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The map label for this gene is ipk [H]

Identifier: 161869808

GI number: 161869808

Start: 837929

End: 838774

Strand: Direct

Name: ipk [H]

Synonym: NMCC_0833

Alternate gene names: 161869808

Gene position: 837929-838774 (Clockwise)

Preceding gene: 161869807

Following gene: 161871038

Centisome position: 38.91

GC content: 48.35

Gene sequence:

>846_bases
ATGAATATTGCGGACGGACGGCAGGCGTTTCCCGCACCTGCAAAACTGAATCTCGATTTGAGGATTACCGGCAGGCGGGA
AGACGGTTATCACAATATCGAAAGCATATTCTGCCTGATAGATTTGCAGGATACCGTATATTTGAAACCGAGGGACGACG
GCAAAATCATCCTGCACAATCCTGTCGGCGGAATACCGCAGGAAGCCGATTTGAGCTACCGTGCCGCATCGTTGCTGCAA
AAATATGCGCGCAACCCCGCCGGCGTGGAAATATGGCTGGACAAAAAAATCCCGACAGGGGCGGGTTTGGGCGGCGGAAG
CTCGGATGCGGCAACCGTTTTGCTGGTGTTGAACCGTTGGTGGCAGTGTTCCCGAACGACGCAGCAGCTGATTGACTTGG
GCGCAACTTTGGGTGCGGACGTACCATTTTTTATTTTCGGGAAAAATGCTTTTGCAAGCGGGATAGGTGAAAAACTGATA
GGAATGGATATTCCGAAACAGTGGTATGTCATCGTCAAACCGCCCGTCCACGTTTCCACTGCAAAAATTTTCACACACGA
AGGCTTGACACGAAATTCCGCCTCAAGCATAATGCCGACTTTCCAAAACCTGCAACCGTTTAGAAATGATATGCAGGCAG
TTGTATTTAAAGAATACCCTGAAGTTTGGAAAGCCTATTCCGAATTGTCCCGATATGGATTTGCCTTAATGACAGGTTCT
GGTGCGTGTGTATTCACGGCGTGTCAAGATAGGGATAGCGCATACAATATATACCGACAAGTTTCAGGTTTGTACGAGGC
ATATTTGGCAGAGGGTCTTTCAAAACATCCTTTGTTGTCCGTATAA

Upstream 100 bases:

>100_bases
CGGAAATTTGAACATCAGGCTGGTTTTCACCGAAATCGGTATGCCGTCTGAAACCGAAACCCCGGAACGCTGTGCGGCGC
GCACGAGATAAGGCGGACAG

Downstream 100 bases:

>100_bases
ACATTGTTGGGGAGTCGTCAAGCGGTTAAGACACTGGATTTTGATTCCAGCATGCGAAGGTTCGAATCCTTCCTCCCCAG
CCAAGCCAAACGAGTTGGGG

Product: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Products: NA

Alternate protein names: CMK; 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MNIADGRQAFPAPAKLNLDLRITGRREDGYHNIESIFCLIDLQDTVYLKPRDDGKIILHNPVGGIPQEADLSYRAASLLQ
KYARNPAGVEIWLDKKIPTGAGLGGGSSDAATVLLVLNRWWQCSRTTQQLIDLGATLGADVPFFIFGKNAFASGIGEKLI
GMDIPKQWYVIVKPPVHVSTAKIFTHEGLTRNSASSIMPTFQNLQPFRNDMQAVVFKEYPEVWKAYSELSRYGFALMTGS
GACVFTACQDRDSAYNIYRQVSGLYEAYLAEGLSKHPLLSV

Sequences:

>Translated_281_residues
MNIADGRQAFPAPAKLNLDLRITGRREDGYHNIESIFCLIDLQDTVYLKPRDDGKIILHNPVGGIPQEADLSYRAASLLQ
KYARNPAGVEIWLDKKIPTGAGLGGGSSDAATVLLVLNRWWQCSRTTQQLIDLGATLGADVPFFIFGKNAFASGIGEKLI
GMDIPKQWYVIVKPPVHVSTAKIFTHEGLTRNSASSIMPTFQNLQPFRNDMQAVVFKEYPEVWKAYSELSRYGFALMTGS
GACVFTACQDRDSAYNIYRQVSGLYEAYLAEGLSKHPLLSV
>Mature_281_residues
MNIADGRQAFPAPAKLNLDLRITGRREDGYHNIESIFCLIDLQDTVYLKPRDDGKIILHNPVGGIPQEADLSYRAASLLQ
KYARNPAGVEIWLDKKIPTGAGLGGGSSDAATVLLVLNRWWQCSRTTQQLIDLGATLGADVPFFIFGKNAFASGIGEKLI
GMDIPKQWYVIVKPPVHVSTAKIFTHEGLTRNSASSIMPTFQNLQPFRNDMQAVVFKEYPEVWKAYSELSRYGFALMTGS
GACVFTACQDRDSAYNIYRQVSGLYEAYLAEGLSKHPLLSV

Specific function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol [H]

COG id: COG1947

COG function: function code I; 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. IspE subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787459, Length=278, Percent_Identity=42.0863309352518, Blast_Score=201, Evalue=6e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR004424
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.148 [H]

Molecular weight: Translated: 31052; Mature: 31052

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIADGRQAFPAPAKLNLDLRITGRREDGYHNIESIFCLIDLQDTVYLKPRDDGKIILHN
CCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCEEEEEEEEECCEEEEEECCCCEEEEEC
PVGGIPQEADLSYRAASLLQKYARNPAGVEIWLDKKIPTGAGLGGGSSDAATVLLVLNRW
CCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHH
WQCSRTTQQLIDLGATLGADVPFFIFGKNAFASGIGEKLIGMDIPKQWYVIVKPPVHVST
HCCCHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEH
AKIFTHEGLTRNSASSIMPTFQNLQPFRNDMQAVVFKEYPEVWKAYSELSRYGFALMTGS
EEEEECCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC
GACVFTACQDRDSAYNIYRQVSGLYEAYLAEGLSKHPLLSV
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MNIADGRQAFPAPAKLNLDLRITGRREDGYHNIESIFCLIDLQDTVYLKPRDDGKIILHN
CCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCEEEEEEEEECCEEEEEECCCCEEEEEC
PVGGIPQEADLSYRAASLLQKYARNPAGVEIWLDKKIPTGAGLGGGSSDAATVLLVLNRW
CCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHH
WQCSRTTQQLIDLGATLGADVPFFIFGKNAFASGIGEKLIGMDIPKQWYVIVKPPVHVST
HCCCHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEH
AKIFTHEGLTRNSASSIMPTFQNLQPFRNDMQAVVFKEYPEVWKAYSELSRYGFALMTGS
EEEEECCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC
GACVFTACQDRDSAYNIYRQVSGLYEAYLAEGLSKHPLLSV
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA