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The map label for this gene is holA [H]

Identifier: 161869650

GI number: 161869650

Start: 681215

End: 682213

Strand: Direct

Name: holA [H]

Synonym: NMCC_0667

Alternate gene names: 161869650

Gene position: 681215-682213 (Clockwise)

Preceding gene: 161869649

Following gene: 161869651

Centisome position: 31.63

GC content: 58.46

Gene sequence:

>999_bases
GTGGCGGCACATATCGGACACATTGATACGGACGCGCCTTTGAAACCCCTGTACGTCATCCACGGCGAGGAAGAACTGTT
GCGTATCGAGGCATTGGACGCATTGAGGGCGGCGGCGAAGAAACAAGGTTACCTTAATCGGGAAGTTTATACGGCAGACA
ATGCCTTCGATTGGAACGAGCTGCTGCAAACCGCAGGCAGTGCGGGTCTGTTTGCCGATTTGAAGCTGTTGGAACTGCAT
ATCCCCAACGGAAAACCCAGCAAAACCGGCGGCGAGGCGTTGCAGGATTTTGCCGCCCGCCTGCCGGAAGATACGGTAAC
GCTGGTTTTACTGCCCAAACTGGAGAAAACCCAGCTCCAGTCCAAATGGTTTGCCGCATTGGCGGCAAAGGGGGAAGTGT
GGGAAGCCAAACCGGTCGGCGCGGCGGCTTTGCCCCAATGGATACGCGGACGGCTGGACAAAATCGATTTGGGTATCGAG
GCAGACGCATTGGCACTGTTTGCCGAGCGCGTGGAAGGCAATCTGTTGGCGGCGCGTCAGGAAATCGACAAGCTCGCGCT
GCTGTATCCGAAAGGGCATACCGTCAATATCGATGAGGCGCAAACCGCCGTCGCCAACGTCGCCCGCTTTGACGCGTTCC
AACTGGCAGGCGCGTGGATGAAGGGCGATGTCCCGCGCGTATGCAGATTGTTGGACGGATTGCAGGAGGAAGGCGAAGAA
CCGGTGCTGTTGCTGTGGGCGGTTGCCGAAGACGTGCGGACGCTGATCCGGCTTGCCGCCGCCTTGAAGCAGGGGCAGAG
TGTCCAATCCGTACGCAACAGTCTCAGGCTTTGGGGCGACAAGCAGACGCTCGCACCGCTTGCAGTCAAGCGGATTTCCG
TCGTCCGCCTGCTTGACGCGCTCAAAACCTGCGCCCAAATCGACCGAATCATCAAAGGTGCGGAAGACGGCGACGCATGG
ACGGTATTCAAACGGCTTGTCGTGTCGCTGGCGGAATAA

Upstream 100 bases:

>100_bases
TTGGGCAAACAGGAAGAGGAAGCGGCATTGTGGGCGGAAATGCGGCAGGATGCCGCCGAACAGATTGTCCGCCGCCTGAC
CTTTCTGAAGGCGGAATGAC

Downstream 100 bases:

>100_bases
AGCGGTAATCCCCAAAATCCGAAAATACTGTAAAATACCGTTAATCCTGAAAAGTATTCACCAATCCGTCCGAAAACATT
TCAGACGGCACGACCACCTC

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MAAHIGHIDTDAPLKPLYVIHGEEELLRIEALDALRAAAKKQGYLNREVYTADNAFDWNELLQTAGSAGLFADLKLLELH
IPNGKPSKTGGEALQDFAARLPEDTVTLVLLPKLEKTQLQSKWFAALAAKGEVWEAKPVGAAALPQWIRGRLDKIDLGIE
ADALALFAERVEGNLLAARQEIDKLALLYPKGHTVNIDEAQTAVANVARFDAFQLAGAWMKGDVPRVCRLLDGLQEEGEE
PVLLLWAVAEDVRTLIRLAAALKQGQSVQSVRNSLRLWGDKQTLAPLAVKRISVVRLLDALKTCAQIDRIIKGAEDGDAW
TVFKRLVVSLAE

Sequences:

>Translated_332_residues
MAAHIGHIDTDAPLKPLYVIHGEEELLRIEALDALRAAAKKQGYLNREVYTADNAFDWNELLQTAGSAGLFADLKLLELH
IPNGKPSKTGGEALQDFAARLPEDTVTLVLLPKLEKTQLQSKWFAALAAKGEVWEAKPVGAAALPQWIRGRLDKIDLGIE
ADALALFAERVEGNLLAARQEIDKLALLYPKGHTVNIDEAQTAVANVARFDAFQLAGAWMKGDVPRVCRLLDGLQEEGEE
PVLLLWAVAEDVRTLIRLAAALKQGQSVQSVRNSLRLWGDKQTLAPLAVKRISVVRLLDALKTCAQIDRIIKGAEDGDAW
TVFKRLVVSLAE
>Mature_331_residues
AAHIGHIDTDAPLKPLYVIHGEEELLRIEALDALRAAAKKQGYLNREVYTADNAFDWNELLQTAGSAGLFADLKLLELHI
PNGKPSKTGGEALQDFAARLPEDTVTLVLLPKLEKTQLQSKWFAALAAKGEVWEAKPVGAAALPQWIRGRLDKIDLGIEA
DALALFAERVEGNLLAARQEIDKLALLYPKGHTVNIDEAQTAVANVARFDAFQLAGAWMKGDVPRVCRLLDGLQEEGEEP
VLLLWAVAEDVRTLIRLAAALKQGQSVQSVRNSLRLWGDKQTLAPLAVKRISVVRLLDALKTCAQIDRIIKGAEDGDAWT
VFKRLVVSLAE

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=303, Percent_Identity=26.7326732673267, Blast_Score=118, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 36351; Mature: 36220

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAHIGHIDTDAPLKPLYVIHGEEELLRIEALDALRAAAKKQGYLNREVYTADNAFDWNE
CCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHH
LLQTAGSAGLFADLKLLELHIPNGKPSKTGGEALQDFAARLPEDTVTLVLLPKLEKTQLQ
HHHHCCCCCHHEEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHH
SKWFAALAAKGEVWEAKPVGAAALPQWIRGRLDKIDLGIEADALALFAERVEGNLLAARQ
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHH
EIDKLALLYPKGHTVNIDEAQTAVANVARFDAFQLAGAWMKGDVPRVCRLLDGLQEEGEE
HHHHEEEECCCCCEECCHHHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHCCCC
PVLLLWAVAEDVRTLIRLAAALKQGQSVQSVRNSLRLWGDKQTLAPLAVKRISVVRLLDA
CEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
LKTCAQIDRIIKGAEDGDAWTVFKRLVVSLAE
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AAHIGHIDTDAPLKPLYVIHGEEELLRIEALDALRAAAKKQGYLNREVYTADNAFDWNE
CCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHH
LLQTAGSAGLFADLKLLELHIPNGKPSKTGGEALQDFAARLPEDTVTLVLLPKLEKTQLQ
HHHHCCCCCHHEEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHH
SKWFAALAAKGEVWEAKPVGAAALPQWIRGRLDKIDLGIEADALALFAERVEGNLLAARQ
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHH
EIDKLALLYPKGHTVNIDEAQTAVANVARFDAFQLAGAWMKGDVPRVCRLLDGLQEEGEE
HHHHEEEECCCCCEECCHHHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHCCCC
PVLLLWAVAEDVRTLIRLAAALKQGQSVQSVRNSLRLWGDKQTLAPLAVKRISVVRLLDA
CEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
LKTCAQIDRIIKGAEDGDAWTVFKRLVVSLAE
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]