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The map label for this gene is rnhA [H]

Identifier: 161870471

GI number: 161870471

Start: 1554168

End: 1554692

Strand: Direct

Name: rnhA [H]

Synonym: NMCC_1527

Alternate gene names: 161870471

Gene position: 1554168-1554692 (Clockwise)

Preceding gene: 161870469

Following gene: 161870472

Centisome position: 72.17

GC content: 56.57

Gene sequence:

>525_bases
ATGCCTATTTCAATCCGCCGCAATCTTTCAGACGGCACGGCGCGCAAACCGCTTATAATCACGCCGGACACCACACAAAG
GCACAATATGGACACACCCGTTTACCTTTACACCGACGGCGCGTGCAAAGGCAATCCCGGCGCGGGCGGCTGGGGCGTGT
TGATGCGCTACGGCAGCCACGAAAAAGAACTTTTCGGCGGCGAAGCGCAAACCACCAACAACCGCATGGAGCTGACCGCC
GTCATCGAAGGACTGAAATCGCTCAAACGCCGCTGCACCGTCATCATCTGCACCGACTCGCAATACGTCAAAAACGGCAT
GGAAAACTGGATACACGGTTGGAAGCGCAACGGCTGGAAAACCGCCGCCAAACAGCCCGTCAAAAACGACGATTTATGGA
AAGAACTCGACACTCTGGTCGGGCAGCACCAAGTCAGTTGGACTTGGGTTAAAGGACACGCGGGACACGCGGAAAACGAA
CGCGCCGACGATTTGGCAAACCGTGGCGCAGCGCAGTTTTCCTGA

Upstream 100 bases:

>100_bases
GTTTTCCGCCTTCCATACGGGCATTTGCCCGAAACAAAACAACTCGCCGCTTTGACCCACTATCCGCTCTTTCATATTCA
AAAATAAAGTTGCACATTAT

Downstream 100 bases:

>100_bases
CTGTCGCACCGACAAGAAAATGCCGTCTGAAACCGCTAATGGGATTCAGACGGCATCGTCCTCCACCGTCATTCCCGCGC
AGGCGGGAATCTAAAAACCC

Product: ribonuclease H

Products: NA

Alternate protein names: RNase H [H]

Number of amino acids: Translated: 174; Mature: 173

Protein sequence:

>174_residues
MPISIRRNLSDGTARKPLIITPDTTQRHNMDTPVYLYTDGACKGNPGAGGWGVLMRYGSHEKELFGGEAQTTNNRMELTA
VIEGLKSLKRRCTVIICTDSQYVKNGMENWIHGWKRNGWKTAAKQPVKNDDLWKELDTLVGQHQVSWTWVKGHAGHAENE
RADDLANRGAAQFS

Sequences:

>Translated_174_residues
MPISIRRNLSDGTARKPLIITPDTTQRHNMDTPVYLYTDGACKGNPGAGGWGVLMRYGSHEKELFGGEAQTTNNRMELTA
VIEGLKSLKRRCTVIICTDSQYVKNGMENWIHGWKRNGWKTAAKQPVKNDDLWKELDTLVGQHQVSWTWVKGHAGHAENE
RADDLANRGAAQFS
>Mature_173_residues
PISIRRNLSDGTARKPLIITPDTTQRHNMDTPVYLYTDGACKGNPGAGGWGVLMRYGSHEKELFGGEAQTTNNRMELTAV
IEGLKSLKRRCTVIICTDSQYVKNGMENWIHGWKRNGWKTAAKQPVKNDDLWKELDTLVGQHQVSWTWVKGHAGHAENER
ADDLANRGAAQFS

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids [H]

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain [H]

Homologues:

Organism=Homo sapiens, GI21359816, Length=149, Percent_Identity=36.241610738255, Blast_Score=84, Evalue=7e-17,
Organism=Escherichia coli, GI1786408, Length=141, Percent_Identity=58.1560283687943, Blast_Score=180, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI115532542, Length=148, Percent_Identity=41.8918918918919, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17137476, Length=150, Percent_Identity=37.3333333333333, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI45552509, Length=150, Percent_Identity=37.3333333333333, Blast_Score=91, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156 [H]

Pfam domain/function: PF00075 RnaseH [H]

EC number: =3.1.26.4 [H]

Molecular weight: Translated: 19492; Mature: 19361

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPISIRRNLSDGTARKPLIITPDTTQRHNMDTPVYLYTDGACKGNPGAGGWGVLMRYGSH
CCCEECCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHCCCC
EKELFGGEAQTTNNRMELTAVIEGLKSLKRRCTVIICTDSQYVKNGMENWIHGWKRNGWK
CHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHHHHHCCCCC
TAAKQPVKNDDLWKELDTLVGQHQVSWTWVKGHAGHAENERADDLANRGAAQFS
HHHCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHCCCCCCC
>Mature Secondary Structure 
PISIRRNLSDGTARKPLIITPDTTQRHNMDTPVYLYTDGACKGNPGAGGWGVLMRYGSH
CCEECCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHCCCC
EKELFGGEAQTTNNRMELTAVIEGLKSLKRRCTVIICTDSQYVKNGMENWIHGWKRNGWK
CHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHHHHHCCCCC
TAAKQPVKNDDLWKELDTLVGQHQVSWTWVKGHAGHAENERADDLANRGAAQFS
HHHCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA