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The map label for this gene is mtr [H]

Identifier: 161869171

GI number: 161869171

Start: 170464

End: 171705

Strand: Reverse

Name: mtr [H]

Synonym: NMCC_0168

Alternate gene names: 161869171

Gene position: 171705-170464 (Counterclockwise)

Preceding gene: 161869174

Following gene: 161869170

Centisome position: 7.97

GC content: 56.92

Gene sequence:

>1242_bases
ATGCCCACCAAAACCCCTTCACTGTTCGGCGGCGCGATGATTATCGCCGGCACGGTCATCGGCGCAGGTATGCTCGCCAA
CCCGACCGCCACATCCGGCGTATGGTTTACCGGCTCGCTGGCCGTGTTGCTGTACACCTGGTTTTCCATGCTCTCCAGCG
GCCTGATGATTTTGGAAGTCAACACCCACTACCCCCACGGCGCGAGCTTCGACACCATGGTTAAAGACCTGCTCGGACGG
AGCTGGAACATCATCAACGGCATCGCCGTCGCCTTCGTTTTATACCTGCTTACTTACGCTTATATCTTCGTCGGCGGCGA
CCTGACCGCCAAAGGCTTAGGCAGCGCGGCAGGCGGCAATGTTTCACTCACCGTCGGACAACTCGTCTTCTTCGGCATTC
TCGCCTTTTGCGTATGGGCATCCGCACGCTTGGTCGACCGATTCACCAGCGTCCTCATCGGCGGCATGGTATTAACCTTT
ATTTGGGCAACCGGCGGCCTGATTGCCGATGCCAAACTGCCCGTCCTCTTCGACACCCAAGCCCCTACCGGCACCAACTA
CTGGATTTATGTCGCCACCGCCCTGCCCGTCTGCCTTGCGTCATTCGGTTTCCACGGCAACGTCTCCAGCCTGCTCAAAT
ACTTTAAAGGCGACGCGCCCAAAGTGGCTAAATCCATCTGGACGGGCACACTGATTGCGCTGGTAATTTACGTCCTCTGG
CAAACCGCCATCCAAGGCAACCTGCCGCGCAACGAGTTCGCCCCCGTGATTGCCGCCGAAGGGCAAGTCTCCGTCCTGAT
TGAAACCCTGTCCAAATTCGCCCAAACCGGCAATATGGACAAAATATTGTCCCTGTTTTCCTATATGGCGATCGCCACCT
CGTTTTTAGGCGTAACGCTCGGACTCTTCGACTACATCGCCGACATCTTCAAATGGAACGACAGCGTGTCCGGCCGCACC
AAAACCGCCGCGCTGACCTTCCTGCCGCCTCTAATTTCCTGCCTGCTCTTCCCCACCGGCTTTGTTACCGCCATCGGCTA
CGTCGGCCTGGCGGCAACCGTCTGGACAGGCATCATCCCCGCCATGCTGCTCTACCGTTCGCGCAAAAAATTCGGCGCAG
GCAAAACCTATAAAGTTTACGGCGGCTTGTGGCTGATGGTTTGGGTCTTCCTTTTCGGCATCGTCAACATCGCCGCACAG
GTATTGAGCCAAATGGAACTCGTCCCCGTATTTAAAGGATAA

Upstream 100 bases:

>100_bases
CGTCTGAAAGCCTTTTCGGGCGGCGCGGCGCAAATACCTTACAAATCCTTACACTTTACGGCATAATGGCGGCTCGCTTT
TTCTGGCAGAAAGACAAAAT

Downstream 100 bases:

>100_bases
AGGCAAAATGCCGTCTGAACGAGTTTTCAGACGGCATTTTCGCAACCGTTGCAGCCATGCGGCAAAAAGCTAACGGGCAA
TTTTCAAAACGTCGTACAGA

Product: amino-acid transport protein

Products: Indole [Cytoplasm]; L-tryptophan [Cytoplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Tryptophan permease [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MPTKTPSLFGGAMIIAGTVIGAGMLANPTATSGVWFTGSLAVLLYTWFSMLSSGLMILEVNTHYPHGASFDTMVKDLLGR
SWNIINGIAVAFVLYLLTYAYIFVGGDLTAKGLGSAAGGNVSLTVGQLVFFGILAFCVWASARLVDRFTSVLIGGMVLTF
IWATGGLIADAKLPVLFDTQAPTGTNYWIYVATALPVCLASFGFHGNVSSLLKYFKGDAPKVAKSIWTGTLIALVIYVLW
QTAIQGNLPRNEFAPVIAAEGQVSVLIETLSKFAQTGNMDKILSLFSYMAIATSFLGVTLGLFDYIADIFKWNDSVSGRT
KTAALTFLPPLISCLLFPTGFVTAIGYVGLAATVWTGIIPAMLLYRSRKKFGAGKTYKVYGGLWLMVWVFLFGIVNIAAQ
VLSQMELVPVFKG

Sequences:

>Translated_413_residues
MPTKTPSLFGGAMIIAGTVIGAGMLANPTATSGVWFTGSLAVLLYTWFSMLSSGLMILEVNTHYPHGASFDTMVKDLLGR
SWNIINGIAVAFVLYLLTYAYIFVGGDLTAKGLGSAAGGNVSLTVGQLVFFGILAFCVWASARLVDRFTSVLIGGMVLTF
IWATGGLIADAKLPVLFDTQAPTGTNYWIYVATALPVCLASFGFHGNVSSLLKYFKGDAPKVAKSIWTGTLIALVIYVLW
QTAIQGNLPRNEFAPVIAAEGQVSVLIETLSKFAQTGNMDKILSLFSYMAIATSFLGVTLGLFDYIADIFKWNDSVSGRT
KTAALTFLPPLISCLLFPTGFVTAIGYVGLAATVWTGIIPAMLLYRSRKKFGAGKTYKVYGGLWLMVWVFLFGIVNIAAQ
VLSQMELVPVFKG
>Mature_412_residues
PTKTPSLFGGAMIIAGTVIGAGMLANPTATSGVWFTGSLAVLLYTWFSMLSSGLMILEVNTHYPHGASFDTMVKDLLGRS
WNIINGIAVAFVLYLLTYAYIFVGGDLTAKGLGSAAGGNVSLTVGQLVFFGILAFCVWASARLVDRFTSVLIGGMVLTFI
WATGGLIADAKLPVLFDTQAPTGTNYWIYVATALPVCLASFGFHGNVSSLLKYFKGDAPKVAKSIWTGTLIALVIYVLWQ
TAIQGNLPRNEFAPVIAAEGQVSVLIETLSKFAQTGNMDKILSLFSYMAIATSFLGVTLGLFDYIADIFKWNDSVSGRTK
TAALTFLPPLISCLLFPTGFVTAIGYVGLAATVWTGIIPAMLLYRSRKKFGAGKTYKVYGGLWLMVWVFLFGIVNIAAQV
LSQMELVPVFKG

Specific function: Involved in transporting tryptophan across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789552, Length=408, Percent_Identity=47.0588235294118, Blast_Score=346, Evalue=2e-96,
Organism=Escherichia coli, GI1790145, Length=409, Percent_Identity=43.520782396088, Blast_Score=317, Evalue=1e-87,
Organism=Escherichia coli, GI1788218, Length=400, Percent_Identity=37, Blast_Score=227, Evalue=1e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 44254; Mature: 44123

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: PS00594 AROMATIC_AA_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTKTPSLFGGAMIIAGTVIGAGMLANPTATSGVWFTGSLAVLLYTWFSMLSSGLMILEV
CCCCCCCHHCCHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCEEEEEE
NTHYPHGASFDTMVKDLLGRSWNIINGIAVAFVLYLLTYAYIFVGGDLTAKGLGSAAGGN
ECCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
VSLTVGQLVFFGILAFCVWASARLVDRFTSVLIGGMVLTFIWATGGLIADAKLPVLFDTQ
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEECC
APTGTNYWIYVATALPVCLASFGFHGNVSSLLKYFKGDAPKVAKSIWTGTLIALVIYVLW
CCCCCCEEEEHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
QTAIQGNLPRNEFAPVIAAEGQVSVLIETLSKFAQTGNMDKILSLFSYMAIATSFLGVTL
HHHHCCCCCCHHCCCEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
GLFDYIADIFKWNDSVSGRTKTAALTFLPPLISCLLFPTGFVTAIGYVGLAATVWTGIIP
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMLLYRSRKKFGAGKTYKVYGGLWLMVWVFLFGIVNIAAQVLSQMELVPVFKG
HHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PTKTPSLFGGAMIIAGTVIGAGMLANPTATSGVWFTGSLAVLLYTWFSMLSSGLMILEV
CCCCCCHHCCHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCEEEEEE
NTHYPHGASFDTMVKDLLGRSWNIINGIAVAFVLYLLTYAYIFVGGDLTAKGLGSAAGGN
ECCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
VSLTVGQLVFFGILAFCVWASARLVDRFTSVLIGGMVLTFIWATGGLIADAKLPVLFDTQ
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEECC
APTGTNYWIYVATALPVCLASFGFHGNVSSLLKYFKGDAPKVAKSIWTGTLIALVIYVLW
CCCCCCEEEEHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
QTAIQGNLPRNEFAPVIAAEGQVSVLIETLSKFAQTGNMDKILSLFSYMAIATSFLGVTL
HHHHCCCCCCHHCCCEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
GLFDYIADIFKWNDSVSGRTKTAALTFLPPLISCLLFPTGFVTAIGYVGLAATVWTGIIP
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMLLYRSRKKFGAGKTYKVYGGLWLMVWVFLFGIVNIAAQVLSQMELVPVFKG
HHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Indole [Periplasm]; L-tryptophan [Periplasm]; Proton [Periplasm] [C]

Specific reaction: Proton [Periplasm] + indole [Periplasm] = Proton [Cytoplasm] + indole [Cytoplasm] L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]