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The map label for this gene is hom [H]

Identifier: 162146850

GI number: 162146850

Start: 1047612

End: 1048967

Strand: Reverse

Name: hom [H]

Synonym: GDI_1033

Alternate gene names: 162146850

Gene position: 1048967-1047612 (Counterclockwise)

Preceding gene: 162146851

Following gene: 162146849

Centisome position: 26.6

GC content: 73.3

Gene sequence:

>1356_bases
TTGCCACGAACGACGACAGGACATCAGGTGACCGGACGGAACATGAACGCTGACGAGTTGCGGATCGGCATCGCGGGGCT
GGGCACGGTGGGTGCCGGGCTGGTCAAGCTGCTGCGCGCCAACGAATCGATCGTGGCCGCGCGGGCCGGCCGGCGGGTCG
TGGTGACCGCCGTGGCCGCCCGCGACCGCACCCGCGACCGGGGCATCGACCTGGGCGGCGTGACCTGGCACGACGACGCG
CTGGCCCTGGCGCGGGACCCGGACGTCGATGTCGTGGTCGAGCTGATCGGCGGGGCCGAGGGCATCGCCCGCGAGCTGGT
CACGGCGGCGCTGCGGGCCGGCCGCCCGGTGGTCACGGCGAACAAGGCGCTGATCGCCGTCCACGGCGCCGAACTGGCCG
AGCTGGCCGAACTGTCCGGCGTGCCCCTGATGTTCGAGGCCGCGGTGGCCGGCGGCATCCCCGCGATCAAGGCGGTGCGC
GAGGGCCTGGCCGCCGACCGGCTGACGCGGGTGGGCGGCATCCTGAACGGCACCTGCAACTACATCATGACCGCGATGCG
CGAGAGCGGCCGCCCCTTCGCCGACGTGCTGGCCGAGGCCCAGGCGCTGGGCTACGCCGAGGCCGATCCGTCCACCGATG
TCGACGGCATCGACGCGGCGCACAAGCTGGCCATCCTGGCCGGGCTGGCGTTCGGCCGGCCGGTGGCGTTCTCCTCGGTC
CATGTCGAGGGGATTCGCGGCATCGACGCGCTGGACCTCGGCTTCGCCCGGGCGCTGGGCTACCGCATCAAGCTGCTGGG
CCTGGCCCGCCGGCGCGAGGACGGGATCGAGGCCCGCGTCCATCCGTGCCTGGTGCCGGAAAAGGCGCCGATCGCGCAGG
TGGACGGCGTGTTCAACGCCGTGGTAGCCGAGGGCGCGTTCGTCGGCCGCCTGATGCTGGAGGGACGGGGCGCCGGCGAG
GGCCCGACCGCCACCGCCGTGGCCGCCGACCTGATCGACATCGCGCGCGGCATCGCCGTGCCGGTCTGGGGCCGCAGCGC
CGACGGGCTGACGCAGGTCGAGGCCCTGCCGCGCACCGCGTTCCACGAGGAATATTACCTGCGCCTGAACGTCCATGACC
GCCCCGGCGTGATTGCCGACGTCACGGCCGTCCTGCGCGATCACGGCGTTTCGCTGCGCAGCATGCTGCAGCACGGACGC
GCCGGCGCGGACGATACATCCGGCGAGCCCTCGGTGCCGCTGGTGCTGGTCACCCACCGCACGCGCGAATCCGCGATGAT
GGAGGCTCTGGCCCGGATCGCCGCCCTGCCGGCGGTGATCGGCGAACCGGCGATGATCCGCATCGAAGCCGGCTGA

Upstream 100 bases:

>100_bases
CCGGCCCGCGCCGAGCCGGTGCCCGACGCGGCGCTTTGACCCACCCTTCCCGCCCGGGCACGGACCGGGCGGGGAAAAAT
CGCACCCCGCACAAGGGGGT

Downstream 100 bases:

>100_bases
CCCCCGCCGGCGCAAGAACCGGCGAAAAAAAGAGAGAGGAAGACAGCGATGACGTCCACACCGACTTCCGGCAAACCCAG
CTCCAGCAAACCGAACGCCG

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MPRTTTGHQVTGRNMNADELRIGIAGLGTVGAGLVKLLRANESIVAARAGRRVVVTAVAARDRTRDRGIDLGGVTWHDDA
LALARDPDVDVVVELIGGAEGIARELVTAALRAGRPVVTANKALIAVHGAELAELAELSGVPLMFEAAVAGGIPAIKAVR
EGLAADRLTRVGGILNGTCNYIMTAMRESGRPFADVLAEAQALGYAEADPSTDVDGIDAAHKLAILAGLAFGRPVAFSSV
HVEGIRGIDALDLGFARALGYRIKLLGLARRREDGIEARVHPCLVPEKAPIAQVDGVFNAVVAEGAFVGRLMLEGRGAGE
GPTATAVAADLIDIARGIAVPVWGRSADGLTQVEALPRTAFHEEYYLRLNVHDRPGVIADVTAVLRDHGVSLRSMLQHGR
AGADDTSGEPSVPLVLVTHRTRESAMMEALARIAALPAVIGEPAMIRIEAG

Sequences:

>Translated_451_residues
MPRTTTGHQVTGRNMNADELRIGIAGLGTVGAGLVKLLRANESIVAARAGRRVVVTAVAARDRTRDRGIDLGGVTWHDDA
LALARDPDVDVVVELIGGAEGIARELVTAALRAGRPVVTANKALIAVHGAELAELAELSGVPLMFEAAVAGGIPAIKAVR
EGLAADRLTRVGGILNGTCNYIMTAMRESGRPFADVLAEAQALGYAEADPSTDVDGIDAAHKLAILAGLAFGRPVAFSSV
HVEGIRGIDALDLGFARALGYRIKLLGLARRREDGIEARVHPCLVPEKAPIAQVDGVFNAVVAEGAFVGRLMLEGRGAGE
GPTATAVAADLIDIARGIAVPVWGRSADGLTQVEALPRTAFHEEYYLRLNVHDRPGVIADVTAVLRDHGVSLRSMLQHGR
AGADDTSGEPSVPLVLVTHRTRESAMMEALARIAALPAVIGEPAMIRIEAG
>Mature_450_residues
PRTTTGHQVTGRNMNADELRIGIAGLGTVGAGLVKLLRANESIVAARAGRRVVVTAVAARDRTRDRGIDLGGVTWHDDAL
ALARDPDVDVVVELIGGAEGIARELVTAALRAGRPVVTANKALIAVHGAELAELAELSGVPLMFEAAVAGGIPAIKAVRE
GLAADRLTRVGGILNGTCNYIMTAMRESGRPFADVLAEAQALGYAEADPSTDVDGIDAAHKLAILAGLAFGRPVAFSSVH
VEGIRGIDALDLGFARALGYRIKLLGLARRREDGIEARVHPCLVPEKAPIAQVDGVFNAVVAEGAFVGRLMLEGRGAGEG
PTATAVAADLIDIARGIAVPVWGRSADGLTQVEALPRTAFHEEYYLRLNVHDRPGVIADVTAVLRDHGVSLRSMLQHGRA
GADDTSGEPSVPLVLVTHRTRESAMMEALARIAALPAVIGEPAMIRIEAG

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=251, Percent_Identity=30.6772908366534, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790376, Length=360, Percent_Identity=26.3888888888889, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 47037; Mature: 46906

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRTTTGHQVTGRNMNADELRIGIAGLGTVGAGLVKLLRANESIVAARAGRRVVVTAVAA
CCCCCCCCEECCCCCCHHHEEEEEECCCHHHHHHHHHHHCCCCEEECCCCCEEEEEEEHH
RDRTRDRGIDLGGVTWHDDALALARDPDVDVVVELIGGAEGIARELVTAALRAGRPVVTA
CCCHHHCCCCCCCEEECCCCEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEE
NKALIAVHGAELAELAELSGVPLMFEAAVAGGIPAIKAVREGLAADRLTRVGGILNGTCN
CCEEEEEECHHHHHHHHHCCCCEEEHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHH
YIMTAMRESGRPFADVLAEAQALGYAEADPSTDVDGIDAAHKLAILAGLAFGRPVAFSSV
HHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEECEE
HVEGIRGIDALDLGFARALGYRIKLLGLARRREDGIEARVHPCLVPEKAPIAQVDGVFNA
EECCCCCCCHHHHHHHHHHHHHHEEEHHHHHCCCCCCCCCCCEECCCCCCCHHHHHHHHH
VVAEGAFVGRLMLEGRGAGEGPTATAVAADLIDIARGIAVPVWGRSADGLTQVEALPRTA
HHHCCHHEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHH
FHEEYYLRLNVHDRPGVIADVTAVLRDHGVSLRSMLQHGRAGADDTSGEPSVPLVLVTHR
CCCEEEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEECC
TRESAMMEALARIAALPAVIGEPAMIRIEAG
CHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
>Mature Secondary Structure 
PRTTTGHQVTGRNMNADELRIGIAGLGTVGAGLVKLLRANESIVAARAGRRVVVTAVAA
CCCCCCCEECCCCCCHHHEEEEEECCCHHHHHHHHHHHCCCCEEECCCCCEEEEEEEHH
RDRTRDRGIDLGGVTWHDDALALARDPDVDVVVELIGGAEGIARELVTAALRAGRPVVTA
CCCHHHCCCCCCCEEECCCCEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEE
NKALIAVHGAELAELAELSGVPLMFEAAVAGGIPAIKAVREGLAADRLTRVGGILNGTCN
CCEEEEEECHHHHHHHHHCCCCEEEHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHH
YIMTAMRESGRPFADVLAEAQALGYAEADPSTDVDGIDAAHKLAILAGLAFGRPVAFSSV
HHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEECEE
HVEGIRGIDALDLGFARALGYRIKLLGLARRREDGIEARVHPCLVPEKAPIAQVDGVFNA
EECCCCCCCHHHHHHHHHHHHHHEEEHHHHHCCCCCCCCCCCEECCCCCCCHHHHHHHHH
VVAEGAFVGRLMLEGRGAGEGPTATAVAADLIDIARGIAVPVWGRSADGLTQVEALPRTA
HHHCCHHEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHH
FHEEYYLRLNVHDRPGVIADVTAVLRDHGVSLRSMLQHGRAGADDTSGEPSVPLVLVTHR
CCCEEEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEECC
TRESAMMEALARIAALPAVIGEPAMIRIEAG
CHHHHHHHHHHHHHHHHHHHCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]