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The map label for this gene is comA [H]

Identifier: 161869643

GI number: 161869643

Start: 674040

End: 676259

Strand: Direct

Name: comA [H]

Synonym: NMCC_0660

Alternate gene names: 161869643

Gene position: 674040-676259 (Clockwise)

Preceding gene: 161869641

Following gene: 161869644

Centisome position: 31.3

GC content: 59.68

Gene sequence:

>2220_bases
GTGTTCCGTCGTTGGTTTTTGCCGTGTTGGGTTGTCGGTGCGGCGGCTTCGTTTGCGCTGCCGGTCGTGCCGCATTGGCT
GTTTTGGCTGGCGGCTTTTGCGGTTTTTGCTGTGTTTGCAAGGCGTTTTGCGTTTGCCGGTCTGATGCTGTGCGTGTTGG
CGGGCGCGGCTTACGGCGTATTCAGGACGGAGGCGGCATTGTCTTCCCAATGGTGGGCAGAAGCCGTTTCAGGCGTGCCT
TTGACGGTGGAAGTGGCGGATATGCCGAGGTCGGACAGGCGGCGTGTGCAGTTTGCGGCAAAGGCTGTGGACAGCGGTGG
TCGGACGTTTGATTTGCTGCTGTCGGACTACAAACGGCGCGAATGGGCGGTCGGGAGCAGATGGCGGATAACGGCACGTG
TGCACCCTGTCGTCGGGGAGTTGAACCTGCGCGGTTTGAACCGTGAGGCGTGGGCATTATCCAACGGAATAGGCGGCGCG
GGGACGGTCGGTGCGGACAGGGTTTTGCTGCATGGCGGAAGCGGTTGGGGGATTGCGGTTTGGCGCAGCCGCATCAGCCG
TAATTGGCAGCAGGCGGATGCGGACGGCGGGCTTTCAGACGGCATCGGGCTGATGCGCGCGTTGAGCGTGGGCGAACAGT
CGGCATTGCGCCCCGAATTGTGGCAGGCGTTCCGGCCGTTGGGGCTGACGCATTTGGTCAGTATTTCGGGTTTGCACGTT
ACGATGGTGGCGGTAATGTTTGCGTGGCTGGCGAAGCGGCTGCTTGCCTGTTCCCCGCGCCTTCCTGCCCGGCCGCGCGC
GTGGGTTTTGGCGGCGGGGTGTGCAGGCGCGCTGTTTTACGCGCTGCTTGCCGGTTTTTCCGTGCCGACGCAGCGCAGCG
TTTTGATGTTGGCGGCGTTTGCGTGGGCTTGGCGCAGGGGAAGATTGTCGGCGTGGGCGACGTGGTGGCAGGCGTTGGCG
GCGGTGCTGCTGTTCGACCCGTCGGCGGTCTTGGGTGTGGGGACTTGGCTGTCTTTCGGTTTGGTGGCGGCCCTGATATG
GGCGTGCTCGGGGCGTTTGCACGAGGGAAAACGGCAAACTGCTTTGCGCGGGCAGTGGGCGGCTTCGGTGTTGTCGCTGG
TTTTGCTCGGTTATCTGTTTGCTTCGCTGCCTTTAATCAGCCCTTTGGTCAATGCGGTGGCAATTCCGTGGTTTTCTTGG
GTATTGACGCCGCTGGCGTTGCTGGGTTCGGTCGTGCCGTTTGCGCCTTTGCAACAGTTGGGGGCATTTTTGGCGGAATA
TACTTTGCGGTTTTTGGTGTGGCTTGCCGATGTGTCGCCCGAGTTTGCCGTTGCCTCCGCACCTTTGCCGCTGTTGGTGT
TGGCGGTGTGTGCCGCTTTGCTGTTGCTGCTGCCGCGCGGCTTGGGTTTGCGTCCGTGGGCGGTGTTGCTGTTGGCAGGG
TTTGTGTTTTACCGTTCACCCGGCGTGCCGGAAAATGAGGTTGCGGTTACGGTTTGGGATGCGGGGCAGGGTTTGTCGGT
GTCGGTTCAGACGGCAAATCATCATCTTTTGTTTGACACCGGAACGGCAGCGGCGGCGCAGATGGGGATTGTGCCGAGCT
TGAATGCGTCGGGAATCAGGTATTTGGATTATTTGGTTTTGTCGCATCACGACAGCGACCACGACGGCGGTTTTCAGGCA
GTCGGCAAGATACCGAACGGCGGGATTTATGCCGGGCAGCCGGAATTTTATGAGGGGGCGCGGCATTGTGCGGAACAGCG
TTGGCAATGGGACGGCGTGGATTTTGAGTTTTTGATGCCGTCTGAACGCAAAAACATCGATGATAATGGGAAAAGTTGTG
TTTTGCGTGTTGTGGCGGGCGGTGCGGCACTGCTGGTAACGGGCGATTTGGATACGAAGGGCGAGGAAAGCCTGGTCGGC
AAGTATGGAGGCAACCTGTACAGCCAGGTTTTGGTTTTGGGACATCACGGCAGCAATACGTCCTCGTCGGGCGTGTTCCT
CAATGCCGTCTCGCCCGAATATGCCGTTGCTTCAAGCGGTTATGCCAACGCCTACAAACATCCGACCGAAGCGGTGCAGA
ACCGTGTCCGCGCACACGGCATCAAACTGCTGCGTACCGATTTGTCGGGCGCACTGCAATTCGGCTTGGGACGCGGCGGC
GTGAAGGCTCAACGTTTGAGAGGGTATAAATTCTATTGGCAGAAAAAACCGTTTGAATGA

Upstream 100 bases:

>100_bases
TTAAATTTAAACCACTATATCATTTTCAAATCTTGTTATGACGGTTTTTCGGATTTGCTTTATTATCCGTTTATTTTTGA
AATATCTGGGGTGGGGAGAC

Downstream 100 bases:

>100_bases
GGTTTGAAACATAAAATGCCGTCTGAAACGGCTTCAGACGGCATTACGAAGATGGGCTTAATGCCAGTAACGCCACCAGG
GCATATCGTCGGGCTGCCAA

Product: competence protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 739; Mature: 739

Protein sequence:

>739_residues
MFRRWFLPCWVVGAAASFALPVVPHWLFWLAAFAVFAVFARRFAFAGLMLCVLAGAAYGVFRTEAALSSQWWAEAVSGVP
LTVEVADMPRSDRRRVQFAAKAVDSGGRTFDLLLSDYKRREWAVGSRWRITARVHPVVGELNLRGLNREAWALSNGIGGA
GTVGADRVLLHGGSGWGIAVWRSRISRNWQQADADGGLSDGIGLMRALSVGEQSALRPELWQAFRPLGLTHLVSISGLHV
TMVAVMFAWLAKRLLACSPRLPARPRAWVLAAGCAGALFYALLAGFSVPTQRSVLMLAAFAWAWRRGRLSAWATWWQALA
AVLLFDPSAVLGVGTWLSFGLVAALIWACSGRLHEGKRQTALRGQWAASVLSLVLLGYLFASLPLISPLVNAVAIPWFSW
VLTPLALLGSVVPFAPLQQLGAFLAEYTLRFLVWLADVSPEFAVASAPLPLLVLAVCAALLLLLPRGLGLRPWAVLLLAG
FVFYRSPGVPENEVAVTVWDAGQGLSVSVQTANHHLLFDTGTAAAAQMGIVPSLNASGIRYLDYLVLSHHDSDHDGGFQA
VGKIPNGGIYAGQPEFYEGARHCAEQRWQWDGVDFEFLMPSERKNIDDNGKSCVLRVVAGGAALLVTGDLDTKGEESLVG
KYGGNLYSQVLVLGHHGSNTSSSGVFLNAVSPEYAVASSGYANAYKHPTEAVQNRVRAHGIKLLRTDLSGALQFGLGRGG
VKAQRLRGYKFYWQKKPFE

Sequences:

>Translated_739_residues
MFRRWFLPCWVVGAAASFALPVVPHWLFWLAAFAVFAVFARRFAFAGLMLCVLAGAAYGVFRTEAALSSQWWAEAVSGVP
LTVEVADMPRSDRRRVQFAAKAVDSGGRTFDLLLSDYKRREWAVGSRWRITARVHPVVGELNLRGLNREAWALSNGIGGA
GTVGADRVLLHGGSGWGIAVWRSRISRNWQQADADGGLSDGIGLMRALSVGEQSALRPELWQAFRPLGLTHLVSISGLHV
TMVAVMFAWLAKRLLACSPRLPARPRAWVLAAGCAGALFYALLAGFSVPTQRSVLMLAAFAWAWRRGRLSAWATWWQALA
AVLLFDPSAVLGVGTWLSFGLVAALIWACSGRLHEGKRQTALRGQWAASVLSLVLLGYLFASLPLISPLVNAVAIPWFSW
VLTPLALLGSVVPFAPLQQLGAFLAEYTLRFLVWLADVSPEFAVASAPLPLLVLAVCAALLLLLPRGLGLRPWAVLLLAG
FVFYRSPGVPENEVAVTVWDAGQGLSVSVQTANHHLLFDTGTAAAAQMGIVPSLNASGIRYLDYLVLSHHDSDHDGGFQA
VGKIPNGGIYAGQPEFYEGARHCAEQRWQWDGVDFEFLMPSERKNIDDNGKSCVLRVVAGGAALLVTGDLDTKGEESLVG
KYGGNLYSQVLVLGHHGSNTSSSGVFLNAVSPEYAVASSGYANAYKHPTEAVQNRVRAHGIKLLRTDLSGALQFGLGRGG
VKAQRLRGYKFYWQKKPFE
>Mature_739_residues
MFRRWFLPCWVVGAAASFALPVVPHWLFWLAAFAVFAVFARRFAFAGLMLCVLAGAAYGVFRTEAALSSQWWAEAVSGVP
LTVEVADMPRSDRRRVQFAAKAVDSGGRTFDLLLSDYKRREWAVGSRWRITARVHPVVGELNLRGLNREAWALSNGIGGA
GTVGADRVLLHGGSGWGIAVWRSRISRNWQQADADGGLSDGIGLMRALSVGEQSALRPELWQAFRPLGLTHLVSISGLHV
TMVAVMFAWLAKRLLACSPRLPARPRAWVLAAGCAGALFYALLAGFSVPTQRSVLMLAAFAWAWRRGRLSAWATWWQALA
AVLLFDPSAVLGVGTWLSFGLVAALIWACSGRLHEGKRQTALRGQWAASVLSLVLLGYLFASLPLISPLVNAVAIPWFSW
VLTPLALLGSVVPFAPLQQLGAFLAEYTLRFLVWLADVSPEFAVASAPLPLLVLAVCAALLLLLPRGLGLRPWAVLLLAG
FVFYRSPGVPENEVAVTVWDAGQGLSVSVQTANHHLLFDTGTAAAAQMGIVPSLNASGIRYLDYLVLSHHDSDHDGGFQA
VGKIPNGGIYAGQPEFYEGARHCAEQRWQWDGVDFEFLMPSERKNIDDNGKSCVLRVVAGGAALLVTGDLDTKGEESLVG
KYGGNLYSQVLVLGHHGSNTSSSGVFLNAVSPEYAVASSGYANAYKHPTEAVQNRVRAHGIKLLRTDLSGALQFGLGRGG
VKAQRLRGYKFYWQKKPFE

Specific function: Essential for natural transformation. Could be a transporter involved in DNA uptake [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis ComEC, H.influenzae REC2, and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=733, Percent_Identity=26.7394270122783, Blast_Score=178, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 80006; Mature: 80006

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRRWFLPCWVVGAAASFALPVVPHWLFWLAAFAVFAVFARRFAFAGLMLCVLAGAAYGV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FRTEAALSSQWWAEAVSGVPLTVEVADMPRSDRRRVQFAAKAVDSGGRTFDLLLSDYKRR
HHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHHH
EWAVGSRWRITARVHPVVGELNLRGLNREAWALSNGIGGAGTVGADRVLLHGGSGWGIAV
HCCCCCCEEEEEEECCEEECCCCCCCCCHHHHHCCCCCCCCCCCCCEEEEECCCCCHHHH
WRSRISRNWQQADADGGLSDGIGLMRALSVGEQSALRPELWQAFRPLGLTHLVSISGLHV
HHHHHHCCHHHCCCCCCCCHHHHHHHHHHCCCHHCCCHHHHHHHHCCCHHHHHHHCCHHH
TMVAVMFAWLAKRLLACSPRLPARPRAWVLAAGCAGALFYALLAGFSVPTQRSVLMLAAF
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHH
AWAWRRGRLSAWATWWQALAAVLLFDPSAVLGVGTWLSFGLVAALIWACSGRLHEGKRQT
HHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
ALRGQWAASVLSLVLLGYLFASLPLISPLVNAVAIPWFSWVLTPLALLGSVVPFAPLQQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
GAFLAEYTLRFLVWLADVSPEFAVASAPLPLLVLAVCAALLLLLPRGLGLRPWAVLLLAG
HHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
FVFYRSPGVPENEVAVTVWDAGQGLSVSVQTANHHLLFDTGTAAAAQMGIVPSLNASGIR
HHHHCCCCCCCCCEEEEEEECCCCCEEEEEECCEEEEEECCCHHHHHHCCCCCCCCCCHH
YLDYLVLSHHDSDHDGGFQAVGKIPNGGIYAGQPEFYEGARHCAEQRWQWDGVDFEFLMP
HHHHHHHHCCCCCCCCCHHEECCCCCCCEECCCCHHHHHHHHHHHHCCCCCCCCEEEECC
SERKNIDDNGKSCVLRVVAGGAALLVTGDLDTKGEESLVGKYGGNLYSQVLVLGHHGSNT
CCCCCCCCCCCCEEEEEEECCEEEEEECCCCCCCCHHHHHHHCCHHHHHHEEEEECCCCC
SSSGVFLNAVSPEYAVASSGYANAYKHPTEAVQNRVRAHGIKLLRTDLSGALQFGLGRGG
CCCCEEEEECCCCHHCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VKAQRLRGYKFYWQKKPFE
CCHHHHCCCEEEECCCCCC
>Mature Secondary Structure
MFRRWFLPCWVVGAAASFALPVVPHWLFWLAAFAVFAVFARRFAFAGLMLCVLAGAAYGV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FRTEAALSSQWWAEAVSGVPLTVEVADMPRSDRRRVQFAAKAVDSGGRTFDLLLSDYKRR
HHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHHH
EWAVGSRWRITARVHPVVGELNLRGLNREAWALSNGIGGAGTVGADRVLLHGGSGWGIAV
HCCCCCCEEEEEEECCEEECCCCCCCCCHHHHHCCCCCCCCCCCCCEEEEECCCCCHHHH
WRSRISRNWQQADADGGLSDGIGLMRALSVGEQSALRPELWQAFRPLGLTHLVSISGLHV
HHHHHHCCHHHCCCCCCCCHHHHHHHHHHCCCHHCCCHHHHHHHHCCCHHHHHHHCCHHH
TMVAVMFAWLAKRLLACSPRLPARPRAWVLAAGCAGALFYALLAGFSVPTQRSVLMLAAF
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHH
AWAWRRGRLSAWATWWQALAAVLLFDPSAVLGVGTWLSFGLVAALIWACSGRLHEGKRQT
HHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
ALRGQWAASVLSLVLLGYLFASLPLISPLVNAVAIPWFSWVLTPLALLGSVVPFAPLQQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
GAFLAEYTLRFLVWLADVSPEFAVASAPLPLLVLAVCAALLLLLPRGLGLRPWAVLLLAG
HHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
FVFYRSPGVPENEVAVTVWDAGQGLSVSVQTANHHLLFDTGTAAAAQMGIVPSLNASGIR
HHHHCCCCCCCCCEEEEEEECCCCCEEEEEECCEEEEEECCCHHHHHHCCCCCCCCCCHH
YLDYLVLSHHDSDHDGGFQAVGKIPNGGIYAGQPEFYEGARHCAEQRWQWDGVDFEFLMP
HHHHHHHHCCCCCCCCCHHEECCCCCCCEECCCCHHHHHHHHHHHHCCCCCCCCEEEECC
SERKNIDDNGKSCVLRVVAGGAALLVTGDLDTKGEESLVGKYGGNLYSQVLVLGHHGSNT
CCCCCCCCCCCCEEEEEEECCEEEEEECCCCCCCCHHHHHHHCCHHHHHHEEEEECCCCC
SSSGVFLNAVSPEYAVASSGYANAYKHPTEAVQNRVRAHGIKLLRTDLSGALQFGLGRGG
CCCCEEEEECCCCHHCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VKAQRLRGYKFYWQKKPFE
CCHHHHCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7934834; 8830266 [H]