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The map label for this gene is nadC [H]

Identifier: 162146397

GI number: 162146397

Start: 581113

End: 581967

Strand: Direct

Name: nadC [H]

Synonym: GDI_0572

Alternate gene names: 162146397

Gene position: 581113-581967 (Clockwise)

Preceding gene: 162146396

Following gene: 162146398

Centisome position: 14.73

GC content: 71.35

Gene sequence:

>855_bases
ATGACCCCCTTGCCCGATCTCATGCTCGAACCGCTGGTGCGTGCCGGATTGCTGGAGGACCTGGGGTGCGGCGGGGATAT
CACGACCGATGCGCTGGCGGCGCCGGGGCAGGTGCTGCACACCGCCCTGGTCGCGCGCCAGCCCGGCGTGGTGGCGGGCC
TGTCGCTGGCCCGGCTGGCCTTTACCCTGCTGGATTCGTCGGTCCGTTTCACGGTGGACCGGCCGGACGGCAGCCCTGTC
GCCCCGGGTGACCGCATCGCGCGCGTCAGCGGTCCGGCGGCGGCGATCCTGGGGGGCGAACGGGTGGCGCTGAACTTCCT
GTCGCATCTCTGCGGCATCGCCACCGCCACGGCCGGGATCGTGCAGGCCATATCCGGCACGCGCGCGCGCGTCTGCTGCA
CGCGCAAGACCCTGCCGGGCCTGCGCGCGATCCAGAAATATGCGGTGCGGGCCGGCGGCGGCGCCAATCACCGCTTCCGC
CTGGATGACGCGATCCTGATCAAGGACAACCATATCGCCCTGGCCGGCGGCGACGTCGCGCGCGCCCTGGCCGCCGCCCG
CGCCCGCGCCGGCCACCTGGTCAGCATCGAACTGGAGGTCGATACGCTGGACCAGTTGGCCCAGGCCCTGGGGGCCGGCG
GGGCGGATGTGTTCCTGCTGGACAACATGACCCTTCCCCAGCTTCGCGAGGCGGTGGCGATGGTGGACGGCCGCGCCCTG
ACCGATGCATCGGGCGGCATCACCCCCGACACCGCCGCCGATATCGCCCGGACCGGTGTCGATATCCTGTCGGTCGGCTG
GCTGACGCATACGGTGCGCGCGCTGGATATCGGGCTGGATTACGAGGAAGGGTAA

Upstream 100 bases:

>100_bases
AGGCGGTGCATACCCGCCTGACGATGCGCCAGGGCCTGGCCGCGCTCGCATCGCTCGCGCCTGCCGCGGCCTCTCTTTCT
GACAATGGAATCCTCGTGCC

Downstream 100 bases:

>100_bases
CCGGATCAAAGTTTTTTGGTTCTTTTTTTCAAAAAGGAACCGCTAGAGTCGTGCCATGTCCCGCCGTCCCGCCATCCTGT
TCGTCTGCACCGGGAATATC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MTPLPDLMLEPLVRAGLLEDLGCGGDITTDALAAPGQVLHTALVARQPGVVAGLSLARLAFTLLDSSVRFTVDRPDGSPV
APGDRIARVSGPAAAILGGERVALNFLSHLCGIATATAGIVQAISGTRARVCCTRKTLPGLRAIQKYAVRAGGGANHRFR
LDDAILIKDNHIALAGGDVARALAAARARAGHLVSIELEVDTLDQLAQALGAGGADVFLLDNMTLPQLREAVAMVDGRAL
TDASGGITPDTAADIARTGVDILSVGWLTHTVRALDIGLDYEEG

Sequences:

>Translated_284_residues
MTPLPDLMLEPLVRAGLLEDLGCGGDITTDALAAPGQVLHTALVARQPGVVAGLSLARLAFTLLDSSVRFTVDRPDGSPV
APGDRIARVSGPAAAILGGERVALNFLSHLCGIATATAGIVQAISGTRARVCCTRKTLPGLRAIQKYAVRAGGGANHRFR
LDDAILIKDNHIALAGGDVARALAAARARAGHLVSIELEVDTLDQLAQALGAGGADVFLLDNMTLPQLREAVAMVDGRAL
TDASGGITPDTAADIARTGVDILSVGWLTHTVRALDIGLDYEEG
>Mature_283_residues
TPLPDLMLEPLVRAGLLEDLGCGGDITTDALAAPGQVLHTALVARQPGVVAGLSLARLAFTLLDSSVRFTVDRPDGSPVA
PGDRIARVSGPAAAILGGERVALNFLSHLCGIATATAGIVQAISGTRARVCCTRKTLPGLRAIQKYAVRAGGGANHRFRL
DDAILIKDNHIALAGGDVARALAAARARAGHLVSIELEVDTLDQLAQALGAGGADVFLLDNMTLPQLREAVAMVDGRALT
DASGGITPDTAADIARTGVDILSVGWLTHTVRALDIGLDYEEG

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=282, Percent_Identity=39.0070921985816, Blast_Score=149, Evalue=4e-36,
Organism=Escherichia coli, GI1786299, Length=276, Percent_Identity=38.0434782608696, Blast_Score=162, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6321162, Length=251, Percent_Identity=32.6693227091633, Blast_Score=124, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 29225; Mature: 29094

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPLPDLMLEPLVRAGLLEDLGCGGDITTDALAAPGQVLHTALVARQPGVVAGLSLARLA
CCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHH
FTLLDSSVRFTVDRPDGSPVAPGDRIARVSGPAAAILGGERVALNFLSHLCGIATATAGI
HHHHCCCEEEEEECCCCCCCCCCCCEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHH
VQAISGTRARVCCTRKTLPGLRAIQKYAVRAGGGANHRFRLDDAILIKDNHIALAGGDVA
HHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEECCCEEEEECCEEEEECCHHH
RALAAARARAGHLVSIELEVDTLDQLAQALGAGGADVFLLDNMTLPQLREAVAMVDGRAL
HHHHHHHHCCCCEEEEEEEHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCEE
TDASGGITPDTAADIARTGVDILSVGWLTHTVRALDIGLDYEEG
ECCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHEECCCCCCC
>Mature Secondary Structure 
TPLPDLMLEPLVRAGLLEDLGCGGDITTDALAAPGQVLHTALVARQPGVVAGLSLARLA
CCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHH
FTLLDSSVRFTVDRPDGSPVAPGDRIARVSGPAAAILGGERVALNFLSHLCGIATATAGI
HHHHCCCEEEEEECCCCCCCCCCCCEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHH
VQAISGTRARVCCTRKTLPGLRAIQKYAVRAGGGANHRFRLDDAILIKDNHIALAGGDVA
HHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEECCCEEEEECCEEEEECCHHH
RALAAARARAGHLVSIELEVDTLDQLAQALGAGGADVFLLDNMTLPQLREAVAMVDGRAL
HHHHHHHHCCCCEEEEEEEHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCEE
TDASGGITPDTAADIARTGVDILSVGWLTHTVRALDIGLDYEEG
ECCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]