQALLPESVLPGPAERLAQRARIDAVLRAAGYRAIGLDHYARPGDALTLAAEGGTMRRNFQGYTVDPAPVLIG
IGASAISSYPQGMTQNALTAAAYARLMGQGTDTLPVVRGVRRTDDDRLRGAVIERLMCDLRVDPAAIGAHHGVPATWFAD
AMPGLHQAAADGIVTLDGAMIRMTDAGRPFLRNIAALFDAHRAPPGAARHAGAL
>Mature_453_residues
PSSDLLIRYGGNLPRYTSYPTAAQFDASVGADDSEAWLRAMAPGTPLSLYLHVPFCDALCLFCGCNTSVMRDPAGRTAYG
ALLMDELRRVAGRLGPDHPVRHVQWGGGTPTTLPPETMRAAMQTIRRLFTIERDAEIAIELDPRHMPDAYPDLLRTLGFN
RVSLGVQDLDPAVQTACGRIQSRAQTEDCVRRVRAAGIASVNVDLIYGLPYQTVDGAGETAATVAAALRPDRLAVFGYAH
VPWKQKRQALLPESVLPGPAERLAQRARIDAVLRAAGYRAIGLDHYARPGDALTLAAEGGTMRRNFQGYTVDPAPVLIGI
GASAISSYPQGMTQNALTAAAYARLMGQGTDTLPVVRGVRRTDDDRLRGAVIERLMCDLRVDPAAIGAHHGVPATWFADA
MPGLHQAAADGIVTLDGAMIRMTDAGRPFLRNIAALFDAHRAPPGAARHAGAL

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=252, Percent_Identity=28.968253968254, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI87082341, Length=439, Percent_Identity=39.8633257403189, Blast_Score=298, Evalue=4e-82,
Organism=Escherichia coli, GI1789325, Length=403, Percent_Identity=27.0471464019851, Blast_Score=100, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 48670; Mature: 48539

Theoretical pI: Translated: 8.08; Mature: 8.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSSDLLIRYGGNLPRYTSYPTAAQFDASVGADDSEAWLRAMAPGTPLSLYLHVPFCDAL
CCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCEEEEEECCHHHHH
CLFCGCNTSVMRDPAGRTAYGALLMDELRRVAGRLGPDHPVRHVQWGGGTPTTLPPETMR
HHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCHHHHH
AAMQTIRRLFTIERDAEIAIELDPRHMPDAYPDLLRTLGFNRVSLGVQDLDPAVQTACGR
HHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCEECCHHHCCHHHHHHHHH
IQSRAQTEDCVRRVRAAGIASVNVDLIYGLPYQTVDGAGETAATVAAALRPDRLAVFGYA
HHHHCHHHHHHHHHHHHCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEE
HVPWKQKRQALLPESVLPGPAERLAQRARIDAVLRAAGYRAIGLDHYARPGDALTLAAEG
CCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEEECC
GTMRRNFQGYTVDPAPVLIGIGASAISSYPQGMTQNALTAAAYARLMGQGTDTLPVVRGV
CCCCCCCCCCEECCCCEEEECCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHC
RRTDDDRLRGAVIERLMCDLRVDPAAIGAHHGVPATWFADAMPGLHQAAADGIVTLDGAM
CCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHCCCCHHHHHCCCEEEECCEE
IRMTDAGRPFLRNIAALFDAHRAPPGAARHAGAL
EEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
PSSDLLIRYGGNLPRYTSYPTAAQFDASVGADDSEAWLRAMAPGTPLSLYLHVPFCDAL
CCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCEEEEEECCHHHHH
CLFCGCNTSVMRDPAGRTAYGALLMDELRRVAGRLGPDHPVRHVQWGGGTPTTLPPETMR
HHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCHHHHH
AAMQTIRRLFTIERDAEIAIELDPRHMPDAYPDLLRTLGFNRVSLGVQDLDPAVQTACGR
HHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCEECCHHHCCHHHHHHHHH
IQSRAQTEDCVRRVRAAGIASVNVDLIYGLPYQTVDGAGETAATVAAALRPDRLAVFGYA
HHHHCHHHHHHHHHHHHCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEE
HVPWKQKRQALLPESVLPGPAERLAQRARIDAVLRAAGYRAIGLDHYARPGDALTLAAEG
CCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEEECC
GTMRRNFQGYTVDPAPVLIGIGASAISSYPQGMTQNALTAAAYARLMGQGTDTLPVVRGV
CCCCCCCCCCEECCCCEEEECCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHC
RRTDDDRLRGAVIERLMCDLRVDPAAIGAHHGVPATWFADAMPGLHQAAADGIVTLDGAM
CCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHCCCCHHHHHCCCEEEECCEE
IRMTDAGRPFLRNIAALFDAHRAPPGAARHAGAL
EEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11157943; 12597275 [H]