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The map label for this gene is purC [H]

Identifier: 161777628

GI number: 161777628

Start: 838755

End: 839522

Strand: Reverse

Name: purC [H]

Synonym: Rru_A0711

Alternate gene names: 161777628

Gene position: 839522-838755 (Counterclockwise)

Preceding gene: 83592051

Following gene: 83592049

Centisome position: 19.29

GC content: 60.94

Gene sequence:

>768_bases
ATGGCACGACGCAAGCAGATTTACGAAGGCAAGGCCAAGGTCCTTTTCGAGGGTCCCGAGCCGGGCACGCTCGTCCAGTA
CTTCAAGGACGACGCGACCGCCTTCAATAACAAGAAGCACGGCACGATCACCGGCAAAGGCGTGCTCAACAACCGCATCA
GCGAATACCTGATGACCCGCCTGACCGAGATCGGCGTGCCCAATCACTTCGTGCGGCGGCTGAACATGCGCGAGCAGCTC
GTGCGTCAGGTCGAGATCATCCCCATCGAGGTGGTGATCCGCAACGTCGCCGCCGGCTCGATTTCGACCAAATTCGCCAT
CCCCGAAGGCACCCAGCTGCCGCGTTCGATCGTCGAGTACTATTACAAGAACGACGAATTGAACGATCCGATGGTGTCCG
AAGAGCATGTGACCGCCTTCGGCTGGGCCAGCGTTCAGGAACTCGACGAGATCTTGTCGCTGTCGCTGCGCATCAATGAT
TACCTCTCGGGCCTGTTCCTCGGCGTTCAGCTCCGCCTTGTCGACTTCAAGCTTGAATTCGGCCGGATCTACAACGAGAA
CGGCGACGTCCAGATCATCCTGGCCGACGAGATTTCGCCCGACAACTGCCGCCTGTGGGATGTCACCACCGGCGAGAAGC
TTGATAAGGACCGCTTCCGCCGCGATCTCGGCGGGGTCGCCGAGGCCTATCAGGAAGTGGCCCGCCGCCTGGGCATCCTT
CCCGAAGGCGGCCCGCGCGACATCAAGGGTCCGCCCGTGATGCAGTGA

Upstream 100 bases:

>100_bases
CTCCAGAGAGACCTCGGAGACCCCGAGGCGGATGTTTTCCTGTCAGCAGTCCGGATCACGGAACCTGGATCCGTGCCGGC
TCACTTCCGGGTTCCGCCCC

Downstream 100 bases:

>100_bases
CCTCGAAGCGGGCGGCGTAAGGCCGCCCGTTCGTTTTTTACAGGTTCCCCGCCCCCGTCCCCGAACGGAGAGGCGCAATG
TCCAAGGAGTACCCAACGGT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MARRKQIYEGKAKVLFEGPEPGTLVQYFKDDATAFNNKKHGTITGKGVLNNRISEYLMTRLTEIGVPNHFVRRLNMREQL
VRQVEIIPIEVVIRNVAAGSISTKFAIPEGTQLPRSIVEYYYKNDELNDPMVSEEHVTAFGWASVQELDEILSLSLRIND
YLSGLFLGVQLRLVDFKLEFGRIYNENGDVQIILADEISPDNCRLWDVTTGEKLDKDRFRRDLGGVAEAYQEVARRLGIL
PEGGPRDIKGPPVMQ

Sequences:

>Translated_255_residues
MARRKQIYEGKAKVLFEGPEPGTLVQYFKDDATAFNNKKHGTITGKGVLNNRISEYLMTRLTEIGVPNHFVRRLNMREQL
VRQVEIIPIEVVIRNVAAGSISTKFAIPEGTQLPRSIVEYYYKNDELNDPMVSEEHVTAFGWASVQELDEILSLSLRIND
YLSGLFLGVQLRLVDFKLEFGRIYNENGDVQIILADEISPDNCRLWDVTTGEKLDKDRFRRDLGGVAEAYQEVARRLGIL
PEGGPRDIKGPPVMQ
>Mature_254_residues
ARRKQIYEGKAKVLFEGPEPGTLVQYFKDDATAFNNKKHGTITGKGVLNNRISEYLMTRLTEIGVPNHFVRRLNMREQLV
RQVEIIPIEVVIRNVAAGSISTKFAIPEGTQLPRSIVEYYYKNDELNDPMVSEEHVTAFGWASVQELDEILSLSLRINDY
LSGLFLGVQLRLVDFKLEFGRIYNENGDVQIILADEISPDNCRLWDVTTGEKLDKDRFRRDLGGVAEAYQEVARRLGILP
EGGPRDIKGPPVMQ

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=252, Percent_Identity=31.3492063492063, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI5453539, Length=252, Percent_Identity=31.3492063492063, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI119220559, Length=259, Percent_Identity=30.1158301158301, Blast_Score=92, Evalue=4e-19,
Organism=Escherichia coli, GI1788820, Length=239, Percent_Identity=41.8410041841004, Blast_Score=203, Evalue=9e-54,
Organism=Caenorhabditis elegans, GI17531275, Length=233, Percent_Identity=29.6137339055794, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI18860083, Length=240, Percent_Identity=27.9166666666667, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24583917, Length=210, Percent_Identity=28.0952380952381, Blast_Score=77, Evalue=9e-15,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 28955; Mature: 28823

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARRKQIYEGKAKVLFEGPEPGTLVQYFKDDATAFNNKKHGTITGKGVLNNRISEYLMTR
CCCCHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHH
LTEIGVPNHFVRRLNMREQLVRQVEIIPIEVVIRNVAAGSISTKFAIPEGTQLPRSIVEY
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHH
YYKNDELNDPMVSEEHVTAFGWASVQELDEILSLSLRINDYLSGLFLGVQLRLVDFKLEF
HHCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEE
GRIYNENGDVQIILADEISPDNCRLWDVTTGEKLDKDRFRRDLGGVAEAYQEVARRLGIL
CCEECCCCCEEEEEECCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
PEGGPRDIKGPPVMQ
CCCCCCCCCCCCCCC
>Mature Secondary Structure 
ARRKQIYEGKAKVLFEGPEPGTLVQYFKDDATAFNNKKHGTITGKGVLNNRISEYLMTR
CCCHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHH
LTEIGVPNHFVRRLNMREQLVRQVEIIPIEVVIRNVAAGSISTKFAIPEGTQLPRSIVEY
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHH
YYKNDELNDPMVSEEHVTAFGWASVQELDEILSLSLRINDYLSGLFLGVQLRLVDFKLEF
HHCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEE
GRIYNENGDVQIILADEISPDNCRLWDVTTGEKLDKDRFRRDLGGVAEAYQEVARRLGIL
CCEECCCCCEEEEEECCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
PEGGPRDIKGPPVMQ
CCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA