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The map label for this gene is thiD [H]

Identifier: 161870469

GI number: 161870469

Start: 1552417

End: 1553223

Strand: Direct

Name: thiD [H]

Synonym: NMCC_1525

Alternate gene names: 161870469

Gene position: 1552417-1553223 (Clockwise)

Preceding gene: 161870468

Following gene: 161870471

Centisome position: 72.09

GC content: 57.13

Gene sequence:

>807_bases
ATGAAAAGCTCTTTTGTGCAAACGCTTACCATCGCCGGTTCGGATTCGGGCGGCGGTGCGGGCATTCAGGCGGATTTGAA
AACGTTTCAGATGCGCGGCGTGTTCGGAACGTGCGTCATCACCGCCGTTACCGCGCAAAATACCTTGGGCGTGTCGGCGG
TTCATCTCGTCCCGACCGAAACCATCACCGCACAAATCCAAGCAATCAGGGAAGACTTTGACATCCGCGCCTACAAAATA
GGAATGCTCGGCACGGCGGAAATCATCGAATGCGTTGCCGACAAGCTGAAACACTGCGACTTCGGCAGGCGCGTACTCGA
CCCTGTGATGATTGCCAAAGGCGGTGCGCCGCTGTTGCAGGATTCCGCCGTTGCGGCACTGACGCGCCTGCTGCTTCCCG
ATACGGATGTATTGACCCCCAACCTGCCCGAGGCGGAAGCCCTGACCGGCGTGCATATCGAAAACCGTAAAGATGCGGAA
CGTGCGGCAAAAATCCTGCTTGATTACGGTGTCAAAAATGTCGTCATCAAAGGCGGACATTTGAATGGCAGCAGCAGCGG
ACGCTGCACGGATTGGCTGTTTACGCAAAACGAAACGCTGGAATTGGACAGCCCGCGCTTTCCGACCGCCCACACGCACG
GCACGGGCTGCACGTTTTCTGCCTGCATTACCGCCGAGTTGGCAAAAGGCTTAGACGTTTGCAAAGCCGTACGGACTGCC
AAGTCCTACATCACGGCGGCAATCTCAAGCCCTTTGGAAATCGGCGCGGGACACGGCCCGGTCAATCATTGGGCCTATCG
GGACTAA

Upstream 100 bases:

>100_bases
ATGCACCACAAACCCCCGCGCTGCGGTTTTCAGACGGCATCGCCGTGCTTTTTTACAGGCATTAGCCCTTTTTATCGGAC
ACAATATTAAGGAGGAACAA

Downstream 100 bases:

>100_bases
CCGTAAAAATGCCGTCTGAAACAAAATGTTCAGACGGCATTTTTGAGGATTATTCAGGCTTTTTCGCCAGCATCGTTACA
AATTTAAACCGTATCGGATT

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MKSSFVQTLTIAGSDSGGGAGIQADLKTFQMRGVFGTCVITAVTAQNTLGVSAVHLVPTETITAQIQAIREDFDIRAYKI
GMLGTAEIIECVADKLKHCDFGRRVLDPVMIAKGGAPLLQDSAVAALTRLLLPDTDVLTPNLPEAEALTGVHIENRKDAE
RAAKILLDYGVKNVVIKGGHLNGSSSGRCTDWLFTQNETLELDSPRFPTAHTHGTGCTFSACITAELAKGLDVCKAVRTA
KSYITAAISSPLEIGAGHGPVNHWAYRD

Sequences:

>Translated_268_residues
MKSSFVQTLTIAGSDSGGGAGIQADLKTFQMRGVFGTCVITAVTAQNTLGVSAVHLVPTETITAQIQAIREDFDIRAYKI
GMLGTAEIIECVADKLKHCDFGRRVLDPVMIAKGGAPLLQDSAVAALTRLLLPDTDVLTPNLPEAEALTGVHIENRKDAE
RAAKILLDYGVKNVVIKGGHLNGSSSGRCTDWLFTQNETLELDSPRFPTAHTHGTGCTFSACITAELAKGLDVCKAVRTA
KSYITAAISSPLEIGAGHGPVNHWAYRD
>Mature_268_residues
MKSSFVQTLTIAGSDSGGGAGIQADLKTFQMRGVFGTCVITAVTAQNTLGVSAVHLVPTETITAQIQAIREDFDIRAYKI
GMLGTAEIIECVADKLKHCDFGRRVLDPVMIAKGGAPLLQDSAVAALTRLLLPDTDVLTPNLPEAEALTGVHIENRKDAE
RAAKILLDYGVKNVVIKGGHLNGSSSGRCTDWLFTQNETLELDSPRFPTAHTHGTGCTFSACITAELAKGLDVCKAVRTA
KSYITAAISSPLEIGAGHGPVNHWAYRD

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=262, Percent_Identity=43.8931297709924, Blast_Score=206, Evalue=9e-55,
Organism=Saccharomyces cerevisiae, GI6325378, Length=270, Percent_Identity=30, Blast_Score=112, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6324517, Length=271, Percent_Identity=33.210332103321, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324997, Length=268, Percent_Identity=32.089552238806, Blast_Score=102, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 28417; Mature: 28417

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSSFVQTLTIAGSDSGGGAGIQADLKTFQMRGVFGTCVITAVTAQNTLGVSAVHLVPTE
CCCCCEEEEEEECCCCCCCCCEEHHHHHHHHCCCHHEEEEEEEECCCCCCCEEEEEECCH
TITAQIQAIREDFDIRAYKIGMLGTAEIIECVADKLKHCDFGRRVLDPVMIAKGGAPLLQ
HHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHH
DSAVAALTRLLLPDTDVLTPNLPEAEALTGVHIENRKDAERAAKILLDYGVKNVVIKGGH
HHHHHHHHHHHCCCCCCCCCCCCCHHHEECEEECCCCCHHHHHHHHHHCCCCEEEEECCC
LNGSSSGRCTDWLFTQNETLELDSPRFPTAHTHGTGCTFSACITAELAKGLDVCKAVRTA
CCCCCCCCEEEEEEECCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KSYITAAISSPLEIGAGHGPVNHWAYRD
HHHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKSSFVQTLTIAGSDSGGGAGIQADLKTFQMRGVFGTCVITAVTAQNTLGVSAVHLVPTE
CCCCCEEEEEEECCCCCCCCCEEHHHHHHHHCCCHHEEEEEEEECCCCCCCEEEEEECCH
TITAQIQAIREDFDIRAYKIGMLGTAEIIECVADKLKHCDFGRRVLDPVMIAKGGAPLLQ
HHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHH
DSAVAALTRLLLPDTDVLTPNLPEAEALTGVHIENRKDAERAAKILLDYGVKNVVIKGGH
HHHHHHHHHHHCCCCCCCCCCCCCHHHEECEEECCCCCHHHHHHHHHHCCCCEEEEECCC
LNGSSSGRCTDWLFTQNETLELDSPRFPTAHTHGTGCTFSACITAELAKGLDVCKAVRTA
CCCCCCCCEEEEEEECCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KSYITAAISSPLEIGAGHGPVNHWAYRD
HHHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]