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The map label for this gene is clcB [H]

Identifier: 162146349

GI number: 162146349

Start: 517817

End: 519619

Strand: Direct

Name: clcB [H]

Synonym: GDI_0524

Alternate gene names: 162146349

Gene position: 517817-519619 (Clockwise)

Preceding gene: 162146346

Following gene: 162146352

Centisome position: 13.13

GC content: 70.33

Gene sequence:

>1803_bases
CTGTCGGAAGGGGGGCCGGCGAAGGGGCTTGCGCGGGACGACCGGGTCTCGCAGGTGCCGCGCGTCCTGCGTGCGCTGGT
GCGGGCGGACGAGATCTGGCTGGTCGTGCTGGCGGCCTGCGTGGGCACCGGGGCCGGCCTGCTGGTCAGCGCCATGACCC
ATGCCACGCTGCTGGCGCATCGGGTGCTGTTCGCCGTCGGCGGGGATGGCCGCATTTCGGGCCTGCCGTCCATCGCGCCC
CTCCGCGCCATCCTGGTGCCCAGCCTGGGCGGGCTGGTGCTGGGGCTGCTGGGTGTGCTGATCGCGCGCTATGCCCCCGG
CCGTCCGGTCGACCCGATCGAGGCGAACGCGCTGCATGGCGGCCGCATGTCCACGCTGGACAGCGCCATCGTCGCCCTTC
AGACGGTCCTGTCGAATTCGGTCGGCGCCTCGGTAGGGCTGGAGGCCGGGTTTACGCAGATCGGTGCCGCTACCGGCTCG
CGACTGGGGCGCATGTTCCGGGTACGGCGCGAGGATCTGCGCCTGCTGGTCGGATGTGGTGCCGCCGGCGCCATCGGCGC
GGCGTTCGACGCGCCGCTGGCCGGGGCGTTCTATGCCTTCGAACTGGTGATCGGCACCTATTCGCTGGCCAACCTGGCGC
CGGTCGCGGCGGCGTCGATCTGCGCCATCGGGGTGACGCACCTGCTGCACAGCGCGGCCCCCGGCGTGACCGTGGACCTG
CCGGCGGGGCTGCGGATGGACGATTACCTGCCGATCGCGACCCTGGGAATCGTGGCCGCCCTGCTGGGGGTGGCCCTGAT
GTATTGCGTGACCCTGGCCGAAACCCTGTTTCGCCGCTCCGGCCTGCCGGCCTGGATGTGTCCGGCCGTGGGCGGGACGA
TCGTCGGCACGATGGCGCTGGTTTCGCCCTCGGTGCTGTCGTCGGGCCACTGGGCGATGCGCGTCGCGCTGGAACAGGGC
CACCCGACCGGATGGATCCTGGTCCTGCTGGCGCTGAAGGCGGTGGCCTCGTCGGTCTCGATCGGGTCGGGGTTCCGGGG
CGGCCTGTTCTTCGCATCGCTGTATCTGGGCGTCCTGACCGGGGCGGCGTTCGGTGGTGGTCTGGCGCTGGTCTCGGCCA
ATCCGCTTTCAGCGGAACTCTGCGCCCTGGTGGGCATGAGCGCCATGGCCGTGGCGGTGGTCGGCGGGCCCATGACGATG
GTGTTCCTGGCGCTGGAAATGACGGGCAGCCTGCCGCTGACCGTCGCGGTGCTGGTGGCGTCGGTGATTTCCGGCCTGAC
CGTGCGCCGGACCTTCGGCTACTCCTTCGCCACCTGGCGGTTCCACCTGCGCGGGGAATCCATCCGTTCGGCGGTCGATG
TCGGCTGGATTCGCACGCTGACGGTCGGGCGGATGATGCGCCGTGACGTGAAGGCGATGTGCCAGACGACGACGGTCCAG
GAGGCCCGGCATGCCTATCCGCTGGGCGCGGCGCAACGCTTCGTCCTGGTCGACGGCGCGGGCCGCTATGTCGGATTGGT
GCAGGTGCCCGACCTGTATGCCGAAACGGCGCGTGCGACCGAGGACCTGACCCGCTTCGCCCAGTATCGCGACGTGATGC
TGATGCCGCAGATGAACCTGCGCGACGCGATCGCCCGTTTCGAACAGGCGGAAAGCGACGCGCTGGTGGTGGTCGATGGC
ATGGAATCCCGCATGGTGCTGGGACTGCTGACCGAACAGCACGCCCTGCGCCGCTATAGCGAGGAACTGGACCGTACTCG
CCGCGAACTGGCGGGTGAGGGTCGTCTCCACGCCCGCGTCTGA

Upstream 100 bases:

>100_bases
GGTGTCCCGCCGCCGCATGGGCGCCGCGCGAAAGTGGCTTGTCGTGTCGTCTTCCACCCTCGGCCTGTTGACTCATCTGT
TCCGTCATCGCGGGGCATCC

Downstream 100 bases:

>100_bases
GGGCGTGCCGAACGAAAAAGGGGCGCCGGACCCAATCGGTCCGGCGCCCCCTTTTTTCGTCAATCCCGCCGGGATCAGAC
GGAGTAGTACATCTCGAACT

Product: voltage-gated ClC-type chloride channel

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 600; Mature: 599

Protein sequence:

>600_residues
MSEGGPAKGLARDDRVSQVPRVLRALVRADEIWLVVLAACVGTGAGLLVSAMTHATLLAHRVLFAVGGDGRISGLPSIAP
LRAILVPSLGGLVLGLLGVLIARYAPGRPVDPIEANALHGGRMSTLDSAIVALQTVLSNSVGASVGLEAGFTQIGAATGS
RLGRMFRVRREDLRLLVGCGAAGAIGAAFDAPLAGAFYAFELVIGTYSLANLAPVAAASICAIGVTHLLHSAAPGVTVDL
PAGLRMDDYLPIATLGIVAALLGVALMYCVTLAETLFRRSGLPAWMCPAVGGTIVGTMALVSPSVLSSGHWAMRVALEQG
HPTGWILVLLALKAVASSVSIGSGFRGGLFFASLYLGVLTGAAFGGGLALVSANPLSAELCALVGMSAMAVAVVGGPMTM
VFLALEMTGSLPLTVAVLVASVISGLTVRRTFGYSFATWRFHLRGESIRSAVDVGWIRTLTVGRMMRRDVKAMCQTTTVQ
EARHAYPLGAAQRFVLVDGAGRYVGLVQVPDLYAETARATEDLTRFAQYRDVMLMPQMNLRDAIARFEQAESDALVVVDG
MESRMVLGLLTEQHALRRYSEELDRTRRELAGEGRLHARV

Sequences:

>Translated_600_residues
MSEGGPAKGLARDDRVSQVPRVLRALVRADEIWLVVLAACVGTGAGLLVSAMTHATLLAHRVLFAVGGDGRISGLPSIAP
LRAILVPSLGGLVLGLLGVLIARYAPGRPVDPIEANALHGGRMSTLDSAIVALQTVLSNSVGASVGLEAGFTQIGAATGS
RLGRMFRVRREDLRLLVGCGAAGAIGAAFDAPLAGAFYAFELVIGTYSLANLAPVAAASICAIGVTHLLHSAAPGVTVDL
PAGLRMDDYLPIATLGIVAALLGVALMYCVTLAETLFRRSGLPAWMCPAVGGTIVGTMALVSPSVLSSGHWAMRVALEQG
HPTGWILVLLALKAVASSVSIGSGFRGGLFFASLYLGVLTGAAFGGGLALVSANPLSAELCALVGMSAMAVAVVGGPMTM
VFLALEMTGSLPLTVAVLVASVISGLTVRRTFGYSFATWRFHLRGESIRSAVDVGWIRTLTVGRMMRRDVKAMCQTTTVQ
EARHAYPLGAAQRFVLVDGAGRYVGLVQVPDLYAETARATEDLTRFAQYRDVMLMPQMNLRDAIARFEQAESDALVVVDG
MESRMVLGLLTEQHALRRYSEELDRTRRELAGEGRLHARV
>Mature_599_residues
SEGGPAKGLARDDRVSQVPRVLRALVRADEIWLVVLAACVGTGAGLLVSAMTHATLLAHRVLFAVGGDGRISGLPSIAPL
RAILVPSLGGLVLGLLGVLIARYAPGRPVDPIEANALHGGRMSTLDSAIVALQTVLSNSVGASVGLEAGFTQIGAATGSR
LGRMFRVRREDLRLLVGCGAAGAIGAAFDAPLAGAFYAFELVIGTYSLANLAPVAAASICAIGVTHLLHSAAPGVTVDLP
AGLRMDDYLPIATLGIVAALLGVALMYCVTLAETLFRRSGLPAWMCPAVGGTIVGTMALVSPSVLSSGHWAMRVALEQGH
PTGWILVLLALKAVASSVSIGSGFRGGLFFASLYLGVLTGAAFGGGLALVSANPLSAELCALVGMSAMAVAVVGGPMTMV
FLALEMTGSLPLTVAVLVASVISGLTVRRTFGYSFATWRFHLRGESIRSAVDVGWIRTLTVGRMMRRDVKAMCQTTTVQE
ARHAYPLGAAQRFVLVDGAGRYVGLVQVPDLYAETARATEDLTRFAQYRDVMLMPQMNLRDAIARFEQAESDALVVVDGM
ESRMVLGLLTEQHALRRYSEELDRTRRELAGEGRLHARV

Specific function: Probably acts as an electrical shunt for an outwardly- directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response [H]

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily [H]

Homologues:

Organism=Escherichia coli, GI87081943, Length=402, Percent_Identity=30.3482587064677, Blast_Score=101, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 62792; Mature: 62660

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEGGPAKGLARDDRVSQVPRVLRALVRADEIWLVVLAACVGTGAGLLVSAMTHATLLAH
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RVLFAVGGDGRISGLPSIAPLRAILVPSLGGLVLGLLGVLIARYAPGRPVDPIEANALHG
HHHHEECCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
GRMSTLDSAIVALQTVLSNSVGASVGLEAGFTQIGAATGSRLGRMFRVRREDLRLLVGCG
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECC
AAGAIGAAFDAPLAGAFYAFELVIGTYSLANLAPVAAASICAIGVTHLLHSAAPGVTVDL
CCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEC
PAGLRMDDYLPIATLGIVAALLGVALMYCVTLAETLFRRSGLPAWMCPAVGGTIVGTMAL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHCCHHHHHHHHH
VSPSVLSSGHWAMRVALEQGHPTGWILVLLALKAVASSVSIGSGFRGGLFFASLYLGVLT
HCHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
GAAFGGGLALVSANPLSAELCALVGMSAMAVAVVGGPMTMVFLALEMTGSLPLTVAVLVA
HHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHH
SVISGLTVRRTFGYSFATWRFHLRGESIRSAVDVGWIRTLTVGRMMRRDVKAMCQTTTVQ
HHHCCCEEEHHCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EARHAYPLGAAQRFVLVDGAGRYVGLVQVPDLYAETARATEDLTRFAQYRDVMLMPQMNL
HHHHCCCCCCCCEEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCEEECCCCCH
RDAIARFEQAESDALVVVDGMESRMVLGLLTEQHALRRYSEELDRTRRELAGEGRLHARV
HHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCC
>Mature Secondary Structure 
SEGGPAKGLARDDRVSQVPRVLRALVRADEIWLVVLAACVGTGAGLLVSAMTHATLLAH
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RVLFAVGGDGRISGLPSIAPLRAILVPSLGGLVLGLLGVLIARYAPGRPVDPIEANALHG
HHHHEECCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
GRMSTLDSAIVALQTVLSNSVGASVGLEAGFTQIGAATGSRLGRMFRVRREDLRLLVGCG
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECC
AAGAIGAAFDAPLAGAFYAFELVIGTYSLANLAPVAAASICAIGVTHLLHSAAPGVTVDL
CCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEC
PAGLRMDDYLPIATLGIVAALLGVALMYCVTLAETLFRRSGLPAWMCPAVGGTIVGTMAL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHCCHHHHHHHHH
VSPSVLSSGHWAMRVALEQGHPTGWILVLLALKAVASSVSIGSGFRGGLFFASLYLGVLT
HCHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
GAAFGGGLALVSANPLSAELCALVGMSAMAVAVVGGPMTMVFLALEMTGSLPLTVAVLVA
HHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHH
SVISGLTVRRTFGYSFATWRFHLRGESIRSAVDVGWIRTLTVGRMMRRDVKAMCQTTTVQ
HHHCCCEEEHHCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EARHAYPLGAAQRFVLVDGAGRYVGLVQVPDLYAETARATEDLTRFAQYRDVMLMPQMNL
HHHHCCCCCCCCEEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCEEECCCCCH
RDAIARFEQAESDALVVVDGMESRMVLGLLTEQHALRRYSEELDRTRRELAGEGRLHARV
HHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA