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The map label for this gene is atpB

Identifier: 162146975

GI number: 162146975

Start: 1176084

End: 1176833

Strand: Reverse

Name: atpB

Synonym: GDI_1180

Alternate gene names: 162146975

Gene position: 1176833-1176084 (Counterclockwise)

Preceding gene: 162146976

Following gene: 162146974

Centisome position: 29.84

GC content: 63.33

Gene sequence:

>750_bases
TTGGCGGCTGGATCCACCATCGACGCACTGGGTCAGTTCGAACTCCATCCCGTCCTGGGCGGACTGGGCGAATCCTTGCG
CTTCAGCCAGTCGCCCGTCATGATGATCGTGGCGTCCGTCCTGGTCCTGGCGTTCCTGTATGTCGGCATGCGTCCCGCCG
CCATCGTGCCCGGCCGCCTGCAGGCGGCGGCGGAAATCTGCTACGATTTCATCCATGACATGGCGGTGGACACGATCGGG
CCCGAGGGTCGGGCGTTCTTCCCGTTCATCTTTACGCTGTTCTTCTTCATCCTGGCCGGCAACTATCTCGGCCTGCTGCC
CTTCTCGTTCGCCTTTACCAGCCATATCGCCGTGACGCTCGCGCTCGCGCTGCTGGTGTTCGTGCTGGCGGTCATCGTCT
CGCTCAAGGCGCAGGGCCCGAAGTTCTTCGCGCATTTCATGCCGGCGGGGGCGCCCGTCGCCCTGGCCCCACTGCTGGTG
CCGATCGAAATCCTCTCATTCCTTTCCCGTCCCGTCAGCCTGTCGATCCGTCTGTTCGCCAACATGGTCGCCGGTCACGT
GATGCTGGAAATGTTCGCCGCCTTCACGATCATGCTGGCCGGGCTCGGACTGTTCGGCGACGTGCTCGCCGTCGGGCCGG
TGGTCATCAATGTCGCGTTGATGGCACTTGAATTGCTAGTGGGTGCGCTGCAGGCCTATGTCTTCGCCATTCTCACCTGC
ATCTACCTGCGGGAGGCGGTCGCGCACTGA

Upstream 100 bases:

>100_bases
TGCGGGTGTGCTGAATGTCTGGCGTCTGGTCAGGCCCATGGACACGCCGGGGGACAAGCCGGACCCGTAGGCGGGCCGGC
GCGGTAGAGGGAAGACGAAG

Downstream 100 bases:

>100_bases
TCGCGACGTATCCCCAGCCTCTTTGAACGCCTGAACAACCAAGGAAAGCCTCGCTATGGACATCGCTGCAGCCCGGGAAA
TTGGTGCCGGTATCGCCGTT

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MAAGSTIDALGQFELHPVLGGLGESLRFSQSPVMMIVASVLVLAFLYVGMRPAAIVPGRLQAAAEICYDFIHDMAVDTIG
PEGRAFFPFIFTLFFFILAGNYLGLLPFSFAFTSHIAVTLALALLVFVLAVIVSLKAQGPKFFAHFMPAGAPVALAPLLV
PIEILSFLSRPVSLSIRLFANMVAGHVMLEMFAAFTIMLAGLGLFGDVLAVGPVVINVALMALELLVGALQAYVFAILTC
IYLREAVAH

Sequences:

>Translated_249_residues
MAAGSTIDALGQFELHPVLGGLGESLRFSQSPVMMIVASVLVLAFLYVGMRPAAIVPGRLQAAAEICYDFIHDMAVDTIG
PEGRAFFPFIFTLFFFILAGNYLGLLPFSFAFTSHIAVTLALALLVFVLAVIVSLKAQGPKFFAHFMPAGAPVALAPLLV
PIEILSFLSRPVSLSIRLFANMVAGHVMLEMFAAFTIMLAGLGLFGDVLAVGPVVINVALMALELLVGALQAYVFAILTC
IYLREAVAH
>Mature_248_residues
AAGSTIDALGQFELHPVLGGLGESLRFSQSPVMMIVASVLVLAFLYVGMRPAAIVPGRLQAAAEICYDFIHDMAVDTIGP
EGRAFFPFIFTLFFFILAGNYLGLLPFSFAFTSHIAVTLALALLVFVLAVIVSLKAQGPKFFAHFMPAGAPVALAPLLVP
IEILSFLSRPVSLSIRLFANMVAGHVMLEMFAAFTIMLAGLGLFGDVLAVGPVVINVALMALELLVGALQAYVFAILTCI
YLREAVAH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Homo sapiens, GI251831112, Length=191, Percent_Identity=30.8900523560209, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1790176, Length=217, Percent_Identity=28.110599078341, Blast_Score=74, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6226527, Length=245, Percent_Identity=34.6938775510204, Blast_Score=141, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_GLUDA (A9HDN1)

Other databases:

- EMBL:   AM889285
- EMBL:   CP001189
- RefSeq:   YP_001601436.1
- RefSeq:   YP_002276268.1
- ProteinModelPortal:   A9HDN1
- SMR:   A9HDN1
- GeneID:   5791620
- GeneID:   6975316
- GenomeReviews:   AM889285_GR
- GenomeReviews:   CP001189_GR
- KEGG:   gdj:Gdia_1893
- HOGENOM:   HBG734175
- OMA:   NISPNAR
- ProtClustDB:   PRK05815
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 26520; Mature: 26389

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x135ddf1c)-; HASH(0x1470ab18)-; HASH(0x1438d3f0)-; HASH(0x1419151c)-; HASH(0x14702728)-; HASH(0x1442ea08)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHCH
>Mature Secondary Structure 
AAGSTIDALGQFELHPVLGGLGESLRFSQSPVMMIVASVLVLAFLYVGMRPAAIVPGRL
CCCCHHHHHCCHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
QAAAEICYDFIHDMAVDTIGPEGRAFFPFIFTLFFFILAGNYLGLLPFSFAFTSHIAVTL
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
ALALLVFVLAVIVSLKAQGPKFFAHFMPAGAPVALAPLLVPIEILSFLSRPVSLSIRLFA
HHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
NMVAGHVMLEMFAAFTIMLAGLGLFGDVLAVGPVVINVALMALELLVGALQAYVFAILTC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYLREAVAH
HHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA