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The map label for this gene is trpC [H]

Identifier: 162139481

GI number: 162139481

Start: 18516

End: 19874

Strand: Reverse

Name: trpC [H]

Synonym: Hac_0015

Alternate gene names: 162139481

Gene position: 19874-18516 (Counterclockwise)

Preceding gene: 109946655

Following gene: 109946653

Centisome position: 1.28

GC content: 36.94

Gene sequence:

>1359_bases
ATGCCTAGCGTGTTAGAGAATATCCTTAAAGACAAACTCTTAGAAGTCTCTGCACTTAAAAAAAATTACACCTTGCCCGC
AAACATAAGCCCAAGCGATAGGGATTTTAAAAAAGCGTTATTGGAAAAAAAAACAAGCTTTATTTTAGAGTGTAAAAAAG
CATCGCCCTCTAAAGGCTTGATCAGAAAAGATTTTGATTTACTAAAAATAGCGAAGGTTTATGAAAAATTTGCCTCTTGC
ATTTCGGTTTTAGCCGACGCCAAGCATTTTTTAGGATCTTATGAAAACATTAAGATTGTCTCAAAGCATTCCACCAAGCC
TATTTTATGCAAAGACTTTATCATTGATAGTTTCCAGATCAAACTCGCTAGGGTTATGGGGGCTAATGCGGTGCTTTTAA
TGTTAAGCGTGCTAGATGACAAAAACTATTTAGAGCTTTTTGAACTCGCCAAGTCCTTAAAAATGAGCGTGTTGAGTGAA
GTTTCCAACAAGCAAGAAATCCAGCGCTTACTCAAACTTAAATACGACATTATAGGCATTAACAATAGGGATTTACACAC
CTTAAAAACCGATATGTTTCACACGCTAGAATTACGCCCCTTATTGCCTAAAGACACGCTCATCATCAGTGAGTCCGGTA
TCCATTCGCATGCACAAATCAAAGCCCTAGCCCCTTATGTGAATGGCTTTTTAGTGGGAAGCTCTTTAATGAAAGAAAAG
GATTTGAAAAAAGCGTGCATTAAATTGATTTTAGGCGAAAATAAAGTGTGCGGGCTTACAAGAATCAAAGACGCTAAAGC
CGTCTATAAAAACCATTTTATTTATGGGGGTTTGATTTTTGAAAAATCTTCGCCCAGATACATTAAACCCAAAGAAGCCC
TAAAAATCACAAAAGCGGTTAAAAAATTGGATTTTGTGGGCGTGTTTGTGAAAAATAAAATTAAAAAAATCGTAAAAATC
GCTCAAAAGCTTGATTTAAAAGCGGTGCAGCTTTATAACTATTCGCCTAAAAAAATCGCTCAATTAAAAAAATCGCTCCC
TAAAACTTGTGCAATCTGGCAAGTAGTGAGCGTCGCGGATTCTAAAGATTTAGCCCCTAAAACTGAAGAAGCCTCTTTAA
TCTTATACGACACTAAAGGGGATAAATATGGAGGCAATGGCGTGAGTTTTGATTGGGATATTTTAGACCATGTCAAAACG
CCTTTCATGCTAGCCGGTGGGCTTGATTTGGATAACGCTCAAAAAGCCTTAAAGGTCAAAGCGTTGGGTCTGGATTTTAA
TTCAGGTTTGGAAATAAGCCCTGGTATTAAAAATAAGGATAAAATCAAGCGGTTAGCCCGAATTTTAAGAGAGTATTAA

Upstream 100 bases:

>100_bases
AATAGAGCTAAAGATTTAAAAGAGGGCGTGAGCATGACTTTAGAGCATTTAAAAACCAAAGCGCCTTATACGCATTTACA
AAAAATCATAAGATTAAGCC

Downstream 100 bases:

>100_bases
AATGAATAAAAAAGCGTATTTTGGGGAGTTTGGGGGGAGTTTTGTTTCAGAATTGTTAGTGCCTGCGTTAAGAGAGTTAG
AACAAGCGTTTGATGCTTGT

Product: bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: Indole-3-glycerol phosphate synthase; IGPS; N-(5'-phospho-ribosyl)anthranilate isomerase; PRAI [H]

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MPSVLENILKDKLLEVSALKKNYTLPANISPSDRDFKKALLEKKTSFILECKKASPSKGLIRKDFDLLKIAKVYEKFASC
ISVLADAKHFLGSYENIKIVSKHSTKPILCKDFIIDSFQIKLARVMGANAVLLMLSVLDDKNYLELFELAKSLKMSVLSE
VSNKQEIQRLLKLKYDIIGINNRDLHTLKTDMFHTLELRPLLPKDTLIISESGIHSHAQIKALAPYVNGFLVGSSLMKEK
DLKKACIKLILGENKVCGLTRIKDAKAVYKNHFIYGGLIFEKSSPRYIKPKEALKITKAVKKLDFVGVFVKNKIKKIVKI
AQKLDLKAVQLYNYSPKKIAQLKKSLPKTCAIWQVVSVADSKDLAPKTEEASLILYDTKGDKYGGNGVSFDWDILDHVKT
PFMLAGGLDLDNAQKALKVKALGLDFNSGLEISPGIKNKDKIKRLARILREY

Sequences:

>Translated_452_residues
MPSVLENILKDKLLEVSALKKNYTLPANISPSDRDFKKALLEKKTSFILECKKASPSKGLIRKDFDLLKIAKVYEKFASC
ISVLADAKHFLGSYENIKIVSKHSTKPILCKDFIIDSFQIKLARVMGANAVLLMLSVLDDKNYLELFELAKSLKMSVLSE
VSNKQEIQRLLKLKYDIIGINNRDLHTLKTDMFHTLELRPLLPKDTLIISESGIHSHAQIKALAPYVNGFLVGSSLMKEK
DLKKACIKLILGENKVCGLTRIKDAKAVYKNHFIYGGLIFEKSSPRYIKPKEALKITKAVKKLDFVGVFVKNKIKKIVKI
AQKLDLKAVQLYNYSPKKIAQLKKSLPKTCAIWQVVSVADSKDLAPKTEEASLILYDTKGDKYGGNGVSFDWDILDHVKT
PFMLAGGLDLDNAQKALKVKALGLDFNSGLEISPGIKNKDKIKRLARILREY
>Mature_451_residues
PSVLENILKDKLLEVSALKKNYTLPANISPSDRDFKKALLEKKTSFILECKKASPSKGLIRKDFDLLKIAKVYEKFASCI
SVLADAKHFLGSYENIKIVSKHSTKPILCKDFIIDSFQIKLARVMGANAVLLMLSVLDDKNYLELFELAKSLKMSVLSEV
SNKQEIQRLLKLKYDIIGINNRDLHTLKTDMFHTLELRPLLPKDTLIISESGIHSHAQIKALAPYVNGFLVGSSLMKEKD
LKKACIKLILGENKVCGLTRIKDAKAVYKNHFIYGGLIFEKSSPRYIKPKEALKITKAVKKLDFVGVFVKNKIKKIVKIA
QKLDLKAVQLYNYSPKKIAQLKKSLPKTCAIWQVVSVADSKDLAPKTEEASLILYDTKGDKYGGNGVSFDWDILDHVKTP
FMLAGGLDLDNAQKALKVKALGLDFNSGLEISPGIKNKDKIKRLARILREY

Specific function: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the trpF domain; the second reaction is catalyzed by the synthase, coded by the trpC domain [H]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=463, Percent_Identity=46.0043196544276, Blast_Score=382, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6322638, Length=238, Percent_Identity=38.2352941176471, Blast_Score=126, Evalue=8e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS; PF00697 PRAI [H]

EC number: =4.1.1.48; =5.3.1.24 [H]

Molecular weight: Translated: 50753; Mature: 50622

Theoretical pI: Translated: 10.29; Mature: 10.29

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSVLENILKDKLLEVSALKKNYTLPANISPSDRDFKKALLEKKTSFILECKKASPSKGL
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEECCCCCCCCC
IRKDFDLLKIAKVYEKFASCISVLADAKHFLGSYENIKIVSKHSTKPILCKDFIIDSFQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEHHHHHHHHHHH
KLARVMGANAVLLMLSVLDDKNYLELFELAKSLKMSVLSEVSNKQEIQRLLKLKYDIIGI
HHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEC
NNRDLHTLKTDMFHTLELRPLLPKDTLIISESGIHSHAQIKALAPYVNGFLVGSSLMKEK
CCCCCHHHHHHHHHEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
DLKKACIKLILGENKVCGLTRIKDAKAVYKNHFIYGGLIFEKSSPRYIKPKEALKITKAV
HHHHHHHHHHHCCCCEECCHHHHHHHHHHHCCEEEEEEEEECCCCCCCCHHHHHHHHHHH
KKLDFVGVFVKNKIKKIVKIAQKLDLKAVQLYNYSPKKIAQLKKSLPKTCAIWQVVSVAD
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHCC
SKDLAPKTEEASLILYDTKGDKYGGNGVSFDWDILDHVKTPFMLAGGLDLDNAQKALKVK
CCCCCCCCCCCEEEEEECCCCCCCCCCCCEEHHHHHHCCCCEEEECCCCCCCHHHHHEEE
ALGLDFNSGLEISPGIKNKDKIKRLARILREY
EEECCCCCCCEECCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
PSVLENILKDKLLEVSALKKNYTLPANISPSDRDFKKALLEKKTSFILECKKASPSKGL
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEECCCCCCCCC
IRKDFDLLKIAKVYEKFASCISVLADAKHFLGSYENIKIVSKHSTKPILCKDFIIDSFQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEHHHHHHHHHHH
KLARVMGANAVLLMLSVLDDKNYLELFELAKSLKMSVLSEVSNKQEIQRLLKLKYDIIGI
HHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEC
NNRDLHTLKTDMFHTLELRPLLPKDTLIISESGIHSHAQIKALAPYVNGFLVGSSLMKEK
CCCCCHHHHHHHHHEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
DLKKACIKLILGENKVCGLTRIKDAKAVYKNHFIYGGLIFEKSSPRYIKPKEALKITKAV
HHHHHHHHHHHCCCCEECCHHHHHHHHHHHCCEEEEEEEEECCCCCCCCHHHHHHHHHHH
KKLDFVGVFVKNKIKKIVKIAQKLDLKAVQLYNYSPKKIAQLKKSLPKTCAIWQVVSVAD
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHCC
SKDLAPKTEEASLILYDTKGDKYGGNGVSFDWDILDHVKTPFMLAGGLDLDNAQKALKVK
CCCCCCCCCCCEEEEEECCCCCCCCCCCCEEHHHHHHCCCCEEEECCCCCCCHHHHHEEE
ALGLDFNSGLEISPGIKNKDKIKRLARILREY
EEECCCCCCCEECCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]