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The map label for this gene is hpt [H]

Identifier: 161869145

GI number: 161869145

Start: 140294

End: 140896

Strand: Direct

Name: hpt [H]

Synonym: NMCC_0139

Alternate gene names: 161869145

Gene position: 140294-140896 (Clockwise)

Preceding gene: 161869144

Following gene: 161869146

Centisome position: 6.51

GC content: 54.23

Gene sequence:

>603_bases
TTGGTTTATAATTTTCCTTTTACCGACCGATTCCGACATATGACCGATTTAGAAACCAAACGCCTTGAAACACAGGCGAT
GCTTGAAAACGCCGAGCTTTTGTTCGACCAAGGCCAATGCCGTGCCGCACTGCAAAAAGTGGCGGACGAGATTACGCGCG
ATTTGGGCGGCAAATATCCGCTGCTGCTGCCCGTGATGGGCGGCGCGGTGGTGTTTACGGGGCAGTTGCTGCCGCTGTTG
CGTTTTCCCTTAGATTTTGATTATGTTCACGTTTCCCGTTACGGCGACAAGCTGGAGGGCGGCGCGTTCAACTGGAAGCG
TATGCCCGATGCGGAACAAATCCGGGGCAGGCACGTCGTCGTGCTGGACGATATTTTGGACGAAGGGCATACGATGTCCG
CCATTCAAGCCAAACTTTTGGAAATGGGTGCGGCAAGCTGCCGTGCGGCGGTGTTCGCCAACAAGCTGATCGACAAACCC
AAGCCTATCCGAGCCGATTATGTCGGACTGGCTGTGCCGAACCGTTATGTTTTCGGTTACGGCATGGATGCGGCAGGCTG
CTGGCGCAATTTGGGCGAGATTTACGCATTGGACGGAAAATAA

Upstream 100 bases:

>100_bases
GCTACCGTGGTTTTACGCGGAAAGGCACGCCGAAATTCGCCACGTTTGTGCGCGCGCGTACCGACCGCTGAGCAGGACAG
TTCAGACGGCATCCGATACT

Downstream 100 bases:

>100_bases
GGATGCAATGCCGTCTGAAGGCCTTTCAGACGGCATTGCGCCCATACGCCGGCAGGACAACGAGGAACAGGACGCATAAT
ATGATAGGGCTTTTAATCAT

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MVYNFPFTDRFRHMTDLETKRLETQAMLENAELLFDQGQCRAALQKVADEITRDLGGKYPLLLPVMGGAVVFTGQLLPLL
RFPLDFDYVHVSRYGDKLEGGAFNWKRMPDAEQIRGRHVVVLDDILDEGHTMSAIQAKLLEMGAASCRAAVFANKLIDKP
KPIRADYVGLAVPNRYVFGYGMDAAGCWRNLGEIYALDGK

Sequences:

>Translated_200_residues
MVYNFPFTDRFRHMTDLETKRLETQAMLENAELLFDQGQCRAALQKVADEITRDLGGKYPLLLPVMGGAVVFTGQLLPLL
RFPLDFDYVHVSRYGDKLEGGAFNWKRMPDAEQIRGRHVVVLDDILDEGHTMSAIQAKLLEMGAASCRAAVFANKLIDKP
KPIRADYVGLAVPNRYVFGYGMDAAGCWRNLGEIYALDGK
>Mature_200_residues
MVYNFPFTDRFRHMTDLETKRLETQAMLENAELLFDQGQCRAALQKVADEITRDLGGKYPLLLPVMGGAVVFTGQLLPLL
RFPLDFDYVHVSRYGDKLEGGAFNWKRMPDAEQIRGRHVVVLDDILDEGHTMSAIQAKLLEMGAASCRAAVFANKLIDKP
KPIRADYVGLAVPNRYVFGYGMDAAGCWRNLGEIYALDGK

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=159, Percent_Identity=21.3836477987421, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI87081689, Length=179, Percent_Identity=24.5810055865922, Blast_Score=66, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17510817, Length=172, Percent_Identity=25.5813953488372, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 22445; Mature: 22445

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVYNFPFTDRFRHMTDLETKRLETQAMLENAELLFDQGQCRAALQKVADEITRDLGGKYP
CEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCC
LLLPVMGGAVVFTGQLLPLLRFPLDFDYVHVSRYGDKLEGGAFNWKRMPDAEQIRGRHVV
EEEEECCCCEEEHHHHHHHHHCCCCCCEEEHHHCCCCCCCCCCCCCCCCCHHHHCCCEEE
VLDDILDEGHTMSAIQAKLLEMGAASCRAAVFANKLIDKPKPIRADYVGLAVPNRYVFGY
EEHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEE
GMDAAGCWRNLGEIYALDGK
CCCHHHHHHCCCCEEEECCC
>Mature Secondary Structure
MVYNFPFTDRFRHMTDLETKRLETQAMLENAELLFDQGQCRAALQKVADEITRDLGGKYP
CEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCC
LLLPVMGGAVVFTGQLLPLLRFPLDFDYVHVSRYGDKLEGGAFNWKRMPDAEQIRGRHVV
EEEEECCCCEEEHHHHHHHHHCCCCCCEEEHHHCCCCCCCCCCCCCCCCCHHHHCCCEEE
VLDDILDEGHTMSAIQAKLLEMGAASCRAAVFANKLIDKPKPIRADYVGLAVPNRYVFGY
EEHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEE
GMDAAGCWRNLGEIYALDGK
CCCHHHHHHCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]