Click here to switch to the map view.

The map label for this gene is tmk [H]

Identifier: 161869607

GI number: 161869607

Start: 640470

End: 640991

Strand: Direct

Name: tmk [H]

Synonym: NMCC_0623

Alternate gene names: 161869607

Gene position: 640470-640991 (Clockwise)

Preceding gene: 161869606

Following gene: 161869608

Centisome position: 29.74

GC content: 56.32

Gene sequence:

>522_bases
GTGCTGTTCACGCGCGAACCGGGCGGAACGCCGGTCGGTGAGGCCTTGCGCGAAATCCTGCTCAACCCTGAAACCAAAGC
CGGTTTGCGTGCGGAAACACTGATGATGTTCGCCGCCAGAATGCAGCATATTGAAGACGTGATATTGCCCGCGCTTTCAG
ACGGCATACACGTCGTATCCGATCGTTTTACCGATGCGACCTTCGCCTATCAGGGCGGCGGGCGGGGGATGCCGTCTGAA
GACATTGAAATTTTGGAACATTGGGTGCAGGGCGGTTTGCGCCCCGATTTGACCCTGCTGTTGGATGTGCCGCTGGAAGT
GTCGATGGCGCGTATCGGGCAGACGCGCGAGAAAGACCGATTCGAGCAGGAACAGGCAGATTTCTTCATGCGTGTGCGCA
GCGTTTATCTGAACCGTGCCGCCGCCTGTCCCGAACGGTACGCCATTATCGACAGTAACCGCAGCTTGGATGAAGTCAGA
AACAGCATAGAAAAAGTGTTGGACGGACATTTCGGCTGTTAA

Upstream 100 bases:

>100_bases
CATGAAACCGCAATTCATCACTTTGGACGGCATAGACGGTGCCGGCAAATCCACCAACCTTGCCGTCATCAAGGCATGGT
TTGAACGGAGGGGGCTGCCC

Downstream 100 bases:

>100_bases
TGCGGCAAATATTGAAACAAGCGCATCCACCCGCGCCGAAAATCAAACGGCAGTGCCGCAGGTGAAAATGGCGGTATGCG
CCAAACTTTCGGCATGATAG

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 173; Mature: 173

Protein sequence:

>173_residues
MLFTREPGGTPVGEALREILLNPETKAGLRAETLMMFAARMQHIEDVILPALSDGIHVVSDRFTDATFAYQGGGRGMPSE
DIEILEHWVQGGLRPDLTLLLDVPLEVSMARIGQTREKDRFEQEQADFFMRVRSVYLNRAAACPERYAIIDSNRSLDEVR
NSIEKVLDGHFGC

Sequences:

>Translated_173_residues
MLFTREPGGTPVGEALREILLNPETKAGLRAETLMMFAARMQHIEDVILPALSDGIHVVSDRFTDATFAYQGGGRGMPSE
DIEILEHWVQGGLRPDLTLLLDVPLEVSMARIGQTREKDRFEQEQADFFMRVRSVYLNRAAACPERYAIIDSNRSLDEVR
NSIEKVLDGHFGC
>Mature_173_residues
MLFTREPGGTPVGEALREILLNPETKAGLRAETLMMFAARMQHIEDVILPALSDGIHVVSDRFTDATFAYQGGGRGMPSE
DIEILEHWVQGGLRPDLTLLLDVPLEVSMARIGQTREKDRFEQEQADFFMRVRSVYLNRAAACPERYAIIDSNRSLDEVR
NSIEKVLDGHFGC

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=167, Percent_Identity=44.9101796407186, Blast_Score=125, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 19435; Mature: 19435

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFTREPGGTPVGEALREILLNPETKAGLRAETLMMFAARMQHIEDVILPALSDGIHVVS
CCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
DRFTDATFAYQGGGRGMPSEDIEILEHWVQGGLRPDLTLLLDVPLEVSMARIGQTREKDR
HCCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHCCHHHHHH
FEQEQADFFMRVRSVYLNRAAACPERYAIIDSNRSLDEVRNSIEKVLDGHFGC
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLFTREPGGTPVGEALREILLNPETKAGLRAETLMMFAARMQHIEDVILPALSDGIHVVS
CCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
DRFTDATFAYQGGGRGMPSEDIEILEHWVQGGLRPDLTLLLDVPLEVSMARIGQTREKDR
HCCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHCCHHHHHH
FEQEQADFFMRVRSVYLNRAAACPERYAIIDSNRSLDEVRNSIEKVLDGHFGC
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA