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The map label for this gene is gmk [H]

Identifier: 162146927

GI number: 162146927

Start: 1123768

End: 1124460

Strand: Direct

Name: gmk [H]

Synonym: GDI_1132

Alternate gene names: 162146927

Gene position: 1123768-1124460 (Clockwise)

Preceding gene: 162146923

Following gene: 162146928

Centisome position: 28.49

GC content: 71.14

Gene sequence:

>693_bases
ATGACGCACAGCCGCGAACGACAGCCGGGCGAACGCCCCCCCGCCCATCACCAGGGTCCGGCGGGCGGCCCGGTCGTGGC
GCGGCGCGGGGTGTGCCTGGTGATCTCGGCCCCGTCGGGGGCCGGAAAATCGACCATTGCCAATGCGTTGCGCGCGGCCG
AGCCCCGGCTGCTGCATTCGGTTTCCGTCACCACCCGCCAGCCCCGGCCCGGCGAGACCGACGGCGTCCACTATCATTTC
CGCAGCATGGAACAGTTCCAGCAGATGGCCGAGGCCGGCGAATTGCTGGAATGGGCGACGGTGTTCGGCCGGGGCTACGG
CACGCCGCGCGGCCCGGTCGAATCGGCCCTGGCCGAGGGGCGGGACATGGTGTTCGACATCGACTGGCAGGGCCACCGGC
AGATCCGCGCCGCCCTGCCCGACGACGTCATCAGCCTGTTCGTGCTGCCGCCGTCACTGGCGGAACTGGAGCGCCGGCTG
TGCAATCGCGCGTCCGACCACCCCGAGGAGATCGAGCGGCGGATGAAGGCGGCGCGCGACGAAATCGCGCACTGGCAGGA
ATTTGATCACGTCATCATCAATGCCGACCTGGACCGGGCGATCGGCGAGGCCCGGTCGGTCCTGACGGCAGCGCGGCTGC
AGACCCGGCGGCAGGCAGGGCTGGCGGCCTTCGTCGCCGGATTCGGCGCGTAG

Upstream 100 bases:

>100_bases
TATCCTGTTTCATATTCGCCAGAATAGAGACCTCCTGATAAAAGACCGCAAATCCGCGCGGCCGGCGCGGACCGGTTCAG
GACCCAAGGACACGCCGCCG

Downstream 100 bases:

>100_bases
CCGGCCATGGATTTTTCATCGATCACGGTGCTGTGCATCGGGGACATCATGCTGGACCGTTTCGTCTATGGCGAAATGGA
GCGCATTTCCCCCGAGGCCC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 230; Mature: 229

Protein sequence:

>230_residues
MTHSRERQPGERPPAHHQGPAGGPVVARRGVCLVISAPSGAGKSTIANALRAAEPRLLHSVSVTTRQPRPGETDGVHYHF
RSMEQFQQMAEAGELLEWATVFGRGYGTPRGPVESALAEGRDMVFDIDWQGHRQIRAALPDDVISLFVLPPSLAELERRL
CNRASDHPEEIERRMKAARDEIAHWQEFDHVIINADLDRAIGEARSVLTAARLQTRRQAGLAAFVAGFGA

Sequences:

>Translated_230_residues
MTHSRERQPGERPPAHHQGPAGGPVVARRGVCLVISAPSGAGKSTIANALRAAEPRLLHSVSVTTRQPRPGETDGVHYHF
RSMEQFQQMAEAGELLEWATVFGRGYGTPRGPVESALAEGRDMVFDIDWQGHRQIRAALPDDVISLFVLPPSLAELERRL
CNRASDHPEEIERRMKAARDEIAHWQEFDHVIINADLDRAIGEARSVLTAARLQTRRQAGLAAFVAGFGA
>Mature_229_residues
THSRERQPGERPPAHHQGPAGGPVVARRGVCLVISAPSGAGKSTIANALRAAEPRLLHSVSVTTRQPRPGETDGVHYHFR
SMEQFQQMAEAGELLEWATVFGRGYGTPRGPVESALAEGRDMVFDIDWQGHRQIRAALPDDVISLFVLPPSLAELERRLC
NRASDHPEEIERRMKAARDEIAHWQEFDHVIINADLDRAIGEARSVLTAARLQTRRQAGLAAFVAGFGA

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=183, Percent_Identity=40.4371584699454, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI4504221, Length=183, Percent_Identity=40.4371584699454, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI226874831, Length=183, Percent_Identity=40.4371584699454, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI262118255, Length=189, Percent_Identity=28.042328042328, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI4505237, Length=189, Percent_Identity=28.042328042328, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI262118259, Length=189, Percent_Identity=28.042328042328, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI262118263, Length=189, Percent_Identity=28.042328042328, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI14780902, Length=192, Percent_Identity=28.125, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1790080, Length=192, Percent_Identity=45.8333333333333, Blast_Score=173, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI193203132, Length=181, Percent_Identity=38.121546961326, Blast_Score=117, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17508835, Length=181, Percent_Identity=38.121546961326, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17557440, Length=154, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71988041, Length=172, Percent_Identity=27.3255813953488, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71988048, Length=172, Percent_Identity=27.3255813953488, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=38.2513661202186, Blast_Score=134, Evalue=1e-32,
Organism=Drosophila melanogaster, GI21356141, Length=190, Percent_Identity=35.7894736842105, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI116007136, Length=170, Percent_Identity=31.1764705882353, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI85724806, Length=170, Percent_Identity=31.1764705882353, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45554481, Length=170, Percent_Identity=31.1764705882353, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45554489, Length=170, Percent_Identity=30.5882352941176, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24640542, Length=170, Percent_Identity=30.5882352941176, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI161077626, Length=170, Percent_Identity=30.5882352941176, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 25272; Mature: 25141

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHSRERQPGERPPAHHQGPAGGPVVARRGVCLVISAPSGAGKSTIANALRAAEPRLLHS
CCCCCCCCCCCCCCCCCCCCCCCCCEECCCEEEEEECCCCCCHHHHHHHHHHCCCHHHHH
VSVTTRQPRPGETDGVHYHFRSMEQFQQMAEAGELLEWATVFGRGYGTPRGPVESALAEG
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCC
RDMVFDIDWQGHRQIRAALPDDVISLFVLPPSLAELERRLCNRASDHPEEIERRMKAARD
CCEEEECCCCCCHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
EIAHWQEFDHVIINADLDRAIGEARSVLTAARLQTRRQAGLAAFVAGFGA
HHHHHHHHCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
THSRERQPGERPPAHHQGPAGGPVVARRGVCLVISAPSGAGKSTIANALRAAEPRLLHS
CCCCCCCCCCCCCCCCCCCCCCCCEECCCEEEEEECCCCCCHHHHHHHHHHCCCHHHHH
VSVTTRQPRPGETDGVHYHFRSMEQFQQMAEAGELLEWATVFGRGYGTPRGPVESALAEG
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCC
RDMVFDIDWQGHRQIRAALPDDVISLFVLPPSLAELERRLCNRASDHPEEIERRMKAARD
CCEEEECCCCCCHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
EIAHWQEFDHVIINADLDRAIGEARSVLTAARLQTRRQAGLAAFVAGFGA
HHHHHHHHCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA