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The map label for this gene is panB [H]

Identifier: 161869804

GI number: 161869804

Start: 833499

End: 834236

Strand: Direct

Name: panB [H]

Synonym: NMCC_0829

Alternate gene names: 161869804

Gene position: 833499-834236 (Clockwise)

Preceding gene: 161869801

Following gene: 161869805

Centisome position: 38.71

GC content: 57.18

Gene sequence:

>738_bases
ATGCTGACCGCTTACGAATCCAGTTTTGCCGCACTGATGGACGATGCCGGCGTGGAAATGCTGCTGGTCGGCGATTCTTT
GGGGATGGCGGTTCAGGGGCGGAAATCGACGCTGCCCGTCAGCCTGCGCGATATGTGCTATCACACCGAATGTGTAGCAC
GCAGTGCAAAAAATGCGATGATTGTCAGCGATTTGCCGTTTGGTGCATATCAGCAGAGTAAGGAGCAGGCGTTTGCCGCC
GCCGCCGAACTGATGGCGGCCGGCGCGCATATGGTCAAACTCGAAGGCGGCGTGTGGATGGCGGAAACGACTGAATTTCT
GCAAATGCGCGGTATTCCGGTCTGTGCCCACATCGGTCTGACGCCGCAATCCGTGTTTGCCTTTGGCGGATATAAGGTTC
AGGGGCGCGGCGGCAAGGCGCAGGCGTTGCTTAACGATGCCAAGGCGCATGACGATGCGGGGGCGGCGGTCGTGCTGATG
GAGTGCGTACCGGCGGAACTGGCAAAAAAGGTAACTGAAACTGTTTCCTGTCCGACCATCGGCATCGGTGCGGGCGCGGA
TTGCGACGGTCAGGTTTTGGTGATGCACGATATGCTGGGCATTTTCCCGGGTAAGACGGCGAAATTCGTCAAAAACTTTA
TGCACGGGCAAAGCAGCATTCAGGCGGCGGTTCGGGCGTATGTTGCCGAAGTCAAAGCCAAAACCTTCCCTGCTGCGGAA
CATATTTTTGCAGACTGA

Upstream 100 bases:

>100_bases
TTCAAACTGAAAAGGCCGTCTGAAAAGGGCGGGGTAACAATATCTGATGATTACTGTGAACACACTGCAAAAAATGAAGG
CGGCGGGCGAAAAAATCGCT

Downstream 100 bases:

>100_bases
ACAAGGTTTGCTGCTGATGCCGTCTGAAAGCCGTTTCAGACGGCATTTTGTTTTGCCGTGCGCGGCGCGTATAATCGGCG
CGTTTTGTCGGGCAGGAAGC

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MLTAYESSFAALMDDAGVEMLLVGDSLGMAVQGRKSTLPVSLRDMCYHTECVARSAKNAMIVSDLPFGAYQQSKEQAFAA
AAELMAAGAHMVKLEGGVWMAETTEFLQMRGIPVCAHIGLTPQSVFAFGGYKVQGRGGKAQALLNDAKAHDDAGAAVVLM
ECVPAELAKKVTETVSCPTIGIGAGADCDGQVLVMHDMLGIFPGKTAKFVKNFMHGQSSIQAAVRAYVAEVKAKTFPAAE
HIFAD

Sequences:

>Translated_245_residues
MLTAYESSFAALMDDAGVEMLLVGDSLGMAVQGRKSTLPVSLRDMCYHTECVARSAKNAMIVSDLPFGAYQQSKEQAFAA
AAELMAAGAHMVKLEGGVWMAETTEFLQMRGIPVCAHIGLTPQSVFAFGGYKVQGRGGKAQALLNDAKAHDDAGAAVVLM
ECVPAELAKKVTETVSCPTIGIGAGADCDGQVLVMHDMLGIFPGKTAKFVKNFMHGQSSIQAAVRAYVAEVKAKTFPAAE
HIFAD
>Mature_245_residues
MLTAYESSFAALMDDAGVEMLLVGDSLGMAVQGRKSTLPVSLRDMCYHTECVARSAKNAMIVSDLPFGAYQQSKEQAFAA
AAELMAAGAHMVKLEGGVWMAETTEFLQMRGIPVCAHIGLTPQSVFAFGGYKVQGRGGKAQALLNDAKAHDDAGAAVVLM
ECVPAELAKKVTETVSCPTIGIGAGADCDGQVLVMHDMLGIFPGKTAKFVKNFMHGQSSIQAAVRAYVAEVKAKTFPAAE
HIFAD

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=243, Percent_Identity=55.9670781893004, Blast_Score=274, Evalue=3e-75,
Organism=Saccharomyces cerevisiae, GI6319653, Length=253, Percent_Identity=38.7351778656126, Blast_Score=167, Evalue=2e-42,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 25810; Mature: 25810

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
8.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
8.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTAYESSFAALMDDAGVEMLLVGDSLGMAVQGRKSTLPVSLRDMCYHTECVARSAKNAM
CCCCCCHHHHHHHCCCCEEEEEEECCCCCEECCCCCCCCCHHHHHHHHHHHHHHCCCCEE
IVSDLPFGAYQQSKEQAFAAAAELMAAGAHMVKLEGGVWMAETTEFLQMRGIPVCAHIGL
EEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCEEEHHHHHHHHHCCCCEEEECCC
TPQSVFAFGGYKVQGRGGKAQALLNDAKAHDDAGAAVVLMECVPAELAKKVTETVSCPTI
CHHHHHEECCEEEECCCCCHHHHHHHHHCCCCCCCEEEEEHHCCHHHHHHHHHHHCCCEE
GIGAGADCDGQVLVMHDMLGIFPGKTAKFVKNFMHGQSSIQAAVRAYVAEVKAKTFPAAE
ECCCCCCCCCCEEEEEHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHH
HIFAD
HHCCC
>Mature Secondary Structure
MLTAYESSFAALMDDAGVEMLLVGDSLGMAVQGRKSTLPVSLRDMCYHTECVARSAKNAM
CCCCCCHHHHHHHCCCCEEEEEEECCCCCEECCCCCCCCCHHHHHHHHHHHHHHCCCCEE
IVSDLPFGAYQQSKEQAFAAAAELMAAGAHMVKLEGGVWMAETTEFLQMRGIPVCAHIGL
EEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCEEEHHHHHHHHHCCCCEEEECCC
TPQSVFAFGGYKVQGRGGKAQALLNDAKAHDDAGAAVVLMECVPAELAKKVTETVSCPTI
CHHHHHEECCEEEECCCCCHHHHHHHHHCCCCCCCEEEEEHHCCHHHHHHHHHHHCCCEE
GIGAGADCDGQVLVMHDMLGIFPGKTAKFVKNFMHGQSSIQAAVRAYVAEVKAKTFPAAE
ECCCCCCCCCCEEEEEHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHH
HIFAD
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA