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The map label for this gene is pyrG [H]

Identifier: 161870408

GI number: 161870408

Start: 1482375

End: 1484009

Strand: Reverse

Name: pyrG [H]

Synonym: NMCC_1456

Alternate gene names: 161870408

Gene position: 1484009-1482375 (Counterclockwise)

Preceding gene: 161870409

Following gene: 161870406

Centisome position: 68.91

GC content: 55.35

Gene sequence:

>1635_bases
ATGACCAAATTCATTTTCGTCACCGGCGGCGTTGTCTCCTCACTGGGTAAAGGTATCGCCGCCGCTTCTATTGCCGCCAT
CCTCGAATCGCGCGGCTTGAACGTTACCATGCTCAAGCTCGATCCTTATATCAACGTCGATCCCGGCACGATGAGCCCGT
TCCAACACGGCGAAGTGTTCGTAACCGACGACGGCGCGGAAACCGACCTCGACTTGGGACACTACGAACGGTTTATCGAT
TCCACGATGACCCGCCGCAACAGCTTCAGCACGGGGCAGGTGTACGAAAACGTCATCGCCAAAGAACGACGGGGCGACTA
CCTCGGCGGCACGGTTCAAGTCATCCCGCACATTACCGACGAAATCAAACGCCGCATCCACGAAGGCGCGGCAGGTTACG
ATGTGGCGATTGTCGAAATCGGCGGCACGGTCGGCGACATCGAATCGCTGCCGTTTTTGGAAGCCATCCGCCAGATGCGA
AGCCAGTTGGGACGCAACAACACCCTGTTCGCCCACTTGAGCTACGTCCCCTACATCGCCGCTGCAGGCGAAATCAAAAC
CAAGCCGACCCAGCACACCGTTAAAGAAATGTTGAGCATCGGTTTGCAACCCGACATCCTGATTTGCCGTATGGACAGGA
CAATGCCTGCGGACGAACGCCGCAAAATCGCCTTGTTCTGCAACGTGGAAGAACGCGCGATTGTCGGCAGCTACGATGTG
GACAGCATCTACGAATGCCCCGAAATGCTGCACGACCAAGGCATCGACAACATCATTACCGAGCAGTTGCAGCTTAATGT
GCAACAGGCGGATTTGACCGCGTGGAAAAAAATCGTCCACGCCATCCAAAACCCGAAACACACCGTCAAAATCGCCATGG
TCGGCAAATACGTCGATTTGACCGAGTCCTACAAATCATTGATCGAAGCCTTGAAACACGCAGGCATTCACACCGAAACC
GACGTACAAATTACCTTTGTCGATAGCGAAAGCATCGAGAAAAACAACGGCGACGTTTCTATGCTCAAAGATATGGATGC
CATCCTCGTTCCCGGCGGTTTCGGTTCGCGCGGCGTGGAAGGCAAAATCGCCGCTGTGCGCTATGCCCGTGAAAACAACG
TGCCATACTTGGGTATCTGCCTCGGTATGCAGATTGCGCTGATTGAATACGCCCGCGACGTGGCAGGTTTGAAAGGTGCG
AATTCCACTGAGTTCGACCTCAAATGCGCCGCCCCCGTCGTTGCCCTGATTGACGAATGGCAAACTGCCGACGGCAGCGT
CGAAACCCGCGATGAATCCGCCGATTTGGGCGGCACCATGCGTTTGGGCGCGCAAGAAGTCGAATTGAAAGCAGGCAGCC
TCGCCGCCAAAATCTACGGCAGCGGACATATCCGCGAACGCCACCGCCACCGCTACGAAGTCAACAACAACTATGTTCCT
CAGTTGGAAAAAGCAGGCTTGGTTATCGGCGGCGTATCCGCCGGACGCGAACGCTTGGTCGAAACCATCGAGCTGCCGAA
CCACCCTTGGTTCTTCGCCTGCCAGTTCCATCCCGAATTCACTTCCAACCCGCGCAAAGGGCATCCCTTGTTCACCGCGT
TTGTCAAAGCTGCGTTGAACAATAAAAAAGCCTGA

Upstream 100 bases:

>100_bases
CGTCTGAAAACAGCCGTCCACCGTTCAGACGGCATCCGCCTGTTTGCCAGAACCGCGCGCTTCACGTTAAAATCACGCAT
TCCAATACGGGTATTTCATT

Downstream 100 bases:

>100_bases
TAAAGCGTTACTTGATGATCAAAATGCCGTCTGAAAGCCTGAATGAAGACTTTCAGACGGCATTTTCGCAAATCGGGGAT
TATAAAAGCCATCAATTTAA

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 544; Mature: 543

Protein sequence:

>544_residues
MTKFIFVTGGVVSSLGKGIAAASIAAILESRGLNVTMLKLDPYINVDPGTMSPFQHGEVFVTDDGAETDLDLGHYERFID
STMTRRNSFSTGQVYENVIAKERRGDYLGGTVQVIPHITDEIKRRIHEGAAGYDVAIVEIGGTVGDIESLPFLEAIRQMR
SQLGRNNTLFAHLSYVPYIAAAGEIKTKPTQHTVKEMLSIGLQPDILICRMDRTMPADERRKIALFCNVEERAIVGSYDV
DSIYECPEMLHDQGIDNIITEQLQLNVQQADLTAWKKIVHAIQNPKHTVKIAMVGKYVDLTESYKSLIEALKHAGIHTET
DVQITFVDSESIEKNNGDVSMLKDMDAILVPGGFGSRGVEGKIAAVRYARENNVPYLGICLGMQIALIEYARDVAGLKGA
NSTEFDLKCAAPVVALIDEWQTADGSVETRDESADLGGTMRLGAQEVELKAGSLAAKIYGSGHIRERHRHRYEVNNNYVP
QLEKAGLVIGGVSAGRERLVETIELPNHPWFFACQFHPEFTSNPRKGHPLFTAFVKAALNNKKA

Sequences:

>Translated_544_residues
MTKFIFVTGGVVSSLGKGIAAASIAAILESRGLNVTMLKLDPYINVDPGTMSPFQHGEVFVTDDGAETDLDLGHYERFID
STMTRRNSFSTGQVYENVIAKERRGDYLGGTVQVIPHITDEIKRRIHEGAAGYDVAIVEIGGTVGDIESLPFLEAIRQMR
SQLGRNNTLFAHLSYVPYIAAAGEIKTKPTQHTVKEMLSIGLQPDILICRMDRTMPADERRKIALFCNVEERAIVGSYDV
DSIYECPEMLHDQGIDNIITEQLQLNVQQADLTAWKKIVHAIQNPKHTVKIAMVGKYVDLTESYKSLIEALKHAGIHTET
DVQITFVDSESIEKNNGDVSMLKDMDAILVPGGFGSRGVEGKIAAVRYARENNVPYLGICLGMQIALIEYARDVAGLKGA
NSTEFDLKCAAPVVALIDEWQTADGSVETRDESADLGGTMRLGAQEVELKAGSLAAKIYGSGHIRERHRHRYEVNNNYVP
QLEKAGLVIGGVSAGRERLVETIELPNHPWFFACQFHPEFTSNPRKGHPLFTAFVKAALNNKKA
>Mature_543_residues
TKFIFVTGGVVSSLGKGIAAASIAAILESRGLNVTMLKLDPYINVDPGTMSPFQHGEVFVTDDGAETDLDLGHYERFIDS
TMTRRNSFSTGQVYENVIAKERRGDYLGGTVQVIPHITDEIKRRIHEGAAGYDVAIVEIGGTVGDIESLPFLEAIRQMRS
QLGRNNTLFAHLSYVPYIAAAGEIKTKPTQHTVKEMLSIGLQPDILICRMDRTMPADERRKIALFCNVEERAIVGSYDVD
SIYECPEMLHDQGIDNIITEQLQLNVQQADLTAWKKIVHAIQNPKHTVKIAMVGKYVDLTESYKSLIEALKHAGIHTETD
VQITFVDSESIEKNNGDVSMLKDMDAILVPGGFGSRGVEGKIAAVRYARENNVPYLGICLGMQIALIEYARDVAGLKGAN
STEFDLKCAAPVVALIDEWQTADGSVETRDESADLGGTMRLGAQEVELKAGSLAAKIYGSGHIRERHRHRYEVNNNYVPQ
LEKAGLVIGGVSAGRERLVETIELPNHPWFFACQFHPEFTSNPRKGHPLFTAFVKAALNNKKA

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=559, Percent_Identity=42.7549194991055, Blast_Score=470, Evalue=1e-132,
Organism=Homo sapiens, GI28559085, Length=564, Percent_Identity=42.7304964539007, Blast_Score=461, Evalue=1e-130,
Organism=Homo sapiens, GI28559083, Length=564, Percent_Identity=42.7304964539007, Blast_Score=461, Evalue=1e-130,
Organism=Homo sapiens, GI221316689, Length=564, Percent_Identity=42.7304964539007, Blast_Score=461, Evalue=1e-130,
Organism=Escherichia coli, GI1789142, Length=542, Percent_Identity=65.1291512915129, Blast_Score=725, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25148299, Length=607, Percent_Identity=38.8797364085667, Blast_Score=431, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6319432, Length=569, Percent_Identity=41.3005272407733, Blast_Score=435, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6322563, Length=568, Percent_Identity=41.1971830985916, Blast_Score=430, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24664469, Length=560, Percent_Identity=44.2857142857143, Blast_Score=482, Evalue=1e-136,
Organism=Drosophila melanogaster, GI21357815, Length=505, Percent_Identity=42.7722772277228, Blast_Score=410, Evalue=1e-114,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 59886; Mature: 59755

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKFIFVTGGVVSSLGKGIAAASIAAILESRGLNVTMLKLDPYINVDPGTMSPFQHGEVF
CCEEEEEECHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFIDSTMTRRNSFSTGQVYENVIAKERRGDYLGGTVQVIPHITD
EECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECHHHH
EIKRRIHEGAAGYDVAIVEIGGTVGDIESLPFLEAIRQMRSQLGRNNTLFAHLSYVPYIA
HHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEHHCHHE
AAGEIKTKPTQHTVKEMLSIGLQPDILICRMDRTMPADERRKIALFCNVEERAIVGSYDV
ECCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCEEEEEEECCCCEEECCCCH
DSIYECPEMLHDQGIDNIITEQLQLNVQQADLTAWKKIVHAIQNPKHTVKIAMVGKYVDL
HHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHH
TESYKSLIEALKHAGIHTETDVQITFVDSESIEKNNGDVSMLKDMDAILVPGGFGSRGVE
HHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCEEECCCEEEECCCCCCCCCC
GKIAAVRYARENNVPYLGICLGMQIALIEYARDVAGLKGANSTEFDLKCAAPVVALIDEW
CCEEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHH
QTADGSVETRDESADLGGTMRLGAQEVELKAGSLAAKIYGSGHIRERHRHRYEVNNNYVP
CCCCCCCCCCCCCCCCCCEEECCCHHEEEECCCEEEEEECCCCHHHHHHHHEECCCCCCC
QLEKAGLVIGGVSAGRERLVETIELPNHPWFFACQFHPEFTSNPRKGHPLFTAFVKAALN
CHHHCCEEEECCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHC
NKKA
CCCC
>Mature Secondary Structure 
TKFIFVTGGVVSSLGKGIAAASIAAILESRGLNVTMLKLDPYINVDPGTMSPFQHGEVF
CEEEEEECHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFIDSTMTRRNSFSTGQVYENVIAKERRGDYLGGTVQVIPHITD
EECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECHHHH
EIKRRIHEGAAGYDVAIVEIGGTVGDIESLPFLEAIRQMRSQLGRNNTLFAHLSYVPYIA
HHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEHHCHHE
AAGEIKTKPTQHTVKEMLSIGLQPDILICRMDRTMPADERRKIALFCNVEERAIVGSYDV
ECCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCEEEEEEECCCCEEECCCCH
DSIYECPEMLHDQGIDNIITEQLQLNVQQADLTAWKKIVHAIQNPKHTVKIAMVGKYVDL
HHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHH
TESYKSLIEALKHAGIHTETDVQITFVDSESIEKNNGDVSMLKDMDAILVPGGFGSRGVE
HHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCEEECCCEEEECCCCCCCCCC
GKIAAVRYARENNVPYLGICLGMQIALIEYARDVAGLKGANSTEFDLKCAAPVVALIDEW
CCEEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHH
QTADGSVETRDESADLGGTMRLGAQEVELKAGSLAAKIYGSGHIRERHRHRYEVNNNYVP
CCCCCCCCCCCCCCCCCCEEECCCHHEEEECCCEEEEEECCCCHHHHHHHHEECCCCCCC
QLEKAGLVIGGVSAGRERLVETIELPNHPWFFACQFHPEFTSNPRKGHPLFTAFVKAALN
CHHHCCEEEECCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHC
NKKA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA