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The map label for this gene is nhaA

Identifier: 162146056

GI number: 162146056

Start: 239716

End: 240903

Strand: Reverse

Name: nhaA

Synonym: GDI_0224

Alternate gene names: 162146056

Gene position: 240903-239716 (Counterclockwise)

Preceding gene: 162146057

Following gene: 162146054

Centisome position: 6.11

GC content: 62.12

Gene sequence:

>1188_bases
ATGGCTGAATCAGTTGCTGCGCGCGTTGCCTCTCTCCGACGTTTCCTGGGCTCTCCCTCCGGTGGGGCATGCGTCCTGCT
GCTCGCGTCCCTTGCAGGCTTTGTCCTGGCAAACTCGCCGTGGGCGGCGGGTTATACCGCCCTTACGACAACGCCCCTGA
CGCTTTCCGTCCTTGGGAAACGGGGACCGGACACGATCGACGCATGGGTCTCCGACGGGTTCATGACCCTGTTTTTCCTG
GTGGTCATTCTCGAAATCAAGACCGAAATCGTCACGGGCCACCTCTCGTCACCACGGCGCGTCGCCCTTCCGCTGATCGG
CGCGCTGGGCGGAATGATCGTACCGGCCCTGACATACCTGCTGGTGACATGCGGACATCCGGAAGCGACGCGCGGCTGGG
CCATCCCCGTCGCGACCGATGCAGCGTTCACGTTGCCGATCATTCTGGCTCTTGGTCGGCATGTCTCGGCCGGAGCCAGG
GCCTGGCTGATGGCGCTCGCGATCTTCGATGATGTGCTGGGCATCGTCGTCATCGCCGTGTTTTACGGGAATGCCCTGTA
CTGGCCGGCACTGGCGGCGGCCGTGGTTGTCACGGCGGCGCTGATCGGGGCAAACAGGATCGGAATCAGGACAGTGTGGG
GTTACGCCACCGGCTGCATCCTGCTGTGGATCGCTCTTCTGGGGTCCGGCCTGCATCCGACCCTTGCCGGGGTCATAACC
GGTCTGTGCCTGCCCGCAACGGCCCTGGGACGGAACGTCGGACAGGCGACACCTCTCGACAGAGCGGCATCCGCACTGAC
ACCTGTCGTCACATGGGTAATTCTGCCGCTTTTCGGCTTCATGAACGTGGGTGTCTCACTCAGGGGTATCCATCCCGACA
TGATGGTGGACGCTGTTCCATTGGGGATCATGTCGGGACTGCTCATCGGCAAACCTGTCGGCGTCTTCAGCGCGACACTG
CTTTCGACCCGGCTGAGGATCGCCACGCTTCCGGCAGAAACGTCGATGGGAAAGGTGTTTGGCCTTTCGCTCCTGTGCGG
CATCGGATTTACGATCAGCCTGTTTATCGCGAACCTGTCATTTCCCGACTCTGGTCTTGTAATCCCTGCCAAGATGGGAA
TCTTCGCCGGCTCGGTCCTCTCCGCCCTGGCGGGATGGCTCTGGCTGCGTTTCTCGCCTGAGCAATGA

Upstream 100 bases:

>100_bases
CCCCGGCTTCCGCTTCCTGCGTTCAGGAAGGCCGTCGTCAGGAAGGCAGGCGCAGGGCTGTCGGCTTGTATGGCCGACCT
GAATCATTCAACAGAGATGA

Downstream 100 bases:

>100_bases
TCGCAGATCGATTACTGCGCCGTCTTGAACACATCCTGGAAAATGAGCGGTCCCCAAACGCGGCCGCGTGCATGCACCAG
CGCGCCACCTTCATAAAGTT

Product: Na(+)/H(+) antiporter 1

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MAESVAARVASLRRFLGSPSGGACVLLLASLAGFVLANSPWAAGYTALTTTPLTLSVLGKRGPDTIDAWVSDGFMTLFFL
VVILEIKTEIVTGHLSSPRRVALPLIGALGGMIVPALTYLLVTCGHPEATRGWAIPVATDAAFTLPIILALGRHVSAGAR
AWLMALAIFDDVLGIVVIAVFYGNALYWPALAAAVVVTAALIGANRIGIRTVWGYATGCILLWIALLGSGLHPTLAGVIT
GLCLPATALGRNVGQATPLDRAASALTPVVTWVILPLFGFMNVGVSLRGIHPDMMVDAVPLGIMSGLLIGKPVGVFSATL
LSTRLRIATLPAETSMGKVFGLSLLCGIGFTISLFIANLSFPDSGLVIPAKMGIFAGSVLSALAGWLWLRFSPEQ

Sequences:

>Translated_395_residues
MAESVAARVASLRRFLGSPSGGACVLLLASLAGFVLANSPWAAGYTALTTTPLTLSVLGKRGPDTIDAWVSDGFMTLFFL
VVILEIKTEIVTGHLSSPRRVALPLIGALGGMIVPALTYLLVTCGHPEATRGWAIPVATDAAFTLPIILALGRHVSAGAR
AWLMALAIFDDVLGIVVIAVFYGNALYWPALAAAVVVTAALIGANRIGIRTVWGYATGCILLWIALLGSGLHPTLAGVIT
GLCLPATALGRNVGQATPLDRAASALTPVVTWVILPLFGFMNVGVSLRGIHPDMMVDAVPLGIMSGLLIGKPVGVFSATL
LSTRLRIATLPAETSMGKVFGLSLLCGIGFTISLFIANLSFPDSGLVIPAKMGIFAGSVLSALAGWLWLRFSPEQ
>Mature_394_residues
AESVAARVASLRRFLGSPSGGACVLLLASLAGFVLANSPWAAGYTALTTTPLTLSVLGKRGPDTIDAWVSDGFMTLFFLV
VILEIKTEIVTGHLSSPRRVALPLIGALGGMIVPALTYLLVTCGHPEATRGWAIPVATDAAFTLPIILALGRHVSAGARA
WLMALAIFDDVLGIVVIAVFYGNALYWPALAAAVVVTAALIGANRIGIRTVWGYATGCILLWIALLGSGLHPTLAGVITG
LCLPATALGRNVGQATPLDRAASALTPVVTWVILPLFGFMNVGVSLRGIHPDMMVDAVPLGIMSGLLIGKPVGVFSATLL
STRLRIATLPAETSMGKVFGLSLLCGIGFTISLFIANLSFPDSGLVIPAKMGIFAGSVLSALAGWLWLRFSPEQ

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family

Homologues:

Organism=Escherichia coli, GI1786201, Length=385, Percent_Identity=42.8571428571429, Blast_Score=254, Evalue=5e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAA_GLUDA (A9H2L4)

Other databases:

- EMBL:   AM889285
- EMBL:   CP001189
- RefSeq:   YP_001600514.1
- RefSeq:   YP_002276663.1
- ProteinModelPortal:   A9H2L4
- SMR:   A9H2L4
- GeneID:   5789746
- GeneID:   6975723
- GenomeReviews:   AM889285_GR
- GenomeReviews:   CP001189_GR
- KEGG:   gdj:Gdia_2293
- HOGENOM:   HBG665619
- OMA:   LTWTHIT
- ProtClustDB:   CLSK933020
- HAMAP:   MF_01844
- InterPro:   IPR023171
- InterPro:   IPR004670
- TIGRFAMs:   TIGR00773

Pfam domain/function: PF06965 Na_H_antiport_1

EC number: NA

Molecular weight: Translated: 40976; Mature: 40845

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1131fea4)-; HASH(0x11bb4fec)-; HASH(0x125418e8)-; HASH(0x12dc9dcc)-; HASH(0x11afa094)-; HASH(0x121ed7e4)-; HASH(0x12db629c)-; HASH(0x1246fe78)-; HASH(0x12e9e6fc)-; HASH(0x13114650)-;

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAESVAARVASLRRFLGSPSGGACVLLLASLAGFVLANSPWAAGYTALTTTPLTLSVLGK
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCEEEEECCC
RGPDTIDAWVSDGFMTLFFLVVILEIKTEIVTGHLSSPRRVALPLIGALGGMIVPALTYL
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LVTCGHPEATRGWAIPVATDAAFTLPIILALGRHVSAGARAWLMALAIFDDVLGIVVIAV
HHCCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
FYGNALYWPALAAAVVVTAALIGANRIGIRTVWGYATGCILLWIALLGSGLHPTLAGVIT
HHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
GLCLPATALGRNVGQATPLDRAASALTPVVTWVILPLFGFMNVGVSLRGIHPDMMVDAVP
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHH
LGIMSGLLIGKPVGVFSATLLSTRLRIATLPAETSMGKVFGLSLLCGIGFTISLFIANLS
HHHHHHHHHCCCHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
FPDSGLVIPAKMGIFAGSVLSALAGWLWLRFSPEQ
CCCCCEEEEHHHHHHHHHHHHHHHHHHEEEECCCH
>Mature Secondary Structure 
AESVAARVASLRRFLGSPSGGACVLLLASLAGFVLANSPWAAGYTALTTTPLTLSVLGK
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCEEEEECCC
RGPDTIDAWVSDGFMTLFFLVVILEIKTEIVTGHLSSPRRVALPLIGALGGMIVPALTYL
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LVTCGHPEATRGWAIPVATDAAFTLPIILALGRHVSAGARAWLMALAIFDDVLGIVVIAV
HHCCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
FYGNALYWPALAAAVVVTAALIGANRIGIRTVWGYATGCILLWIALLGSGLHPTLAGVIT
HHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
GLCLPATALGRNVGQATPLDRAASALTPVVTWVILPLFGFMNVGVSLRGIHPDMMVDAVP
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHH
LGIMSGLLIGKPVGVFSATLLSTRLRIATLPAETSMGKVFGLSLLCGIGFTISLFIANLS
HHHHHHHHHCCCHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
FPDSGLVIPAKMGIFAGSVLSALAGWLWLRFSPEQ
CCCCCEEEEHHHHHHHHHHHHHHHHHHEEEECCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA