BacMap

Definition	Neisseria meningitidis 053442, complete genome.
Accession	NC_010120
Length	2,153,416

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The map label for this gene is fbp [H]

Identifier: 161869045

GI number: 161869045

Start: 21339

End: 21668

Strand: Reverse

Name: fbp [H]

Synonym: NMCC_0028

Alternate gene names: 161869045

Gene position: 21668-21339 (Counterclockwise)

Preceding gene: 161869046

Following gene: 161869044

Centisome position: 1.01

GC content: 55.15

Gene sequence:

>330_bases
ATGGGCAGCCTGATTATTGAAGATTTGCAGGAAGGCTTCGGAAAAGAAGCAGTTAAAGGCAAAGAGATTACCGTGCATTA
CACAGGTTGGCTGGAAGACGGTACCAAATTCGACTCCAGCCTCGACCGCCGCCAGCCGCTGACCATCACGCTCGGCGTCG
GACAAGTCATCAAAGGCTGGGACGAAGGCTTCGGCGGAATGAAGGAAGGCGGCAAACGCAAGCTGACCATCCCTTCGGAA
ATGGGCTACGGCGCACACGGTGCCGGCGGCGTGATTCCCCCGCACGCCACTTTGATATTTGAAGTCGAGCTGCTGAAAGT
GTACGAATAA

Upstream 100 bases:

>100_bases
TTCAGCTGCACCGGAGCAGCTGACGTTTGAGCGGCATTTGACTTCGCCGGACGGTATGTTACCCTTGCCGTTTTAACCAA
CAAGCAACGAAAGGACAAAT

Downstream 100 bases:

>100_bases
AGCTGCCCGGGCAATACCGTCTGACATAATGGCTTCAAGCGGCGTAAACAACGAAATCAAAGGCAAAAAACTCTCCCTGT
GGGCCAAGCGTCAAGACGGT

Product: peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase [H]

Number of amino acids: Translated: 109; Mature: 108

Protein sequence:

>109_residues
MGSLIIEDLQEGFGKEAVKGKEITVHYTGWLEDGTKFDSSLDRRQPLTITLGVGQVIKGWDEGFGGMKEGGKRKLTIPSE
MGYGAHGAGGVIPPHATLIFEVELLKVYE

Sequences:

>Translated_109_residues
MGSLIIEDLQEGFGKEAVKGKEITVHYTGWLEDGTKFDSSLDRRQPLTITLGVGQVIKGWDEGFGGMKEGGKRKLTIPSE
MGYGAHGAGGVIPPHATLIFEVELLKVYE
>Mature_108_residues
GSLIIEDLQEGFGKEAVKGKEITVHYTGWLEDGTKFDSSLDRRQPLTITLGVGQVIKGWDEGFGGMKEGGKRKLTIPSEM
GYGAHGAGGVIPPHATLIFEVELLKVYE

Specific function: PPIases accelerate the folding of proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm And Periplasmic Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI206725530, Length=89, Percent_Identity=65.1685393258427, Blast_Score=115, Evalue=1e-26,
Organism=Homo sapiens, GI17149844, Length=89, Percent_Identity=65.1685393258427, Blast_Score=115, Evalue=1e-26,
Organism=Homo sapiens, GI17149842, Length=89, Percent_Identity=65.1685393258427, Blast_Score=115, Evalue=1e-26,
Organism=Homo sapiens, GI17149836, Length=103, Percent_Identity=52.4271844660194, Blast_Score=107, Evalue=3e-24,
Organism=Homo sapiens, GI4503725, Length=103, Percent_Identity=52.4271844660194, Blast_Score=107, Evalue=3e-24,
Organism=Homo sapiens, GI4758380, Length=103, Percent_Identity=49.5145631067961, Blast_Score=98, Evalue=1e-21,
Organism=Homo sapiens, GI4503729, Length=98, Percent_Identity=51.0204081632653, Blast_Score=97, Evalue=2e-21,
Organism=Homo sapiens, GI192448443, Length=95, Percent_Identity=46.3157894736842, Blast_Score=91, Evalue=3e-19,
Organism=Homo sapiens, GI224809329, Length=86, Percent_Identity=50, Blast_Score=87, Evalue=3e-18,
Organism=Homo sapiens, GI224809327, Length=86, Percent_Identity=50, Blast_Score=87, Evalue=3e-18,
Organism=Homo sapiens, GI4758384, Length=86, Percent_Identity=50, Blast_Score=87, Evalue=3e-18,
Organism=Homo sapiens, GI224809331, Length=86, Percent_Identity=50, Blast_Score=85, Evalue=1e-17,
Organism=Homo sapiens, GI8923659, Length=107, Percent_Identity=45.7943925233645, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI206725547, Length=100, Percent_Identity=47, Blast_Score=81, Evalue=2e-16,
Organism=Homo sapiens, GI31317231, Length=101, Percent_Identity=47.5247524752475, Blast_Score=79, Evalue=9e-16,
Organism=Homo sapiens, GI33469985, Length=91, Percent_Identity=39.5604395604396, Blast_Score=77, Evalue=2e-15,
Organism=Homo sapiens, GI4503727, Length=97, Percent_Identity=42.2680412371134, Blast_Score=74, Evalue=2e-14,
Organism=Homo sapiens, GI150010552, Length=112, Percent_Identity=37.5, Blast_Score=74, Evalue=3e-14,
Organism=Homo sapiens, GI7706131, Length=95, Percent_Identity=40, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI87082390, Length=99, Percent_Identity=47.4747474747475, Blast_Score=87, Evalue=2e-19,
Organism=Escherichia coli, GI1789745, Length=104, Percent_Identity=44.2307692307692, Blast_Score=71, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17540882, Length=97, Percent_Identity=49.4845360824742, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71993519, Length=89, Percent_Identity=51.685393258427, Blast_Score=92, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17561782, Length=87, Percent_Identity=52.8735632183908, Blast_Score=86, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17561778, Length=97, Percent_Identity=42.2680412371134, Blast_Score=75, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17506167, Length=101, Percent_Identity=39.6039603960396, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17506169, Length=101, Percent_Identity=39.6039603960396, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17561780, Length=102, Percent_Identity=40.1960784313725, Blast_Score=71, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI71993555, Length=65, Percent_Identity=47.6923076923077, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324194, Length=107, Percent_Identity=51.4018691588785, Blast_Score=107, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6320727, Length=93, Percent_Identity=56.989247311828, Blast_Score=106, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6323482, Length=106, Percent_Identity=40.5660377358491, Blast_Score=77, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6323566, Length=106, Percent_Identity=38.6792452830189, Blast_Score=75, Evalue=2e-15,
Organism=Drosophila melanogaster, GI281363946, Length=94, Percent_Identity=59.5744680851064, Blast_Score=120, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17352457, Length=94, Percent_Identity=59.5744680851064, Blast_Score=120, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24655568, Length=89, Percent_Identity=55.0561797752809, Blast_Score=106, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24647110, Length=107, Percent_Identity=48.5981308411215, Blast_Score=95, Evalue=7e-21,
Organism=Drosophila melanogaster, GI21356629, Length=103, Percent_Identity=55.3398058252427, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24583150, Length=105, Percent_Identity=48.5714285714286, Blast_Score=92, Evalue=7e-20,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179 [H]

Pfam domain/function: PF00254 FKBP_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 11820; Mature: 11689

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSLIIEDLQEGFGKEAVKGKEITVHYTGWLEDGTKFDSSLDRRQPLTITLGVGQVIKGW
CCCCHHHHHHHCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCEEEEECCCHHHHHH
DEGFGGMKEGGKRKLTIPSEMGYGAHGAGGVIPPHATLIFEVELLKVYE
HCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEEEEECC
>Mature Secondary Structure 
GSLIIEDLQEGFGKEAVKGKEITVHYTGWLEDGTKFDSSLDRRQPLTITLGVGQVIKGW
CCCHHHHHHHCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCEEEEECCCHHHHHH
DEGFGGMKEGGKRKLTIPSEMGYGAHGAGGVIPPHATLIFEVELLKVYE
HCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]