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The map label for this gene is hemK [H]

Identifier: 161869127

GI number: 161869127

Start: 121834

End: 122538

Strand: Direct

Name: hemK [H]

Synonym: NMCC_0121

Alternate gene names: 161869127

Gene position: 121834-122538 (Clockwise)

Preceding gene: 161869126

Following gene: 161869128

Centisome position: 5.66

GC content: 59.01

Gene sequence:

>705_bases
ATGCCGGACGAAGTCCGACAGCGGGCGGACAGGCTGGCGCAATGCCGTCTGAACGGCGAGCCGGTTGCCTATATTTTAGG
TGTGCGCGAATTTTATGGCAGACGCTTTACAGTCAATCCGAGCGTGCTGATTCCGCGCCCCGAAACCGAACATTTGGTCG
AAGCCGTATTGGCGCGCCTGCCCGAAAACGGGCGCGTGTGGGATTTGGGGACGGGCAGCGGCGCGGTTGCCGTAACCGTC
GCGCTCGAACGCCCCGATGCGTTTGTGCGCGCATCCGACATCAGCCCGCCCGCCCTTGAAACGGCGCGGGAAAATGCGGC
GGATTTGGGCGCGCGGGTCGAATTTGCACACGGTTCGTGGTTCGACACCGATATGCCGTCTGAAGGGAAATGGGACATCA
TCGTGTCCAACCCGCCCTATATCGAAAACGGCGATAAACATTTGTTGCAAGGCGATTTGCGGTTTGAGCCGCAAATCGCG
CTGACCGACTTTTCAGACGGCCTAAGCTGCATCCGTACCTTGGCGCAAGGCGCGCCCGACCGTTTGGCGGAAGGCGGTTT
TTTATTGCTGGAACACGGTTTCGATCAGGGCGCGGCGGTGCGCGGCGTGTTGGCGGAGAATGGTTTTTCAGGAGTGGAAA
CCCTGCCGGATTTGGCGGGTTTGGACAGGGTTACGCTGGGGAAGTATATGAAGCATTTGAAATAA

Upstream 100 bases:

>100_bases
GTTGGGCTTGTCAAAACTGCCTAAAATTGAAGCAAGAATGCTGCTGCAATATGTTTCGGAATATACGCGCGTGCAGTTGT
TGACGCGGGGCGGGGAAGAA

Downstream 100 bases:

>100_bases
TTGTTTGCAAAATTGGCGGGTTTCCCGTTATTGGGTTATGATGTGTTTCGATATGTAAACATTTATAGGTTTGGAGCGAT
AAACAATGAATGCAGTCGTA

Product: HemK protein

Products: NA

Alternate protein names: M.VchAHemK2P [H]

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MPDEVRQRADRLAQCRLNGEPVAYILGVREFYGRRFTVNPSVLIPRPETEHLVEAVLARLPENGRVWDLGTGSGAVAVTV
ALERPDAFVRASDISPPALETARENAADLGARVEFAHGSWFDTDMPSEGKWDIIVSNPPYIENGDKHLLQGDLRFEPQIA
LTDFSDGLSCIRTLAQGAPDRLAEGGFLLLEHGFDQGAAVRGVLAENGFSGVETLPDLAGLDRVTLGKYMKHLK

Sequences:

>Translated_234_residues
MPDEVRQRADRLAQCRLNGEPVAYILGVREFYGRRFTVNPSVLIPRPETEHLVEAVLARLPENGRVWDLGTGSGAVAVTV
ALERPDAFVRASDISPPALETARENAADLGARVEFAHGSWFDTDMPSEGKWDIIVSNPPYIENGDKHLLQGDLRFEPQIA
LTDFSDGLSCIRTLAQGAPDRLAEGGFLLLEHGFDQGAAVRGVLAENGFSGVETLPDLAGLDRVTLGKYMKHLK
>Mature_233_residues
PDEVRQRADRLAQCRLNGEPVAYILGVREFYGRRFTVNPSVLIPRPETEHLVEAVLARLPENGRVWDLGTGSGAVAVTVA
LERPDAFVRASDISPPALETARENAADLGARVEFAHGSWFDTDMPSEGKWDIIVSNPPYIENGDKHLLQGDLRFEPQIAL
TDFSDGLSCIRTLAQGAPDRLAEGGFLLLEHGFDQGAAVRGVLAENGFSGVETLPDLAGLDRVTLGKYMKHLK

Specific function: Probable protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=200, Percent_Identity=34.5, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI1787463, Length=233, Percent_Identity=45.0643776824034, Blast_Score=187, Evalue=4e-49,
Organism=Escherichia coli, GI87082085, Length=177, Percent_Identity=36.7231638418079, Blast_Score=97, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24582226, Length=204, Percent_Identity=30.8823529411765, Blast_Score=84, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR019874
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 2.1.1.-

Molecular weight: Translated: 25545; Mature: 25414

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDEVRQRADRLAQCRLNGEPVAYILGVREFYGRRFTVNPSVLIPRPETEHLVEAVLARL
CCHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHCCEEECCCCEEECCCCHHHHHHHHHHHC
PENGRVWDLGTGSGAVAVTVALERPDAFVRASDISPPALETARENAADLGARVEFAHGSW
CCCCCEEEECCCCCEEEEEEEEECCCCEEEECCCCCHHHHHHHHHHHHCCCEEEECCCCC
FDTDMPSEGKWDIIVSNPPYIENGDKHLLQGDLRFEPQIALTDFSDGLSCIRTLAQGAPD
CCCCCCCCCCEEEEECCCCCCCCCCCEEEECCCEECCEEEEECCHHHHHHHHHHHCCCCH
RLAEGGFLLLEHGFDQGAAVRGVLAENGFSGVETLPDLAGLDRVTLGKYMKHLK
HHHCCCEEEEECCCCCCCCEEEHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHCC
>Mature Secondary Structure 
PDEVRQRADRLAQCRLNGEPVAYILGVREFYGRRFTVNPSVLIPRPETEHLVEAVLARL
CHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHCCEEECCCCEEECCCCHHHHHHHHHHHC
PENGRVWDLGTGSGAVAVTVALERPDAFVRASDISPPALETARENAADLGARVEFAHGSW
CCCCCEEEECCCCCEEEEEEEEECCCCEEEECCCCCHHHHHHHHHHHHCCCEEEECCCCC
FDTDMPSEGKWDIIVSNPPYIENGDKHLLQGDLRFEPQIALTDFSDGLSCIRTLAQGAPD
CCCCCCCCCCEEEEECCCCCCCCCCCEEEECCCEECCEEEEECCHHHHHHHHHHHCCCCH
RLAEGGFLLLEHGFDQGAAVRGVLAENGFSGVETLPDLAGLDRVTLGKYMKHLK
HHHCCCEEEEECCCCCCCCEEEHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]