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The map label for this gene is betA [C]

Identifier: 162146149

GI number: 162146149

Start: 329486

End: 331141

Strand: Direct

Name: betA [C]

Synonym: GDI_0321

Alternate gene names: 162146149

Gene position: 329486-331141 (Clockwise)

Preceding gene: 162146148

Following gene: 162146150

Centisome position: 8.35

GC content: 65.94

Gene sequence:

>1656_bases
ATGGCATATGACTATGTGATTGTGGGCGGAGGGCCGGCGGGCTGCGTTCTCGCCGCCCGCCTGAGCGAGGACCCCCGGGT
CCGGGTCCTCCTGCTCGAGGCCGGCGGAAGCGACCGGAACATGCTGTATCGCATCCCCGCCGGCTTCGCGAAAATGACCA
AGGGCATCGGCAGCCGAGGGTGGGAGACCGTTCCCCAGAGGCACATGCAGGGCCGCGTGCTGCGCTATACGCAGGCCATG
GTGATCGGGGGCGGATCGTCGATCAACGCGCAGATCTACACCCGTGGCAACGCGGGCGATTATGACGGCTGGGCACGGGA
AAAGGGCTGCGAGGCCTGGGAATATCGTCGCGTCCTGCCTTATTTCAAACGGGCGGAAAACAACCAGCGCTTCCTCGACG
ACTATCATGGTGCCGGGGGGCCGCTGGGTGTGTCGATGCCCGCGGCGCCCCTGCCGATCTGCGAGGCCTATATCAAGGCC
GCCCAGGAACTTGGTATTCCCTACAACCATGATTTCAATGGACCCCGTCAGGCCGGCATCGGGTTCTTCCAGCTGACGCA
GCGCAATCACGAACGGTCGTCGGCATCCCGTGCCTATCTCGGCGCGGCGCGGGGGCGGAAAAACCTGACCGTGCGGCTCA
ATGCCCAGGTGCTGCGGGTCGTGGTCGAGAAGGGGCGGGCAATCGGGGTCGAGCTTTCGTTTTCCGGCCGGACGGGATTC
GTCCGGGCGGAGCGCGAGGTCATTCTCTGCTCGGGGGCCATAGGCTCGCCCAAGCTGCTGCTGCAATCGGGCATCGGCCC
GGCCGACGAACTGTGCGCCCTGGATATCCCCGTCATGCACGATCTGCCGGGCGTGGGCCGCAACCTGCAGGACCATCTGG
ATCTTTTCGTCATTGCCGAATGTAGGGGCGATTTCACCTATGACGGTGTCGCGCGGCCGCATCGGACGCTTGCCGCCGGC
CTGCAATACCTGATCTACAGAAACGGCCCGGCAGCCTCGAGCCTTTTCGAGACGGGAGGGTTCTGGTACGTCGATCCCAG
GGCCGCATATCCGGATCTTCAGTTTCACCTGGGCCTGGGTTCGGGGATCGAGGCAGGCGTCGCGCGGCTTCGGAACGCGG
GCGTGACCCTGAATACCGCCTATCTGCGCCCCCGGTCGCGCGGCACCGTGACGCTGCGGTCCGCCGACCCGGCGGCCGCC
CCGCTGATCGATCCGAATTATTTCAGCGATCCGCATGATCGAACCATGTCGATCGAGGGCCTGAAGATCGCGCGCGAGAT
CATCCTGCAGCCGGCGATGCAGGATTTCGTCCTGGCCGAGCGTCTGCCCGGTCCCGCCGTGCGCACCGACGCCGAACTGT
TCGATTACGCGTGCCGGAACGCCAAGACCGACCACCATCCGGTGGGGACGTGCCGGATGGGCGTCGGGGCGGATGCCGTG
GTGGACCCGGAACTGCGCCTGCACGGCATTGCCGGGCTGCGCGTCTGCGATGCGTCGGTGATGCCGAAGATACCCTCATG
CAACACCAACAGCCCGACCATCATGGTGGGCGAGAAAGGTGCGGACATGATCCTCGGCCGGCAGCCCCTGGCGCCGGCGA
TCCTTGACGACCAGCGCAACGATATCCCGCAGCACGCGCGGCGCGAGGTCGCCTGA

Upstream 100 bases:

>100_bases
GCCGCGATTCAGGGGCGGCTGGTCGTGACCACACGACGGATGGCCAGGCCCTGAGGGGCACGCGACCCGACCCTGCTGCA
ATCCGCTCCGGGAGAAAGAC

Downstream 100 bases:

>100_bases
CGACCCGGGCCCGTGCCCGCAATGGTGTGCCTCAAAACAGGGGCGTGGAGACACACATGTCGTTCATCAAGGCCTACATT
GAACAGCAGACGATCAGCCG

Product: GMC oxidoreductase

Products: NA

Alternate protein names: SDH [H]

Number of amino acids: Translated: 551; Mature: 550

Protein sequence:

>551_residues
MAYDYVIVGGGPAGCVLAARLSEDPRVRVLLLEAGGSDRNMLYRIPAGFAKMTKGIGSRGWETVPQRHMQGRVLRYTQAM
VIGGGSSINAQIYTRGNAGDYDGWAREKGCEAWEYRRVLPYFKRAENNQRFLDDYHGAGGPLGVSMPAAPLPICEAYIKA
AQELGIPYNHDFNGPRQAGIGFFQLTQRNHERSSASRAYLGAARGRKNLTVRLNAQVLRVVVEKGRAIGVELSFSGRTGF
VRAEREVILCSGAIGSPKLLLQSGIGPADELCALDIPVMHDLPGVGRNLQDHLDLFVIAECRGDFTYDGVARPHRTLAAG
LQYLIYRNGPAASSLFETGGFWYVDPRAAYPDLQFHLGLGSGIEAGVARLRNAGVTLNTAYLRPRSRGTVTLRSADPAAA
PLIDPNYFSDPHDRTMSIEGLKIAREIILQPAMQDFVLAERLPGPAVRTDAELFDYACRNAKTDHHPVGTCRMGVGADAV
VDPELRLHGIAGLRVCDASVMPKIPSCNTNSPTIMVGEKGADMILGRQPLAPAILDDQRNDIPQHARREVA

Sequences:

>Translated_551_residues
MAYDYVIVGGGPAGCVLAARLSEDPRVRVLLLEAGGSDRNMLYRIPAGFAKMTKGIGSRGWETVPQRHMQGRVLRYTQAM
VIGGGSSINAQIYTRGNAGDYDGWAREKGCEAWEYRRVLPYFKRAENNQRFLDDYHGAGGPLGVSMPAAPLPICEAYIKA
AQELGIPYNHDFNGPRQAGIGFFQLTQRNHERSSASRAYLGAARGRKNLTVRLNAQVLRVVVEKGRAIGVELSFSGRTGF
VRAEREVILCSGAIGSPKLLLQSGIGPADELCALDIPVMHDLPGVGRNLQDHLDLFVIAECRGDFTYDGVARPHRTLAAG
LQYLIYRNGPAASSLFETGGFWYVDPRAAYPDLQFHLGLGSGIEAGVARLRNAGVTLNTAYLRPRSRGTVTLRSADPAAA
PLIDPNYFSDPHDRTMSIEGLKIAREIILQPAMQDFVLAERLPGPAVRTDAELFDYACRNAKTDHHPVGTCRMGVGADAV
VDPELRLHGIAGLRVCDASVMPKIPSCNTNSPTIMVGEKGADMILGRQPLAPAILDDQRNDIPQHARREVA
>Mature_550_residues
AYDYVIVGGGPAGCVLAARLSEDPRVRVLLLEAGGSDRNMLYRIPAGFAKMTKGIGSRGWETVPQRHMQGRVLRYTQAMV
IGGGSSINAQIYTRGNAGDYDGWAREKGCEAWEYRRVLPYFKRAENNQRFLDDYHGAGGPLGVSMPAAPLPICEAYIKAA
QELGIPYNHDFNGPRQAGIGFFQLTQRNHERSSASRAYLGAARGRKNLTVRLNAQVLRVVVEKGRAIGVELSFSGRTGFV
RAEREVILCSGAIGSPKLLLQSGIGPADELCALDIPVMHDLPGVGRNLQDHLDLFVIAECRGDFTYDGVARPHRTLAAGL
QYLIYRNGPAASSLFETGGFWYVDPRAAYPDLQFHLGLGSGIEAGVARLRNAGVTLNTAYLRPRSRGTVTLRSADPAAAP
LIDPNYFSDPHDRTMSIEGLKIAREIILQPAMQDFVLAERLPGPAVRTDAELFDYACRNAKTDHHPVGTCRMGVGADAVV
DPELRLHGIAGLRVCDASVMPKIPSCNTNSPTIMVGEKGADMILGRQPLAPAILDDQRNDIPQHARREVA

Specific function: Can Catalyze The Oxidation Of Choline To Betaine Aldehyde And Betaine Aldehyde To Glycine Betaine At The Same Rate. [C]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=559, Percent_Identity=40.608228980322, Blast_Score=384, Evalue=1e-106,
Organism=Escherichia coli, GI1786503, Length=537, Percent_Identity=40.0372439478585, Blast_Score=371, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17532301, Length=551, Percent_Identity=37.7495462794918, Blast_Score=357, Evalue=1e-98,
Organism=Drosophila melanogaster, GI24642055, Length=578, Percent_Identity=38.5813148788927, Blast_Score=342, Evalue=5e-94,
Organism=Drosophila melanogaster, GI24642059, Length=571, Percent_Identity=37.8283712784588, Blast_Score=317, Evalue=2e-86,
Organism=Drosophila melanogaster, GI24642048, Length=565, Percent_Identity=36.9911504424779, Blast_Score=311, Evalue=6e-85,
Organism=Drosophila melanogaster, GI24642042, Length=567, Percent_Identity=37.3897707231041, Blast_Score=309, Evalue=3e-84,
Organism=Drosophila melanogaster, GI17137792, Length=561, Percent_Identity=36.3636363636364, Blast_Score=302, Evalue=3e-82,
Organism=Drosophila melanogaster, GI45549471, Length=568, Percent_Identity=36.9718309859155, Blast_Score=299, Evalue=4e-81,
Organism=Drosophila melanogaster, GI45551458, Length=569, Percent_Identity=37.0826010544815, Blast_Score=299, Evalue=4e-81,
Organism=Drosophila melanogaster, GI24642037, Length=578, Percent_Identity=36.5051903114187, Blast_Score=295, Evalue=7e-80,
Organism=Drosophila melanogaster, GI24642039, Length=564, Percent_Identity=36.7021276595745, Blast_Score=293, Evalue=3e-79,
Organism=Drosophila melanogaster, GI24650267, Length=577, Percent_Identity=34.8353552859619, Blast_Score=275, Evalue=4e-74,
Organism=Drosophila melanogaster, GI18859995, Length=564, Percent_Identity=35.9929078014184, Blast_Score=274, Evalue=1e-73,
Organism=Drosophila melanogaster, GI24642035, Length=568, Percent_Identity=33.4507042253521, Blast_Score=271, Evalue=6e-73,
Organism=Drosophila melanogaster, GI24642051, Length=564, Percent_Identity=34.0425531914894, Blast_Score=254, Evalue=7e-68,
Organism=Drosophila melanogaster, GI18859993, Length=566, Percent_Identity=33.3922261484099, Blast_Score=245, Evalue=5e-65,
Organism=Drosophila melanogaster, GI24642057, Length=591, Percent_Identity=29.9492385786802, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24645930, Length=582, Percent_Identity=27.4914089347079, Blast_Score=154, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.32 [H]

Molecular weight: Translated: 59881; Mature: 59750

Theoretical pI: Translated: 8.52; Mature: 8.52

Prosite motif: PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYDYVIVGGGPAGCVLAARLSEDPRVRVLLLEAGGSDRNMLYRIPAGFAKMTKGIGSRG
CCEEEEEECCCCCCEEEEEECCCCCCEEEEEEECCCCCCCEEEECCCCHHHHHHHCCCCC
WETVPQRHMQGRVLRYTQAMVIGGGSSINAQIYTRGNAGDYDGWAREKGCEAWEYRRVLP
CHHHHHHHHCCCEEEEEEEEEEECCCCEEEEEEECCCCCCCCCHHHHCCCCHHHHHHHHH
YFKRAENNQRFLDDYHGAGGPLGVSMPAAPLPICEAYIKAAQELGIPYNHDFNGPRQAGI
HHHHCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHCC
GFFQLTQRNHERSSASRAYLGAARGRKNLTVRLNAQVLRVVVEKGRAIGVELSFSGRTGF
CEEEEHHCCCHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHCCCEEEEEEEECCCCCE
VRAEREVILCSGAIGSPKLLLQSGIGPADELCALDIPVMHDLPGVGRNLQDHLDLFVIAE
EEECCEEEEEECCCCCCHHHHHCCCCCHHHHEEECCCHHHCCCCCCCCHHHCCCEEEEEE
CRGDFTYDGVARPHRTLAAGLQYLIYRNGPAASSLFETGGFWYVDPRAAYPDLQFHLGLG
CCCCCCCCCCCCCHHHHHHHHEEEEEECCCCHHHHHHCCCEEEECCCCCCCCCEEEECCC
SGIEAGVARLRNAGVTLNTAYLRPRSRGTVTLRSADPAAAPLIDPNYFSDPHDRTMSIEG
CCHHHHHHHHHCCCEEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEHH
LKIAREIILQPAMQDFVLAERLPGPAVRTDAELFDYACRNAKTDHHPVGTCRMGVGADAV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEECCCCCCE
VDPELRLHGIAGLRVCDASVMPKIPSCNTNSPTIMVGEKGADMILGRQPLAPAILDDQRN
ECCCCEEECCCCEEEECHHHCCCCCCCCCCCCEEEECCCCCCEEECCCCCCCHHHCCCCC
DIPQHARREVA
CCCHHHHHCCC
>Mature Secondary Structure 
AYDYVIVGGGPAGCVLAARLSEDPRVRVLLLEAGGSDRNMLYRIPAGFAKMTKGIGSRG
CEEEEEECCCCCCEEEEEECCCCCCEEEEEEECCCCCCCEEEECCCCHHHHHHHCCCCC
WETVPQRHMQGRVLRYTQAMVIGGGSSINAQIYTRGNAGDYDGWAREKGCEAWEYRRVLP
CHHHHHHHHCCCEEEEEEEEEEECCCCEEEEEEECCCCCCCCCHHHHCCCCHHHHHHHHH
YFKRAENNQRFLDDYHGAGGPLGVSMPAAPLPICEAYIKAAQELGIPYNHDFNGPRQAGI
HHHHCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHCC
GFFQLTQRNHERSSASRAYLGAARGRKNLTVRLNAQVLRVVVEKGRAIGVELSFSGRTGF
CEEEEHHCCCHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHCCCEEEEEEEECCCCCE
VRAEREVILCSGAIGSPKLLLQSGIGPADELCALDIPVMHDLPGVGRNLQDHLDLFVIAE
EEECCEEEEEECCCCCCHHHHHCCCCCHHHHEEECCCHHHCCCCCCCCHHHCCCEEEEEE
CRGDFTYDGVARPHRTLAAGLQYLIYRNGPAASSLFETGGFWYVDPRAAYPDLQFHLGLG
CCCCCCCCCCCCCHHHHHHHHEEEEEECCCCHHHHHHCCCEEEECCCCCCCCCEEEECCC
SGIEAGVARLRNAGVTLNTAYLRPRSRGTVTLRSADPAAAPLIDPNYFSDPHDRTMSIEG
CCHHHHHHHHHCCCEEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEHH
LKIAREIILQPAMQDFVLAERLPGPAVRTDAELFDYACRNAKTDHHPVGTCRMGVGADAV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEECCCCCCE
VDPELRLHGIAGLRVCDASVMPKIPSCNTNSPTIMVGEKGADMILGRQPLAPAILDDQRN
ECCCCEEECCCCEEEECHHHCCCCCCCCCCCCEEEECCCCCCEEECCCCCCCHHHCCCCC
DIPQHARREVA
CCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9023923 [H]