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The map label for this gene is hisG [H]

Identifier: 161870434

GI number: 161870434

Start: 1511395

End: 1512117

Strand: Direct

Name: hisG [H]

Synonym: NMCC_1483

Alternate gene names: 161870434

Gene position: 1511395-1512117 (Clockwise)

Preceding gene: 161870433

Following gene: 161870435

Centisome position: 70.19

GC content: 55.05

Gene sequence:

>723_bases
ATGCCGTCTGCACCGTCGGCGCCTATTCAGACGGCATTATTGTTTCAACCGACAAAGGACATCCACACCATGCAGGATAA
TGCTTTGACCATCGCCTTATCCAAGGGGCGCATTTTTGAGGAGACGCTGCCGCTGCTTGCCGCTGCCGGCATTGTTCCGA
CTGAAGAGCCTGAAAAATCGCGCAAGCTGATTATCGGGACGAACCATGAAAACATCCGCCTTGTCATTGTCCGCGCAACC
GATGTGCCGACTTATGTCCGCTACGGCGCGGCGGACTTCGGCATTGCGGGCAAAGACGTGCTGATCGAACACGGCGGCAC
GGGGCTTTACCGGCCTTTGGATTTGGAGATTGCCAAGTGCCGCATGATGGTTGCTGTGCGTAAAGGGTTTGATTACGAAG
CAGCTTCGCAACCCGGATGCCGTCTGAAGATTGCCACGAAGTATCCTGAAATCGCGGCATCTCATTTTGCCGGCAAGGGT
GTCCATGTGGACATTATCAAACTGTACGGCTCGATGGAACTTGCGCCGCTGGTCGGCTTGAGCGATGCGATTGTGGACTT
GGTTTCGACGGGCAACACCTTGAAGGCAAACGGCTTGGAAGCAGTCGAACACATCGTCGACATTTCCAGCCGCCTGGTGG
TCAACAAGGCTGCTTTGAAAACGAAATACGCGCTGCTGGAGCCGATTATTCAGGCGTTCGGCGGCGCAGTGAAGGCGAAG
TAA

Upstream 100 bases:

>100_bases
TCTCATCGACAAAAACGGTGAGGTTGCCATTTTCTCGCCTTACGGAAGCGAGCCGGAAACGATTGCTGCCGATGTAAGGA
CTCTGCTCTGATAAAACCGT

Downstream 100 bases:

>100_bases
GCATCCATTTGAATAAAGATGCGTTTTCAGACGACCCTATCCGTTCCCGCCGACAGGTCGTCTGAAAATATCACCGGCAG
TAAACTGTATAGGAGAAGTT

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MPSAPSAPIQTALLFQPTKDIHTMQDNALTIALSKGRIFEETLPLLAAAGIVPTEEPEKSRKLIIGTNHENIRLVIVRAT
DVPTYVRYGAADFGIAGKDVLIEHGGTGLYRPLDLEIAKCRMMVAVRKGFDYEAASQPGCRLKIATKYPEIAASHFAGKG
VHVDIIKLYGSMELAPLVGLSDAIVDLVSTGNTLKANGLEAVEHIVDISSRLVVNKAALKTKYALLEPIIQAFGGAVKAK

Sequences:

>Translated_240_residues
MPSAPSAPIQTALLFQPTKDIHTMQDNALTIALSKGRIFEETLPLLAAAGIVPTEEPEKSRKLIIGTNHENIRLVIVRAT
DVPTYVRYGAADFGIAGKDVLIEHGGTGLYRPLDLEIAKCRMMVAVRKGFDYEAASQPGCRLKIATKYPEIAASHFAGKG
VHVDIIKLYGSMELAPLVGLSDAIVDLVSTGNTLKANGLEAVEHIVDISSRLVVNKAALKTKYALLEPIIQAFGGAVKAK
>Mature_239_residues
PSAPSAPIQTALLFQPTKDIHTMQDNALTIALSKGRIFEETLPLLAAAGIVPTEEPEKSRKLIIGTNHENIRLVIVRATD
VPTYVRYGAADFGIAGKDVLIEHGGTGLYRPLDLEIAKCRMMVAVRKGFDYEAASQPGCRLKIATKYPEIAASHFAGKGV
HVDIIKLYGSMELAPLVGLSDAIVDLVSTGNTLKANGLEAVEHIVDISSRLVVNKAALKTKYALLEPIIQAFGGAVKAK

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=230, Percent_Identity=34.7826086956522, Blast_Score=94, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320896, Length=227, Percent_Identity=27.7533039647577, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 25710; Mature: 25579

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSAPSAPIQTALLFQPTKDIHTMQDNALTIALSKGRIFEETLPLLAAAGIVPTEEPEKS
CCCCCCCCCEEEEEECCCCHHHCCCCCEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCC
RKLIIGTNHENIRLVIVRATDVPTYVRYGAADFGIAGKDVLIEHGGTGLYRPLDLEIAKC
CEEEEECCCCCEEEEEEEECCCCHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHH
RMMVAVRKGFDYEAASQPGCRLKIATKYPEIAASHFAGKGVHVDIIKLYGSMELAPLVGL
HHHHHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHCCCCCEEEEEEECCCCEEHHHCCC
SDAIVDLVSTGNTLKANGLEAVEHIVDISSRLVVNKAALKTKYALLEPIIQAFGGAVKAK
HHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PSAPSAPIQTALLFQPTKDIHTMQDNALTIALSKGRIFEETLPLLAAAGIVPTEEPEKS
CCCCCCCCEEEEEECCCCHHHCCCCCEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCC
RKLIIGTNHENIRLVIVRATDVPTYVRYGAADFGIAGKDVLIEHGGTGLYRPLDLEIAKC
CEEEEECCCCCEEEEEEEECCCCHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHH
RMMVAVRKGFDYEAASQPGCRLKIATKYPEIAASHFAGKGVHVDIIKLYGSMELAPLVGL
HHHHHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHCCCCCEEEEEEECCCCEEHHHCCC
SDAIVDLVSTGNTLKANGLEAVEHIVDISSRLVVNKAALKTKYALLEPIIQAFGGAVKAK
HHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA