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The map label for this gene is prsA

Identifier: 161871038

GI number: 161871038

Start: 839196

End: 840179

Strand: Direct

Name: prsA

Synonym: NMCC_0837

Alternate gene names: 161871038

Gene position: 839196-840179 (Clockwise)

Preceding gene: 161869808

Following gene: 161869809

Centisome position: 38.97

GC content: 52.85

Gene sequence:

>984_bases
ATGGCTGCGTACGACAGTTTGATGGTATTTACAGGCAATGCCAATCCCGAATTGGCACAACGTGTTGTCAGGCATTTGGA
CATTTCTTTGGGCAATGCTTCCGTATCCAAGTTTTCAGACGGCGAAGTTGCCGTCGAACTGTTGGAAAACGTACGCGGGC
GCGATGTTTTCATCCTTCAGCCGACCTGTGCGCCGACCAATGACAACCTGATGGAAATCCTGACGATGGCGGATGCACTG
AAGCGTGCTTCGGCAGGTCGTATTACCACAGCCATTCCGTATTTCGGCTATGCGCGCCAAGACCGCCGTCCGCGTTCCGT
CCGCGTTCCGATTTCTGCCAAACTGGTGGCAAATATGCTGTATTCGGCAGGGATCGACCGTGTTTTGACTGTCGATTTGC
ATGCCGACCAGATTCAAGGTTTCTTCGATATTCCAGTGGACAATATTTATGCCACCCCGATTCTGTTGAACGACATCAAA
CAACAGCGGATTGAAAATCTGACCGTCGTCAGCCCGGACATCGGCGGTGTCGTCCGCGCCCGCGCCGTGGCAAAATCCCT
GAATGCCGACTTGGCAATCATCGACAAACGCCGCCCGAAAGCCAATGTGGCGGAAGTCATGAACATCATCGGCGATATTC
AAGGCAGAACCTGTCTGATTGTGGACGATATGATTGACACTGCAAATACGCTGTGCAAAGCCGCCGTCGCTCTGAAAGAG
CGGGGGGCGGAACGTGTCTTGGCATATGCCAGCCACGCCGTATTCTCCGGAGAGGCGGTCAGCCGTATCGCCTCATCCGA
AATCGACCAGGTGGTCGTAACCGATACCATTCCTTTGTCTGAAGCGGCTAAAAACTGCGACCGTATCCGTCAGGTAACGA
TTGCCGGTCTGTTGGCCGAAACCGTCCGCCGCATCAGCAATGAAGAATCCGTTTCATATCTCTTTAATGAAGAAGTGATG
ACAGGCAGTATGTTGCTGCCATAA

Upstream 100 bases:

>100_bases
GTTTGTGTCGGATGTTGCAGGTATAATGTCGGGCTTGGTACAAGCAGAGGGAAGCATTGTGTTTTCTGAGCGGAAGTTAA
ACATAAAATCAGGTGAGAAT

Downstream 100 bases:

>100_bases
GCCCGAAGCCGTCTTAAGCTGGTCGCGGCCGATGACGGTAGTTTTATTTAAATTGGAGTATTTAACATGACTTATGAAAT
TCAAGCCTCTGTTCGTGAAG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MAAYDSLMVFTGNANPELAQRVVRHLDISLGNASVSKFSDGEVAVELLENVRGRDVFILQPTCAPTNDNLMEILTMADAL
KRASAGRITTAIPYFGYARQDRRPRSVRVPISAKLVANMLYSAGIDRVLTVDLHADQIQGFFDIPVDNIYATPILLNDIK
QQRIENLTVVSPDIGGVVRARAVAKSLNADLAIIDKRRPKANVAEVMNIIGDIQGRTCLIVDDMIDTANTLCKAAVALKE
RGAERVLAYASHAVFSGEAVSRIASSEIDQVVVTDTIPLSEAAKNCDRIRQVTIAGLLAETVRRISNEESVSYLFNEEVM
TGSMLLP

Sequences:

>Translated_327_residues
MAAYDSLMVFTGNANPELAQRVVRHLDISLGNASVSKFSDGEVAVELLENVRGRDVFILQPTCAPTNDNLMEILTMADAL
KRASAGRITTAIPYFGYARQDRRPRSVRVPISAKLVANMLYSAGIDRVLTVDLHADQIQGFFDIPVDNIYATPILLNDIK
QQRIENLTVVSPDIGGVVRARAVAKSLNADLAIIDKRRPKANVAEVMNIIGDIQGRTCLIVDDMIDTANTLCKAAVALKE
RGAERVLAYASHAVFSGEAVSRIASSEIDQVVVTDTIPLSEAAKNCDRIRQVTIAGLLAETVRRISNEESVSYLFNEEVM
TGSMLLP
>Mature_326_residues
AAYDSLMVFTGNANPELAQRVVRHLDISLGNASVSKFSDGEVAVELLENVRGRDVFILQPTCAPTNDNLMEILTMADALK
RASAGRITTAIPYFGYARQDRRPRSVRVPISAKLVANMLYSAGIDRVLTVDLHADQIQGFFDIPVDNIYATPILLNDIKQ
QRIENLTVVSPDIGGVVRARAVAKSLNADLAIIDKRRPKANVAEVMNIIGDIQGRTCLIVDDMIDTANTLCKAAVALKER
GAERVLAYASHAVFSGEAVSRIASSEIDQVVVTDTIPLSEAAKNCDRIRQVTIAGLLAETVRRISNEESVSYLFNEEVMT
GSMLLP

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family

Homologues:

Organism=Homo sapiens, GI4506127, Length=314, Percent_Identity=49.6815286624204, Blast_Score=312, Evalue=3e-85,
Organism=Homo sapiens, GI4506129, Length=314, Percent_Identity=48.7261146496815, Blast_Score=309, Evalue=2e-84,
Organism=Homo sapiens, GI28557709, Length=314, Percent_Identity=49.0445859872611, Blast_Score=308, Evalue=5e-84,
Organism=Homo sapiens, GI84875539, Length=316, Percent_Identity=48.1012658227848, Blast_Score=306, Evalue=1e-83,
Organism=Homo sapiens, GI194018537, Length=349, Percent_Identity=37.8223495702006, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI4506133, Length=345, Percent_Identity=35.9420289855072, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI310128524, Length=149, Percent_Identity=34.2281879194631, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI310115209, Length=149, Percent_Identity=34.2281879194631, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI310118259, Length=149, Percent_Identity=34.2281879194631, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI310119946, Length=149, Percent_Identity=34.2281879194631, Blast_Score=89, Evalue=7e-18,
Organism=Escherichia coli, GI1787458, Length=312, Percent_Identity=66.025641025641, Blast_Score=432, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17554704, Length=314, Percent_Identity=48.4076433121019, Blast_Score=309, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI17554702, Length=314, Percent_Identity=48.0891719745223, Blast_Score=309, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI25149168, Length=314, Percent_Identity=48.0891719745223, Blast_Score=309, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI71989924, Length=314, Percent_Identity=48.0891719745223, Blast_Score=307, Evalue=4e-84,
Organism=Caenorhabditis elegans, GI17570245, Length=344, Percent_Identity=33.7209302325581, Blast_Score=200, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6319403, Length=319, Percent_Identity=44.5141065830721, Blast_Score=270, Evalue=3e-73,
Organism=Saccharomyces cerevisiae, GI6320946, Length=316, Percent_Identity=43.3544303797468, Blast_Score=264, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6321776, Length=313, Percent_Identity=44.0894568690096, Blast_Score=261, Evalue=9e-71,
Organism=Saccharomyces cerevisiae, GI6322667, Length=196, Percent_Identity=40.3061224489796, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6324511, Length=111, Percent_Identity=37.8378378378378, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21355239, Length=313, Percent_Identity=49.5207667731629, Blast_Score=300, Evalue=6e-82,
Organism=Drosophila melanogaster, GI45551540, Length=335, Percent_Identity=45.9701492537313, Blast_Score=290, Evalue=1e-78,
Organism=Drosophila melanogaster, GI24651458, Length=354, Percent_Identity=34.180790960452, Blast_Score=208, Evalue=3e-54,
Organism=Drosophila melanogaster, GI24651456, Length=354, Percent_Identity=34.180790960452, Blast_Score=208, Evalue=3e-54,
Organism=Drosophila melanogaster, GI281362873, Length=354, Percent_Identity=34.180790960452, Blast_Score=208, Evalue=4e-54,
Organism=Drosophila melanogaster, GI24651454, Length=354, Percent_Identity=34.180790960452, Blast_Score=208, Evalue=4e-54,
Organism=Drosophila melanogaster, GI24651462, Length=202, Percent_Identity=37.1287128712871, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24651464, Length=202, Percent_Identity=37.1287128712871, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI45552010, Length=202, Percent_Identity=37.1287128712871, Blast_Score=136, Evalue=2e-32,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): KPRS_NEIMA (P65234)

Other databases:

- EMBL:   AL157959
- RefSeq:   YP_002342499.1
- ProteinModelPortal:   P65234
- SMR:   P65234
- EnsemblBacteria:   EBNEIT00000000045
- GeneID:   907063
- GenomeReviews:   AL157959_GR
- KEGG:   nma:NMA1093
- GeneTree:   EBGT00050000020345
- HOGENOM:   HBG519284
- OMA:   CATHAVF
- ProtClustDB:   PRK01259
- BioCyc:   NMEN122587:NMA1093-MONOMER
- BRENDA:   2.7.6.1
- GO:   GO:0005737
- HAMAP:   MF_00583_B
- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01251

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.7.6.1

Molecular weight: Translated: 35598; Mature: 35467

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00114 PRPP_SYNTHASE; PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAYDSLMVFTGNANPELAQRVVRHLDISLGNASVSKFSDGEVAVELLENVRGRDVFILQ
CCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEC
PTCAPTNDNLMEILTMADALKRASAGRITTAIPYFGYARQDRRPRSVRVPISAKLVANML
CCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEECCHHHHHHHHHH
YSAGIDRVLTVDLHADQIQGFFDIPVDNIYATPILLNDIKQQRIENLTVVSPDIGGVVRA
HHCCCCEEEEEEEEHHHHCCEEECCCCCEEECHHHHHHHHHHHHCCCEEECCCCCHHHHH
RAVAKSLNADLAIIDKRRPKANVAEVMNIIGDIQGRTCLIVDDMIDTANTLCKAAVALKE
HHHHHHCCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHH
RGAERVLAYASHAVFSGEAVSRIASSEIDQVVVTDTIPLSEAAKNCDRIRQVTIAGLLAE
CCHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
TVRRISNEESVSYLFNEEVMTGSMLLP
HHHHHCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AAYDSLMVFTGNANPELAQRVVRHLDISLGNASVSKFSDGEVAVELLENVRGRDVFILQ
CCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEC
PTCAPTNDNLMEILTMADALKRASAGRITTAIPYFGYARQDRRPRSVRVPISAKLVANML
CCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEECCHHHHHHHHHH
YSAGIDRVLTVDLHADQIQGFFDIPVDNIYATPILLNDIKQQRIENLTVVSPDIGGVVRA
HHCCCCEEEEEEEEHHHHCCEEECCCCCEEECHHHHHHHHHHHHCCCEEECCCCCHHHHH
RAVAKSLNADLAIIDKRRPKANVAEVMNIIGDIQGRTCLIVDDMIDTANTLCKAAVALKE
HHHHHHCCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHH
RGAERVLAYASHAVFSGEAVSRIASSEIDQVVVTDTIPLSEAAKNCDRIRQVTIAGLLAE
CCHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
TVRRISNEESVSYLFNEEVMTGSMLLP
HHHHHCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10761919