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The map label for this gene is hutH [H]

Identifier: 162139172

GI number: 162139172

Start: 1829750

End: 1831291

Strand: Direct

Name: hutH [H]

Synonym: MGAS10750_Spy1869

Alternate gene names: 162139172

Gene position: 1829750-1831291 (Clockwise)

Preceding gene: 94995264

Following gene: 94995266

Centisome position: 94.46

GC content: 45.65

Gene sequence:

>1542_bases
ATGACAAGAGTGATTAATTTAGATGGCGAAAGCCTTACTATCGAAGACGTGATTGCGATTGCTCGCCAAGGCATAGCCTG
TCGCATTGATGATAGTGCTATTGAAGCTGTGAATGCCTCTCGTAAAATTGTTGATGACATTGTCAGTGAAAAACGGGTGG
TTTACGGGGTGACCACCGGTTTTGGATCCCTTTGTAACGTGAGCATCTCACCAGAAGATACAGTTCAACTCCAAGAAAAT
TTGATTCGTACCCATGCTAGTGGATTTGGTGACCCATTGCCAGAAGATGCCGTGCGCGCTATCATGCTGATCCGTATCAA
CTCTCTCGTCAAAGGGTATTCTGGTATTCGTCTATCCACCATTGAAAAGCTGTTGGAACTGCTCAATAAAGGGGTTCATC
CTTACATTCCTGAAAAAGGGTCTCTAGGGGCTTCAGGAGATTTGGCGCCGCTTGCTCACATGGTGCTTCCTATGCTTGGT
CTAGGGAAAGCTTACTACAAAGGAGAGCTTCTTTCTGGTCAAGAAGCTCTTGATAAAGCTGGTATTGACAAGATTTCTTT
AGCCGCTAAAGAAGGACTCGCCCTTATCAACGGAACAACTGTTCTCACTGCAATCGGTGCCCTTGCAACCTATGACGCCA
TTCAATTATTGAAACTGTCAGACCTAGCTGGTGCCCTATCCCTTGAAGTGCATAACGGGATTACTAGTCCATTTGAAGAA
AACCTTCACACCATTCGCCCACAAAGCGGCCAGTTGGCAACAGCCCGCAATATCCGAAACCTCATTGAAGGCAGCCAAAA
CACAACCGTAGCTACTCAATCTCGTGTGCAAGACCCTTACACCTTGCGCTGCATGCCTCAAATTCATGGGGCTAGCAAAG
ACAGTATCGCCTATGTCAAATCCAAAGTTGACATTGAAATCAATTCTGTCACAGATAATCCAATTATCTGTAAAGATGGC
CACGTTATTTCAGGAGGTAACTTCCACGGAGAACCAATGGCACAGCCATTTGACTTCTTAGGCATCGCCATTTCTGAAAT
TGGAAATGTTTCTGAACGCCGCGTGGAACGTTTGGTCAATAGCCAGCTCAGCAAATTGCCATCCTTTCTTGTCAAATACC
CAGGTCTCAATTCAGGCTTTATGATTACCCAGTACGCCTGTGCCTCTCTTGCTTCTGAAAACAAGGTTTTGGCACATCCA
GCCAGTGTGGATTCTATCCCATCTTGTGAGAACCAAGAAGACTTTGTCAGCATGGGCACCACCGCTGCTCGCAAGGCCTT
TGAAATCCTTAAAAATTCTCGCCGCATCGTGGCTACTGAAATCATGGCAGCCTGCCAAGCTCTTGATCTCAAATCTGAAA
ATCATGAACTAGGTAAAGGGACTAAGGTTGCCTACGATCTCTTCCGCAAGGAAGTCAACTTTATCGAACACGATAAACAC
ATCGAAATCTACGATGAACTAAACAAGGCATCAACAGTCATTGAAGACCCAAGCTTCCTCGAAGCGGTTGAGCAGGCAGT
TGAGTTGAGTATCCAATTTTAG

Upstream 100 bases:

>100_bases
GTTGGTGTCATCATTGCAAGTAGTGTGTACTACCTTATGCACGGACGTAACCACCAAATGGACCAAATGCCCCCTAAGGA
ACAAATCTAGGAGAAAAACT

Downstream 100 bases:

>100_bases
TGAATAAGGTACTTCTTTAACTGAGAGGGGCTGTGGCAGAGGTCATGGCCTCTTTAGACTAACTAACTGGGACCAAAAGC
AGACGATTTTATTGCTCTGC

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MTRVINLDGESLTIEDVIAIARQGIACRIDDSAIEAVNASRKIVDDIVSEKRVVYGVTTGFGSLCNVSISPEDTVQLQEN
LIRTHASGFGDPLPEDAVRAIMLIRINSLVKGYSGIRLSTIEKLLELLNKGVHPYIPEKGSLGASGDLAPLAHMVLPMLG
LGKAYYKGELLSGQEALDKAGIDKISLAAKEGLALINGTTVLTAIGALATYDAIQLLKLSDLAGALSLEVHNGITSPFEE
NLHTIRPQSGQLATARNIRNLIEGSQNTTVATQSRVQDPYTLRCMPQIHGASKDSIAYVKSKVDIEINSVTDNPIICKDG
HVISGGNFHGEPMAQPFDFLGIAISEIGNVSERRVERLVNSQLSKLPSFLVKYPGLNSGFMITQYACASLASENKVLAHP
ASVDSIPSCENQEDFVSMGTTAARKAFEILKNSRRIVATEIMAACQALDLKSENHELGKGTKVAYDLFRKEVNFIEHDKH
IEIYDELNKASTVIEDPSFLEAVEQAVELSIQF

Sequences:

>Translated_513_residues
MTRVINLDGESLTIEDVIAIARQGIACRIDDSAIEAVNASRKIVDDIVSEKRVVYGVTTGFGSLCNVSISPEDTVQLQEN
LIRTHASGFGDPLPEDAVRAIMLIRINSLVKGYSGIRLSTIEKLLELLNKGVHPYIPEKGSLGASGDLAPLAHMVLPMLG
LGKAYYKGELLSGQEALDKAGIDKISLAAKEGLALINGTTVLTAIGALATYDAIQLLKLSDLAGALSLEVHNGITSPFEE
NLHTIRPQSGQLATARNIRNLIEGSQNTTVATQSRVQDPYTLRCMPQIHGASKDSIAYVKSKVDIEINSVTDNPIICKDG
HVISGGNFHGEPMAQPFDFLGIAISEIGNVSERRVERLVNSQLSKLPSFLVKYPGLNSGFMITQYACASLASENKVLAHP
ASVDSIPSCENQEDFVSMGTTAARKAFEILKNSRRIVATEIMAACQALDLKSENHELGKGTKVAYDLFRKEVNFIEHDKH
IEIYDELNKASTVIEDPSFLEAVEQAVELSIQF
>Mature_512_residues
TRVINLDGESLTIEDVIAIARQGIACRIDDSAIEAVNASRKIVDDIVSEKRVVYGVTTGFGSLCNVSISPEDTVQLQENL
IRTHASGFGDPLPEDAVRAIMLIRINSLVKGYSGIRLSTIEKLLELLNKGVHPYIPEKGSLGASGDLAPLAHMVLPMLGL
GKAYYKGELLSGQEALDKAGIDKISLAAKEGLALINGTTVLTAIGALATYDAIQLLKLSDLAGALSLEVHNGITSPFEEN
LHTIRPQSGQLATARNIRNLIEGSQNTTVATQSRVQDPYTLRCMPQIHGASKDSIAYVKSKVDIEINSVTDNPIICKDGH
VISGGNFHGEPMAQPFDFLGIAISEIGNVSERRVERLVNSQLSKLPSFLVKYPGLNSGFMITQYACASLASENKVLAHPA
SVDSIPSCENQEDFVSMGTTAARKAFEILKNSRRIVATEIMAACQALDLKSENHELGKGTKVAYDLFRKEVNFIEHDKHI
EIYDELNKASTVIEDPSFLEAVEQAVELSIQF

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=486, Percent_Identity=43.0041152263374, Blast_Score=409, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17567831, Length=517, Percent_Identity=41.779497098646, Blast_Score=378, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 55497; Mature: 55366

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRVINLDGESLTIEDVIAIARQGIACRIDDSAIEAVNASRKIVDDIVSEKRVVYGVTTG
CCEEEECCCCEEEHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHCCCEEEEEEECC
FGSLCNVSISPEDTVQLQENLIRTHASGFGDPLPEDAVRAIMLIRINSLVKGYSGIRLST
CCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHH
IEKLLELLNKGVHPYIPEKGSLGASGDLAPLAHMVLPMLGLGKAYYKGELLSGQEALDKA
HHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHC
GIDKISLAAKEGLALINGTTVLTAIGALATYDAIQLLKLSDLAGALSLEVHNGITSPFEE
CCCHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHH
NLHTIRPQSGQLATARNIRNLIEGSQNTTVATQSRVQDPYTLRCMPQIHGASKDSIAYVK
HHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEHHHCCCCEEEEEEHHHCCCCCCCHHEEE
SKVDIEINSVTDNPIICKDGHVISGGNFHGEPMAQPFDFLGIAISEIGNVSERRVERLVN
EEEEEEEEEECCCCEEECCCCEECCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHH
SQLSKLPSFLVKYPGLNSGFMITQYACASLASENKVLAHPASVDSIPSCENQEDFVSMGT
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCHHHHHHCH
TAARKAFEILKNSRRIVATEIMAACQALDLKSENHELGKGTKVAYDLFRKEVNFIEHDKH
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
IEIYDELNKASTVIEDPSFLEAVEQAVELSIQF
EEHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TRVINLDGESLTIEDVIAIARQGIACRIDDSAIEAVNASRKIVDDIVSEKRVVYGVTTG
CEEEECCCCEEEHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHCCCEEEEEEECC
FGSLCNVSISPEDTVQLQENLIRTHASGFGDPLPEDAVRAIMLIRINSLVKGYSGIRLST
CCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHH
IEKLLELLNKGVHPYIPEKGSLGASGDLAPLAHMVLPMLGLGKAYYKGELLSGQEALDKA
HHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHC
GIDKISLAAKEGLALINGTTVLTAIGALATYDAIQLLKLSDLAGALSLEVHNGITSPFEE
CCCHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHH
NLHTIRPQSGQLATARNIRNLIEGSQNTTVATQSRVQDPYTLRCMPQIHGASKDSIAYVK
HHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEHHHCCCCEEEEEEHHHCCCCCCCHHEEE
SKVDIEINSVTDNPIICKDGHVISGGNFHGEPMAQPFDFLGIAISEIGNVSERRVERLVN
EEEEEEEEEECCCCEEECCCCEECCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHH
SQLSKLPSFLVKYPGLNSGFMITQYACASLASENKVLAHPASVDSIPSCENQEDFVSMGT
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCHHHHHHCH
TAARKAFEILKNSRRIVATEIMAACQALDLKSENHELGKGTKVAYDLFRKEVNFIEHDKH
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
IEIYDELNKASTVIEDPSFLEAVEQAVELSIQF
EEHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]