Click here to switch to the map view.

The map label for this gene is pgl [H]

Identifier: 162146121

GI number: 162146121

Start: 304182

End: 304919

Strand: Direct

Name: pgl [H]

Synonym: GDI_0291

Alternate gene names: 162146121

Gene position: 304182-304919 (Clockwise)

Preceding gene: 162146120

Following gene: 162146122

Centisome position: 7.71

GC content: 68.43

Gene sequence:

>738_bases
ATGAGCGGTCATGATGTGAAAACCGGCGAAATGATCGTCCTCGCCGATGGCGAGGCGATCGCGCAATATATGGCCAGATG
GCTGACGGAACAGGCCCTGGCCAAGACGGACGGCCCCTTCGTGGTCGCGCTGTCCGGCGGGTCCACCCCCAAGCGACTGT
ATGAAATCCTGGGCTCGGCCGATTTCGCCACCCGCTTTCCGTGGGACCGCACGCAGCTCTTCTTCGGGGACGAACGGTTC
GTGCCGGCCACCGACCCGGCCAGCAACTACACCATGACGCGCACGGCGCTGCTGTCGCACATTTCCATTCCGCCGGCCAA
CGTCCACCCGATGCCGACCGAGGGCGACCCCGCCGCCGCCGCCGCACGCTACCAGGCGGAACTGCAGGCGGTGTACGGCG
CGGACACGCTGCAACCCGGCCGCCCGCTGTTCGACGTCGTGATGCTGGGCCTGGGCGACAACGGCCATACCGCGTCGCTG
TTCCCCCGCCAGCCGGTGCTGCAGGAACGCAGGCTGTGGGTTTCGACCTGCGTGCCGGACGACGCGCCGCATACCCGCCT
GACCCTGACCTACCCCGCCATCCATTCCAGCCGGCATGTCGTGTTCATGCTGGCCGGTGCCGGCAAGCGGGAAGCCTTCG
CCAAGGTTCGGGCCGGCGACCCCGCCGAACCCGCCAGCCACATCACGACCGAGGGCGAACTGGTCTGGCTGCTGGACAAG
GCGGCCGCCGCCGTCTGA

Upstream 100 bases:

>100_bases
TAGACGAGGTCAAGGCACAGGCCACCCACGTTTCCACCTCCTCCGAGGAGGAAGGATTCGCCATCGGGGTGGAACGCTAT
ATTCTCGGAGACGATGTCTG

Downstream 100 bases:

>100_bases
AAATCGGCCGGCGCGAAAGACAAGAGGACCGCCGGAACACCGGCAGGTTCCGGGAGGAAGCAAGATGGGCGTCCAGAATT
CGGACCCGATGATTGAACTG

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 245; Mature: 244

Protein sequence:

>245_residues
MSGHDVKTGEMIVLADGEAIAQYMARWLTEQALAKTDGPFVVALSGGSTPKRLYEILGSADFATRFPWDRTQLFFGDERF
VPATDPASNYTMTRTALLSHISIPPANVHPMPTEGDPAAAAARYQAELQAVYGADTLQPGRPLFDVVMLGLGDNGHTASL
FPRQPVLQERRLWVSTCVPDDAPHTRLTLTYPAIHSSRHVVFMLAGAGKREAFAKVRAGDPAEPASHITTEGELVWLLDK
AAAAV

Sequences:

>Translated_245_residues
MSGHDVKTGEMIVLADGEAIAQYMARWLTEQALAKTDGPFVVALSGGSTPKRLYEILGSADFATRFPWDRTQLFFGDERF
VPATDPASNYTMTRTALLSHISIPPANVHPMPTEGDPAAAAARYQAELQAVYGADTLQPGRPLFDVVMLGLGDNGHTASL
FPRQPVLQERRLWVSTCVPDDAPHTRLTLTYPAIHSSRHVVFMLAGAGKREAFAKVRAGDPAEPASHITTEGELVWLLDK
AAAAV
>Mature_244_residues
SGHDVKTGEMIVLADGEAIAQYMARWLTEQALAKTDGPFVVALSGGSTPKRLYEILGSADFATRFPWDRTQLFFGDERFV
PATDPASNYTMTRTALLSHISIPPANVHPMPTEGDPAAAAARYQAELQAVYGADTLQPGRPLFDVVMLGLGDNGHTASLF
PRQPVLQERRLWVSTCVPDDAPHTRLTLTYPAIHSSRHVVFMLAGAGKREAFAKVRAGDPAEPASHITTEGELVWLLDKA
AAAV

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI52145310, Length=216, Percent_Identity=38.4259259259259, Blast_Score=126, Evalue=1e-29,
Organism=Homo sapiens, GI6912586, Length=234, Percent_Identity=34.6153846153846, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI115533058, Length=243, Percent_Identity=27.5720164609054, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI115533060, Length=243, Percent_Identity=27.5720164609054, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6321957, Length=216, Percent_Identity=30.5555555555556, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321687, Length=226, Percent_Identity=28.3185840707965, Blast_Score=89, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6324362, Length=217, Percent_Identity=31.7972350230415, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6319918, Length=217, Percent_Identity=32.7188940092166, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24641119, Length=246, Percent_Identity=34.1463414634146, Blast_Score=95, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 26493; Mature: 26362

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGHDVKTGEMIVLADGEAIAQYMARWLTEQALAKTDGPFVVALSGGSTPKRLYEILGSA
CCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCC
DFATRFPWDRTQLFFGDERFVPATDPASNYTMTRTALLSHISIPPANVHPMPTEGDPAAA
CHHHCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHH
AARYQAELQAVYGADTLQPGRPLFDVVMLGLGDNGHTASLFPRQPVLQERRLWVSTCVPD
HHHHHHHHHHHHCCCCCCCCCCHHHEEEEECCCCCCEEEECCCCCHHHHHHEEEEECCCC
DAPHTRLTLTYPAIHSSRHVVFMLAGAGKREAFAKVRAGDPAEPASHITTEGELVWLLDK
CCCCCEEEEEECCCCCCCEEEEEEECCCCHHHHHHCCCCCCCCCHHHCCCCCCEEEEEEC
AAAAV
HHHCC
>Mature Secondary Structure 
SGHDVKTGEMIVLADGEAIAQYMARWLTEQALAKTDGPFVVALSGGSTPKRLYEILGSA
CCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCC
DFATRFPWDRTQLFFGDERFVPATDPASNYTMTRTALLSHISIPPANVHPMPTEGDPAAA
CHHHCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHH
AARYQAELQAVYGADTLQPGRPLFDVVMLGLGDNGHTASLFPRQPVLQERRLWVSTCVPD
HHHHHHHHHHHHCCCCCCCCCCHHHEEEEECCCCCCEEEECCCCCHHHHHHEEEEECCCC
DAPHTRLTLTYPAIHSSRHVVFMLAGAGKREAFAKVRAGDPAEPASHITTEGELVWLLDK
CCCCCEEEEEECCCCCCCEEEEEEECCCCHHHHHHCCCCCCCCCHHHCCCCCCEEEEEEC
AAAAV
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]