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The map label for this gene is alsR [H]

Identifier: 162146005

GI number: 162146005

Start: 182752

End: 183696

Strand: Direct

Name: alsR [H]

Synonym: GDI_0173

Alternate gene names: 162146005

Gene position: 182752-183696 (Clockwise)

Preceding gene: 162146001

Following gene: 162146008

Centisome position: 4.63

GC content: 70.05

Gene sequence:

>945_bases
ATGCCAACGTCAAATATATGGTATGTGTCGATTCCATATACAGGATATATGGATATGGACCTGCGTCATCTGCGCTATTT
CGTGGCGGTCGCCGAACGGGGCGGCTTCACCCGCGCGGCCGAAAGCCTGCACATGGAGCAGCCGCCGCTCAGCCAGCAGA
TCCGCCAGCTTGAACAGGAACTGGGCGTGACGCTGTTCGAGCGTCTGAGCCGCGGCGTCCGCCTGACCGAGGCCGGGGCC
TGCCTGATCGACCAGGCGCGGACCATCCTGGCGATGGACGCGCAGTTCCGCACCGATGCCGGCGGCATCGCGCGGGGCGA
GCAGGGGCGGCTGCGCATCGGCCTGGCGGGGGCGGTGTCCCTGCTGCCACTGATCCCGCAGGCGATCCGGCTGTTTCGCG
ACCGCTGGCCCGGCATCGTCCTGACGATGGAGGACAGCAACACCCCCGCGCTGATCGACGCCCTGCGCCAGCGCCGGCTG
GACATCGCGATCATCCGCCCCCCGGTCGTCGAGCCCGACATCGCAACGACGCCCCTGCTGGACGAACCGACGGTGATCGC
CCTGCCCAGCGGCCACCCGGCGGGAGAGGAGGAGGAGATCGACCTGGCACGCATCGCGGGCGAACCGCTGATCATCTTCG
ACCGCGCCCTGGGCCCGGGCTTCTACGACGCGATCCTGTCGGCCTGCCAGGCGGCGGGCTTCACGCCCGCGTTCGGCCAG
GGGGCGCCGCAGATCGCCTCCACCGTGCCGCTGGTGGCCGCCGGGCTGGGGGTGTCGATCGTGCCGGACTGCCTGCGCCA
GATCCACGCCGGCGGCGTCACCTACCACGCCATTCGCGGCACCGCGCCGCTGGCCTCGCTGGCCATCGCGACGCTGGCGG
GCGCATCGGGGCCGCTGGTGCCGCGCTTTGTCGAGACGCTGCGGGAGCGGGTGGTTCTTTTTTGA

Upstream 100 bases:

>100_bases
GCTTCAGCCCGATCTGGGCCAGCCGATCCGCGAGATAGCGTCCAACGGTATAGGTCATCACATGGCTCCTTGCATCGTCC
GGCCATGGTGATCCTGCCTT

Downstream 100 bases:

>100_bases
AAAAAAGAGCCAAAAAACTTCTGATTTGTTCAGGTCTTTTCAGGACTGACCCTGGCTCTGATCCTGCTCGGGCGGGGCTT
CGGGCATCGTGGGCGGCCAG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MPTSNIWYVSIPYTGYMDMDLRHLRYFVAVAERGGFTRAAESLHMEQPPLSQQIRQLEQELGVTLFERLSRGVRLTEAGA
CLIDQARTILAMDAQFRTDAGGIARGEQGRLRIGLAGAVSLLPLIPQAIRLFRDRWPGIVLTMEDSNTPALIDALRQRRL
DIAIIRPPVVEPDIATTPLLDEPTVIALPSGHPAGEEEEIDLARIAGEPLIIFDRALGPGFYDAILSACQAAGFTPAFGQ
GAPQIASTVPLVAAGLGVSIVPDCLRQIHAGGVTYHAIRGTAPLASLAIATLAGASGPLVPRFVETLRERVVLF

Sequences:

>Translated_314_residues
MPTSNIWYVSIPYTGYMDMDLRHLRYFVAVAERGGFTRAAESLHMEQPPLSQQIRQLEQELGVTLFERLSRGVRLTEAGA
CLIDQARTILAMDAQFRTDAGGIARGEQGRLRIGLAGAVSLLPLIPQAIRLFRDRWPGIVLTMEDSNTPALIDALRQRRL
DIAIIRPPVVEPDIATTPLLDEPTVIALPSGHPAGEEEEIDLARIAGEPLIIFDRALGPGFYDAILSACQAAGFTPAFGQ
GAPQIASTVPLVAAGLGVSIVPDCLRQIHAGGVTYHAIRGTAPLASLAIATLAGASGPLVPRFVETLRERVVLF
>Mature_313_residues
PTSNIWYVSIPYTGYMDMDLRHLRYFVAVAERGGFTRAAESLHMEQPPLSQQIRQLEQELGVTLFERLSRGVRLTEAGAC
LIDQARTILAMDAQFRTDAGGIARGEQGRLRIGLAGAVSLLPLIPQAIRLFRDRWPGIVLTMEDSNTPALIDALRQRRLD
IAIIRPPVVEPDIATTPLLDEPTVIALPSGHPAGEEEEIDLARIAGEPLIIFDRALGPGFYDAILSACQAAGFTPAFGQG
APQIASTVPLVAAGLGVSIVPDCLRQIHAGGVTYHAIRGTAPLASLAIATLAGASGPLVPRFVETLRERVVLF

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=259, Percent_Identity=35.9073359073359, Blast_Score=168, Evalue=5e-43,
Organism=Escherichia coli, GI1788887, Length=293, Percent_Identity=35.1535836177474, Blast_Score=164, Evalue=6e-42,
Organism=Escherichia coli, GI1790399, Length=244, Percent_Identity=35.2459016393443, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI157672245, Length=253, Percent_Identity=32.8063241106719, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI2367136, Length=268, Percent_Identity=31.7164179104478, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1788748, Length=247, Percent_Identity=28.7449392712551, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788297, Length=269, Percent_Identity=28.996282527881, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI145693105, Length=248, Percent_Identity=26.2096774193548, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1787530, Length=246, Percent_Identity=27.6422764227642, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787806, Length=249, Percent_Identity=27.3092369477912, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1790262, Length=244, Percent_Identity=26.6393442622951, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1787601, Length=185, Percent_Identity=31.3513513513514, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1786401, Length=174, Percent_Identity=32.7586206896552, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1789204, Length=245, Percent_Identity=27.3469387755102, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI87081904, Length=219, Percent_Identity=29.6803652968037, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI48994962, Length=193, Percent_Identity=29.5336787564767, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI87082132, Length=147, Percent_Identity=31.2925170068027, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788481, Length=246, Percent_Identity=26.0162601626016, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1786713, Length=119, Percent_Identity=32.7731092436975, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI145693193, Length=139, Percent_Identity=32.3741007194245, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787949, Length=139, Percent_Identity=33.8129496402878, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1790208, Length=253, Percent_Identity=28.0632411067194, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33797; Mature: 33665

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTSNIWYVSIPYTGYMDMDLRHLRYFVAVAERGGFTRAAESLHMEQPPLSQQIRQLEQE
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHH
LGVTLFERLSRGVRLTEAGACLIDQARTILAMDAQFRTDAGGIARGEQGRLRIGLAGAVS
HCHHHHHHHHCCCEEECCCHHHHHHCHHEEEECCCCCCCCCCCCCCCCCCEEEEHHHHHH
LLPLIPQAIRLFRDRWPGIVLTMEDSNTPALIDALRQRRLDIAIIRPPVVEPDIATTPLL
HHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCC
DEPTVIALPSGHPAGEEEEIDLARIAGEPLIIFDRALGPGFYDAILSACQAAGFTPAFGQ
CCCCEEEECCCCCCCCCCCCHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCC
GAPQIASTVPLVAAGLGVSIVPDCLRQIHAGGVTYHAIRGTAPLASLAIATLAGASGPLV
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCCCCH
PRFVETLRERVVLF
HHHHHHHHHHHCCC
>Mature Secondary Structure 
PTSNIWYVSIPYTGYMDMDLRHLRYFVAVAERGGFTRAAESLHMEQPPLSQQIRQLEQE
CCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHH
LGVTLFERLSRGVRLTEAGACLIDQARTILAMDAQFRTDAGGIARGEQGRLRIGLAGAVS
HCHHHHHHHHCCCEEECCCHHHHHHCHHEEEECCCCCCCCCCCCCCCCCCEEEEHHHHHH
LLPLIPQAIRLFRDRWPGIVLTMEDSNTPALIDALRQRRLDIAIIRPPVVEPDIATTPLL
HHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCC
DEPTVIALPSGHPAGEEEEIDLARIAGEPLIIFDRALGPGFYDAILSACQAAGFTPAFGQ
CCCCEEEECCCCCCCCCCCCHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCC
GAPQIASTVPLVAAGLGVSIVPDCLRQIHAGGVTYHAIRGTAPLASLAIATLAGASGPLV
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCCCCH
PRFVETLRERVVLF
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]