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The map label for this gene is obgE

Identifier: 161898395

GI number: 161898395

Start: 2288743

End: 2289777

Strand: Direct

Name: obgE

Synonym: Jann_2283

Alternate gene names: 161898395

Gene position: 2288743-2289777 (Clockwise)

Preceding gene: 89054773

Following gene: 89054775

Centisome position: 53.0

GC content: 63.0

Gene sequence:

>1035_bases
ATGAAATTTCTTGATCTTGCAAAGGTATATATCCGATCTGGTGCGGGCGGCGGCGGGTCTGTCTCGTTCCGGCGCGAGAA
ATATATCGAATACGGTGGCCCCGACGGTGGCGACGGCGGCGGCGGCGGCAATGTCTATATCGAAGTTGTCGAAGGCCTGA
ACACCCTGATCGACTTTCGCTATCAACAGCATTTCTTCGCCAAGAACGGCCAGCCCGGCATGGGCAAGCAGCGCACTGGC
AAGGATGGCGCGGACATCGTGCTGCGCGTGCCCGCGGGCACAGAGGTGCTGGAAGAGGATCAGGAGACGCTGATCGCCGA
TCTGGAAGAGGTGGGCCAACGGATCTGCATCGCCAAGGGCGGCAATGGCGGCTTCGGCAACCTGCATTTCAAGAGCGCCA
CCAACCAGGCCCCGCGCCGCGCAAATCCCGGCCAGGAGGGCGTGGAGCGCACGATCTGGCTGCGCCTGAAGCTGATTGCT
GACGTTGGTCTGTTGGGCCTGCCCAATGCGGGCAAGTCGACGTTTCTGGCGGCGACCTCCAACGCGCGGCCCAAGATTGC
GGACTATCCCTTCACGACCCTCGTGCCGAACCTGGGCGTTGTTGGCGTGGATGGGGCGGAGTTTGTCATCGCCGATATCC
CCGGCCTCATTGAAGGGGCAAGCGAGGGCAGGGGCCTTGGTGATACCTTCCTGGGCCATGTGGAGCGGTGTGCGGCGCTG
TTGCATTTGGTCGACGGCACATCCGAGGATGTCGTGGGCGATTATCAGACCATTATCGCAGAGTTGGAAGCCTATGGCGG
GGAGCTGGCGTTGAAGCCACGGATCACCGCGCTCAACAAGATCGACGCGATTGAGCCCGAAGAGCTGGCCAAGAAGCGGG
CCGCCCTTGGCAAGGTTGCAGGCAACCTGATGGAAATGTCCGGCGTTGCCCGCACCGGCGTGACGGAGGTGTTGCGCGTC
TTGCGGGCGCGGGTCGATGCGGACCGGAAAGCGGCCCGGGATGCGCTGGAGGAGCCGGACCGATGGCGTCCCTGA

Upstream 100 bases:

>100_bases
GGCGTAAGAGGCCGGTCTCGGACAGGCGGGGGCCAGCCCCCACACCCCCGGGATATTTTTGGAACAGGGAAGAGGGGCCC
GTTGGACCCCGGACGGGCCG

Downstream 100 bases:

>100_bases
CGGGGGCCAAGCGCGTTGTCGTCAAGATCGGCTCGGCCCTGTTGGTGGACCGACACACGGGCGATTTGCGTGCCGATTGG
CTGGCGGCTTTGGCCGATGA

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MKFLDLAKVYIRSGAGGGGSVSFRREKYIEYGGPDGGDGGGGGNVYIEVVEGLNTLIDFRYQQHFFAKNGQPGMGKQRTG
KDGADIVLRVPAGTEVLEEDQETLIADLEEVGQRICIAKGGNGGFGNLHFKSATNQAPRRANPGQEGVERTIWLRLKLIA
DVGLLGLPNAGKSTFLAATSNARPKIADYPFTTLVPNLGVVGVDGAEFVIADIPGLIEGASEGRGLGDTFLGHVERCAAL
LHLVDGTSEDVVGDYQTIIAELEAYGGELALKPRITALNKIDAIEPEELAKKRAALGKVAGNLMEMSGVARTGVTEVLRV
LRARVDADRKAARDALEEPDRWRP

Sequences:

>Translated_344_residues
MKFLDLAKVYIRSGAGGGGSVSFRREKYIEYGGPDGGDGGGGGNVYIEVVEGLNTLIDFRYQQHFFAKNGQPGMGKQRTG
KDGADIVLRVPAGTEVLEEDQETLIADLEEVGQRICIAKGGNGGFGNLHFKSATNQAPRRANPGQEGVERTIWLRLKLIA
DVGLLGLPNAGKSTFLAATSNARPKIADYPFTTLVPNLGVVGVDGAEFVIADIPGLIEGASEGRGLGDTFLGHVERCAAL
LHLVDGTSEDVVGDYQTIIAELEAYGGELALKPRITALNKIDAIEPEELAKKRAALGKVAGNLMEMSGVARTGVTEVLRV
LRARVDADRKAARDALEEPDRWRP
>Mature_344_residues
MKFLDLAKVYIRSGAGGGGSVSFRREKYIEYGGPDGGDGGGGGNVYIEVVEGLNTLIDFRYQQHFFAKNGQPGMGKQRTG
KDGADIVLRVPAGTEVLEEDQETLIADLEEVGQRICIAKGGNGGFGNLHFKSATNQAPRRANPGQEGVERTIWLRLKLIA
DVGLLGLPNAGKSTFLAATSNARPKIADYPFTTLVPNLGVVGVDGAEFVIADIPGLIEGASEGRGLGDTFLGHVERCAAL
LHLVDGTSEDVVGDYQTIIAELEAYGGELALKPRITALNKIDAIEPEELAKKRAALGKVAGNLMEMSGVARTGVTEVLRV
LRARVDADRKAARDALEEPDRWRP

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=345, Percent_Identity=40, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI111955139, Length=288, Percent_Identity=36.1111111111111, Blast_Score=148, Evalue=7e-36,
Organism=Homo sapiens, GI111955063, Length=214, Percent_Identity=34.1121495327103, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI58761500, Length=146, Percent_Identity=31.5068493150685, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI4758796, Length=114, Percent_Identity=35.9649122807018, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI4557537, Length=117, Percent_Identity=35.8974358974359, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1789574, Length=307, Percent_Identity=52.7687296416938, Blast_Score=275, Evalue=4e-75,
Organism=Escherichia coli, GI1787454, Length=106, Percent_Identity=37.7358490566038, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17508313, Length=336, Percent_Identity=36.6071428571429, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17552324, Length=308, Percent_Identity=31.1688311688312, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17509631, Length=131, Percent_Identity=36.6412213740458, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71981008, Length=114, Percent_Identity=35.9649122807018, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17555344, Length=114, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6321962, Length=181, Percent_Identity=42.5414364640884, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6319281, Length=190, Percent_Identity=30, Blast_Score=73, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6321612, Length=91, Percent_Identity=38.4615384615385, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI20129375, Length=285, Percent_Identity=39.6491228070175, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24585318, Length=292, Percent_Identity=38.6986301369863, Blast_Score=144, Evalue=7e-35,
Organism=Drosophila melanogaster, GI24640873, Length=144, Percent_Identity=31.25, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24640877, Length=144, Percent_Identity=31.25, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24640875, Length=144, Percent_Identity=31.25, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19921908, Length=179, Percent_Identity=30.7262569832402, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17981711, Length=114, Percent_Identity=34.2105263157895, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21356473, Length=117, Percent_Identity=35.8974358974359, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_JANSC (Q28Q12)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_510225.2
- HSSP:   Q5SJ29
- STRING:   Q28Q12
- GeneID:   3934739
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_2283
- eggNOG:   COG0536
- HOGENOM:   HBG716038
- PhylomeDB:   Q28Q12
- ProtClustDB:   PRK12299
- BioCyc:   JSP290400:JANN_2283-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 36638; Mature: 36638

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFLDLAKVYIRSGAGGGGSVSFRREKYIEYGGPDGGDGGGGGNVYIEVVEGLNTLIDFR
CCHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHH
YQQHFFAKNGQPGMGKQRTGKDGADIVLRVPAGTEVLEEDQETLIADLEEVGQRICIAKG
HHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCEEEEEEC
GNGGFGNLHFKSATNQAPRRANPGQEGVERTIWLRLKLIADVGLLGLPNAGKSTFLAATS
CCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECC
NARPKIADYPFTTLVPNLGVVGVDGAEFVIADIPGLIEGASEGRGLGDTFLGHVERCAAL
CCCCCCCCCCHHHHCCCCCEEECCCCCEEEECCCHHHCCCCCCCCCCHHHHHHHHHHHHH
LHLVDGTSEDVVGDYQTIIAELEAYGGELALKPRITALNKIDAIEPEELAKKRAALGKVA
HHHHCCCCCHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHCCCCCHHHHHHHHHHHHHHH
GNLMEMSGVARTGVTEVLRVLRARVDADRKAARDALEEPDRWRP
HHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKFLDLAKVYIRSGAGGGGSVSFRREKYIEYGGPDGGDGGGGGNVYIEVVEGLNTLIDFR
CCHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHH
YQQHFFAKNGQPGMGKQRTGKDGADIVLRVPAGTEVLEEDQETLIADLEEVGQRICIAKG
HHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCEEEEEEC
GNGGFGNLHFKSATNQAPRRANPGQEGVERTIWLRLKLIADVGLLGLPNAGKSTFLAATS
CCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECC
NARPKIADYPFTTLVPNLGVVGVDGAEFVIADIPGLIEGASEGRGLGDTFLGHVERCAAL
CCCCCCCCCCHHHHCCCCCEEECCCCCEEEECCCHHHCCCCCCCCCCHHHHHHHHHHHHH
LHLVDGTSEDVVGDYQTIIAELEAYGGELALKPRITALNKIDAIEPEELAKKRAALGKVA
HHHHCCCCCHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHCCCCCHHHHHHHHHHHHHHH
GNLMEMSGVARTGVTEVLRVLRARVDADRKAARDALEEPDRWRP
HHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA