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The map label for this gene is lon [H]

Identifier: 162146015

GI number: 162146015

Start: 196213

End: 196887

Strand: Reverse

Name: lon [H]

Synonym: GDI_0183

Alternate gene names: 162146015

Gene position: 196887-196213 (Counterclockwise)

Preceding gene: 162146016

Following gene: 162146014

Centisome position: 4.99

GC content: 67.85

Gene sequence:

>675_bases
ATGACGCTGGCGGACCTGCCGCCCGAACTGGGATTGTTCCCGCTGCGCGATACGGTGCTGCTGCCCCGGGCCAAGCTGCC
GCTGAATATCTTCGAACCGCGCTATATCGCCCTGGTCGAGGACGCGATGGCCGGGTCGCGCCTGATCGGCATGATCCAGC
CCCGCCGCGATGCGATGGACGAGGATGACGGCGACGAGATGCAGCCGGCGCCGCTGCCCGCCCTGTACGATATCGGGTGC
GCCGGGCGCATCACGTCGATGACCGAGCGGTCGGACGGCACCTATGCCGTGACGCTGCTGGGAATGGTGCGATTCCGGCT
GTTGCGCGAAACCGGGCTGCATCGGGGATACCGCCGGGCGCGGATCGACGCGTCATCCTTCGCCAGCGACCTGACCGATG
GCGAGGACCCGTTCTATGACCGGCCCCGCATGATCACGGCGCTGCGCCGCTATTGCCGCCGGCGGGGCTTCGGCGCCCGC
TGGAGCGTGATCGAGCAGATGGACGACGAAGCCCTGCTGATCACCCTGCCGATGATCTGCCCCTTCCCGGCGGCCGAAAA
GCAGGCGCTGCTGGAATCCGGGTCGCTGAACGACAGGGCCCGAACGTTGCAGACCCTGCTGGACCTGGCTGGACATGAGC
CCGAGGAGGGTGCATCTGACCACCCGCCGTCGTAA

Upstream 100 bases:

>100_bases
GCCCGGCGGCGTATGTCCGCGCTGCTGTTTTCATGATGCGGGGGGCGGCACGGCATTGAGCGGCGACGATATTCCGCGCG
CCGTGCCGCGCCCGCACGAC

Downstream 100 bases:

>100_bases
GGATGGCAGGAGAGAGGACCGATCCGATGACCGAAACCGCCCAAGCCCCCCTGGACCCCCGCCTGCTGTCCGTCCTGGTC
TGCCCCGTCACCAAGGGGCC

Product: ATP-dependent protease

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 224; Mature: 223

Protein sequence:

>224_residues
MTLADLPPELGLFPLRDTVLLPRAKLPLNIFEPRYIALVEDAMAGSRLIGMIQPRRDAMDEDDGDEMQPAPLPALYDIGC
AGRITSMTERSDGTYAVTLLGMVRFRLLRETGLHRGYRRARIDASSFASDLTDGEDPFYDRPRMITALRRYCRRRGFGAR
WSVIEQMDDEALLITLPMICPFPAAEKQALLESGSLNDRARTLQTLLDLAGHEPEEGASDHPPS

Sequences:

>Translated_224_residues
MTLADLPPELGLFPLRDTVLLPRAKLPLNIFEPRYIALVEDAMAGSRLIGMIQPRRDAMDEDDGDEMQPAPLPALYDIGC
AGRITSMTERSDGTYAVTLLGMVRFRLLRETGLHRGYRRARIDASSFASDLTDGEDPFYDRPRMITALRRYCRRRGFGAR
WSVIEQMDDEALLITLPMICPFPAAEKQALLESGSLNDRARTLQTLLDLAGHEPEEGASDHPPS
>Mature_223_residues
TLADLPPELGLFPLRDTVLLPRAKLPLNIFEPRYIALVEDAMAGSRLIGMIQPRRDAMDEDDGDEMQPAPLPALYDIGCA
GRITSMTERSDGTYAVTLLGMVRFRLLRETGLHRGYRRARIDASSFASDLTDGEDPFYDRPRMITALRRYCRRRGFGARW
SVIEQMDDEALLITLPMICPFPAAEKQALLESGSLNDRARTLQTLLDLAGHEPEEGASDHPPS

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG2802

COG function: function code R; Uncharacterized protein, similar to the N-terminal domain of Lon protease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

None

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 25046; Mature: 24915

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLADLPPELGLFPLRDTVLLPRAKLPLNIFEPRYIALVEDAMAGSRLIGMIQPRRDAMD
CCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHCHHHHHCCCCCHHCCC
EDDGDEMQPAPLPALYDIGCAGRITSMTERSDGTYAVTLLGMVRFRLLRETGLHRGYRRA
CCCCCCCCCCCCCHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RIDASSFASDLTDGEDPFYDRPRMITALRRYCRRRGFGARWSVIEQMDDEALLITLPMIC
HCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEECCCC
PFPAAEKQALLESGSLNDRARTLQTLLDLAGHEPEEGASDHPPS
CCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
TLADLPPELGLFPLRDTVLLPRAKLPLNIFEPRYIALVEDAMAGSRLIGMIQPRRDAMD
CCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHCHHHHHCCCCCHHCCC
EDDGDEMQPAPLPALYDIGCAGRITSMTERSDGTYAVTLLGMVRFRLLRETGLHRGYRRA
CCCCCCCCCCCCCHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RIDASSFASDLTDGEDPFYDRPRMITALRRYCRRRGFGARWSVIEQMDDEALLITLPMIC
HCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEECCCC
PFPAAEKQALLESGSLNDRARTLQTLLDLAGHEPEEGASDHPPS
CCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8331083; 8331082 [H]