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The map label for this gene is fkpA [H]

Identifier: 161870422

GI number: 161870422

Start: 1496335

End: 1497243

Strand: Reverse

Name: fkpA [H]

Synonym: NMCC_1470

Alternate gene names: 161870422

Gene position: 1497243-1496335 (Counterclockwise)

Preceding gene: 161870423

Following gene: 161870421

Centisome position: 69.53

GC content: 52.59

Gene sequence:

>909_bases
TTGACGCTTTATGTGTCATCCTGTGTGTTGAAACATTCAAACTCGGCTATAATCCCGTTTTTCCGACCTTATCGACAGCG
AAGATCCATCATGAACACCATTTTCAAAATCAGCGCACTGACCCTTTCCGCCGCTTTGGCACTTTCCGCCTGCGGCAAAA
AAGAAGCCGCCCCCGCATCTGCATCCGAACCTGCCGCCGCTTCTTCCGCGCAGGACGACACCTCTTCGATCGGCAGCACG
ATGCAGCAGGCAAGCTATGCGATGGGCGTGGACATCGGACGCTCCCTGAAGCAAATGAAGGAACAGGGCGCGGAAATCGA
TTTGAAAGTCTTTACCGAAGCCATGCAGGCAGTGTATGACGGCAAAGAAATCAAAATGACTGAAGAGCAGGCTCAGGAAG
TCATGATGAAATTCCTTCAGGAACAACAGGCTAAAGCCGTAGAAAAACACAAGGCGGACGCGAAGGCCAATAAAGAAAAA
GGCGAAGCCTTTCTGAAAGAAAATGCCGCCAAAGACGGCGTGAAGACCACTGCTTCCGGCCTGCAATACAAAATCACCAA
ACAGGGTGAAGGCAAACAGCCGACCAAAGACGACATCGTTACCGTGGAATACGAAGGCCGCCTGATTGACGGTACGGTAT
TCGACAGCAGCAAAGCCAACGGCGGCCCGGTCACCTTCCCTTTGAGCCAAGTGATTCCGGGTTGGACCGAAGGCGTACAG
CTTCTGAAAGAAGGCGGCGAAGCCACGTTCTACATCCCGTCCAACCTTGCTTACCGCGAACAGGGTGCGGGCGACAAAAT
CGGCCCGAACGCCACTTTGGTATTTGATGTGAAACTGGTCAAAATCGGCGCACCCGAAAACGCGCCCGCCAAGCAGCCGG
CTCAAGTCGACATCAAAAAAGTAAATTAA

Upstream 100 bases:

>100_bases
ATCGGTTGAACCCCGCCACTTGGACATCTGTCCCTCGGGGCGGTAGAATCAAAACTTATTTTGGAAGGTTCAATCCCTTC
CAAAACAGGGCAACACACGA

Downstream 100 bases:

>100_bases
GTCCGAATCCATGCCCGAAACAGGTTTTCGGGCATTTTTACGGCAAATGCCGTCTGAAACCACCAAACAGCGGTTCAGAT
GGCATCCCTTTCAAAAGCGC

Product: peptidyl-prolyl isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MTLYVSSCVLKHSNSAIIPFFRPYRQRRSIMNTIFKISALTLSAALALSACGKKEAAPASASEPAAASSAQDDTSSIGST
MQQASYAMGVDIGRSLKQMKEQGAEIDLKVFTEAMQAVYDGKEIKMTEEQAQEVMMKFLQEQQAKAVEKHKADAKANKEK
GEAFLKENAAKDGVKTTASGLQYKITKQGEGKQPTKDDIVTVEYEGRLIDGTVFDSSKANGGPVTFPLSQVIPGWTEGVQ
LLKEGGEATFYIPSNLAYREQGAGDKIGPNATLVFDVKLVKIGAPENAPAKQPAQVDIKKVN

Sequences:

>Translated_302_residues
MTLYVSSCVLKHSNSAIIPFFRPYRQRRSIMNTIFKISALTLSAALALSACGKKEAAPASASEPAAASSAQDDTSSIGST
MQQASYAMGVDIGRSLKQMKEQGAEIDLKVFTEAMQAVYDGKEIKMTEEQAQEVMMKFLQEQQAKAVEKHKADAKANKEK
GEAFLKENAAKDGVKTTASGLQYKITKQGEGKQPTKDDIVTVEYEGRLIDGTVFDSSKANGGPVTFPLSQVIPGWTEGVQ
LLKEGGEATFYIPSNLAYREQGAGDKIGPNATLVFDVKLVKIGAPENAPAKQPAQVDIKKVN
>Mature_301_residues
TLYVSSCVLKHSNSAIIPFFRPYRQRRSIMNTIFKISALTLSAALALSACGKKEAAPASASEPAAASSAQDDTSSIGSTM
QQASYAMGVDIGRSLKQMKEQGAEIDLKVFTEAMQAVYDGKEIKMTEEQAQEVMMKFLQEQQAKAVEKHKADAKANKEKG
EAFLKENAAKDGVKTTASGLQYKITKQGEGKQPTKDDIVTVEYEGRLIDGTVFDSSKANGGPVTFPLSQVIPGWTEGVQL
LKEGGEATFYIPSNLAYREQGAGDKIGPNATLVFDVKLVKIGAPENAPAKQPAQVDIKKVN

Specific function: Ppiases Accelerate The Folding Of Proteins. It Catalyzes The Cis-Trans Isomerization Of Proline Imidic Peptide Bonds In Oligopeptides. [C]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI206725530, Length=89, Percent_Identity=47.1910112359551, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI17149844, Length=89, Percent_Identity=47.1910112359551, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI17149842, Length=89, Percent_Identity=47.1910112359551, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI17149836, Length=106, Percent_Identity=39.622641509434, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4503725, Length=106, Percent_Identity=39.622641509434, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4503727, Length=99, Percent_Identity=40.4040404040404, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI87082390, Length=212, Percent_Identity=41.9811320754717, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1789745, Length=266, Percent_Identity=34.2105263157895, Blast_Score=135, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17540882, Length=106, Percent_Identity=40.5660377358491, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17561782, Length=110, Percent_Identity=39.0909090909091, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6320727, Length=88, Percent_Identity=47.7272727272727, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324194, Length=91, Percent_Identity=42.8571428571429, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI281363946, Length=95, Percent_Identity=46.3157894736842, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17352457, Length=95, Percent_Identity=46.3157894736842, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21356629, Length=88, Percent_Identity=47.7272727272727, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24655568, Length=106, Percent_Identity=40.5660377358491, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24647110, Length=119, Percent_Identity=39.4957983193277, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008104
- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 32505; Mature: 32374

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLYVSSCVLKHSNSAIIPFFRPYRQRRSIMNTIFKISALTLSAALALSACGKKEAAPAS
CEEEEEEHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
ASEPAAASSAQDDTSSIGSTMQQASYAMGVDIGRSLKQMKEQGAEIDLKVFTEAMQAVYD
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
GKEIKMTEEQAQEVMMKFLQEQQAKAVEKHKADAKANKEKGEAFLKENAAKDGVKTTASG
CCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHCC
LQYKITKQGEGKQPTKDDIVTVEYEGRLIDGTVFDSSKANGGPVTFPLSQVIPGWTEGVQ
CEEEEECCCCCCCCCCCCEEEEEECCEEEECEEECCCCCCCCCEEEEHHHHCCCHHHHHH
LLKEGGEATFYIPSNLAYREQGAGDKIGPNATLVFDVKLVKIGAPENAPAKQPAQVDIKK
HHHCCCCEEEEECCCCCCHHCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCEEEEEE
VN
CC
>Mature Secondary Structure 
TLYVSSCVLKHSNSAIIPFFRPYRQRRSIMNTIFKISALTLSAALALSACGKKEAAPAS
EEEEEEHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
ASEPAAASSAQDDTSSIGSTMQQASYAMGVDIGRSLKQMKEQGAEIDLKVFTEAMQAVYD
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
GKEIKMTEEQAQEVMMKFLQEQQAKAVEKHKADAKANKEKGEAFLKENAAKDGVKTTASG
CCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHCC
LQYKITKQGEGKQPTKDDIVTVEYEGRLIDGTVFDSSKANGGPVTFPLSQVIPGWTEGVQ
CEEEEECCCCCCCCCCCCEEEEEECCEEEECEEECCCCCCCCCEEEEHHHHCCCHHHHHH
LLKEGGEATFYIPSNLAYREQGAGDKIGPNATLVFDVKLVKIGAPENAPAKQPAQVDIKK
HHHCCCCEEEEECCCCCCHHCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCEEEEEE
VN
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10710307 [H]