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The map label for this gene is galE2 [H]

Identifier: 161869096

GI number: 161869096

Start: 84655

End: 85296

Strand: Direct

Name: galE2 [H]

Synonym: NMCC_0086

Alternate gene names: 161869096

Gene position: 84655-85296 (Clockwise)

Preceding gene: 161869095

Following gene: 161869097

Centisome position: 3.93

GC content: 54.05

Gene sequence:

>642_bases
ATGCGTCGCGCCATGATACGTAAAATGCCCTATACGGAAGATATGCGCCCGGGCGATACCGCTAATCCTTATGGCGCATC
CAAAGCGATGGTGGAACGGATGTTAACCGACATCCAAAAGGCCGATCCGCGTTGGAGCGTGATTTTGTTGCGCTATTTCA
ACCCGATTGGGGCGCACGAAAGCGGCTTGATCGGCGAACAGCCCAACGGTATTCCCAACAACCTTTTGCCCTATATCTGC
CAAGTGGCTTCGGGCAGGCTGCCGCAACTGTCGGTATTCGGCGGCGATTATCCGACCCCCGACGGTACGGGAATGCGCGA
CTACATTCATGTGATGGATTTGGCAGAAGGCCATGTCGCGGCTATGCAGGCAAAAAGTAATGTAGCAGGCACGCATTTGT
TGAACTTAGGTTCCGGTCGCGCTTCTTCGGTGTTGGAAATCATCCGCGCATTTGAAGCGGCTTCGGGTTTGACGATTCCG
TATGAAGTCAAACCGCGCCGTGCCGGTGATTTGGCGTGCTTCTATGCCGACCCTTCCTATACAAAGGCGCAAATCGGCTG
GCAAACCCAGCGTGATTTGGCGCAGATGATGGAAGACTCATGGCGTTGGGTCAGCAACAACCCAAATGGCTACGACGATT
AA

Upstream 100 bases:

>100_bases
AAAATTCTATTTTCACGATGAATACCAACAACTTGATTTGTAACGTAAAAATATAGGGAAACTGGATAACCAGTATAAAC
GCGCTTTGGCGTTTACTTTA

Downstream 100 bases:

>100_bases
GTTGACCTGATACAGGCCGTCTGAAAGAGATGTTTTCAGACGGCCTCTTTATCTGAAAAACACACATTCTGTCTGCTATA
ATCTGTTTATATTTTTTGGC

Product: UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MRRAMIRKMPYTEDMRPGDTANPYGASKAMVERMLTDIQKADPRWSVILLRYFNPIGAHESGLIGEQPNGIPNNLLPYIC
QVASGRLPQLSVFGGDYPTPDGTGMRDYIHVMDLAEGHVAAMQAKSNVAGTHLLNLGSGRASSVLEIIRAFEAASGLTIP
YEVKPRRAGDLACFYADPSYTKAQIGWQTQRDLAQMMEDSWRWVSNNPNGYDD

Sequences:

>Translated_213_residues
MRRAMIRKMPYTEDMRPGDTANPYGASKAMVERMLTDIQKADPRWSVILLRYFNPIGAHESGLIGEQPNGIPNNLLPYIC
QVASGRLPQLSVFGGDYPTPDGTGMRDYIHVMDLAEGHVAAMQAKSNVAGTHLLNLGSGRASSVLEIIRAFEAASGLTIP
YEVKPRRAGDLACFYADPSYTKAQIGWQTQRDLAQMMEDSWRWVSNNPNGYDD
>Mature_213_residues
MRRAMIRKMPYTEDMRPGDTANPYGASKAMVERMLTDIQKADPRWSVILLRYFNPIGAHESGLIGEQPNGIPNNLLPYIC
QVASGRLPQLSVFGGDYPTPDGTGMRDYIHVMDLAEGHVAAMQAKSNVAGTHLLNLGSGRASSVLEIIRAFEAASGLTIP
YEVKPRRAGDLACFYADPSYTKAQIGWQTQRDLAQMMEDSWRWVSNNPNGYDD

Specific function: Plays an essential role in the incorporation of galactose into meningococcal lipopolysaccharide surface molecules, which are important for pathogenesis [H]

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=203, Percent_Identity=52.2167487684729, Blast_Score=231, Evalue=3e-61,
Organism=Homo sapiens, GI56118217, Length=203, Percent_Identity=52.2167487684729, Blast_Score=231, Evalue=3e-61,
Organism=Homo sapiens, GI189083684, Length=203, Percent_Identity=52.2167487684729, Blast_Score=231, Evalue=3e-61,
Organism=Escherichia coli, GI1786974, Length=206, Percent_Identity=54.8543689320388, Blast_Score=248, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI71982035, Length=207, Percent_Identity=48.3091787439614, Blast_Score=219, Evalue=6e-58,
Organism=Caenorhabditis elegans, GI71982038, Length=207, Percent_Identity=48.3091787439614, Blast_Score=219, Evalue=6e-58,
Organism=Saccharomyces cerevisiae, GI6319493, Length=208, Percent_Identity=49.0384615384615, Blast_Score=204, Evalue=1e-53,
Organism=Drosophila melanogaster, GI19923002, Length=205, Percent_Identity=53.6585365853659, Blast_Score=243, Evalue=8e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 23596; Mature: 23596

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRAMIRKMPYTEDMRPGDTANPYGASKAMVERMLTDIQKADPRWSVILLRYFNPIGAHE
CCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCC
SGLIGEQPNGIPNNLLPYICQVASGRLPQLSVFGGDYPTPDGTGMRDYIHVMDLAEGHVA
CCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCHHH
AMQAKSNVAGTHLLNLGSGRASSVLEIIRAFEAASGLTIPYEVKPRRAGDLACFYADPSY
HHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEECCCCC
TKAQIGWQTQRDLAQMMEDSWRWVSNNPNGYDD
CEECCCCCHHHHHHHHHHHHCEEECCCCCCCCC
>Mature Secondary Structure
MRRAMIRKMPYTEDMRPGDTANPYGASKAMVERMLTDIQKADPRWSVILLRYFNPIGAHE
CCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCC
SGLIGEQPNGIPNNLLPYICQVASGRLPQLSVFGGDYPTPDGTGMRDYIHVMDLAEGHVA
CCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCHHH
AMQAKSNVAGTHLLNLGSGRASSVLEIIRAFEAASGLTIPYEVKPRRAGDLACFYADPSY
HHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEECCCCC
TKAQIGWQTQRDLAQMMEDSWRWVSNNPNGYDD
CEECCCCCHHHHHHHHHHHHCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]