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The map label for this gene is ubiE

Identifier: 161621790

GI number: 161621790

Start: 2103936

End: 2104694

Strand: Direct

Name: ubiE

Synonym: PPA1943

Alternate gene names: 161621790

Gene position: 2103936-2104694 (Clockwise)

Preceding gene: 50843389

Following gene: 50843393

Centisome position: 82.18

GC content: 61.79

Gene sequence:

>759_bases
GTGTTGACAACCCGAGCCACCCTGGACAAGCACCACGCTGACGTCGCATCGATGTTCGACGGGGTAGCGAAACGCTATGA
CCTCATGAACCAGATTATGACGCTCGGGGCGGTCGATACCTGGCGCGACCTCGTCGTCGACGCAGTAGAGCCCGAGCCCG
GCCAGACCATCCTCGATTTGGCGGCTGGAACCGGCACCTCTTCAGCTACCTTTGCCGCCCGCGGTGCGCAGGTTTATCCC
ACCGATATTTCCACCGGGATGCTGGCGGTGGGTAAGCAACGTCAGCCTCATCTGCACTTTGTCGCCGGGGATGCCACCTG
TTTGCCCTATGCCGATAATTCTTTTGACGCGGTGACGATCTCTTATGGTCTACGCAACGTCGAGGACCCCCACCAGGCGC
TGCGTGAGATGCTACGAGTCGCCAAACCGGGCGGTCGCGTCGTCATCTGCGAATTCTCGTACCCAACCTGGGCACCGTTC
CGTCACGTTTACACCAAGTATTTGCTGGCCGCGATCCCGGCGATGGCGCGGTTGGCCTCCTCAAACCGGCAAGCCTACGA
CTACCTGGCTGAGTCGATCCTCACTTGGCCCGATCAGCCACACCTGGCGGACATGATGACTGAAACCGGCTGGCAGGCCG
TGGCATGGCGCAATATTTGCGGTGGTGTGGTGGCTCTGCACCGTGGCTGGAAGGGTAGCGTCAGCCCGCGTTCCGGCGAC
CACCACGGCGACCCCGGGGAAGGAGATGGCCTGAGGTGA

Upstream 100 bases:

>100_bases
ACCCGCTCGAAGGGGCCAAGGGGGGGGGAGTCCCCCGCCGCACAAACTCAACCCGCTCGAGGGGGTCAAGGGGGAGTCGT
CTCCCCCTTACAATAAAACC

Downstream 100 bases:

>100_bases
GAGGCGCCTCCTCCCCCATCCTCCTCGATGCCTGGGCAGCTCGAAGTTGCCCGGTCAAAACCCAGAATGCCTTCGACCCA
CAACTGTCCGAGTCCGTTGG

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MLTTRATLDKHHADVASMFDGVAKRYDLMNQIMTLGAVDTWRDLVVDAVEPEPGQTILDLAAGTGTSSATFAARGAQVYP
TDISTGMLAVGKQRQPHLHFVAGDATCLPYADNSFDAVTISYGLRNVEDPHQALREMLRVAKPGGRVVICEFSYPTWAPF
RHVYTKYLLAAIPAMARLASSNRQAYDYLAESILTWPDQPHLADMMTETGWQAVAWRNICGGVVALHRGWKGSVSPRSGD
HHGDPGEGDGLR

Sequences:

>Translated_252_residues
MLTTRATLDKHHADVASMFDGVAKRYDLMNQIMTLGAVDTWRDLVVDAVEPEPGQTILDLAAGTGTSSATFAARGAQVYP
TDISTGMLAVGKQRQPHLHFVAGDATCLPYADNSFDAVTISYGLRNVEDPHQALREMLRVAKPGGRVVICEFSYPTWAPF
RHVYTKYLLAAIPAMARLASSNRQAYDYLAESILTWPDQPHLADMMTETGWQAVAWRNICGGVVALHRGWKGSVSPRSGD
HHGDPGEGDGLR
>Mature_252_residues
MLTTRATLDKHHADVASMFDGVAKRYDLMNQIMTLGAVDTWRDLVVDAVEPEPGQTILDLAAGTGTSSATFAARGAQVYP
TDISTGMLAVGKQRQPHLHFVAGDATCLPYADNSFDAVTISYGLRNVEDPHQALREMLRVAKPGGRVVICEFSYPTWAPF
RHVYTKYLLAAIPAMARLASSNRQAYDYLAESILTWPDQPHLADMMTETGWQAVAWRNICGGVVALHRGWKGSVSPRSGD
HHGDPGEGDGLR

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=259, Percent_Identity=33.5907335907336, Blast_Score=152, Evalue=2e-37,
Organism=Escherichia coli, GI48994983, Length=226, Percent_Identity=41.1504424778761, Blast_Score=188, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17557039, Length=227, Percent_Identity=35.6828193832599, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6323526, Length=241, Percent_Identity=28.6307053941909, Blast_Score=109, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24641702, Length=239, Percent_Identity=34.7280334728033, Blast_Score=149, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 27495; Mature: 27495

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTTRATLDKHHADVASMFDGVAKRYDLMNQIMTLGAVDTWRDLVVDAVEPEPGQTILDL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCEEEEE
AAGTGTSSATFAARGAQVYPTDISTGMLAVGKQRQPHLHFVAGDATCLPYADNSFDAVTI
CCCCCCCCCEEEECCCEEECCCCCCCHHHHCCCCCCCEEEEECCCEEECCCCCCCCEEEE
SYGLRNVEDPHQALREMLRVAKPGGRVVICEFSYPTWAPFRHVYTKYLLAAIPAMARLAS
ECCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
SNRQAYDYLAESILTWPDQPHLADMMTETGWQAVAWRNICGGVVALHRGWKGSVSPRSGD
CCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
HHGDPGEGDGLR
CCCCCCCCCCCC
>Mature Secondary Structure
MLTTRATLDKHHADVASMFDGVAKRYDLMNQIMTLGAVDTWRDLVVDAVEPEPGQTILDL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCEEEEE
AAGTGTSSATFAARGAQVYPTDISTGMLAVGKQRQPHLHFVAGDATCLPYADNSFDAVTI
CCCCCCCCCEEEECCCEEECCCCCCCHHHHCCCCCCCEEEEECCCEEECCCCCCCCEEEE
SYGLRNVEDPHQALREMLRVAKPGGRVVICEFSYPTWAPFRHVYTKYLLAAIPAMARLAS
ECCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
SNRQAYDYLAESILTWPDQPHLADMMTETGWQAVAWRNICGGVVALHRGWKGSVSPRSGD
CCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
HHGDPGEGDGLR
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572948; 12692562 [H]