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The map label for this gene is purC

Identifier: 161869701

GI number: 161869701

Start: 725049

End: 725912

Strand: Direct

Name: purC

Synonym: NMCC_0721

Alternate gene names: 161869701

Gene position: 725049-725912 (Clockwise)

Preceding gene: 161869698

Following gene: 161869702

Centisome position: 33.67

GC content: 48.73

Gene sequence:

>864_bases
ATGAGTGAGATTGGTTTGGTAAAGATCTATTCTGGAAAAGTGCGCGATTTATATGAAATCGACGATAAACGTATGCTGAT
GGTCGCTTCCGACCGCCTGTCCGCGTTTGATGTGATTTTGGACGACCCGATTCCGAGCAAAGGGGAGATTCTGACGCAGA
TTTCCAATTTTTGGTTTAAAAAACTGGCGCATATTATGCCCAACCACTTTACCGGTCAAACGGTTTACGATGTTTTGCCT
GAAAACGAAGCCAAAGTTTTAGAAAAACGCGCCGTCGTGGCTAAAAAGCTCACTCCGGTGAAAGTAGAGGCGATTGTGCG
CGGTTATCTGGCAGGCAGCGGTTGGAAAGATTATCAAAAAACCGGCTCGGTTTGCGGTATTCGGCTGCCCGAAGGTATGC
AGGAAGCGCAACAACTGCCTGAAGTGATTTTTACGCCATCGACCAAAGCCGCAGTCGGCGATCACGATGAAAACATCAGC
TTTGAAGAATGCGGACGCATTATCGGCAAAGAATTGGCGGAAGAAGTGCGCGCCAAGGCGGTTCGGCTTTACACCGAAGC
GGCGGAATATGCCAAATCGCGCGGTATTATTATTTGCGATACCAAATTTGAATTCGGTTTGGATACAAACGGTACGCTGA
CGCTGATGGATGAGGTATTGACCCCCGATTCGAGCCGCTTCTGGCCTGCCGACCAATATAAAGTCGGCACAAATCCGCCG
TCTTTTGACAAACAATTTGTCCGCGACTGGCTGGAACAAAGCGGTTGGAACAAAAAAGCCCCTGCGCCGAAAGTGCCTGC
CGATGTGATTCAGAAAACTGTCGAGAAGTATCGGGAAGCATTGACTTTGCTGACTCAGGATTGA

Upstream 100 bases:

>100_bases
TGGGTATTGTTTTGCGCCGACTTCGGCTAGAATATCGGTTTGCGATTCAAACCTGTCGGGTGTCGGGTCGGTATTTTCAA
GATATTTTCAGGGGGGCGAA

Downstream 100 bases:

>100_bases
TTTTTAAGTTTGAAGGCCGTCTGAAAGAAATATGTTTCAGACGGCCTTTTTATTGTATCAATACTGGATTTTAAGGATGG
TTGCCTTTATAATCCGCAAT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MSEIGLVKIYSGKVRDLYEIDDKRMLMVASDRLSAFDVILDDPIPSKGEILTQISNFWFKKLAHIMPNHFTGQTVYDVLP
ENEAKVLEKRAVVAKKLTPVKVEAIVRGYLAGSGWKDYQKTGSVCGIRLPEGMQEAQQLPEVIFTPSTKAAVGDHDENIS
FEECGRIIGKELAEEVRAKAVRLYTEAAEYAKSRGIIICDTKFEFGLDTNGTLTLMDEVLTPDSSRFWPADQYKVGTNPP
SFDKQFVRDWLEQSGWNKKAPAPKVPADVIQKTVEKYREALTLLTQD

Sequences:

>Translated_287_residues
MSEIGLVKIYSGKVRDLYEIDDKRMLMVASDRLSAFDVILDDPIPSKGEILTQISNFWFKKLAHIMPNHFTGQTVYDVLP
ENEAKVLEKRAVVAKKLTPVKVEAIVRGYLAGSGWKDYQKTGSVCGIRLPEGMQEAQQLPEVIFTPSTKAAVGDHDENIS
FEECGRIIGKELAEEVRAKAVRLYTEAAEYAKSRGIIICDTKFEFGLDTNGTLTLMDEVLTPDSSRFWPADQYKVGTNPP
SFDKQFVRDWLEQSGWNKKAPAPKVPADVIQKTVEKYREALTLLTQD
>Mature_286_residues
SEIGLVKIYSGKVRDLYEIDDKRMLMVASDRLSAFDVILDDPIPSKGEILTQISNFWFKKLAHIMPNHFTGQTVYDVLPE
NEAKVLEKRAVVAKKLTPVKVEAIVRGYLAGSGWKDYQKTGSVCGIRLPEGMQEAQQLPEVIFTPSTKAAVGDHDENISF
EECGRIIGKELAEEVRAKAVRLYTEAAEYAKSRGIIICDTKFEFGLDTNGTLTLMDEVLTPDSSRFWPADQYKVGTNPPS
FDKQFVRDWLEQSGWNKKAPAPKVPADVIQKTVEKYREALTLLTQD

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Saccharomyces cerevisiae, GI6319326, Length=284, Percent_Identity=48.943661971831, Blast_Score=275, Evalue=6e-75,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_NEIM0 (A9M3I9)

Other databases:

- EMBL:   CP000381
- RefSeq:   YP_001598868.1
- ProteinModelPortal:   A9M3I9
- SMR:   A9M3I9
- EnsemblBacteria:   EBNEIT00000011528
- GeneID:   5795720
- GenomeReviews:   CP000381_GR
- KEGG:   nmn:NMCC_0721
- GeneTree:   EBGT00050000020981
- HOGENOM:   HBG555040
- OMA:   LTLMDEV
- ProtClustDB:   PRK13961
- BioCyc:   NMEN374833:NMCC_0721-MONOMER
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 32251; Mature: 32120

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEIGLVKIYSGKVRDLYEIDDKRMLMVASDRLSAFDVILDDPIPSKGEILTQISNFWFK
CCCCCEEEEECCCCHHHHHCCCCEEEEEECCCCHHHHEEECCCCCCCHHHHHHHHHHHHH
KLAHIMPNHFTGQTVYDVLPENEAKVLEKRAVVAKKLTPVKVEAIVRGYLAGSGWKDYQK
HHHHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHH
TGSVCGIRLPEGMQEAQQLPEVIFTPSTKAAVGDHDENISFEECGRIIGKELAEEVRAKA
CCCEEEEECCHHHHHHHHCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VRLYTEAAEYAKSRGIIICDTKFEFGLDTNGTLTLMDEVLTPDSSRFWPADQYKVGTNPP
HHHHHHHHHHHHHCCEEEEECCEEECCCCCCEEEEHHHHHCCCCCCCCCCCCEECCCCCC
SFDKQFVRDWLEQSGWNKKAPAPKVPADVIQKTVEKYREALTLLTQD
CCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SEIGLVKIYSGKVRDLYEIDDKRMLMVASDRLSAFDVILDDPIPSKGEILTQISNFWFK
CCCCEEEEECCCCHHHHHCCCCEEEEEECCCCHHHHEEECCCCCCCHHHHHHHHHHHHH
KLAHIMPNHFTGQTVYDVLPENEAKVLEKRAVVAKKLTPVKVEAIVRGYLAGSGWKDYQK
HHHHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHH
TGSVCGIRLPEGMQEAQQLPEVIFTPSTKAAVGDHDENISFEECGRIIGKELAEEVRAKA
CCCEEEEECCHHHHHHHHCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VRLYTEAAEYAKSRGIIICDTKFEFGLDTNGTLTLMDEVLTPDSSRFWPADQYKVGTNPP
HHHHHHHHHHHHHCCEEEEECCEEECCCCCCEEEEHHHHHCCCCCCCCCCCCEECCCCCC
SFDKQFVRDWLEQSGWNKKAPAPKVPADVIQKTVEKYREALTLLTQD
CCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA