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The map label for this gene is envZ [H]

Identifier: 162146555

GI number: 162146555

Start: 750178

End: 751572

Strand: Reverse

Name: envZ [H]

Synonym: GDI_0732

Alternate gene names: 162146555

Gene position: 751572-750178 (Counterclockwise)

Preceding gene: 162146556

Following gene: 162146554

Centisome position: 19.06

GC content: 69.53

Gene sequence:

>1395_bases
ATGGCCGGCTGGCTGCGCCCCCGGTCGCTGGCCGCCCGCACCAGCCTGCTGCTGATCGTGGGCCTGGGGATCATCGAATC
GATCGGCCTGACCATCCACGCGCTGGACCGGATCGATTTCGATCGCCGCATGATCCAGCAGGAAAGCCAGAACCGGGTCG
GCATGATCTACCGCTCGATCGTCGAGACGCCGTCCGAGGACCGCGAGGCGGAACTGGAATCGCTGCACCTGCCCCCGACC
TTCCATGCCACGCTGACCCCCGGCCCCGAGCCCGACATGGTCGAACAGGCCGTGGACGGCCCCCCGCCGATGGACCGCAT
GGACATGCGGATGGAGCGGATGAATTTCGGCCGGCCGCACGACAACATGCCGCCCCTGCCGCCGCATCTGCGGCCGCGGC
AGATGCTGTTCGGCGCGGCGCGTCCCTCGCCGCAGCGCGCCGTGGCCTTCCTGCTGCCGGACGAGACGCGGTGGCTGACG
ATCCATTATGTGGTGCCCGCGCCCAACCCGTTCCGTTCGCCGACCTTTCCCACCGCCTTCGCGCTGATGACCGTGGCCGG
CAGTATCCTGATCGTCTGGGGCGTGCGGCGGGTGATCCGGCCGGTGGGCACCCTGGCCGCCGCCGCCGAGGCATTGGGGC
GCGACGTCAACGCCCCGCCGCTGCCCGAGGACGGGCCGCTGGAAATCGCGCGGGCCGGGCGGGCGTTCAATGTCATGGCC
AGCCGCATCCGCCGGTTCCTGACCGACCGGACCCTGCTGCTGACGGCGATCGGGCACGATCTGCGCACGCCGATCACACG
GCTGAAACTGCGGTCGGAATTCATCGACGACGACGAATTGCGCGCCAAGTTCCTGATGGACCTGGACGAACTGGAATCCA
TGGTCGCGGCCACCCTGTCCTTCGGCCGGGACACGTCGCGGCGCGAGCCGATGGGATCGCTGGACCTGACCGCGCTGCTG
CAGACCATCCTGGACGAGGCCGCCGAGACCCACCCCGACATCGCCGAGGCCATCGGATTCGCCGATGACCCCCCGGCGGT
GACGATCCATGCCCGTCCGGTCGCGCTGAAGCGGGCGCTGAACAACCTGGTACAGAATGCGGTGAACTACGGCGGCGGCG
TGCGCATCACGCTGCAACCGCCCTACCCCGGCGCCGCGGGCGAGATGCTGACGACCATCCTGATCGAGGATGACGGGCCG
GGACTGCCGCCCGAGGACCTGGAGAGAATGTTCGAACCCTTCGTCCGGGCCGAGACCAGCCGCAACCGCGAAACGGGGGG
AACCGGGCTGGGCCTGGCGATCGCCCGGAACATCATCTGGGGGCTGGGCGGGGATATCCGCCTGGGCAACCGCACCCCAC
ACGGACTGAGGGCGACCGTCACGCTGGTCTGCTGA

Upstream 100 bases:

>100_bases
TGATCCGGCGCGCGGTGCCGCGGACACGATTCTGAACGCCCCCGCCCCCGCGTCCTCGTCCTCTTCCGATGGCGACGCGG
CGGCCGGGCCGATCCGCCGG

Downstream 100 bases:

>100_bases
TCACGTCTTCCTTGCGGCGCGGCGCGGCGAATGGCATTGCTGGATGCAATCGGTGCAACGCGGACCTTCCTCCCGCCGTT
AGCGGGGCGCGACCCTTTGC

Product: two component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MAGWLRPRSLAARTSLLLIVGLGIIESIGLTIHALDRIDFDRRMIQQESQNRVGMIYRSIVETPSEDREAELESLHLPPT
FHATLTPGPEPDMVEQAVDGPPPMDRMDMRMERMNFGRPHDNMPPLPPHLRPRQMLFGAARPSPQRAVAFLLPDETRWLT
IHYVVPAPNPFRSPTFPTAFALMTVAGSILIVWGVRRVIRPVGTLAAAAEALGRDVNAPPLPEDGPLEIARAGRAFNVMA
SRIRRFLTDRTLLLTAIGHDLRTPITRLKLRSEFIDDDELRAKFLMDLDELESMVAATLSFGRDTSRREPMGSLDLTALL
QTILDEAAETHPDIAEAIGFADDPPAVTIHARPVALKRALNNLVQNAVNYGGGVRITLQPPYPGAAGEMLTTILIEDDGP
GLPPEDLERMFEPFVRAETSRNRETGGTGLGLAIARNIIWGLGGDIRLGNRTPHGLRATVTLVC

Sequences:

>Translated_464_residues
MAGWLRPRSLAARTSLLLIVGLGIIESIGLTIHALDRIDFDRRMIQQESQNRVGMIYRSIVETPSEDREAELESLHLPPT
FHATLTPGPEPDMVEQAVDGPPPMDRMDMRMERMNFGRPHDNMPPLPPHLRPRQMLFGAARPSPQRAVAFLLPDETRWLT
IHYVVPAPNPFRSPTFPTAFALMTVAGSILIVWGVRRVIRPVGTLAAAAEALGRDVNAPPLPEDGPLEIARAGRAFNVMA
SRIRRFLTDRTLLLTAIGHDLRTPITRLKLRSEFIDDDELRAKFLMDLDELESMVAATLSFGRDTSRREPMGSLDLTALL
QTILDEAAETHPDIAEAIGFADDPPAVTIHARPVALKRALNNLVQNAVNYGGGVRITLQPPYPGAAGEMLTTILIEDDGP
GLPPEDLERMFEPFVRAETSRNRETGGTGLGLAIARNIIWGLGGDIRLGNRTPHGLRATVTLVC
>Mature_463_residues
AGWLRPRSLAARTSLLLIVGLGIIESIGLTIHALDRIDFDRRMIQQESQNRVGMIYRSIVETPSEDREAELESLHLPPTF
HATLTPGPEPDMVEQAVDGPPPMDRMDMRMERMNFGRPHDNMPPLPPHLRPRQMLFGAARPSPQRAVAFLLPDETRWLTI
HYVVPAPNPFRSPTFPTAFALMTVAGSILIVWGVRRVIRPVGTLAAAAEALGRDVNAPPLPEDGPLEIARAGRAFNVMAS
RIRRFLTDRTLLLTAIGHDLRTPITRLKLRSEFIDDDELRAKFLMDLDELESMVAATLSFGRDTSRREPMGSLDLTALLQ
TILDEAAETHPDIAEAIGFADDPPAVTIHARPVALKRALNNLVQNAVNYGGGVRITLQPPYPGAAGEMLTTILIEDDGPG
LPPEDLERMFEPFVRAETSRNRETGGTGLGLAIARNIIWGLGGDIRLGNRTPHGLRATVTLVC

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=288, Percent_Identity=34.0277777777778, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1790346, Length=270, Percent_Identity=31.4814814814815, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1787894, Length=287, Percent_Identity=31.0104529616725, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1786783, Length=316, Percent_Identity=25.3164556962025, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788393, Length=281, Percent_Identity=28.1138790035587, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1790551, Length=289, Percent_Identity=27.3356401384083, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87082128, Length=290, Percent_Identity=23.7931034482759, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786600, Length=236, Percent_Identity=26.6949152542373, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1789149, Length=223, Percent_Identity=28.2511210762332, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1786912, Length=230, Percent_Identity=30.8695652173913, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI145693157, Length=243, Percent_Identity=24.6913580246914, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790861, Length=296, Percent_Identity=23.9864864864865, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51094; Mature: 50963

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGWLRPRSLAARTSLLLIVGLGIIESIGLTIHALDRIDFDRRMIQQESQNRVGMIYRSI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHCCHHHHHHHHHHCCHHHHHHHHH
VETPSEDREAELESLHLPPTFHATLTPGPEPDMVEQAVDGPPPMDRMDMRMERMNFGRPH
HCCCCCCHHHHHHHCCCCCCCEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCC
DNMPPLPPHLRPRQMLFGAARPSPQRAVAFLLPDETRWLTIHYVVPAPNPFRSPTFPTAF
CCCCCCCCCCCHHHHHHCCCCCCCCCEEEEEECCCCEEEEEEEEECCCCCCCCCCCHHHH
ALMTVAGSILIVWGVRRVIRPVGTLAAAAEALGRDVNAPPLPEDGPLEIARAGRAFNVMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCHHHHHH
SRIRRFLTDRTLLLTAIGHDLRTPITRLKLRSEFIDDDELRAKFLMDLDELESMVAATLS
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHH
FGRDTSRREPMGSLDLTALLQTILDEAAETHPDIAEAIGFADDPPAVTIHARPVALKRAL
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCEEEEECCHHHHHHHH
NNLVQNAVNYGGGVRITLQPPYPGAAGEMLTTILIEDDGPGLPPEDLERMFEPFVRAETS
HHHHHHHHHCCCCEEEEECCCCCCCHHHEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHC
RNRETGGTGLGLAIARNIIWGLGGDIRLGNRTPHGLRATVTLVC
CCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCEEEEEEEC
>Mature Secondary Structure 
AGWLRPRSLAARTSLLLIVGLGIIESIGLTIHALDRIDFDRRMIQQESQNRVGMIYRSI
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHCCHHHHHHHHHHCCHHHHHHHHH
VETPSEDREAELESLHLPPTFHATLTPGPEPDMVEQAVDGPPPMDRMDMRMERMNFGRPH
HCCCCCCHHHHHHHCCCCCCCEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCC
DNMPPLPPHLRPRQMLFGAARPSPQRAVAFLLPDETRWLTIHYVVPAPNPFRSPTFPTAF
CCCCCCCCCCCHHHHHHCCCCCCCCCEEEEEECCCCEEEEEEEEECCCCCCCCCCCHHHH
ALMTVAGSILIVWGVRRVIRPVGTLAAAAEALGRDVNAPPLPEDGPLEIARAGRAFNVMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCHHHHHH
SRIRRFLTDRTLLLTAIGHDLRTPITRLKLRSEFIDDDELRAKFLMDLDELESMVAATLS
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHH
FGRDTSRREPMGSLDLTALLQTILDEAAETHPDIAEAIGFADDPPAVTIHARPVALKRAL
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCEEEEECCHHHHHHHH
NNLVQNAVNYGGGVRITLQPPYPGAAGEMLTTILIEDDGPGLPPEDLERMFEPFVRAETS
HHHHHHHHHCCCCEEEEECCCCCCCHHHEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHC
RNRETGGTGLGLAIARNIIWGLGGDIRLGNRTPHGLRATVTLVC
CCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]