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The map label for this gene is bdhA [H]

Identifier: 161869536

GI number: 161869536

Start: 572572

End: 573636

Strand: Reverse

Name: bdhA [H]

Synonym: NMCC_0550

Alternate gene names: 161869536

Gene position: 573636-572572 (Counterclockwise)

Preceding gene: 161869537

Following gene: 161869535

Centisome position: 26.64

GC content: 56.06

Gene sequence:

>1065_bases
ATGAAAGCAGCACGTTTTTACGACAAAGGCGACATCCGCATCGAAGACATCCCCGAACCGACCGTCGCCCCCGGCACCGT
CGGCATCAATGTTGCCTGGTGCGGCATCTGCGGTACCGACCTGCACGAATTCATGGAAGGCCCGATTTTCATTCCGCCTT
GCGGTCATCCGCACCCGATTTCCGGCGAGTCCGCACCCGTCACGATGGGACACGAGTTCTCCGGCGTGGTCTATGCCGTC
GGCGAAGGCGTGGACGACATCAAAGTCGGTCAACACGTCGTGGTCGAGCCTTACATCGTACACGACGACGTACCGACCGG
CTCGGGCAGCAACTACCACCTCTCCAAAGACATGAACTTTATCGGCTTGGGCGGCTGCGGCGGCGGCCTGTCCGAAAAAA
TCGCCGTCAAACGCCGTTGGGTGCATCCGATTTCCGACAAAATCCCGTTGGATCAAGCCGCTTTGATCGAACCGCTGTCT
GTCGGACACCACGCCTATGTACGCAGCGGCGCGAAAGCAGGCGACGTCGCATTGGTCGGCGGTGCAGGTCCGATCGGTTT
GCTGTTGGCTGCCGTGTTGAAAGCCAAAGGCATCAAAGTCATCATCACCGAGTTGAGTAAAGCACGCAAAGACAAAGCGC
GCGAATCTGGCGTTGCCGACTACATCCTCGACCCGTCCGAAGTCGATGTTGTCGAAGAAGTGAAAAAACTGACCAACGGC
GAAGGCGTGGACGTGGCATTCGAATGTACCAGCGTGAACAAAGTGTTGGATACTTTGGTCGAAGCCTGCAAACCTGCCGC
CAATTTGGTTATCGTATCCATCTGGAGCCACCCTGCAACCGTCAACGTCCACAGCGTCGTGATGAAAGAGCTGGATGTGC
GCGGCACGATTGCCTACTGTAACGACCACGCCGAAACCATCAAACTGGTCGAAGAAGGCAAAATCAACCTCGAACCCTTC
ATCACCCAGCGCATCAAGCTGGACGAACTGGTTTCCGAAGGCTTCGAGCGTCTGATCCACAACAACGAATCCGCCGTTAA
AATTATTGTGAGTCCAAACCTGTAA

Upstream 100 bases:

>100_bases
ATTCAACTGGAAACGGTCAGGCTTCTTCACGCCATTCCCATTTCAACCGCCGCCTGCCAGATTCAGACGGTATTCCTACT
TGAAAACAAGGAGCGTTACA

Downstream 100 bases:

>100_bases
GCAAATTACATTTGCAACAGCACAAATGCCGTCTGAAACGCTCAGACGGCATTTTCCAACGAAGCGCAACAGGCGTATTG
CCCGAGAGCAGCCGTTTAGC

Product: zinc-binding alcohol dehydrogenase

Products: NA

Alternate protein names: Acetoin reductase/2,3-butanediol dehydrogenase; AR/BDH [H]

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MKAARFYDKGDIRIEDIPEPTVAPGTVGINVAWCGICGTDLHEFMEGPIFIPPCGHPHPISGESAPVTMGHEFSGVVYAV
GEGVDDIKVGQHVVVEPYIVHDDVPTGSGSNYHLSKDMNFIGLGGCGGGLSEKIAVKRRWVHPISDKIPLDQAALIEPLS
VGHHAYVRSGAKAGDVALVGGAGPIGLLLAAVLKAKGIKVIITELSKARKDKARESGVADYILDPSEVDVVEEVKKLTNG
EGVDVAFECTSVNKVLDTLVEACKPAANLVIVSIWSHPATVNVHSVVMKELDVRGTIAYCNDHAETIKLVEEGKINLEPF
ITQRIKLDELVSEGFERLIHNNESAVKIIVSPNL

Sequences:

>Translated_354_residues
MKAARFYDKGDIRIEDIPEPTVAPGTVGINVAWCGICGTDLHEFMEGPIFIPPCGHPHPISGESAPVTMGHEFSGVVYAV
GEGVDDIKVGQHVVVEPYIVHDDVPTGSGSNYHLSKDMNFIGLGGCGGGLSEKIAVKRRWVHPISDKIPLDQAALIEPLS
VGHHAYVRSGAKAGDVALVGGAGPIGLLLAAVLKAKGIKVIITELSKARKDKARESGVADYILDPSEVDVVEEVKKLTNG
EGVDVAFECTSVNKVLDTLVEACKPAANLVIVSIWSHPATVNVHSVVMKELDVRGTIAYCNDHAETIKLVEEGKINLEPF
ITQRIKLDELVSEGFERLIHNNESAVKIIVSPNL
>Mature_354_residues
MKAARFYDKGDIRIEDIPEPTVAPGTVGINVAWCGICGTDLHEFMEGPIFIPPCGHPHPISGESAPVTMGHEFSGVVYAV
GEGVDDIKVGQHVVVEPYIVHDDVPTGSGSNYHLSKDMNFIGLGGCGGGLSEKIAVKRRWVHPISDKIPLDQAALIEPLS
VGHHAYVRSGAKAGDVALVGGAGPIGLLLAAVLKAKGIKVIITELSKARKDKARESGVADYILDPSEVDVVEEVKKLTNG
EGVDVAFECTSVNKVLDTLVEACKPAANLVIVSIWSHPATVNVHSVVMKELDVRGTIAYCNDHAETIKLVEEGKINLEPF
ITQRIKLDELVSEGFERLIHNNESAVKIIVSPNL

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=334, Percent_Identity=32.6347305389222, Blast_Score=160, Evalue=2e-39,
Organism=Escherichia coli, GI226510992, Length=324, Percent_Identity=28.7037037037037, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1788073, Length=343, Percent_Identity=23.9067055393586, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1788407, Length=339, Percent_Identity=29.7935103244838, Blast_Score=104, Evalue=7e-24,
Organism=Escherichia coli, GI1788075, Length=373, Percent_Identity=26.5415549597855, Blast_Score=104, Evalue=8e-24,
Organism=Escherichia coli, GI1787863, Length=353, Percent_Identity=26.9121813031161, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1790045, Length=351, Percent_Identity=27.0655270655271, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1790718, Length=303, Percent_Identity=24.7524752475248, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562876, Length=338, Percent_Identity=31.0650887573964, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17562878, Length=353, Percent_Identity=29.1784702549575, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6319258, Length=378, Percent_Identity=35.1851851851852, Blast_Score=213, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6319257, Length=379, Percent_Identity=33.7730870712401, Blast_Score=204, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6323099, Length=350, Percent_Identity=31.1428571428571, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6319955, Length=357, Percent_Identity=29.9719887955182, Blast_Score=145, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6322619, Length=354, Percent_Identity=29.3785310734463, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6320033, Length=391, Percent_Identity=24.5524296675192, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17737897, Length=345, Percent_Identity=29.2753623188406, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI17137530, Length=346, Percent_Identity=28.3236994219653, Blast_Score=135, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.4 [H]

Molecular weight: Translated: 37833; Mature: 37833

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAARFYDKGDIRIEDIPEPTVAPGTVGINVAWCGICGTDLHEFMEGPIFIPPCGHPHPI
CCCCCEECCCCEEEECCCCCCCCCCCEEEEEEEECCCHHHHHHHHCCCEEECCCCCCCCC
SGESAPVTMGHEFSGVVYAVGEGVDDIKVGQHVVVEPYIVHDDVPTGSGSNYHLSKDMNF
CCCCCCEEECCCCCCEEEEECCCCCCHHCCCEEEEEEEEEECCCCCCCCCCEEEECCCCE
IGLGGCGGGLSEKIAVKRRWVHPISDKIPLDQAALIEPLSVGHHAYVRSGAKAGDVALVG
EEECCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHCCCCCCCEEEEC
GAGPIGLLLAAVLKAKGIKVIITELSKARKDKARESGVADYILDPSEVDVVEEVKKLTNG
CCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHCCCHHEEECCCHHHHHHHHHHHHCC
EGVDVAFECTSVNKVLDTLVEACKPAANLVIVSIWSHPATVNVHSVVMKELDVRGTIAYC
CCCEEEEEECHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEHHHHHHHHHCCCEEEEEE
NDHAETIKLVEEGKINLEPFITQRIKLDELVSEGFERLIHNNESAVKIIVSPNL
CCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCC
>Mature Secondary Structure
MKAARFYDKGDIRIEDIPEPTVAPGTVGINVAWCGICGTDLHEFMEGPIFIPPCGHPHPI
CCCCCEECCCCEEEECCCCCCCCCCCEEEEEEEECCCHHHHHHHHCCCEEECCCCCCCCC
SGESAPVTMGHEFSGVVYAVGEGVDDIKVGQHVVVEPYIVHDDVPTGSGSNYHLSKDMNF
CCCCCCEEECCCCCCEEEEECCCCCCHHCCCEEEEEEEEEECCCCCCCCCCEEEECCCCE
IGLGGCGGGLSEKIAVKRRWVHPISDKIPLDQAALIEPLSVGHHAYVRSGAKAGDVALVG
EEECCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHCCCCCCCEEEEC
GAGPIGLLLAAVLKAKGIKVIITELSKARKDKARESGVADYILDPSEVDVVEEVKKLTNG
CCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHCCCHHEEECCCHHHHHHHHHHHHCC
EGVDVAFECTSVNKVLDTLVEACKPAANLVIVSIWSHPATVNVHSVVMKELDVRGTIAYC
CCCEEEEEECHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEHHHHHHHHHCCCEEEEEE
NDHAETIKLVEEGKINLEPFITQRIKLDELVSEGFERLIHNNESAVKIIVSPNL
CCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9455482; 9384377 [H]