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The map label for this gene is hrpA' [H]

Identifier: 161869194

GI number: 161869194

Start: 198361

End: 199884

Strand: Reverse

Name: hrpA' [H]

Synonym: NMCC_0197

Alternate gene names: 161869194

Gene position: 199884-198361 (Counterclockwise)

Preceding gene: 161869195

Following gene: 161869193

Centisome position: 9.28

GC content: 55.77

Gene sequence:

>1524_bases
TTGAAACTTCAGCAACAATGCCGTCTGAACGACAGAATGCGGTTTTCAGACGGCATTTCCCCATCCCGATATTGCCCGAA
CCCAACCAAAGCGTTTGCTATAATTCTATTTTTTACCGCATACGCACCAATCATGTTTCCCGATTTCTCCCAAACCCTCT
CCAAAGACCGCCACTTCCTGCAATCCGCCTTCAAAAATCCCAACAAATACGGCGGCTTGTCCAAAGTCGAAGAAAAATAC
CGAAAATCGCACGAAATCTTTTTGAAACGTTTGGCAGCCTTGCCCAAACCCGAATTCGACAACACCCTGCCCGTTCACGA
AAAACTTGACGAAATCAAAAAAACCGTTGCCGAACATCAGGTAACGATTATTTGCGGCGAAACCGGTTCGGGCAAGACCA
CTCAGTTGCCCAAGATTTGTCTGGAACTCGGGCGCGGGGCGGCGGGTTTGATCGGGCATACCCAGCCGCGCCGTTTGGCG
GCGCGTTCCGTAGCAGAGCGGATTGCCGAAGAGCTGAAATCCGAAATCGGCAGCGCGGTCGGCTATAAAGTGCGCTTCAC
CGACCACACCTCGCGCGATGCCTGCGTCAAGCTGATGACCGACGGCATCCTGCTGGCGGAAACCCAGACCGACCGTTATC
TCGCCGCCTACGACACGATTATCATCGACGAAGCGCACGAGCGCAGCCTGAACATCGACTTCCTTTTGGGCTATTTGAAA
CAACTCCTGCCGCGCCGCCCCGATTTGAAAGTCATCATCACCTCGGCAACGATAGACGCAGAACGCTTTTCCCAACACTT
CAACGGCGCGCCCGTGCTGGAAGTGAGCGGACGCACCTATCCCGTCGAAATCCTCTACCGACCGCTGATCGGCAAAGACG
AAGACGACGCGGAAATAGAATTGACCGACGCGATTGTCGATGCGGCGGACGAATTGGCGCGATATGGCGAAGGCGATATT
TTGGTATTCCTGCCGGGCGAACGCGAAATCCGCGAAGCCGCCGAAGCCCTGCGCAAATCCACGCTACGCCGCAACGACGA
AATCCTGCCCCTGTTCGCACGCCTGTCGCACGCCGAGCAGCACAAAATCTTTCACCCCTCCGGAGCGAAACGCCGCATCG
TGCTGGCAACCAACGTCGCCGAAACCTCGCTTACCGTGCCGGGCATCAAATACGTCATCGACACCGGCCTCGCGCGCGTC
AAACGCTATTCCGCACGGGCGAAAGTGGAGCAGCTTCATATCGAAAAAATCTCCCAAGCCGCCGCCCGCCAACGCTCCGG
CCGCTGCGGACGCGTCTCCGCAGGCGTATGTATCCAATTGTTTTCAGAAGAAAATTTCAACAACCGCCCCGAATTTACCG
ACCCCGAAATCGCCCGCAGCAACCTCGCCGCCGTCATCCTGCGCATGGCATCGCTGAAACTCGGCGACGTAGCGGCATTC
CCATTTTTAGAAATGCCCGATTCGAGGTATATTAATGATGGGTTTCAGGTGTTGCTGGAATTAGGGGCAGTGGAGGCCGC
CTGA

Upstream 100 bases:

>100_bases
GCAAACAGCAAACAGCAAAACGGGAATGCCGTCTGAAAATTAAAACGCCCCCGATCAAACGCCGGCAGCCGCCTTGATTT
GAATACCGTTCCGCCGCCGC

Downstream 100 bases:

>100_bases
AAACAAGTAGGATATACACTTCTACCTGACAAAGACCAACAAACGATAAAACTACGGCACATCTAGATGCCCAACCTACA
ACATTGCACACGGTAAAAAC

Product: ATP-dependent DNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MKLQQQCRLNDRMRFSDGISPSRYCPNPTKAFAIILFFTAYAPIMFPDFSQTLSKDRHFLQSAFKNPNKYGGLSKVEEKY
RKSHEIFLKRLAALPKPEFDNTLPVHEKLDEIKKTVAEHQVTIICGETGSGKTTQLPKICLELGRGAAGLIGHTQPRRLA
ARSVAERIAEELKSEIGSAVGYKVRFTDHTSRDACVKLMTDGILLAETQTDRYLAAYDTIIIDEAHERSLNIDFLLGYLK
QLLPRRPDLKVIITSATIDAERFSQHFNGAPVLEVSGRTYPVEILYRPLIGKDEDDAEIELTDAIVDAADELARYGEGDI
LVFLPGEREIREAAEALRKSTLRRNDEILPLFARLSHAEQHKIFHPSGAKRRIVLATNVAETSLTVPGIKYVIDTGLARV
KRYSARAKVEQLHIEKISQAAARQRSGRCGRVSAGVCIQLFSEENFNNRPEFTDPEIARSNLAAVILRMASLKLGDVAAF
PFLEMPDSRYINDGFQVLLELGAVEAA

Sequences:

>Translated_507_residues
MKLQQQCRLNDRMRFSDGISPSRYCPNPTKAFAIILFFTAYAPIMFPDFSQTLSKDRHFLQSAFKNPNKYGGLSKVEEKY
RKSHEIFLKRLAALPKPEFDNTLPVHEKLDEIKKTVAEHQVTIICGETGSGKTTQLPKICLELGRGAAGLIGHTQPRRLA
ARSVAERIAEELKSEIGSAVGYKVRFTDHTSRDACVKLMTDGILLAETQTDRYLAAYDTIIIDEAHERSLNIDFLLGYLK
QLLPRRPDLKVIITSATIDAERFSQHFNGAPVLEVSGRTYPVEILYRPLIGKDEDDAEIELTDAIVDAADELARYGEGDI
LVFLPGEREIREAAEALRKSTLRRNDEILPLFARLSHAEQHKIFHPSGAKRRIVLATNVAETSLTVPGIKYVIDTGLARV
KRYSARAKVEQLHIEKISQAAARQRSGRCGRVSAGVCIQLFSEENFNNRPEFTDPEIARSNLAAVILRMASLKLGDVAAF
PFLEMPDSRYINDGFQVLLELGAVEAA
>Mature_507_residues
MKLQQQCRLNDRMRFSDGISPSRYCPNPTKAFAIILFFTAYAPIMFPDFSQTLSKDRHFLQSAFKNPNKYGGLSKVEEKY
RKSHEIFLKRLAALPKPEFDNTLPVHEKLDEIKKTVAEHQVTIICGETGSGKTTQLPKICLELGRGAAGLIGHTQPRRLA
ARSVAERIAEELKSEIGSAVGYKVRFTDHTSRDACVKLMTDGILLAETQTDRYLAAYDTIIIDEAHERSLNIDFLLGYLK
QLLPRRPDLKVIITSATIDAERFSQHFNGAPVLEVSGRTYPVEILYRPLIGKDEDDAEIELTDAIVDAADELARYGEGDI
LVFLPGEREIREAAEALRKSTLRRNDEILPLFARLSHAEQHKIFHPSGAKRRIVLATNVAETSLTVPGIKYVIDTGLARV
KRYSARAKVEQLHIEKISQAAARQRSGRCGRVSAGVCIQLFSEENFNNRPEFTDPEIARSNLAAVILRMASLKLGDVAAF
PFLEMPDSRYINDGFQVLLELGAVEAA

Specific function: Not yet known [H]

COG id: COG1643

COG function: function code L; HrpA-like helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI68509926, Length=418, Percent_Identity=41.1483253588517, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI4826690, Length=417, Percent_Identity=41.0071942446043, Blast_Score=312, Evalue=4e-85,
Organism=Homo sapiens, GI17999539, Length=428, Percent_Identity=40.4205607476636, Blast_Score=304, Evalue=2e-82,
Organism=Homo sapiens, GI20336302, Length=434, Percent_Identity=38.9400921658986, Blast_Score=302, Evalue=6e-82,
Organism=Homo sapiens, GI255982614, Length=412, Percent_Identity=42.2330097087379, Blast_Score=300, Evalue=3e-81,
Organism=Homo sapiens, GI256000749, Length=412, Percent_Identity=42.2330097087379, Blast_Score=300, Evalue=3e-81,
Organism=Homo sapiens, GI20544129, Length=467, Percent_Identity=37.6873661670236, Blast_Score=297, Evalue=2e-80,
Organism=Homo sapiens, GI261878478, Length=428, Percent_Identity=38.3177570093458, Blast_Score=286, Evalue=3e-77,
Organism=Homo sapiens, GI38158022, Length=417, Percent_Identity=39.568345323741, Blast_Score=286, Evalue=3e-77,
Organism=Homo sapiens, GI299829255, Length=388, Percent_Identity=39.1752577319588, Blast_Score=266, Evalue=4e-71,
Organism=Homo sapiens, GI20336294, Length=431, Percent_Identity=35.7308584686775, Blast_Score=238, Evalue=8e-63,
Organism=Homo sapiens, GI20336290, Length=431, Percent_Identity=35.7308584686775, Blast_Score=238, Evalue=8e-63,
Organism=Homo sapiens, GI100913206, Length=459, Percent_Identity=32.0261437908497, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI261878481, Length=381, Percent_Identity=33.8582677165354, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI166851804, Length=448, Percent_Identity=32.1428571428571, Blast_Score=192, Evalue=7e-49,
Organism=Homo sapiens, GI67782362, Length=491, Percent_Identity=30.5498981670061, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI167830436, Length=469, Percent_Identity=29.8507462686567, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI20336300, Length=421, Percent_Identity=28.0285035629454, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI163914394, Length=399, Percent_Identity=30.0751879699248, Blast_Score=150, Evalue=4e-36,
Organism=Homo sapiens, GI167830433, Length=202, Percent_Identity=42.5742574257426, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI269847874, Length=191, Percent_Identity=41.3612565445026, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI29029601, Length=250, Percent_Identity=37.2, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI39777586, Length=190, Percent_Identity=41.5789473684211, Blast_Score=145, Evalue=6e-35,
Organism=Escherichia coli, GI145693127, Length=417, Percent_Identity=67.6258992805755, Blast_Score=573, Evalue=1e-164,
Organism=Escherichia coli, GI87081693, Length=410, Percent_Identity=35.3658536585366, Blast_Score=216, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17554326, Length=412, Percent_Identity=43.6893203883495, Blast_Score=313, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI17531507, Length=415, Percent_Identity=44.0963855421687, Blast_Score=312, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI17535281, Length=418, Percent_Identity=40.6698564593301, Blast_Score=304, Evalue=6e-83,
Organism=Caenorhabditis elegans, GI32565154, Length=423, Percent_Identity=39.0070921985816, Blast_Score=287, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI25144243, Length=423, Percent_Identity=39.0070921985816, Blast_Score=286, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI17556386, Length=421, Percent_Identity=39.667458432304, Blast_Score=278, Evalue=4e-75,
Organism=Caenorhabditis elegans, GI71990212, Length=414, Percent_Identity=38.1642512077295, Blast_Score=275, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI71996313, Length=428, Percent_Identity=37.8504672897196, Blast_Score=256, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI86562256, Length=474, Percent_Identity=31.6455696202532, Blast_Score=174, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI17552054, Length=251, Percent_Identity=36.2549800796813, Blast_Score=138, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI17507503, Length=194, Percent_Identity=39.1752577319588, Blast_Score=133, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6321318, Length=400, Percent_Identity=44.5, Blast_Score=325, Evalue=1e-89,
Organism=Saccharomyces cerevisiae, GI6320850, Length=465, Percent_Identity=39.3548387096774, Blast_Score=317, Evalue=3e-87,
Organism=Saccharomyces cerevisiae, GI6324338, Length=414, Percent_Identity=42.0289855072464, Blast_Score=299, Evalue=8e-82,
Organism=Saccharomyces cerevisiae, GI6322772, Length=417, Percent_Identity=40.0479616306954, Blast_Score=291, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6322939, Length=428, Percent_Identity=42.0560747663551, Blast_Score=281, Evalue=2e-76,
Organism=Saccharomyces cerevisiae, GI6323451, Length=453, Percent_Identity=29.5805739514349, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6323776, Length=258, Percent_Identity=40.6976744186046, Blast_Score=164, Evalue=4e-41,
Organism=Drosophila melanogaster, GI19921728, Length=418, Percent_Identity=41.3875598086124, Blast_Score=319, Evalue=3e-87,
Organism=Drosophila melanogaster, GI20129977, Length=412, Percent_Identity=41.0194174757282, Blast_Score=306, Evalue=2e-83,
Organism=Drosophila melanogaster, GI18859729, Length=409, Percent_Identity=41.5647921760391, Blast_Score=304, Evalue=1e-82,
Organism=Drosophila melanogaster, GI19921526, Length=465, Percent_Identity=40.2150537634409, Blast_Score=297, Evalue=1e-80,
Organism=Drosophila melanogaster, GI19920696, Length=417, Percent_Identity=38.3693045563549, Blast_Score=281, Evalue=5e-76,
Organism=Drosophila melanogaster, GI45550174, Length=419, Percent_Identity=37.4701670644391, Blast_Score=269, Evalue=4e-72,
Organism=Drosophila melanogaster, GI24643238, Length=408, Percent_Identity=35.5392156862745, Blast_Score=241, Evalue=7e-64,
Organism=Drosophila melanogaster, GI24585491, Length=495, Percent_Identity=30.9090909090909, Blast_Score=231, Evalue=8e-61,
Organism=Drosophila melanogaster, GI24642763, Length=404, Percent_Identity=35.3960396039604, Blast_Score=223, Evalue=3e-58,
Organism=Drosophila melanogaster, GI24585920, Length=444, Percent_Identity=33.1081081081081, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI17136342, Length=444, Percent_Identity=32.8828828828829, Blast_Score=207, Evalue=2e-53,
Organism=Drosophila melanogaster, GI17136508, Length=452, Percent_Identity=32.0796460176991, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI24641942, Length=254, Percent_Identity=35.0393700787402, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI17136242, Length=246, Percent_Identity=36.5853658536585, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24641139, Length=195, Percent_Identity=43.0769230769231, Blast_Score=134, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR011709
- InterPro:   IPR007502
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010222 [H]

Pfam domain/function: PF00270 DEAD; PF07717 DUF1605; PF04408 HA2; PF00271 Helicase_C [H]

EC number: =3.6.4.13 [H]

Molecular weight: Translated: 56724; Mature: 56724

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLQQQCRLNDRMRFSDGISPSRYCPNPTKAFAIILFFTAYAPIMFPDFSQTLSKDRHFL
CCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
QSAFKNPNKYGGLSKVEEKYRKSHEIFLKRLAALPKPEFDNTLPVHEKLDEIKKTVAEHQ
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCE
VTIICGETGSGKTTQLPKICLELGRGAAGLIGHTQPRRLAARSVAERIAEELKSEIGSAV
EEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GYKVRFTDHTSRDACVKLMTDGILLAETQTDRYLAAYDTIIIDEAHERSLNIDFLLGYLK
CEEEEECCCCCHHHHHHHHHCCEEEEECCCCCEEEHHHEEEEECHHCCCCCHHHHHHHHH
QLLPRRPDLKVIITSATIDAERFSQHFNGAPVLEVSGRTYPVEILYRPLIGKDEDDAEIE
HHCCCCCCCEEEEEECCCCHHHHHHHCCCCCEEEECCCEEEHHEEEECCCCCCCCCCCEE
LTDAIVDAADELARYGEGDILVFLPGEREIREAAEALRKSTLRRNDEILPLFARLSHAEQ
HHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
HKIFHPSGAKRRIVLATNVAETSLTVPGIKYVIDTGLARVKRYSARAKVEQLHIEKISQA
CCEECCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AARQRSGRCGRVSAGVCIQLFSEENFNNRPEFTDPEIARSNLAAVILRMASLKLGDVAAF
HHHHHCCCCCCCCCCHHEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEECC
PFLEMPDSRYINDGFQVLLELGAVEAA
CCEECCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLQQQCRLNDRMRFSDGISPSRYCPNPTKAFAIILFFTAYAPIMFPDFSQTLSKDRHFL
CCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
QSAFKNPNKYGGLSKVEEKYRKSHEIFLKRLAALPKPEFDNTLPVHEKLDEIKKTVAEHQ
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCE
VTIICGETGSGKTTQLPKICLELGRGAAGLIGHTQPRRLAARSVAERIAEELKSEIGSAV
EEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GYKVRFTDHTSRDACVKLMTDGILLAETQTDRYLAAYDTIIIDEAHERSLNIDFLLGYLK
CEEEEECCCCCHHHHHHHHHCCEEEEECCCCCEEEHHHEEEEECHHCCCCCHHHHHHHHH
QLLPRRPDLKVIITSATIDAERFSQHFNGAPVLEVSGRTYPVEILYRPLIGKDEDDAEIE
HHCCCCCCCEEEEEECCCCHHHHHHHCCCCCEEEECCCEEEHHEEEECCCCCCCCCCCEE
LTDAIVDAADELARYGEGDILVFLPGEREIREAAEALRKSTLRRNDEILPLFARLSHAEQ
HHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
HKIFHPSGAKRRIVLATNVAETSLTVPGIKYVIDTGLARVKRYSARAKVEQLHIEKISQA
CCEECCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AARQRSGRCGRVSAGVCIQLFSEENFNNRPEFTDPEIARSNLAAVILRMASLKLGDVAAF
HHHHHCCCCCCCCCCHHEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEECC
PFLEMPDSRYINDGFQVLLELGAVEAA
CCEECCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7899078; 9097039; 9278503 [H]