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The map label for this gene is lrp [H]

Identifier: 162146247

GI number: 162146247

Start: 420817

End: 421311

Strand: Direct

Name: lrp [H]

Synonym: GDI_0422

Alternate gene names: 162146247

Gene position: 420817-421311 (Clockwise)

Preceding gene: 162146240

Following gene: 162146248

Centisome position: 10.67

GC content: 59.19

Gene sequence:

>495_bases
ATGCTGCCATTGCCCAAGCTCGACCGGATCGACCTGCGTATCCTGGCACAGCTTCAAAGCAACGGGCGCCTGACGAATGT
CGAACTGGCGCGCCGGGTCGGGCTGTCGGCCAGTCCCTGCCTGATCCGCGTCAAGCGGCTGGAGAAGAGCGGATACATCG
TCAGCTACGGGGCGCAGATCAACCTGCAGAAGATCAGCAGCCTGCTGACCGTGTTCACCGAGGTCACGCTGTCCGACCAC
CGCCGCGACGATTTCTCGCGATTCGAGGGCCATATCCAGAAAATTCCCTCGGTCGTGGAATGCCATCTGGTCAGCGGCGG
GTACGACTACCTGCTGAAATTCATGACCCGCAGCGTCGAGCATTACCAGGGCGTGATCGAGGCGCTGCTGGACAGCAATA
TCGGCATCGAGAAATATTTCAGCTACATCGTGATCAAGTCGCCGATCATCAAGCCGGCCATCTCGATCGAGAGCATCATA
GACTCCGGGACCTGA

Upstream 100 bases:

>100_bases
CGATCGAACGCCGCGTGGGGCATGGCGTTCGGCCCGGTCGGGGGCGGTTGTGCGGGACGGCGGCGCGTCTGGCGTATAGT
TGGAACAAGGTGACGGAATC

Downstream 100 bases:

>100_bases
AGGCCGGATCGGCCGATCCGGCTGATCCCGGGGGCGAAACGGCAGGATCTTTTCCCGCCGGGCGGATTTCCCGCCACATC
GTCTGTGTCGCCTGGGCACA

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MLPLPKLDRIDLRILAQLQSNGRLTNVELARRVGLSASPCLIRVKRLEKSGYIVSYGAQINLQKISSLLTVFTEVTLSDH
RRDDFSRFEGHIQKIPSVVECHLVSGGYDYLLKFMTRSVEHYQGVIEALLDSNIGIEKYFSYIVIKSPIIKPAISIESII
DSGT

Sequences:

>Translated_164_residues
MLPLPKLDRIDLRILAQLQSNGRLTNVELARRVGLSASPCLIRVKRLEKSGYIVSYGAQINLQKISSLLTVFTEVTLSDH
RRDDFSRFEGHIQKIPSVVECHLVSGGYDYLLKFMTRSVEHYQGVIEALLDSNIGIEKYFSYIVIKSPIIKPAISIESII
DSGT
>Mature_164_residues
MLPLPKLDRIDLRILAQLQSNGRLTNVELARRVGLSASPCLIRVKRLEKSGYIVSYGAQINLQKISSLLTVFTEVTLSDH
RRDDFSRFEGHIQKIPSVVECHLVSGGYDYLLKFMTRSVEHYQGVIEALLDSNIGIEKYFSYIVIKSPIIKPAISIESII
DSGT

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=145, Percent_Identity=42.7586206896552, Blast_Score=122, Evalue=1e-29,
Organism=Escherichia coli, GI87081742, Length=151, Percent_Identity=29.1390728476821, Blast_Score=75, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 18450; Mature: 18450

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPLPKLDRIDLRILAQLQSNGRLTNVELARRVGLSASPCLIRVKRLEKSGYIVSYGAQI
CCCCCCCCHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEECCEE
NLQKISSLLTVFTEVTLSDHRRDDFSRFEGHIQKIPSVVECHLVSGGYDYLLKFMTRSVE
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHEEEECCCCHHHHHHHHHHHHH
HYQGVIEALLDSNIGIEKYFSYIVIKSPIIKPAISIESIIDSGT
HHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MLPLPKLDRIDLRILAQLQSNGRLTNVELARRVGLSASPCLIRVKRLEKSGYIVSYGAQI
CCCCCCCCHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEECCEE
NLQKISSLLTVFTEVTLSDHRRDDFSRFEGHIQKIPSVVECHLVSGGYDYLLKFMTRSVE
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHEEEECCCCHHHHHHHHHHHHH
HYQGVIEALLDSNIGIEKYFSYIVIKSPIIKPAISIESIIDSGT
HHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]