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The map label for this gene is ubiB [H]

Identifier: 161869492

GI number: 161869492

Start: 525826

End: 527409

Strand: Direct

Name: ubiB [H]

Synonym: NMCC_0505

Alternate gene names: 161869492

Gene position: 525826-527409 (Clockwise)

Preceding gene: 161869491

Following gene: 161869494

Centisome position: 24.42

GC content: 53.98

Gene sequence:

>1584_bases
TTGCCTTTTTGGGCTATCTGCTCGGTAAGATTTTTTGATTGTCCGATAAATGCTGTATTCGGGATTTTATATATGAAATG
GTTGAAACGCCTGACGGTTATTGTCGGGACTTTTTACCGCTATCGGCTGGCAGGTCTGTGTGCTTCGCTGATGGGTAGCG
GTTGGATATGCGCTCTGCTGAAAATGATGCCGCAGTCGTCCAAATTGAAAAACGAACCGCCTGCTGTCCGTCTGCGCCTT
GCCTTGGAAAGCCTGGGGCCGATTTTCATCAAGTTCGGGCAGGTTTTGTCCACACGCCCCGATTTGATTCCGCACGATTA
CGCCGTCGAACTGGCAAAGCTGCAAGACAAAGTGCCGCCTTTTGACGCGCGGCTTTCGCGTGAACAAATCGAAAAATCGT
TGGGTCAGTCCATCGAAAAGCTGTATGCGGAATTTGAAACCGAGCCCATCGCCAGCGCGTCCATCGCCCAAGTACACAAA
GCCCGCCTGCATTCGGGCGAACGAGTGGCGGTTAAAGTTTTGCGCCCCAACCTTTTGCCCCTTATCGAACAGGATTTGTC
GCTGATGCGTTTCGGCGCGGCCTGGGTCGAACGCTTGTTTTCAGACGGCAGGCGTCTGAAGCCGCTCGAAGTGGTGGCGG
AGTTCGACAAATACCTGCACGACGAGTTGGATTTGATGCGCGAAGCCGCCAATGCCGGACAGCTCGGGCGCAATTTCCAA
AACAGCAATATGCTGATTGTGCCCAAGGTGTTTTACGACTACTGCACCAGCGACGTGCTGACAATCGAATGGATGGACGG
CACGCCGGTTGCCGACATCGCCAAACTCAAAGCAGACGGCATCGATTTGCACAAACTCGCCGATTACGGCGTGGAAATCT
TTTTCACGCAGGTCTTCCGCGACGGCTTTTTCCACGCGGATATGCACCCCGGCAATATTTTGGTTGCCGCCGACAACCGC
TACATCGCCCTCGATTTCGGCATCGTCGGCACGCTGACCGATTACGACAAACGTTATCTCGCCATCAATTTCCTCGCCTT
TTTCAACCGCGATTACCGGCGCGTCGCCACCGCCCACATCGAATCGGGCTGGGTGCCTGCCGACACGCGTGCGGAAGAAT
TGGAAGCCGCCGTCCGCGCCGTGTGCGAACCGGTGTTCAACAAACCGATTTCGCAGATTTCCTTCGGCTTGGTGCTGATG
CGCCTGTTTGAAGTCAGCCGCCGCTTCAATGTCGAAATCCAACCGCAGCTTGTGCTGCTGCAAAAAACGCTGCTCAACAT
CGAAGGCTTGGGCCGCCAGCTCGATCCCGATTTGGACTTGTGGAAAACCGCCAAACCGTTTTTGGTGAAATGGATAAACG
GGCAGGTCGGCCCTAAAGCCCTTTGGCGCAACCTCAAAAACGAAGCCCCCGACTGGGCGCAAATCATCCCTTCATTGCCG
CGCAAAATCAGTGCGTTGATTGATGAAAACCGCCAGCAGGAAATGCGTGATGCCTATATCCATTTGGTCAAAGTGCAGCA
GCGGCAAAGCCTGTGGCTGGCTGTGATTGCGGTTGTTTTGCTGCTGATTTTGCTTTTGAAATAG

Upstream 100 bases:

>100_bases
TATCTTGAACTTCACGGCGGGCGGGAAGATGATATTTCCGCACCTTCGCAACCCGAACCGCCGTCCCGCAATATCAAACT
GCTGGTTTTCGGGCTGCTGA

Downstream 100 bases:

>100_bases
GCTTTGTCCGAATCATCGCCCGACTCCGCCCGTTTATAAGGAAATCGGTTATAGTGGATTAACAAAAACCAGTACGGCGT
TGCCTCGCCTTAGCTCAAAG

Product: putative ubiquinone biosynthesis protein UbiB

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 527; Mature: 526

Protein sequence:

>527_residues
MPFWAICSVRFFDCPINAVFGILYMKWLKRLTVIVGTFYRYRLAGLCASLMGSGWICALLKMMPQSSKLKNEPPAVRLRL
ALESLGPIFIKFGQVLSTRPDLIPHDYAVELAKLQDKVPPFDARLSREQIEKSLGQSIEKLYAEFETEPIASASIAQVHK
ARLHSGERVAVKVLRPNLLPLIEQDLSLMRFGAAWVERLFSDGRRLKPLEVVAEFDKYLHDELDLMREAANAGQLGRNFQ
NSNMLIVPKVFYDYCTSDVLTIEWMDGTPVADIAKLKADGIDLHKLADYGVEIFFTQVFRDGFFHADMHPGNILVAADNR
YIALDFGIVGTLTDYDKRYLAINFLAFFNRDYRRVATAHIESGWVPADTRAEELEAAVRAVCEPVFNKPISQISFGLVLM
RLFEVSRRFNVEIQPQLVLLQKTLLNIEGLGRQLDPDLDLWKTAKPFLVKWINGQVGPKALWRNLKNEAPDWAQIIPSLP
RKISALIDENRQQEMRDAYIHLVKVQQRQSLWLAVIAVVLLLILLLK

Sequences:

>Translated_527_residues
MPFWAICSVRFFDCPINAVFGILYMKWLKRLTVIVGTFYRYRLAGLCASLMGSGWICALLKMMPQSSKLKNEPPAVRLRL
ALESLGPIFIKFGQVLSTRPDLIPHDYAVELAKLQDKVPPFDARLSREQIEKSLGQSIEKLYAEFETEPIASASIAQVHK
ARLHSGERVAVKVLRPNLLPLIEQDLSLMRFGAAWVERLFSDGRRLKPLEVVAEFDKYLHDELDLMREAANAGQLGRNFQ
NSNMLIVPKVFYDYCTSDVLTIEWMDGTPVADIAKLKADGIDLHKLADYGVEIFFTQVFRDGFFHADMHPGNILVAADNR
YIALDFGIVGTLTDYDKRYLAINFLAFFNRDYRRVATAHIESGWVPADTRAEELEAAVRAVCEPVFNKPISQISFGLVLM
RLFEVSRRFNVEIQPQLVLLQKTLLNIEGLGRQLDPDLDLWKTAKPFLVKWINGQVGPKALWRNLKNEAPDWAQIIPSLP
RKISALIDENRQQEMRDAYIHLVKVQQRQSLWLAVIAVVLLLILLLK
>Mature_526_residues
PFWAICSVRFFDCPINAVFGILYMKWLKRLTVIVGTFYRYRLAGLCASLMGSGWICALLKMMPQSSKLKNEPPAVRLRLA
LESLGPIFIKFGQVLSTRPDLIPHDYAVELAKLQDKVPPFDARLSREQIEKSLGQSIEKLYAEFETEPIASASIAQVHKA
RLHSGERVAVKVLRPNLLPLIEQDLSLMRFGAAWVERLFSDGRRLKPLEVVAEFDKYLHDELDLMREAANAGQLGRNFQN
SNMLIVPKVFYDYCTSDVLTIEWMDGTPVADIAKLKADGIDLHKLADYGVEIFFTQVFRDGFFHADMHPGNILVAADNRY
IALDFGIVGTLTDYDKRYLAINFLAFFNRDYRRVATAHIESGWVPADTRAEELEAAVRAVCEPVFNKPISQISFGLVLMR
LFEVSRRFNVEIQPQLVLLQKTLLNIEGLGRQLDPDLDLWKTAKPFLVKWINGQVGPKALWRNLKNEAPDWAQIIPSLPR
KISALIDENRQQEMRDAYIHLVKVQQRQSLWLAVIAVVLLLILLLK

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=251, Percent_Identity=33.0677290836653, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI41393593, Length=284, Percent_Identity=29.5774647887324, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI217035081, Length=250, Percent_Identity=31.2, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI32261307, Length=343, Percent_Identity=28.5714285714286, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI27363457, Length=287, Percent_Identity=26.1324041811847, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI217416386, Length=219, Percent_Identity=27.3972602739726, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI34147522, Length=309, Percent_Identity=26.537216828479, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI2367309, Length=512, Percent_Identity=51.3671875, Blast_Score=494, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17559152, Length=280, Percent_Identity=32.8571428571429, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI32565180, Length=272, Percent_Identity=25.7352941176471, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6325148, Length=452, Percent_Identity=28.0973451327434, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6323282, Length=295, Percent_Identity=28.8135593220339, Blast_Score=100, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6321319, Length=246, Percent_Identity=26.4227642276423, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24662575, Length=270, Percent_Identity=34.8148148148148, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI22024280, Length=265, Percent_Identity=33.5849056603774, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI18859849, Length=279, Percent_Identity=27.5985663082437, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 60081; Mature: 59950

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFWAICSVRFFDCPINAVFGILYMKWLKRLTVIVGTFYRYRLAGLCASLMGSGWICALL
CCCHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
KMMPQSSKLKNEPPAVRLRLALESLGPIFIKFGQVLSTRPDLIPHDYAVELAKLQDKVPP
HHCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCC
FDARLSREQIEKSLGQSIEKLYAEFETEPIASASIAQVHKARLHSGERVAVKVLRPNLLP
CHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHH
LIEQDLSLMRFGAAWVERLFSDGRRLKPLEVVAEFDKYLHDELDLMREAANAGQLGRNFQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NSNMLIVPKVFYDYCTSDVLTIEWMDGTPVADIAKLKADGIDLHKLADYGVEIFFTQVFR
CCCEEEEHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
DGFFHADMHPGNILVAADNRYIALDFGIVGTLTDYDKRYLAINFLAFFNRDYRRVATAHI
CCCEECCCCCCEEEEEECCEEEEEECCCEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHH
ESGWVPADTRAEELEAAVRAVCEPVFNKPISQISFGLVLMRLFEVSRRFNVEIQPQLVLL
HCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEECHHHHHH
QKTLLNIEGLGRQLDPDLDLWKTAKPFLVKWINGQVGPKALWRNLKNEAPDWAQIIPSLP
HHHHHHHHHCCCCCCCCCCHHHCCCHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHH
RKISALIDENRQQEMRDAYIHLVKVQQRQSLWLAVIAVVLLLILLLK
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PFWAICSVRFFDCPINAVFGILYMKWLKRLTVIVGTFYRYRLAGLCASLMGSGWICALL
CCHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
KMMPQSSKLKNEPPAVRLRLALESLGPIFIKFGQVLSTRPDLIPHDYAVELAKLQDKVPP
HHCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCC
FDARLSREQIEKSLGQSIEKLYAEFETEPIASASIAQVHKARLHSGERVAVKVLRPNLLP
CHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHH
LIEQDLSLMRFGAAWVERLFSDGRRLKPLEVVAEFDKYLHDELDLMREAANAGQLGRNFQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NSNMLIVPKVFYDYCTSDVLTIEWMDGTPVADIAKLKADGIDLHKLADYGVEIFFTQVFR
CCCEEEEHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
DGFFHADMHPGNILVAADNRYIALDFGIVGTLTDYDKRYLAINFLAFFNRDYRRVATAHI
CCCEECCCCCCEEEEEECCEEEEEECCCEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHH
ESGWVPADTRAEELEAAVRAVCEPVFNKPISQISFGLVLMRLFEVSRRFNVEIQPQLVLL
HCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEECHHHHHH
QKTLLNIEGLGRQLDPDLDLWKTAKPFLVKWINGQVGPKALWRNLKNEAPDWAQIIPSLP
HHHHHHHHHCCCCCCCCCCHHHCCCHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHH
RKISALIDENRQQEMRDAYIHLVKVQQRQSLWLAVIAVVLLLILLLK
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]