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The map label for this gene is mltA [H]

Identifier: 161869051

GI number: 161869051

Start: 28454

End: 29788

Strand: Reverse

Name: mltA [H]

Synonym: NMCC_0034

Alternate gene names: 161869051

Gene position: 29788-28454 (Counterclockwise)

Preceding gene: 161869055

Following gene: 161869049

Centisome position: 1.38

GC content: 58.88

Gene sequence:

>1335_bases
TTGTCCATTATGAAAAAATACCTGTTCCGCGCCGCCCTGTGCGGCATCGCCGCCGCCATCCTCGCCGCCTGCCAAAGCAA
GAGCATCCAAACCTTTCCGCAACCCGACACATCCGTCATCAACGGCCCGGACCGGCCGGTCGGCATCCCCGACCCCGCCG
GAACGACGGTCGGCGGCGGCGGGGCCGTTTATACCGTTGTGCCGCACCTGTCCCTGCCCCACTGGGCGGCGCAGGATTTC
GCCAAAAGCCTGCAATCCTTCCGCCTCGGCTGCGCCAATTTGAAAAACCGCCAAGGCTGGCAGGATGTGTGCGCCCAAGC
CTTTCAAACCCCCGTCCATTCCTTTCAGGCAAAACAGTTTTTTGAACGCTATTTCACGCCGTGGCAGGTTGCAGGCAACG
GAAGCCTTGCCGGTACGGTTACCGGCTATTACGAGCCGGTGCTGAAGGGCGACGACAGGCGGACGGCACAAGCCCGCTTC
CCGATTTACGGTATTCCCGACGATTTTATCTCCGTCCCCCTGCCTGCCGGTTTGCGGAGCGGAAAAGCCCTTGTCCGCAT
CAGGCAGACGGGAAAAAACAGCGGCACAATCGACAATACCGGCGGCACACATACCGCCGACCTCTCCCAATTCCCCATCA
CTGCGCGCACAACGGCAATCAAAGGCAGGTTTGAAGGAAGCCGCTTCCTCCCCTACCACACGCGCAACCAAATCAACGGC
GGCGCGCTTGACGGCAAAGCACCGATACTCGGTTACGCCGAAGACCCTGTCGAACTTTTTTTTATGCACATCCAAGGCTC
GGGCCGTCTGAAAACCCCGTCCGGCAAATACATCCGCATCGGCTATGCCGACAAAAACGAGCATCCGTATGTTTCCATCG
GAAAATACATGGCGGATAAGGGCTACCTCAAACTCGGACAAACCTCCATGCAGGGCATTAAGTCTTATATGCGGCAAAAT
CCGCAACGCCTCGCCGAAGTTTTGGGTCAAAACCCCAGCTATATCTTTTTCCGAGAGCTTACCGGAAGCAGCAATGACGG
CCCTGTCGGCGCACTGGGCACGCCGCTGATGGGCGAGTACGCCGGCGCAGTCGACCGGCACTACATTACCCTTGGCGCGC
CCTTATTTGTCGCCACCGCCCATCCGGTTACCCGCAAAGCCCTCAACCGCCTGATTATGGCGCAGGATACCGGCAGCGCG
ATTAAAGGCGCGGTGCGCGTGGATTATTTCTGGGGTTACGGCGACGAAGCCGGCGAACTTGCCGGCAAACAGAAAACCAC
GGGATATGTCTGGCAACTTCTGCCCAACGGTATGAAGCCCGAATACCGCCCGTAA

Upstream 100 bases:

>100_bases
GTTCCGCAGGCTGCAGCTGCGCCCTGTGTTAAAATCCCCTCTCCACGGCTGCCGCAACGCCGCCCGAAACCATCTTTTTT
TTTTATTACTGCCGGCAACA

Downstream 100 bases:

>100_bases
ACCGGAAAACAATGCCATCTGAAGCCCATCCCTAGGCAATCGGGCGCATTAAGGCGAAGTTTTGCAATACCGCAGGCACA
AAATTCCTTTCTTATTTGAC

Product: membrane-bound lytic murein transglycosylase

Products: Muramic Acid Residue [C]

Alternate protein names: Mlt38; Murein hydrolase A [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MSIMKKYLFRAALCGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDPAGTTVGGGGAVYTVVPHLSLPHWAAQDF
AKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARF
PIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNTGGTHTADLSQFPITARTTAIKGRFEGSRFLPYHTRNQING
GALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGKYMADKGYLKLGQTSMQGIKSYMRQN
PQRLAEVLGQNPSYIFFRELTGSSNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSA
IKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP

Sequences:

>Translated_444_residues
MSIMKKYLFRAALCGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDPAGTTVGGGGAVYTVVPHLSLPHWAAQDF
AKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARF
PIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNTGGTHTADLSQFPITARTTAIKGRFEGSRFLPYHTRNQING
GALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGKYMADKGYLKLGQTSMQGIKSYMRQN
PQRLAEVLGQNPSYIFFRELTGSSNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSA
IKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP
>Mature_443_residues
SIMKKYLFRAALCGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDPAGTTVGGGGAVYTVVPHLSLPHWAAQDFA
KSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFP
IYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNTGGTHTADLSQFPITARTTAIKGRFEGSRFLPYHTRNQINGG
ALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGKYMADKGYLKLGQTSMQGIKSYMRQNP
QRLAEVLGQNPSYIFFRELTGSSNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAI
KGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=440, Percent_Identity=27.9545454545455, Blast_Score=105, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 48254; Mature: 48122

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIMKKYLFRAALCGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDPAGTTVGGG
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCC
GAVYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQF
CEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
FERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRS
HHHHCCCEEEECCCCEEEEECHHCCHHHCCCCCCCHHCCCCEECCCHHHHCCCCCCCCCC
GKALVRIRQTGKNSGTIDNTGGTHTADLSQFPITARTTAIKGRFEGSRFLPYHTRNQING
CCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCEECCCCCCCCCCC
GALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGKYMADK
CCCCCCCCEEECCCCCEEEEEEEEECCCEEECCCCCEEEEEECCCCCCCEEEHHHHHCCC
GYLKLGQTSMQGIKSYMRQNPQRLAEVLGQNPSYIFFRELTGSSNDGPVGALGTPLMGEY
CCEEECHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHH
AGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGEL
HCHHCCEEEEECCCEEEEECCHHHHHHHHHHEEECCCCCHHCCEEEEEEEECCCCCHHHH
AGKQKTTGYVWQLLPNGMKPEYRP
CCCCCCCCHHEEECCCCCCCCCCC
>Mature Secondary Structure 
SIMKKYLFRAALCGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDPAGTTVGGG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCC
GAVYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQF
CEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
FERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRS
HHHHCCCEEEECCCCEEEEECHHCCHHHCCCCCCCHHCCCCEECCCHHHHCCCCCCCCCC
GKALVRIRQTGKNSGTIDNTGGTHTADLSQFPITARTTAIKGRFEGSRFLPYHTRNQING
CCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCEECCCCCCCCCCC
GALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGKYMADK
CCCCCCCCEEECCCCCEEEEEEEEECCCEEECCCCCEEEEEECCCCCCCEEEHHHHHCCC
GYLKLGQTSMQGIKSYMRQNPQRLAEVLGQNPSYIFFRELTGSSNDGPVGALGTPLMGEY
CCEEECHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHH
AGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGEL
HCHHCCEEEEECCCEEEEECCHHHHHHHHHHEEECCCCCHHCCEEEEEEEECCCCCHHHH
AGKQKTTGYVWQLLPNGMKPEYRP
CCCCCCCCHHEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]