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The map label for this gene is rnd [H]

Identifier: 162146523

GI number: 162146523

Start: 710125

End: 711306

Strand: Direct

Name: rnd [H]

Synonym: GDI_0699

Alternate gene names: 162146523

Gene position: 710125-711306 (Clockwise)

Preceding gene: 162146521

Following gene: 162146524

Centisome position: 18.0

GC content: 69.71

Gene sequence:

>1182_bases
ATGGCGCGCACATCCAAAGCGGGTTTTCCCGATCCGGTCCTGATTACCACCACTGAAGACCTGACGGGGGTCGTCGAACG
CCTGCGGCGCGAGCCGTTCGTTTCGATCGATACCGAATTTGTCCGCGAACGGACCTACTGGCCCGAACTGTGCCTGGTAC
AACTGGCCGGCCAGGACGAGGTCGTGGTGGTGGACACGCTGGCCCCGGGCATCGACCTGGCCCCGCTGGGGGTCCTGCTG
GACGACCCGGAGGTCGTCAAGGTCTTCCACGCGGCGCGGCAGGATTTGGAAATCTTCCTGTACCTCTTTGGTCATTTGCC
GGCCGCCCTGTTCGATACCCAGGTCGCGGCGATGGTCGCGGGGTTCGGCGACCAGGTGGGGTACGACAATCTGGTCGCCT
CGCTGACCGGCGCGCATATCGACAAGGCGCACCGGTTTTCCGACTGGTCGGCGCGCCCCCTGTCCGAGGCGCAGATCGCC
TACGCCGCCGCCGACGTCACGCATCTGCGGACGGTCTATCAATTGCTGCTCGAACGGCTGGAGCGCGAGGGCCGGCTGGA
CTGGGTGGCGTCCGACCTGGCCGTCCTGTCCGATCCCGCGACCTTCCGCCCCGATCCCGAAACCCTGTGGGAGCGGATGC
GGCCCCGGACCTCGAACCGGCGCATGTTGGGCGTGCTGCGGGCCATTACCGCGTGGCGCGAGCGCGAGGCCCAGCGGGTG
AACGTTCCGCGCCAGCGGCTGCTGAAGGATGAAAGCCTGCTGGAAATCGCGGCCACCGCCCCGGCGGATGTCGATGCCCT
GGCCCGCATTCGCGGCGTGTCGCGCGGCTTCGCCGAAGGCAAGAGCGGCACCGGCATCCTCGAAGCCGTGGCGGCCGCCC
GGGCGCTGCCCGACGGCGCCCTGCCGCGCCAGCAGAAGGGCAAGGAGGGGCCCCGCCCGTCGCCGGCGCTGGTCGCCCTG
CTGAAGGTCCTGCTGGCTGCCTGCTGCGAGGAACATGACGTGGCGCCGCGGCTGGTCGCCTCGTCCGAGGACCTGGACCG
CCTGGCGCTGGAGCCCGAGCCCGACCTGCCGCTGCTGCAGGGATGGCGCCGCACGGTGTTCGGTGACGAAGCCCTGGCCC
TGAAGGACGGCCGGATGCTGCTGGGGGTCGATGGCACCCGCGTCAAGCGCATTCCCGCCTGA

Upstream 100 bases:

>100_bases
TATCCTTGCGCTTGGGGGTAGGGGGGTGATGTCAGAGCGGGACCGCCGCCGTCAAGCGCCGGGTCTTCGCACCGACCGTG
GCCCATGATAACAGGACGGA

Downstream 100 bases:

>100_bases
CAGGTCGCGCACCTGTTTTACAGGGGTTGCGAACAGGTTATGCCCAGCCTTGTCCACAAGATTTTGTGGTGGAATGGTTG
AGTCGACCACAAGATAGGCT

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MARTSKAGFPDPVLITTTEDLTGVVERLRREPFVSIDTEFVRERTYWPELCLVQLAGQDEVVVVDTLAPGIDLAPLGVLL
DDPEVVKVFHAARQDLEIFLYLFGHLPAALFDTQVAAMVAGFGDQVGYDNLVASLTGAHIDKAHRFSDWSARPLSEAQIA
YAAADVTHLRTVYQLLLERLEREGRLDWVASDLAVLSDPATFRPDPETLWERMRPRTSNRRMLGVLRAITAWREREAQRV
NVPRQRLLKDESLLEIAATAPADVDALARIRGVSRGFAEGKSGTGILEAVAAARALPDGALPRQQKGKEGPRPSPALVAL
LKVLLAACCEEHDVAPRLVASSEDLDRLALEPEPDLPLLQGWRRTVFGDEALALKDGRMLLGVDGTRVKRIPA

Sequences:

>Translated_393_residues
MARTSKAGFPDPVLITTTEDLTGVVERLRREPFVSIDTEFVRERTYWPELCLVQLAGQDEVVVVDTLAPGIDLAPLGVLL
DDPEVVKVFHAARQDLEIFLYLFGHLPAALFDTQVAAMVAGFGDQVGYDNLVASLTGAHIDKAHRFSDWSARPLSEAQIA
YAAADVTHLRTVYQLLLERLEREGRLDWVASDLAVLSDPATFRPDPETLWERMRPRTSNRRMLGVLRAITAWREREAQRV
NVPRQRLLKDESLLEIAATAPADVDALARIRGVSRGFAEGKSGTGILEAVAAARALPDGALPRQQKGKEGPRPSPALVAL
LKVLLAACCEEHDVAPRLVASSEDLDRLALEPEPDLPLLQGWRRTVFGDEALALKDGRMLLGVDGTRVKRIPA
>Mature_392_residues
ARTSKAGFPDPVLITTTEDLTGVVERLRREPFVSIDTEFVRERTYWPELCLVQLAGQDEVVVVDTLAPGIDLAPLGVLLD
DPEVVKVFHAARQDLEIFLYLFGHLPAALFDTQVAAMVAGFGDQVGYDNLVASLTGAHIDKAHRFSDWSARPLSEAQIAY
AAADVTHLRTVYQLLLERLEREGRLDWVASDLAVLSDPATFRPDPETLWERMRPRTSNRRMLGVLRAITAWREREAQRVN
VPRQRLLKDESLLEIAATAPADVDALARIRGVSRGFAEGKSGTGILEAVAAARALPDGALPRQQKGKEGPRPSPALVALL
KVLLAACCEEHDVAPRLVASSEDLDRLALEPEPDLPLLQGWRRTVFGDEALALKDGRMLLGVDGTRVKRIPA

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4505917, Length=259, Percent_Identity=27.027027027027, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI50301240, Length=259, Percent_Identity=27.027027027027, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1788105, Length=359, Percent_Identity=33.4261838440111, Blast_Score=168, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17531757, Length=287, Percent_Identity=25.7839721254355, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324574, Length=181, Percent_Identity=29.8342541436464, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI161078302, Length=268, Percent_Identity=27.2388059701493, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 43232; Mature: 43101

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARTSKAGFPDPVLITTTEDLTGVVERLRREPFVSIDTEFVRERTYWPELCLVQLAGQDE
CCCCCCCCCCCCEEEEECHHHHHHHHHHHHCCCEECCHHHHHHHCCCCHHHHEEECCCCC
VVVVDTLAPGIDLAPLGVLLDDPEVVKVFHAARQDLEIFLYLFGHLPAALFDTQVAAMVA
EEEEECCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFGDQVGYDNLVASLTGAHIDKAHRFSDWSARPLSEAQIAYAAADVTHLRTVYQLLLERL
HCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EREGRLDWVASDLAVLSDPATFRPDPETLWERMRPRTSNRRMLGVLRAITAWREREAQRV
HHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHC
NVPRQRLLKDESLLEIAATAPADVDALARIRGVSRGFAEGKSGTGILEAVAAARALPDGA
CCCHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCC
LPRQQKGKEGPRPSPALVALLKVLLAACCEEHDVAPRLVASSEDLDRLALEPEPDLPLLQ
CCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCHHHHCCCCCCCCHHHH
GWRRTVFGDEALALKDGRMLLGVDGTRVKRIPA
HHHHHHCCCCEEEEECCCEEEECCCCCCCCCCC
>Mature Secondary Structure 
ARTSKAGFPDPVLITTTEDLTGVVERLRREPFVSIDTEFVRERTYWPELCLVQLAGQDE
CCCCCCCCCCCEEEEECHHHHHHHHHHHHCCCEECCHHHHHHHCCCCHHHHEEECCCCC
VVVVDTLAPGIDLAPLGVLLDDPEVVKVFHAARQDLEIFLYLFGHLPAALFDTQVAAMVA
EEEEECCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFGDQVGYDNLVASLTGAHIDKAHRFSDWSARPLSEAQIAYAAADVTHLRTVYQLLLERL
HCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EREGRLDWVASDLAVLSDPATFRPDPETLWERMRPRTSNRRMLGVLRAITAWREREAQRV
HHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHC
NVPRQRLLKDESLLEIAATAPADVDALARIRGVSRGFAEGKSGTGILEAVAAARALPDGA
CCCHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCC
LPRQQKGKEGPRPSPALVALLKVLLAACCEEHDVAPRLVASSEDLDRLALEPEPDLPLLQ
CCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCHHHHCCCCCCCCHHHH
GWRRTVFGDEALALKDGRMLLGVDGTRVKRIPA
HHHHHHCCCCEEEEECCCEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]